Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes.

abstract：BACKGROUND:Previous studies have shown that pericytes can differentiate into osteoblasts and form bone. This study investigated whether pericytes can also differentiate into chondrocytes and adipocytes. METHODS AND RESULTS:Reverse transcription-polymerase chain reaction demonstrated that pericytes express mRNA for the...

journal_title：Circulation

authors： Farrington-Rock C,Crofts NJ,Doherty MJ,Ashton BA,Griffin-Jones C,Canfield AE

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with improved event-free survival. METHODS AND RESULTS:We studied the...

journal_title：Circulation

authors： Muhlbaier LH,Pryor DB,Rankin JS,Smith LR,Mark DB,Jones RH,Glower DD,Harrell FE Jr,Lee KL,Califf RM

更新日期：1992-11-01 00:00:00

abstract：:In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a cl...

journal_title：Circulation

authors： Rinaldi G,Cingolani H

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Although LDL cholesterol (LDL-C) is generally accepted to be a major risk factor for progression of atherosclerosis, the traditional measurement of LDL-C includes measurement of IDL. Little is known about the relationship between IDL and progression of atherosclerosis. Therefore, we investigated the associat...

journal_title：Circulation

authors： Hodis HN,Mack WJ,Dunn M,Liu C,Liu C,Selzer RH,Krauss RM

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:In a correlative functional/histopathologic study, we investigated the regional deformation characteristics of both chronic nontransmural and transmural infarctions before and after a dobutamine challenge. METHODS AND RESULTS:After stenosing copper-coated stent implantation to produce circumflex artery endo...

journal_title：Circulation

authors： Weidemann F,Dommke C,Bijnens B,Claus P,D'hooge J,Mertens P,Verbeken E,Maes A,Van de Werf F,De Scheerder I,Sutherland GR

更新日期：2003-02-18 00:00:00

abstract：BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...

journal_title：Circulation

authors： Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Cardiac mechanical restitution and relaxation restitution are thought to be physiological correlates of the recovery kinetics of Ca2+ release mechanisms and sequestration capacity of the sarcoplasmic reticulum (SR). Since congestive heart failure is characterized by abnormal intracellular Ca2+ handling, we s...

journal_title：Circulation

authors： Prabhu SD,Freeman GL

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Considerable controversy exists on the association between coffee consumption and cardiovascular disease (CVD) risk. A meta-analysis was performed to assess the dose-response relationship of long-term coffee consumption with CVD risk. METHODS AND RESULTS:PubMed and EMBASE were searched for prospective cohor...

journal_title：Circulation

authors： Ding M,Bhupathiraju SN,Satija A,van Dam RM,Hu FB

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not b...

journal_title：Circulation

authors： Stienen S,Salah K,Moons AH,Bakx AL,van Pol P,Kortz RAM,Ferreira JP,Marques I,Schroeder-Tanka JM,Keijer JT,Bayés-Genis A,Tijssen JGP,Pinto YM,Kok WE

更新日期：2018-04-17 00:00:00

abstract：:Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...

journal_title：Circulation

authors： Yasue H,Nagao M,Omote S,Takizawa A,Miwa K,Tanaka S

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND:Memory is a diverse biological phenomenon whose importance in the ventricle has been demonstrated. We hypothesized its occurrence in the atrium, contributing to the modulation of cardiac rhythm. METHODS AND RESULTS:We analyzed P and Ta waves in conscious chronically instrumented dogs with complete heart blo...

journal_title：Circulation

authors： Herweg B,Chang F,Chandra P,Danilo P Jr,Rosen MR

更新日期：2001-01-23 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteris...

journal_title：Circulation

authors： Chiang CE,Chen SA,Tai CT,Wu TJ,Lee SH,Cheng CC,Chiou CW,Ueng KC,Wen ZC,Chang MS

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Denervation supersensitivity has been proposed as a mechanism for the relation between ventricular arrhythmias and the sympathetic nervous system. Evaluation of this phenomenon in humans has become feasible only recently with the development of noninvasive scintigraphic methods for evaluating the pattern of ...

journal_title：Circulation

authors： Calkins H,Allman K,Bolling S,Kirsch M,Wieland D,Morady F,Schwaiger M

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Outcomes for organ transplantation are constantly improving because of advances in organ preservation, surgical techniques, immune clinical monitoring, and immunosuppressive treatment preventing acute transplant rejection. However, chronic rejection including transplant vasculopathy still limits long-term pa...

journal_title：Circulation

authors： Galvani S,Trayssac M,Augé N,Thiers JC,Calise D,Krell HW,Sallusto F,Kamar N,Rostaing L,Thomsen M,Nègre-Salvayre A,Salvayre R

更新日期：2011-12-13 00:00:00

abstract：BACKGROUND:Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric protein that dynamically regulates thick-filament structure and function. In constitutive cMyBP-C knockout (cMyBP-C(-/-)) mice, loss of cMyBP-C has been linked to left ventricular dilation, cardiac hypertrophy, and systolic and diastolic dysfunction,...

journal_title：Circulation

authors： Chen PP,Patel JR,Powers PA,Fitzsimons DP,Moss RL

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefo...

journal_title：Circulation

authors： Zhang L,Zhang ZG,Ding GL,Jiang Q,Liu X,Meng H,Hozeska A,Zhang C,Li L,Morris D,Zhang RL,Lu M,Chopp M

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS:We fitted a locally weighted polynomial regression...

journal_title：Circulation

authors： Phillips DP,Jarvinen JR,Abramson IS,Phillips RR

更新日期：2004-12-21 00:00:00

abstract：:A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...

journal_title：Circulation

authors： Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compa...

journal_title：Circulation

authors： Fearon WF,Nishi T,De Bruyne B,Boothroyd DB,Barbato E,Tonino P,Jüni P,Pijls NHJ,Hlatky MA,FAME 2 Trial Investigators.

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:Development of surgical therapy for aortic aneurysms and dissections has led to treatment of the life-threatening cardiovascular complications associated with Marfan syndrome. The present study determines the effect of surgical therapy on the life expectancy of patients with Marfan syndrome and the clinical ...

journal_title：Circulation

authors： Finkbohner R,Johnston D,Crawford ES,Coselli J,Milewicz DM

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial nitric oxide synthase (eNOS) expression. The mechanism by which hypoxia decreases eNOS expression is not known but may involve Rho-kinase-induced ...

journal_title：Circulation

authors： Takemoto M,Sun J,Hiroki J,Shimokawa H,Liao JK

更新日期：2002-07-02 00:00:00

abstract：:To describe the coronary arteriographic findings during early transmural myocardial infarction and to define the prevalence of coronary thrombosis by arteriography, we performed coronary arteriography and left ventriculography within 24 hours from symptom onset of transmural myocardial infarction in 517 patients. The ...

journal_title：Circulation

authors： DeWood MA,Spores J,Hensley GR,Simpson CS,Eugster GS,Sutherland KI,Grunwald RP,Shields JP

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS:We examined 1) the effects of HS on ANP- or br...

journal_title：Circulation

authors： Hirata Y,Matsuoka H,Suzuki E,Hayakawa H,Sugimoto T,Matsuda Y,Morishita Y,Kangawa K,Minamino N,Matsuo H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The degree of protection provided to the right ventricle during retrograde continuous normothermic blood cardioplegia (RCNBC) remains controversial. The purpose of this study was to determine whether RCNBC is able to provide "adequate" nutritive flow to both ventricles to prevent ischemic metabolism in norma...

journal_title：Circulation

authors： Ye J,Sun J,Shen J,Gregorash L,Summers R,Salerno TA,Deslauriers R

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:More than 300 000 out-of-hospital cardiac arrests (OHCA) occur each year in the United States. The relationship between time of day and OHCA outcomes in the prehospital setting is unknown. Any such association may have important implications for emergency medical services resource allocation. METHODS AND RE...

journal_title：Circulation

authors： Wallace SK,Abella BS,Shofer FS,Leary M,Agarwal AK,Mechem CC,Gaieski DF,Becker LB,Neumar RW,Band RA

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...

journal_title：Circulation

authors： Rimensberger PC,Spahr-Schopfer I,Berner M,Jaeggi E,Kalangos A,Friedli B,Beghetti M

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia (FPVT) is characterized by exercise-induced arrhythmias and sudden cardiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+ release channel required for excitation-contraction coupling in the heart. METHODS AND RESUL...

journal_title：Circulation

authors： Lehnart SE,Wehrens XH,Laitinen PJ,Reiken SR,Deng SX,Cheng Z,Landry DW,Kontula K,Swan H,Marks AR

更新日期：2004-06-29 00:00:00

abstract：BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...

journal_title：Circulation

authors： Felkin LE,Narita T,Germack R,Shintani Y,Takahashi K,Sarathchandra P,López-Olañeta MM,Gómez-Salinero JM,Suzuki K,Barton PJ,Rosenthal N,Lara-Pezzi E

更新日期：2011-06-21 00:00:00

abstract：BACKGROUND:Concern that trans-fatty acids formed in the partial hydrogenation of vegetable oils may increase the risk of coronary disease has existed for several decades, but direct evidence on this relation in humans is limited. METHODS AND RESULTS:With a case-control design, we studied the association between intake...

journal_title：Circulation

authors： Ascherio A,Hennekens CH,Buring JE,Master C,Stampfer MJ,Willett WC

更新日期：1994-01-01 00:00:00