Correlation between scintigraphic evidence of regional sympathetic neuronal dysfunction and ventricular refractoriness in the human heart.

abstract：:In 15 of 126 (12%) patients with truncus arteriosus who were catheterized at the Mayo Clinic from 1967 through 1975, natural agenesis of one pulmonary artery was present. Ten truncus patients with either natural or acquired absence of one pulmonary artery have undergone definitive operation. The criteria for operabili...

journal_title：Circulation

authors： Mair DD,Ritter DG,Danielson GK,Wallace RB,McGoon DC

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:To formally test whether the antiapoptotic protein bcl-2 would prevent programmed cell death in cardiac muscle cells provoked by p53, a known trigger of apoptosis in a variety of different cell types, we used replication defective adenovirus encoding either the bcl-2 and p53 genes to deliver bcl-2 and p53 to...

journal_title：Circulation

authors： Kirshenbaum LA,de Moissac D

更新日期：1997-09-02 00:00:00

abstract：:Fifty patients who presented with angina pectoris were studied to examine the disturbances of regional myocardial perfusion during stress. Each patient underwent 16-point precordial mapping of the ECG during an exercise test, and coronary and left ventricular angiography. Regional myocardial perfusion was assessed usi...

journal_title：Circulation

authors： Selwyn AP,Forse G,Fox K,Jonathan A,Steiner R

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Atrial dysrhythmia patients have exaggerated intra-atrial conduction delays and prolonged relative refractoriness in response to atrial premature depolarizations (APDs). Furthermore, atrial fibrillation (AF) is more readily inducible by APDs from the high right atrium (HRA) than the coronary sinus (CS). In t...

journal_title：Circulation

authors： Papageorgiou P,Monahan K,Boyle NG,Seifert MJ,Beswick P,Zebede J,Epstein LM,Josephson ME

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on eff...

journal_title：Circulation

authors： Gottdiener JS,Reda DJ,Williams DW,Materson BJ,Cushman W,Anderson RJ

更新日期：1998-07-14 00:00:00

abstract：BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...

journal_title：Circulation

authors： Chen LW,Dai XF,Lu L,Zhang GC,Cao H

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:A hallmark of heart failure is impaired cytoplasmic Ca(2+) handling of cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca(2+) handling via altered excitation-transcription coupling contribute to the development and progression of heart failure. METHODS AND RESULTS:Using tissue and...

journal_title：Circulation

authors： Ljubojevic S,Radulovic S,Leitinger G,Sedej S,Sacherer M,Holzer M,Winkler C,Pritz E,Mittler T,Schmidt A,Sereinigg M,Wakula P,Zissimopoulos S,Bisping E,Post H,Marsche G,Bossuyt J,Bers DM,Kockskämper J,Pieske B

更新日期：2014-07-15 00:00:00

abstract：:Using nondenaturing polyacrylamide gel electrophoresis, we have identified two distinct myosin isoenzymes in human atrial tissue that correspond to the V1 and V3 isomyosins found in rat ventricular tissue. Normal left and right atrial appendages have approximately 50% V3. When the left atrium was exposed to hemodynami...

journal_title：Circulation

authors： Buttrick PM,Malhotra A,Brodman R,McDermott L,Lam L

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte a...

journal_title：Circulation

authors： Zhang WJ,Bird KE,McMillen TS,LeBoeuf RC,Hagen TM,Frei B

更新日期：2008-01-22 00:00:00

abstract：:The linearity and sensitivity of the end-systolic pressure-volume (P-Ves) relation to the inotropic state of the left ventricle were investigated in 11 patients with coronary heart disease and one patient with congestive cardiomyopathy. To minimize autonomic reflex responses, propranolol, 0.15 mg/kg, and atropine, 1 m...

journal_title：Circulation

authors： Mehmel HC,Stockins B,Ruffmann K,von Olshausen K,Schuler G,Kübler W

更新日期：1981-06-01 00:00:00

abstract：:The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...

journal_title：Circulation

authors： Adelstein SJ,Jansen C,Wagner HN Jr

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...

journal_title：Circulation

authors： Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK signaling has a role in the regulation of the angiotensin II (Ang II)-induced proliferation signal in rat vascular smooth muscle cells (VSMCs). ...

journal_title：Circulation

authors： Nagata D,Takeda R,Sata M,Satonaka H,Suzuki E,Nagano T,Hirata Y

更新日期：2004-07-27 00:00:00

abstract：:We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...

journal_title：Circulation

authors： Shaddy RE,Sturtevant JE,Judd VE,McGough EC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...

journal_title：Circulation

authors： Fan D,Wannenburg T,de Tombe PP

更新日期：1997-05-06 00:00:00

abstract：BACKGROUND:Recent studies have suggested that endogenous erythropoietin (Epo) plays an important role in the mobilization of bone marrow-derived endothelial progenitor cells (EPCs). However, it remains to be elucidated whether the Epo system exerts protective effects on pulmonary hypertension (PH), a fatal disorder enc...

journal_title：Circulation

authors： Satoh K,Kagaya Y,Nakano M,Ito Y,Ohta J,Tada H,Karibe A,Minegishi N,Suzuki N,Yamamoto M,Ono M,Watanabe J,Shirato K,Ishii N,Sugamura K,Shimokawa H

更新日期：2006-03-21 00:00:00

abstract：BACKGROUND:The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion. METHODS AND RESULTS:Thirty-six patients were prospectively randomiz...

journal_title：Circulation

authors： Shaddy RE,Boucek MM,Sturtevant JE,Ruttenberg HD,Jaffe RB,Tani LY,Judd VE,Veasy LG,McGough EC,Orsmond GS

更新日期：1993-03-01 00:00:00

abstract：:The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two agents that block sodium channels by binding to this receptor are expected to compete for occupancy. Glycylxylidide (GX) is a deethylated metabolite of lidocaine that accumulates in patients ...

journal_title：Circulation

authors： Bennett PB,Woosley RL,Hondeghem LM

更新日期：1988-09-01 00:00:00

abstract：:A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we p...

journal_title：Circulation

authors： Farrar DJ,Compton PG,Dajee H,Fonger JD,Hill JD

更新日期：1984-10-01 00:00:00

abstract：:A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a contradiction to that rule and suggests that further study must ...

journal_title：Circulation

authors： Bisset GS 3rd,Hirschfeld SS

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Long-term beta-adrenergic blockade does not appear to be associated with drug-induced training in patients with congestive heart failure (CHF); whether exercise training can increase peak aerobic capacity in patients with CHF who are treated with beta-adrenergic blockers is currently unknown. METHODS AND RE...

journal_title：Circulation

authors： Demopoulos L,Yeh M,Gentilucci M,Testa M,Bijou R,Katz SD,Mancini D,Jones M,LeJemtel TH

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) and angiotensin II (Ang II) modulate heart failure in part by provoking the hypertrophic response. Signal transduction pathways of those factors are implicated in reactive oxygen intermediates (ROIs). Therefore, we hypothesized that TNF-alpha and Ang II might cause myo...

journal_title：Circulation

authors： Nakamura K,Fushimi K,Kouchi H,Mihara K,Miyazaki M,Ohe T,Namba M

更新日期：1998-08-25 00:00:00

abstract：BACKGROUND:There are several potential physiological differences between the atriopulmonary (AP) and the total cavopulmonary connection (TCPC) Fontan circulations. Studies suggest that the TCPC reduces energy loss due to turbulence and may have more dependence on respiratory movement for pulmonary blood flow. We compar...

journal_title：Circulation

authors： Rosenthal M,Bush A,Deanfield J,Redington A

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxati...

journal_title：Circulation

authors： Opdahl A,Remme EW,Helle-Valle T,Lyseggen E,Vartdal T,Pettersen E,Edvardsen T,Smiseth OA

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

journal_title：Circulation

authors： Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

更新日期：1993-08-01 00:00:00

abstract：:The specific and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AMI) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chlorid...

journal_title：Circulation

authors： Varat MA,Mercer DW

更新日期：1975-05-01 00:00:00

abstract：:In this study we quantitated the region of preserved myocardium between a subendocardial myocardial infarct (SEMI) and the endocardium in dogs and determined whether this preserved zone was within the region at risk and whether infarct extension could occur in this region. We also evaluated whether a similar subendoca...

journal_title：Circulation

authors： Forman R,Cho S,Factor SM,Kirk ES

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The Rho/Rho-associated kinase (Rho-kinase) system is implicated in various cellular functions, including migration, proliferation, and apoptosis. Because a possible role of the system is suggested in neointima formation after vascular injury, we sought to examine whether a new specific Rho-kinase inhibitor, ...

journal_title：Circulation

authors： Shibata R,Kai H,Seki Y,Kato S,Morimatsu M,Kaibuchi K,Imaizumi T

更新日期：2001-01-16 00:00:00

abstract：BACKGROUND:Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of treatment. Obesity is common in HFpEF and has many cardiovascular effects, suggesting that it may be a viable candidate for...

journal_title：Circulation

authors： Obokata M,Reddy YNV,Pislaru SV,Melenovsky V,Borlaug BA

更新日期：2017-07-04 00:00:00

abstract：:To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spre...

journal_title：Circulation

authors： Beppu S,Izumi S,Miyatake K,Nagata S,Park YD,Sakakibara H,Nimura Y

更新日期：1988-07-01 00:00:00