Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.

abstract：BACKGROUND:Friedreich's ataxia (FA), the most common inherited ataxia, is associated frequently with cardiac hypertrophy, and death is often cardiac related. Recently, the disease has been associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the gene encoding frataxin ...

journal_title：Circulation

authors： Isnard R,Kalotka H,Dürr A,Cossée M,Schmitt M,Pousset F,Thomas D,Brice A,Koenig M,Komajda M

更新日期：1997-05-06 00:00:00

abstract：:Reperfusion of the globally ischemic myocardium with mannitol has been shown to preserve myocardial function. However, it remains unclear whether the mechanism of mannitol protection relates to its hyperosmolar or free radical scavenging properties. Three groups of isolated, perfused rabbit hearts underwent 45 min of ...

journal_title：Circulation

authors： Ouriel K,Ginsburg ME,Patti CS,Pearce FJ,Hicks GL

更新日期：1985-09-01 00:00:00

abstract：:Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, ...

journal_title：Circulation

authors： Pritchett EL,Anderson RW,Benditt DG,Kasell J,Harrison L,Wallace AG,Sealy WC,Gallagher JJ

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS:To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared...

journal_title：Circulation

authors： Zhang X,Zhang W,Ma SF,Desai AA,Saraf S,Miasniakova G,Sergueeva A,Ammosova T,Xu M,Nekhai S,Abbasi T,Casanova NG,Steinberg MH,Baldwin CT,Sebastiani P,Prchal JT,Kittles R,Garcia JG,Machado RF,Gordeuk VR

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Continuous whole-body perfusion for > 3 hours with a cold asanguineous blood substitute, hypothermosol (HTS) solution, has been reported to preserve organ function. We used this solution in a survival animal model to evaluate its possible application in extending the safe duration of deep hypothermic circula...

journal_title：Circulation

authors： Miura T,Laussen P,Lidov HG,DuPlessis A,Shin'oka T,Jonas RA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:At physiological concentrations, 17beta-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. METHODS AND RESULTS:To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and mi...

journal_title：Circulation

authors： Guetta V,Quyyumi AA,Prasad A,Panza JA,Waclawiw M,Cannon RO 3rd

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity with no previous evaluation of the literature. This systematic review aims to (1) quantify the prevalence, risk factors, and 12-month prognosis in patients with MINOCA, and (2) evaluate potential pathophysiolog...

journal_title：Circulation

authors： Pasupathy S,Air T,Dreyer RP,Tavella R,Beltrame JF

更新日期：2015-03-10 00:00:00

abstract：:Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...

journal_title：Circulation

authors： Shea S,Cook EF,Kannel WB,Goldman L

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Continuous positive airway pressure (CPAP) can improve cardiac function in patients with congestive heart failure (CHF). We hypothesized that this effect might be related to CPAP-induced increases in intrathoracic pressure, which would reduce left ventricular transmural pressure (LVPtm) during systole, there...

journal_title：Circulation

authors： Naughton MT,Rahman MA,Hara K,Floras JS,Bradley TD

更新日期：1995-03-15 00:00:00

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Systemic administration of heparin can decrease mortality and morbidity of acute ischemic coronary syndromes such as unstable angina and myocardial infarction. Hemorrhage is the major limiting factor in the clinical use of systemic heparin. The objective of the present study was to determine whether local de...

journal_title：Circulation

authors： Nunes GL,Thomas CN,Hanson SR,Barry JJ,King SB 3rd,Scott NA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:We attempted to characterize age-related changes in blood pressure in both normotensive and untreated hypertensive subjects in a population-based cohort from the original Framingham Heart Study and to infer underlying hemodynamic mechanisms. METHODS AND RESULTS:A total of 2036 participants were divided into...

journal_title：Circulation

authors： Franklin SS,Gustin W 4th,Wong ND,Larson MG,Weber MA,Kannel WB,Levy D

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Indications for surgical correction of aortic regurgitation have been established mostly in men and have not been validated in women. The outcome of this surgical correction in women is unknown. METHODS AND RESULTS:Baseline characteristics and postoperative outcomes were compared between 51 women and 198 me...

journal_title：Circulation

authors： Klodas E,Enriquez-Sarano M,Tajik AJ,Mullany CJ,Bailey KR,Seward JB

更新日期：1996-11-15 00:00:00

abstract：:This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and th...

journal_title：Circulation

authors： Yusuf S,Reddy S,Ounpuu S,Anand S

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:Activated fibroblasts (myofibroblasts) play a critical role in cardiac fibrosis; however, their origin in the diseased heart remains unclear, warranting further investigation. Recent studies suggest the contribution of bone marrow fibroblast progenitor cells (BM-FPCs) in pressure overload-induced cardiac fib...

journal_title：Circulation

authors： Verma SK,Garikipati VNS,Krishnamurthy P,Schumacher SM,Grisanti LA,Cimini M,Cheng Z,Khan M,Yue Y,Benedict C,Truongcao MM,Rabinowitz JE,Goukassian DA,Tilley D,Koch WJ,Kishore R

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Depletion of L-arginine (L-arg), the substrate for nitric oxide (NO) synthesis, could be one of the mechanisms responsible for the reduced production of NO and decreased coronary flow (CF) during reperfusion. This, in turn, may adversely affect mechanical function. We aimed to study the benefits of exogenous...

journal_title：Circulation

authors： Amrani M,Gray CC,Smolenski RT,Goodwin AT,London A,Yacoub MH

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined. METHODS AND RESULTS:United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146,973). Medica...

journal_title：Circulation

authors： Guo H,Kalra PA,Gilbertson DT,Liu J,Chen SC,Collins AJ,Foley RN

更新日期：2007-01-02 00:00:00

abstract：BACKGROUND:Congenital long-QT syndrome (LQTS) is a primary arrhythmogenic syndrome stemming from perturbed cardiac repolarization. LQTS, which affects approximately 1 in 3000 persons, is 1 of the most common causes of autopsy-negative sudden death in the young. Since the sentinel discovery of cardiac channel gene mutat...

journal_title：Circulation

authors： Vatta M,Ackerman MJ,Ye B,Makielski JC,Ughanze EE,Taylor EW,Tester DJ,Balijepalli RC,Foell JD,Li Z,Kamp TJ,Towbin JA

更新日期：2006-11-14 00:00:00

abstract：BACKGROUND:Since 1990, sternotomy has been the preferred approach for construction of a modified Blalock-Taussig shunt (MBTS) at Children's Hospital, Boston, Mass. In retrospect, we sought to test the hypothesis that this approach yields less mortality and morbidity than the traditional thoracotomy approach. METHODS A...

journal_title：Circulation

authors： Odim J,Portzky M,Zurakowski D,Wernovsky G,Burke RP,Mayer JE Jr,Castaneda AR,Jonas RA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...

journal_title：Circulation

authors： Fan D,Wannenburg T,de Tombe PP

更新日期：1997-05-06 00:00:00

abstract：:Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common path...

journal_title：Circulation

authors： Miller JM,Rosenthal ME,Vassallo JA,Josephson ME

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Esophageal injury is a potential complication after intraoperative or percutaneous transcatheter ablation of the posterior aspect of the left atrium. Understanding the spatial relations between the esophagus and the left atrium is essential to reduce risks. METHODS AND RESULTS:We examined by gross dissectio...

journal_title：Circulation

authors： Sánchez-Quintana D,Cabrera JA,Climent V,Farré J,Mendonça MC,Ho SY

更新日期：2005-09-06 00:00:00

abstract：:Platelets have been implicated in the pathogenesis of coronary artery disease, and a number of studies have examined platelet function and coagulation parameters in such patients. We have examined platelet coagulant activities, volumes, and aggregate ratios in 23 patients with chest pain, seven of whom had normal coro...

journal_title：Circulation

authors： Rao AK,Mintz PD,Lavine SJ,Bove AA,McDonough MT,Spann JF,Walsh PN

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques has not been studied. Our hypothesis was that the lowest values of ESS are responsible for the development of high-risk c...

journal_title：Circulation

authors： Chatzizisis YS,Jonas M,Coskun AU,Beigel R,Stone BV,Maynard C,Gerrity RG,Daley W,Rogers C,Edelman ER,Feldman CL,Stone PH

更新日期：2008-02-26 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Smoking cessation is a key component of secondary cardiovascular disease prevention. Varenicline, a partial alpha4beta2 nicotinic acetylcholine receptor agonist, is effective for smoking cessation in healthy smokers, but its efficacy and safety in smokers with cardiovascular disease are unknown. METHODS AND...

journal_title：Circulation

authors： Rigotti NA,Pipe AL,Benowitz NL,Arteaga C,Garza D,Tonstad S

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vascular walls. We studied ...

journal_title：Circulation

authors： Mäki JM,Räsänen J,Tikkanen H,Sormunen R,Mäkikallio K,Kivirikko KI,Soininen R

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...

journal_title：Circulation

authors： Miller DD,Donohue TJ,Younis LT,Bach RG,Aguirre FV,Wittry MD,Goodgold HM,Chaitman BR,Kern MJ

更新日期：1994-05-01 00:00:00

abstract：:The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angi...

journal_title：Circulation

authors： Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

更新日期：1986-03-01 00:00:00