Abstract:
:Reperfusion of the globally ischemic myocardium with mannitol has been shown to preserve myocardial function. However, it remains unclear whether the mechanism of mannitol protection relates to its hyperosmolar or free radical scavenging properties. Three groups of isolated, perfused rabbit hearts underwent 45 min of normothermic ischemia without cardioplegia in an experimental paradigm analogous to the clinical situation of coronary artery thrombosis with subsequent reperfusion. Six hearts were reperfused with an isosmolar solution, eight hearts were reperfused with a mannitol-containing solution (20 mOsm/liter), and five hearts were reperfused with a solution containing additional sodium chloride (10 meq/liter, 20 mOsm/liter) to control for the hyperosmotic effects of mannitol. Left ventricular developed pressure, its derivative dP/dt, and diastolic compliance were all significantly improved in the mannitol-reperfused hearts when compared with the hypertonic saline and control groups (p less than .05). There were no intergroup differences in myocardial edema formation, oxygen consumption, or lactate production. These data indicate that mannitol reperfusion offers significant myocardial protection independent of hyperosmolar properties. Free radical scavenging activity appears to be the most credible explanation for these observations, although confirmation of this mechanism awaits further biochemical and cellular investigation.
journal_name
Circulationjournal_title
Circulationauthors
Ouriel K,Ginsburg ME,Patti CS,Pearce FJ,Hicks GLsubject
Has Abstractpub_date
1985-09-01 00:00:00pages
II254-8issue
3 Pt 2eissn
0009-7322issn
1524-4539journal_volume
72pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholester...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000131512.50667.46
更新日期:2004-06-15 00:00:00
abstract::In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.71.4.787
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.2.190
更新日期:1995-07-15 00:00:00
abstract:BACKGROUND:Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity with no previous evaluation of the literature. This systematic review aims to (1) quantify the prevalence, risk factors, and 12-month prognosis in patients with MINOCA, and (2) evaluate potential pathophysiolog...
journal_title:Circulation
pub_type: 杂志文章,meta分析,评审
doi:10.1161/CIRCULATIONAHA.114.011201
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:There are no reported studies on the safety and efficacy of low-dose aspirin with low-intensity oral anticoagulation in patients with heart valve replacement. In this study, we compared the use of 100 mg/d aspirin with 650 mg/d aspirin in the prevention of systemic embolism and vascular death in patients wit...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.94.9.2113
更新日期:1996-11-01 00:00:00
abstract::With the advent of reliable prosthetic valves, the number of aortic valvuloplastic procedures performed in adults has decreased significantly. This is in contradistinction to patients with congenital aortic stenosis, in whom aortic valvuloplasty remains the primary approach. Although only a 25% to 50% incidence of lon...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
abstract::Cardiac allograft vasculopathy (CAV) remains a troublesome long-term complication of heart transplantation. It is manifested by a unique and unusually accelerated form of coronary disease affecting both intramural and epicardial coronary arteries and veins.CAV is characterized by vascular injury induced by a variety o...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.96.6.2069
更新日期:1997-09-16 00:00:00
abstract:BACKGROUND:The heart contains a variety of morphologically distinct nerve terminals known to influence cardiac function. Little is known about the distribution, morphology, and neurochemistry of these terminals in the human heart. METHODS AND RESULTS:We examined the entire endocardial and epicardial surfaces of infant...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.8.2343
更新日期:1995-10-15 00:00:00
abstract::The pulmonary function of ten adult patients with congenital pulmonary valvular stenosis was investigated. The patients clearly showed smaller lungs than healthy control subjects of equivalent age and height; lung elastic recoil pressure was normal at any given percentage of measured total lung capacity, indicating th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.4.647
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000038112.64503.6e
更新日期:2002-11-19 00:00:00
abstract::Expansion (regional dilatation and thinning) of acutely infarcted myocardium in man has been shown to correlate with overall cardiac dilatation and rupture. We studied gross and histopathologic features and the time course of expansion in rats. Infarcts were produced in 84 rats by ligation of the left coronary artery ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.65.7.1446
更新日期:1982-06-01 00:00:00
abstract::Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.6.1179
更新日期:1980-06-01 00:00:00
abstract::Although past reports have identified a variety of prognostic factors in patients with severe chronic heart failure, previous studies have not evaluated the interaction of prognostic variables and drug treatment. We analyzed the association of 30 clinical, hemodynamic, and biochemical variables with survival in 203 co...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.2.257
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.3.1216
更新日期:1991-09-01 00:00:00
abstract::Long-term tocainide therapy has been evaluated in 17 patients with ventricular arrhythmias. Ventricular tachycardia and/or fibrillation was recurrent and sustained in nine patients, and symptomatic but unsustained in three others. Five patients had frequent but only mildly symptomatic ventricular irritability. In all ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.5.1008
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery. METHODS AND RESULTS:Random...
journal_title:Circulation
pub_type: 杂志文章,meta分析
doi:10.1161/CIRCULATIONAHA.108.848218
更新日期:2009-04-14 00:00:00
abstract::The clinical use of citrate-phosphate-dextrose during blood-product transfusion is known to affect ionized calcium levels and can result in depression of myocardial contractility. The immature heart appears to have an intrinsic reduction in contractile state compared with the adult heart and may be more dependent on t...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Myocardial afterload depends on left ventricular (LV) cavity size, pressure, and wall thickness, all of which change markedly throughout ejection. We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.829366
更新日期:2009-06-02 00:00:00
abstract:BACKGROUND:Familial hypercholesterolemia (FH), an autosomal codominant disease, is characterized by high levels of LDL cholesterol and a high incidence of coronary artery disease (CAD). To date, genetic heterogeneity has hindered the proper assessment of the relation between risk factors and CAD in FH patients. METHOD...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.3.290
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical features of 2 new SCN5A mu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0302.102592
更新日期:2002-01-22 00:00:00
abstract:BACKGROUND:The role of angiotensin II receptor subtypes was investigated in focal brain ischemia induced by middle cerebral artery (MCA) occlusion. METHODS AND RESULTS:In Agtr2+ (wild-type) mice, MCA occlusion induced focal ischemia of approximately 20% to 30% of the total area in coronal section of the brain. The isc...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000138848.58269.80
更新日期:2004-08-17 00:00:00
abstract::In 15 of 126 (12%) patients with truncus arteriosus who were catheterized at the Mayo Clinic from 1967 through 1975, natural agenesis of one pulmonary artery was present. Ten truncus patients with either natural or acquired absence of one pulmonary artery have undergone definitive operation. The criteria for operabili...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.4.641
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000129310.17277.E7
更新日期:2004-06-15 00:00:00
abstract:BACKGROUND:This study examined revascularization rates after acute myocardial infarction (AMI) for Aboriginal and non-Aboriginal patients sequentially controlling for admitting hospital and risk factors. METHODS AND RESULTS:Hospital data from the state of New South Wales, Australia (July 2000 through December 2008) we...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.112.000566
更新日期:2013-02-19 00:00:00
abstract:BACKGROUND:ε protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis. METHODS AND RESULTS:Rat models of aortic balloon injury with or without subsequent st...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.927640
更新日期:2010-09-14 00:00:00
abstract::Thirty-one published reports (366 patients) and 48 consecutive patients treated for postinfarction ventricular septal defect at four institutions in northern California were reviewed. Overall hospital mortality was 43% in the reviewed group and was not affected by age, concomitant myocardial revascularization, date of...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
abstract::The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.1.217
更新日期:1987-07-01 00:00:00
abstract::The effect of cycle length on atrial vulnerability was studied in 14 patients manifesting reproducible repetitive atrial firing during atrial extra-stimulus (A2) testing. Repetitive atrial firing was defined as the occurrence of two or more premature atrial responses with return cycle (A2-A3) of 250 msec or less and s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.2.260
更新日期:1977-02-01 00:00:00
abstract::Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs, and lower triglyceride levels in hypertriglyceridemic patients. Statins are well tolerated and have an excellent ...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.101.2.207
更新日期:2000-01-18 00:00:00
abstract:BACKGROUND:Brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP have recently emerged as promising parameters for risk assessment in acute pulmonary embolism (PE). However, their positive predictive value is low, and the prognostic implications of NT-proBNP or troponin elevation alone are questionable. METHODS A...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.105.552216
更新日期:2005-09-13 00:00:00