Perspectives on systolic hypertension. The Framingham study.

abstract：:The clinical significance of perioperative myocardial infarction (MI) after coronary artery bypass surgery is not known. Therefore, strategies for the risk stratification of these patients do not exist. This study was undertaken to define the effect of perioperative MI on prognosis after discharge from the hospital an...

journal_title：Circulation

authors： Force T,Hibberd P,Weeks G,Kemper AJ,Bloomfield P,Tow D,Josa M,Khuri S,Parisi AF

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery. METHODS AND RESULTS:Random...

journal_title：Circulation

authors： Ho KM,Tan JA

更新日期：2009-04-14 00:00:00

abstract：BACKGROUND:Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable, atheromatous plaques) or those less frequently associated with acute thrombotic complication (stable, fibrous plaques). Defining the cellular and molecular mechanisms that underlie these morpholo...

journal_title：Circulation

authors： Sukhova GK,Schönbeck U,Rabkin E,Schoen FJ,Poole AR,Billinghurst RC,Libby P

更新日期：1999-05-18 00:00:00

abstract：BACKGROUND:The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains ...

journal_title：Circulation

authors： Dempsie Y,Morecroft I,Welsh DJ,MacRitchie NA,Herold N,Loughlin L,Nilsen M,Peacock AJ,Harmar A,Bader M,MacLean MR

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...

journal_title：Circulation

authors： Emdin CA,Khera AV,Klarin D,Natarajan P,Zekavat SM,Nomura A,Haas M,Aragam K,Ardissino D,Wilson JG,Schunkert H,McPherson R,Watkins H,Elosua R,Bown MJ,Samani NJ,Baber U,Erdmann J,Gormley P,Palotie A,Stitziel NO,Gup

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...

journal_title：Circulation

authors： Matter CM,Mandinov L,Kaufmann PA,Vassalli G,Jiang Z,Hess OM

更新日期：1999-05-11 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) and adenoviruses (ADVs) have been considered common causes of myocarditis and dilated cardiomyopathy. In the present study, we report on the association of parvovirus B19 (PVB19) genomes in the clinical setting of acute myocarditis. METHODS AND RESULTS:This study included 24 consecutive ...

journal_title：Circulation

authors： Kühl U,Pauschinger M,Bock T,Klingel K,Schwimmbeck CP,Seeberg B,Krautwurm L,Poller W,Schultheiss HP,Kandolf R

更新日期：2003-08-26 00:00:00

abstract：BACKGROUND:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Downstream of gp130, two signal-transducing pathways have been recognized, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the Ras-mitogen-activated protein kinase (MAPK) pathway. To d...

journal_title：Circulation

authors： Kunisada K,Hirota H,Fujio Y,Matsui H,Tani Y,Yamauchi-Takihara K,Kishimoto T

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Exaggerated pulmonary hypertension is thought to play an important part in the pathogenesis of high-altitude pulmonary edema (HAPE). Endothelin-1 is a potent pulmonary vasoconstrictor peptide that also augments microvascular permeability. METHODS AND RESULTS:We measured endothelin-1 plasma levels and pulmon...

journal_title：Circulation

authors： Sartori C,Vollenweider L,Löffler BM,Delabays A,Nicod P,Bärtsch P,Scherrer U

更新日期：1999-05-25 00:00:00

abstract：BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

journal_title：Circulation

authors： Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

更新日期：1996-11-01 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation. METHODS AND RESULTS:superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) ...

journal_title：Circulation

authors： Yu L,Scherlag BJ,Dormer K,Nguyen KT,Pope C,Fung KM,Po SS

更新日期：2010-12-21 00:00:00

abstract：BACKGROUND:Whether and to what extent complement is activated in acute myocardial infarction (AMI) and how it contributes to inflammation of the ischemic area are not yet clear. Fibrinolytic agents used for thrombolysis are known to activate complement in vitro and may contribute to its activation in vivo. The aim of t...

journal_title：Circulation

authors： Frangi D,Gardinali M,Conciato L,Cafaro C,Pozzoni L,Agostoni A

更新日期：1994-01-01 00:00:00

abstract：:Six cases of classical dissecting aneurysm of the aorta complicating aortic valvular disease in which aortic stenosis was dominant are described. In three of the cases the aortic complication occurred after the natural aortic valve had been replaced by a prosthetic valve. The longest postoperative period was four mont...

journal_title：Circulation

authors： Fukuda T,Tadavarthy SM,Edwards JE

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia. METHODS AND RESULTS:Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of...

journal_title：Circulation

authors： Wijffels MC,Kirchhof CJ,Dorland R,Allessie MA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...

journal_title：Circulation

authors： Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

更新日期：2004-11-02 00:00:00

abstract：BACKGROUND:Mechanisms by which neutrophils are attracted to the myocardium in ischemia/reperfusion are not fully defined. Lipopolysaccharide-induced CXC chemokine (LIX), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein-2 (MIP-2) are rodent chemokines with potent neutrophil-chemotact...

journal_title：Circulation

authors： Chandrasekar B,Smith JB,Freeman GL

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:The physiological effects of ACE inhibitors may act in part through a kinin-dependent mechanism. We investigated the effect of chronic ACE-inhibitor treatment on functional kinin B(1)- and B(2)-receptor expression, which are the molecular entities responsible for the biological effects of kinins. METHODS AN...

journal_title：Circulation

authors： Marin-Castaño ME,Schanstra JP,Neau E,Praddaude F,Pecher C,Ader JL,Girolami JP,Bascands JL

更新日期：2002-02-05 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:The countercurrent arrangement of capillary blood flow in the medulla of mammalian kidneys generates a gradient of oxygen tension between the renal cortex and the papillary tip that results in a state of relative hypoxia within the renal medulla. Exploration of the pathophysiological implications of medullar...

journal_title：Circulation

authors： Prasad PV,Edelman RR,Epstein FH

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. METHODS:Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure ...

journal_title：Circulation

authors： Laforest I,Dumesnil JG,Briand M,Cartier PC,Pibarot P

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:This study examines the limitations and complex management problems associated with the use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). METHODS AND RESULTS:The study group comprises the first 154 patients undergoing implantation of tiered-therapy ICDs at our institution. Pulse generat...

journal_title：Circulation

authors： Nunain SO,Roelke M,Trouton T,Osswald S,Kim YH,Sosa-Suarez G,Brooks DR,McGovern B,Guy M,Torchiana DF

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Reperfusion of ischemic rat hearts in the presence of thrombin or norepinephrine but not endothelin-1 causes the generation of inositol 1,4,5-trisphosphate (Ins 1,4,5P3) and arrhythmias. The present study investigates the effect of endothelin-1 on these responses. METHODS AND RESULTS:Ins 1,4,5P3 generation ...

journal_title：Circulation

authors： Woodcock EA,Reyes N,Jacobsen AN,Du XJ

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT increases energy expenditure and is beneficial for metabolic diseases, little is known about the role of PVAT in vascular diseases such as atheroscleros...

journal_title：Circulation

authors： Chang L,Villacorta L,Li R,Hamblin M,Xu W,Dou C,Zhang J,Wu J,Zeng R,Chen YE

更新日期：2012-08-28 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae stimulates chronic inflammation in vascular cells. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) may have an ameliorating effect. We investigated possible mechanisms. METHODS AND RESULTS:We infected human macrophages that in coculture spread infection to vascular smoot...

journal_title：Circulation

authors： Dechend R,Gieffers J,Dietz R,Joerres A,Rupp J,Luft FC,Maass M

更新日期：2003-07-22 00:00:00

abstract：:Finn Waagstein was born in Copenhagen in 1938. He graduated from Aarhus University Medical School in 1964. He received his cardiology training in the Sahlgrenska University Hospital at the University of Gothenburg, Sweden. He was appointed Associate Professor in 1980, and he assisted in establishing and directing the ...

journal_title：Circulation

authors： Waagstein F,Rutherford JD

更新日期：2017-09-05 00:00:00

abstract：:The effect of diabetes on survival after coronary bypass surgery is uncertain. Also, although the overall clinical benefits of internal mammary artery (IMA) grafting are well established, the survival benefit attributable to IMA grafting in diabetics is not well characterized. To determine the influence of diabetes an...

journal_title：Circulation

authors： Morris JJ,Smith LR,Jones RH,Glower DD,Morris PB,Muhlbaier LH,Reves JG,Rankin JS

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Data on outcomes after Stanford type A aortic dissection in patients with Marfan syndrome are limited. We investigated the primary surgery and long-term results in patients with Marfan syndrome who suffered aortic dissection. METHODS AND RESULTS:Among 1324 consecutive patients with aortic dissection type A,...

journal_title：Circulation

authors： Rylski B,Bavaria JE,Beyersdorf F,Branchetti E,Desai ND,Milewski RK,Szeto WY,Vallabhajosyula P,Siepe M,Kari FA

更新日期：2014-04-01 00:00:00

abstract：:Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...

journal_title：Circulation

authors： Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

更新日期：1981-07-01 00:00:00