The Evolution of the Use of β-Blockers to Treat Heart Failure: A Conversation With Finn Waagstein, MD.

abstract：BACKGROUND:Although LDL cholesterol (LDL-C) is generally accepted to be a major risk factor for progression of atherosclerosis, the traditional measurement of LDL-C includes measurement of IDL. Little is known about the relationship between IDL and progression of atherosclerosis. Therefore, we investigated the associat...

journal_title：Circulation

authors： Hodis HN,Mack WJ,Dunn M,Liu C,Liu C,Selzer RH,Krauss RM

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Right ventricular (RV) dilatation that occurs as a consequence of RV infarction is thought to produce hemodynamic instability by reducing left ventricular (LV) preload and compliance. We hypothesized that these geometric changes may also adversely affect LV systolic performance. METHODS AND RESULTS:Twelve 4...

journal_title：Circulation

authors： Brookes C,Ravn H,White P,Moeldrup U,Oldershaw P,Redington A

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined. METHODS AND RESULTS:United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146,973). Medica...

journal_title：Circulation

authors： Guo H,Kalra PA,Gilbertson DT,Liu J,Chen SC,Collins AJ,Foley RN

更新日期：2007-01-02 00:00:00

abstract：:Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor recordings from 15 clinically stable patients with various cardiac disorders. Mean hourly VPD frequencies ranged from 37--1,801 per hour. Data were subjected t...

journal_title：Circulation

authors： Morganroth J,Michelson EL,Horowitz LN,Josephson ME,Pearlman AS,Dunkman WB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Intravenous rt-PA (recombinant tissue-type plasminogen activator) is effective in improving outcomes in ischemic stroke; however, there are few data on the use of rt-PA in patients who are receiving a non-vitamin K antagonist oral anticoagulant (NOAC). METHODS:Using data from the American Heart Association ...

journal_title：Circulation

authors： Xian Y,Federspiel JJ,Hernandez AF,Laskowitz DT,Schwamm LH,Bhatt DL,Smith EE,Fonarow GC,Peterson ED

更新日期：2017-03-14 00:00:00

abstract：:For monotherapy, beta-blockers and calcium-entry blockers are effective and safe antianginal medications. For prophylaxis of myocardial ischemia, a different mechanism of action for each class of drugs is reflected by the different heart rate and rate-pressure product during exercise. In patients who continue to have ...

journal_title：Circulation

authors： Kostuk WJ,Pflugfelder P

更新日期：1987-06-01 00:00:00

abstract：:To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...

journal_title：Circulation

authors： Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KE

更新日期：1990-04-01 00:00:00

abstract：:Global ventricular function was evaluated by both multiple gated cardiac blood pool scans (MUGA) and contrast ventriculograms in a group of 17 patients with suspected coronary artery disease. The contrast ventriculograms were analyzed frame by frame to generate a volume versus time curve for each patient, while the tr...

journal_title：Circulation

authors： Burow RD,Strauss HW,Singleton R,Pond M,Rehn T,Bailey IK,Griffith LC,Nickoloff E,Pitt B

更新日期：1977-12-01 00:00:00

abstract：:Nineteen patients with chronic low output cardiac failure were studied before, during and after infusion of phentolamine in doses of 10, 20, 30 and 40 microgram/kg/min. Significant reduction of left- and right-sided pressures and increases in cardiac index and heart rate (HR) were present within 15 minutes of starting...

journal_title：Circulation

authors： Stern MA,Gohlke HK,Loeb HS,Croke RP,Gunnar RM

更新日期：1978-07-01 00:00:00

abstract：:Reperfusion of the previously ischemic myocardium is associated with the production of oxygen free radicals and their metabolites, which contribute to the ultimate extent of irreversible myocardial injury. The relative importance of polymorphonuclear leukocytes vs intracellular-derived oxygen metabolites has remained ...

journal_title：Circulation

authors： Mitsos SE,Askew TE,Fantone JC,Kunkel SL,Abrams GD,Schork A,Lucchesi BR

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

journal_title：Circulation

authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:The goal of this intravascular ultrasound investigation was to provide a more detailed morphological analysis of the local biological effects of the implantation of a sirolimus-eluting stent compared with an uncoated stent. METHODS AND RESULTS:In the RAVEL trial, 238 patients with single de novo lesions wer...

journal_title：Circulation

authors： Serruys PW,Degertekin M,Tanabe K,Abizaid A,Sousa JE,Colombo A,Guagliumi G,Wijns W,Lindeboom WK,Ligthart J,de Feyter PJ,Morice MC,RAVEL Study Group.

更新日期：2002-08-13 00:00:00

abstract：:A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of opera...

journal_title：Circulation

authors： Morrow AG,Behrendt DM

更新日期：1968-07-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that rigid fixation of the mitral annulus with an annuloplasty ring may impair left ventricular (LV) systolic performance. We used load-insensitive indexes of global and regional LV contractile mechanics to test the hypothesis that rigid fixation of the mitral annulus alters LV systo...

journal_title：Circulation

authors： Rayhill SC,Castro LJ,Nizyporuk MA,Ingels NB Jr,Daughters GT,Derby GC,Tye TL,Bolger AF,Miller DC

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...

journal_title：Circulation

authors： Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:This study proposes 2 new echocardiographic indices with potential application in acute coronary artery occlusion to differentiate between viable and necrotic myocardium and to identify reperfusion. We investigated whether the ratio between systolic lengthening and combined late and postsystolic shortening (...

journal_title：Circulation

authors： Lyseggen E,Skulstad H,Helle-Valle T,Vartdal T,Urheim S,Rabben SI,Opdahl A,Ihlen H,Smiseth OA

更新日期：2005-12-20 00:00:00

abstract：BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

journal_title：Circulation

authors： Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

更新日期：1995-02-15 00:00:00

abstract：:Studies of the correlation of aortic valve gradient determined by continuous-wave Doppler echocardiography and that determined at catheterization have, to date, involved young patients and nonsimultaneous measurements. We therefore obtained simultaneous Doppler echocardiographic and catheter measurements of pressure g...

journal_title：Circulation

authors： Currie PJ,Seward JB,Reeder GS,Vlietstra RE,Bresnahan DR,Bresnahan JF,Smith HC,Hagler DJ,Tajik AJ

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown. METHODS AND RESULTS:This was an open-label, randomized, parallel-group, multicenter study. Patients with persistent AF, dual-chamber implantable...

journal_title：Circulation

authors： Di Biase L,Mohanty P,Mohanty S,Santangeli P,Trivedi C,Lakkireddy D,Reddy M,Jais P,Themistoclakis S,Dello Russo A,Casella M,Pelargonio G,Narducci ML,Schweikert R,Neuzil P,Sanchez J,Horton R,Beheiry S,Hongo R,Hao S,

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a disorder characterized by pulmonary arterial hypertension as a consequence of organized thrombotic material in the central pulmonary arteries. Incomplete resolution of acute pulmonary emboli is believed to be pathogenically important; however, the me...

journal_title：Circulation

authors： Olman MA,Marsh JJ,Lang IM,Moser KM,Binder BR,Schleef RR

更新日期：1992-10-01 00:00:00

abstract：:The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV. At the same time, fibrosis impairs cardiac function, and a growing b...

journal_title：Circulation

authors： Andersen S,Nielsen-Kudsk JE,Vonk Noordegraaf A,de Man FS

更新日期：2019-01-08 00:00:00

abstract：:Acute cardiac rejection, syndrome X, and arterial hypertension can induce small vessel damage and, therefore, restriction of coronary reserve in the presence of normal epicardial coronary arteries. A characteristic response pattern to dipyridamole (DIP) infusion has been previously described in syndrome X and arterial...

journal_title：Circulation

authors： Picano E,De Pieri G,Salerno JA,Arbustini E,Distante A,Martinelli L,Pucci A,Montemartini C,Viganò M,Donato L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and that this effect is mainly mediated by increased bioavailability of nitric oxide (NO). METHODS AND RESULTS:In a r...

journal_title：Circulation

authors： John S,Schlaich M,Langenfeld M,Weihprecht H,Schmitz G,Weidinger G,Schmieder RE

更新日期：1998-07-21 00:00:00

abstract：BACKGROUND:We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental pre...

journal_title：Circulation

authors： Vogel M,Cheung MM,Li J,Kristiansen SB,Schmidt MR,White PA,Sorensen K,Redington AN

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for tumor necrosis factor (TNF)-induced LV structural remodeling in the adult heart are not known. METHODS AND RESULTS:We generated a line of transgenic mice (MHCsTNF) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling from 4 to 12 weeks ...

journal_title：Circulation

authors： Sivasubramanian N,Coker ML,Kurrelmeyer KM,MacLellan WR,DeMayo FJ,Spinale FG,Mann DL

更新日期：2001-08-14 00:00:00

abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

journal_title：Circulation

authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

更新日期：2017-02-14 00:00:00

abstract：:In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

journal_title：Circulation

authors： Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Recently, it has been shown that stem/progenitor cells may repair damaged/lost endothelial cells in vein grafts and wire-injured arteries. In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothel...

journal_title：Circulation

authors： Foteinos G,Hu Y,Xiao Q,Metzler B,Xu Q

更新日期：2008-04-08 00:00:00

abstract：:A patient who had disabling supraventricular tachycardia showed electrophysiologic evidence of coexistent right and left Kent bundles. The supraventricular tachycardia was accelerated by sequential antegrade and retrograde conduction over the right and left Kent bundles, respectively. Spontaneous blocking of the condu...

journal_title：Circulation

authors： Cinca J,Valle V,Gutierrez L,Figueras J,Rius J

更新日期：1980-09-01 00:00:00