Acute right ventricular dilatation in response to ischemia significantly impairs left ventricular systolic performance.

abstract：BACKGROUND:Many clinical trials use composite end points to reduce sample size, but the relative importance of each individual end point within the composite may differ between patients and researchers. METHODS AND RESULTS:We asked 785 cardiovascular patients and 164 clinical trial authors to assign 25 "spending weigh...

journal_title：Circulation

authors： Stolker JM,Spertus JA,Cohen DJ,Jones PG,Jain KK,Bamberger E,Lonergan BB,Chan PS

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS:The effects of quinidine bisulfat...

journal_title：Circulation

authors： Belhassen B,Glick A,Viskin S

更新日期：2004-09-28 00:00:00

abstract：:In Phase I of the NHLBI trial of Thrombolysis in Myocardial Infarction (TIMI), 290 patients admitted within 7 hr after onset of acute infarction were randomly assigned to intravenous treatment with either streptokinase (SK) or recombinant tissue-type plasminogen activator (rt-PA). Left ventricular function was measure...

journal_title：Circulation

authors： Sheehan FH,Braunwald E,Canner P,Dodge HT,Gore J,Van Natta P,Passamani ER,Williams DO,Zaret B

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood press...

journal_title：Circulation

authors： Azizi M,Pereira H,Hamdidouche I,Gosse P,Monge M,Bobrie G,Delsart P,Mounier-Véhier C,Courand PY,Lantelme P,Denolle T,Dourmap-Collas C,Girerd X,Michel Halimi J,Zannad F,Ormezzano O,Vaïsse B,Herpin D,Ribstein J,Chamont

更新日期：2016-09-20 00:00:00

abstract：:The movements of the mitral, tricuspid and aortic valves have been recorded echocardiographically and related to the first heart sound (S1) in patients with various hemodynamic and conduction abnormalities. Closure of the mitral and tricuspid valves has been studied with respect to the corresponding atrioventricular p...

journal_title：Circulation

authors： Mills PG,Chamusco RF,Moos S,Craige E

更新日期：1976-12-01 00:00:00

abstract：:Procainamide, a type 1A antiarrhythmic drug, blocks sodium channels and reduces the maximum rate of rise of the cardiac action potential (Vmax) in a rate-dependent fashion. In vitro, the magnitude of this rate-dependent reduction in Vmax is greater in tissue that is partially depolarized at rest than in tissue with a ...

journal_title：Circulation

authors： Cascio WE,Foster JR,Buchanan JW Jr,Johnson TA,Gettes LS

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation. METHODS AND RESULTS:superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) ...

journal_title：Circulation

authors： Yu L,Scherlag BJ,Dormer K,Nguyen KT,Pope C,Fung KM,Po SS

更新日期：2010-12-21 00:00:00

abstract：:Between 1976 and 1982, 413 consecutive patients underwent valvular replacement with a bioprosthesis. Aortic valve replacement was performed in 240 patients, mitral valve replacement in 132, and multiple-valve replacement in 41. Four prostheses were employed: Carpentier-Edwards porcine (n = 336), Angel-Shiley porcine (...

journal_title：Circulation

authors： Teoh KH,Ivanov J,Weisel RD,Darcel IC,Rakowski H

更新日期：1989-09-01 00:00:00

abstract：:The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...

journal_title：Circulation

authors： Adelstein SJ,Jansen C,Wagner HN Jr

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown. METHODS AND RESULTS:We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. ...

journal_title：Circulation

authors： Burke AP,Farb A,Malcom GT,Liang Y,Smialek J,Virmani R

更新日期：1998-06-02 00:00:00

abstract：BACKGROUND:Heart failure treatment depends partly on the underlying cause of the disease. We evaluated cardiovascular magnetic resonance (CMR) for the problem of differentiating dilated cardiomyopathy (DCM) from left ventricular (LV) dysfunction caused by coronary artery disease (CAD). METHODS AND RESULTS:Late gadolin...

journal_title：Circulation

authors： McCrohon JA,Moon JC,Prasad SK,McKenna WJ,Lorenz CH,Coats AJ,Pennell DJ

更新日期：2003-07-08 00:00:00

abstract：BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...

journal_title：Circulation

authors： Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

更新日期：1995-06-01 00:00:00

abstract：:Neutrophil activation and infiltration into the ischemic myocardium after reperfusion may limit the amount of salvageable myocardium (reperfusion injury). The effects of intravenous perfluorochemicals (Fluosol-DA) on infarct size, ventricular contractility, and neutrophil function were assessed in an occlusion-reperfu...

journal_title：Circulation

authors： Bajaj AK,Cobb MA,Virmani R,Gay JC,Light RT,Forman MB

更新日期：1989-03-01 00:00:00

abstract：:Continuous-wave Doppler echocardiography was used to estimate pulmonary artery pressures by measuring pulmonary regurgitant flow velocity in 21 patients with pulmonary hypertension (mean pulmonary artery pressure greater than or equal to 20 mm Hg) and 24 patients without pulmonary hypertension. The pulmonary regurgita...

journal_title：Circulation

authors： Masuyama T,Kodama K,Kitabatake A,Sato H,Nanto S,Inoue M

更新日期：1986-09-01 00:00:00

abstract：:Acute occlusion of the circumflex branch of the left coronary artery was produced in chronically instrumented conscious dogs. Tracer microspheres were used to measure during an established time period, the distribution of collateral flow within the infarcting myocardium. For up to 2 hours after coronary occlusion the ...

journal_title：Circulation

authors： Schaper W,Pasyk S

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:We have developed a new measure of myocardial viability, the water-perfusable tissue index (PTI), which is calculated from transmission, C15O, and H2(15)O positron emission tomography (PET) data sets. It is defined as the proportion of the total anatomical tissue within a given region of interest (ROI) that ...

journal_title：Circulation

authors： Yamamoto Y,de Silva R,Rhodes CG,Araujo LI,Iida H,Rechavia E,Nihoyannopoulos P,Hackett D,Galassi AR,Taylor CJ

更新日期：1992-07-01 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Continuous whole-body perfusion for > 3 hours with a cold asanguineous blood substitute, hypothermosol (HTS) solution, has been reported to preserve organ function. We used this solution in a survival animal model to evaluate its possible application in extending the safe duration of deep hypothermic circula...

journal_title：Circulation

authors： Miura T,Laussen P,Lidov HG,DuPlessis A,Shin'oka T,Jonas RA

更新日期：1996-11-01 00:00:00

abstract：:Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous ...

journal_title：Circulation

authors： Ferlinz J,Easthope JL,Aronow WS

更新日期：1979-02-01 00:00:00

abstract：:A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotr...

journal_title：Circulation

authors： Moss J,Fahmy NR,Sunder N,Beaven MA

更新日期：1981-01-01 00:00:00

abstract：:Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

journal_title：Circulation

authors： Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

更新日期：1985-07-01 00:00:00

abstract：:More accurate characterization of coronary artery lesions is needed for evaluation of short and long-term interventions in coronary disease. A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms. Coronary lesions are traced from two projected, perpendi...

journal_title：Circulation

authors： Brown BG,Bolson E,Frimer M,Dodge HT

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:An inverse association between moderate alcohol consumption and coronary heart disease (CHD) has been observed in several epidemiological studies. To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and wit...

journal_title：Circulation

authors： Ajani UA,Gaziano JM,Lotufo PA,Liu S,Hennekens CH,Buring JE,Manson JE

更新日期：2000-08-01 00:00:00

abstract：:Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheteri...

journal_title：Circulation

authors： Pastore JO,Akins CW,Zir LM,Buckley MJ,Dinsmore RE

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Mutations in sarcomere protein, PRKAG2, LAMP2, alpha-galactosidase A (GLA), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left ventricular wall thickness (LVWT) in the community is unknown. METHODS AND RESULTS:We studied 1862 unrelated particip...

journal_title：Circulation

authors： Morita H,Larson MG,Barr SC,Vasan RS,O'Donnell CJ,Hirschhorn JN,Levy D,Corey D,Seidman CE,Seidman JG,Benjamin EJ

更新日期：2006-06-13 00:00:00

abstract：BACKGROUND:High-altitude pulmonary edema (HAPE) is characterized by pulmonary hypertension, increased pulmonary capillary permeability, and hypoxemia. Treatment is limited to descent to lower altitude and administration of oxygen. METHODS AND RESULTS:We studied the acute effects of inhaled nitric oxide (NO), 50% oxyge...

journal_title：Circulation

authors： Anand IS,Prasad BA,Chugh SS,Rao KR,Cornfield DN,Milla CE,Singh N,Singh S,Selvamurthy W

更新日期：1998-12-01 00:00:00

abstract：:The pulmonary perfusion of 25 children who had total surgical correction of tetralogy of Fallot was evaluated by radionuclide perfusion scans. In addition, 18 had 133Xe ventilation studies. Eighteen of the children previously had palliative systemic-pulmonary shunts; 14 had aortic-pulmonary shunts (Waterston or Potts-...

journal_title：Circulation

authors： Alderson PO,Boonvisut S,McKnight RC,Hartman AF Jr

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:The time constant of truncated exponential pulses used with implantable defibrillators is determined by the output capacitor size and defibrillation pathway resistance. The optimal capacitor size is unknown. METHODS AND RESULTS:This study compared defibrillation threshold (DFT) for standard 120-microF capac...

journal_title：Circulation

authors： Swerdlow CD,Kass RM,Chen PS,Hwang C,Raissi S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Beneficial effects of exercise training on cardiovascular function in chronic heart failure (CHF) have been suggested previously, but the underlying mechanisms are unknown. We tested whether daily exercise training improves systemic hemodynamics and preserves endothelium-mediated vasodilator function during ...

journal_title：Circulation

authors： Wang J,Yi GH,Knecht M,Cai BL,Poposkis S,Packer M,Burkhoff D

更新日期：1997-10-21 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibition potentiates the tissue-type plasminogen activator (t-PA) response to exogenous bradykinin. This study tested the hypothesis that ACE inhibition increases endothelial t-PA release through endogenous bradykinin. METHODS AND RESULTS:We measured the effect of intra...

journal_title：Circulation

authors： Pretorius M,Rosenbaum D,Vaughan DE,Brown NJ

更新日期：2003-02-04 00:00:00