Physical training alters the pathogenesis of pacing-induced heart failure through endothelium-mediated mechanisms in awake dogs.

Abstract:

BACKGROUND:Beneficial effects of exercise training on cardiovascular function in chronic heart failure (CHF) have been suggested previously, but the underlying mechanisms are unknown. We tested whether daily exercise training improves systemic hemodynamics and preserves endothelium-mediated vasodilator function during development of heart failure. METHODS AND RESULTS:Fifteen dogs were surgically instrumented for hemodynamic measurements. One group of dogs underwent 4 weeks of cardiac pacing (210 bpm for 3 weeks and 240 bpm during week 4), and another group underwent pacing plus daily exercise training (4.4+/-0.3 km/h, 2 h/d). Pacing-alone dogs developed CHF characterized by typical hemodynamic abnormalities, blunted endothelium-mediated vasodilator function in coronary and femoral circulations, and decreased gene expression of endothelial constitutive nitric oxide synthase (ECNOS, normalized to GAPDH expression; normal, 1.15+/-0.31 versus CHF, 0.29+/-0.08, P<.05). Exercise training preserved normal hemodynamics at rest, endothelium-mediated vasodilator function, and gene expression of ECNOS (0.72+/-0.16 versus normal, P=NS). Inhibition of NO synthesis (nitro-L-arginine) in exercise-trained dogs abolished the preserved endothelium-mediated vasodilation of epicardial coronary arteries and elevated left ventricular end-diastolic pressure (7.7+/-0.3 to 19+/-3.4 mm Hg, P<.05), suggesting that the preservation of resting hemodynamics was in large part due to preserved endothelial function concealing the underlying CHF state. CONCLUSIONS:Long-term exercise training altered the natural history of heart failure due to rapid cardiac pacing. One of the underlying mechanisms is through the preservation of endothelial vasodilator function.

journal_name

Circulation

journal_title

Circulation

authors

Wang J,Yi GH,Knecht M,Cai BL,Poposkis S,Packer M,Burkhoff D

doi

10.1161/01.cir.96.8.2683

subject

Has Abstract

pub_date

1997-10-21 00:00:00

pages

2683-92

issue

8

eissn

0009-7322

issn

1524-4539

journal_volume

96

pub_type

杂志文章
  • Sudden death in patients evaluated for ischemic heart disease.

    abstract::Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Oberman A,Ray M,Turner ME,Barnes G,Grooms C

    更新日期:1975-12-01 00:00:00

  • Hemodynamic effects of labetalol, an alpha and beta adrenergic blocking agent, in hypertensive subjects.

    abstract::Labetalol was administered to six hypertensive subjects in increasing doses for seven days. A decrease in both supine and standing arterial pressure and heart rate was observed with no change in cardiac output and few side effects. Exercise tolerance was unaltered by the drug, but the heart rate and arterial pressure ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.55.2.370

    authors: Mehta J,Cohn JN

    更新日期:1977-02-01 00:00:00

  • Brain angiotensin: pathways and pharmacology.

    abstract::The existence of a brain renin-angiotensin system (RAS) as one of various tissue RASs is now firmly established. Angiotensin-containing pathways within brain areas involved in central blood pressure regulation have been described. Evidence from biochemical, neurophysiologic, pharmacologic, and most recently, molecular...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Unger T,Badoer E,Ganten D,Lang RE,Rettig R

    更新日期:1988-06-01 00:00:00

  • iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.

    abstract:BACKGROUND:Production of NO by inducible NO synthase (iNOS) has been implicated in the pathology of spontaneous and antigen-induced autoimmune diseases, and iNOS is expressed in the myocardium of patients with heart failure. It is not clear whether inflammatory murine autoimmune heart disease, an experimental model for...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Bachmaier K,Neu N,Pummerer C,Duncan GS,Mak TW,Matsuyama T,Penninger JM

    更新日期:1997-07-15 00:00:00

  • Asymptomatic left main coronary artery disease in the Coronary Artery Surgery Study (CASS) registry.

    abstract::Left main coronary artery disease (i.e., greater than or equal to 50% stenosis) was found in 1,477 of 20,137 patients in the Coronary Artery Surgery Study (CAS) registry. Of these patients, 53 (3.6%) were asymptomatic. Asymptomatic and symptomatic patients were similar in regard to 1) severity of left main coronary ar...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.79.6.1171

    authors: Taylor HA,Deumite NJ,Chaitman BR,Davis KB,Killip T,Rogers WJ

    更新日期:1989-06-01 00:00:00

  • Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure.

    abstract:BACKGROUND:Chronic heart failure (CHF) is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). There is evidence for increased radical formation in CHF, raising the possibility that nitric oxide is inactivated by radicals, thereby impairing endothelial function...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.97.4.363

    authors: Hornig B,Arakawa N,Kohler C,Drexler H

    更新日期:1998-02-03 00:00:00

  • Exercise conditioning in older coronary patients. Submaximal lactate response and endurance capacity.

    abstract:BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.2.572

    authors: Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

    更新日期:1993-08-01 00:00:00

  • Very long-term survival implications of heart valve replacement with tissue versus mechanical prostheses in adults

    abstract:BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.681429

    authors: Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

    更新日期:2007-09-11 00:00:00

  • Availability and Use of Shared Data From Cardiometabolic Clinical Trials.

    abstract:BACKGROUND:Sharing of patient-level clinical trial data has been widely endorsed. Little is known about how extensively these data have been used for cardiometabolic diseases. We sought to evaluate the availability and use of shared data from cardiometabolic clinical trials. METHODS:We extracted data from ClinicalStud...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.117.031883

    authors: Vaduganathan M,Nagarur A,Qamar A,Patel RB,Navar AM,Peterson ED,Bhatt DL,Fonarow GC,Yancy CW,Butler J

    更新日期:2018-02-27 00:00:00

  • Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions.

    abstract:BACKGROUND:A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis. METHODS AND RES...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000055186.40785.c4

    authors: Cyrus T,Yao Y,Rokach J,Tang LX,Praticò D

    更新日期:2003-02-04 00:00:00

  • The cellular electrophysiologic changes induced by ablation: comparison between argon laser photoablation and high-energy electrical ablation.

    abstract::The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.76.1.217

    authors: Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

    更新日期:1987-07-01 00:00:00

  • Congenital abnormalities of the conduction system in two patients with tachyarrhythmias.

    abstract::Serial sections of the conduction system (CS) were performed in two patients with recurrent tachyarrhythmias. Case 1, a 34-year-old female who had dual atrioventricular (AV) nodal pathways with recurrent paroxysmal supraventricular tachycardia, committed suicide. Autopsy revealed an abnormally formed atrial septum wit...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.59.3.593

    authors: Bharati S,Bauernfiend R,Scheinman M,Massie B,Cheitlin M,Denes P,Wu D,Lev M,Rosen KM

    更新日期:1979-03-01 00:00:00

  • Determinants of survival and left ventricular performance after mitral valve replacement. Department of Veterans Affairs Cooperative Study on Valvular Heart Disease.

    abstract::To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.4.1173

    authors: Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KE

    更新日期:1990-04-01 00:00:00

  • Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).

    abstract:BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044720

    authors: Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

    更新日期:2020-05-05 00:00:00

  • Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass.

    abstract:BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.92.9.2579

    authors: Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

    更新日期:1995-11-01 00:00:00

  • Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis.

    abstract:BACKGROUND:Endothelin-converting enzyme (ECE)-1 activates endothelin-1 (ET-1) and may thus contribute to the regulation of vascular tone and cell growth during atherosclerosis. METHODS AND RESULTS:To evaluate ECE-1 immunoreactivity concerning big ET-1/ET-1, we performed qualitative and quantitative immunohistochemistr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3301.094742

    authors: Ihling C,Szombathy T,Bohrmann B,Brockhaus M,Schaefer HE,Loeffler BM

    更新日期:2001-08-21 00:00:00

  • Mechanism of atrial sounds in atrial fibrillation. Phonoechocardiographic correlation. Report of a case.

    abstract::Audible atrial sounds were noted in a patient with congestive cardiomyopathy and atrial fibrillation with slow ventricular rate. Oscillatory motion of similar periodicity as fibrillation waves in the ECG and the sounds in the phonocardiogram was demonstrated in aortic and left ventricular walls, mitral, tricuspid and ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.53.3.569

    authors: Bamrah VS,Hughes CV,Tristani FE

    更新日期:1976-03-01 00:00:00

  • Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD).

    abstract:BACKGROUND:Diabetes mellitus is a predictor of morbidity and mortality in patients with heart failure. The effect of angiotensin-converting enzyme (ACE) inhibitors on the prevention of diabetes in patients with left ventricular dysfunction is unknown. The aim of this retrospective study was to assess the effect of the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000054611.89228.92

    authors: Vermes E,Ducharme A,Bourassa MG,Lessard M,White M,Tardif JC,Studies Of Left Ventricular Dysfunction.

    更新日期:2003-03-11 00:00:00

  • Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice.

    abstract:BACKGROUND:The role of angiotensin II (Ang II) type 2 (AT2) receptor in atherosclerosis was explored with the use of AT2 receptor/apolipoprotein E (ApoE)-double-knockout (AT2/ApoE-DKO) mice, with a focus on oxidative stress. METHODS AND RESULTS:After treatment with a high-cholesterol diet (1.25% cholesterol) for 10 we...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.525550

    authors: Iwai M,Chen R,Li Z,Shiuchi T,Suzuki J,Ide A,Tsuda M,Okumura M,Min LJ,Mogi M,Horiuchi M

    更新日期:2005-09-13 00:00:00

  • Late dysrhythmias and disturbances of conduction following Mustard operation for complete transposition of the great arteries.

    abstract::Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm pr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.53.3.519

    authors: Clarkson PM,Barratt-Boyles BG,Neutze JM

    更新日期:1976-03-01 00:00:00

  • Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease.

    abstract:BACKGROUND:We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population. METHODS AND RESULTS:The WISE sample comprised 589 white and 122 black women who underwent angiograph...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.CIR.0000074207.85796.36

    authors: Chen Q,Reis SE,Kammerer C,Craig WY,LaPierre SE,Zimmer EL,McNamara DM,Pauly DF,Sharaf B,Holubkov R,Bairey Merz CN,Sopko G,Bontempo F,Kamboh MI

    更新日期:2003-07-01 00:00:00

  • Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month.

    abstract:BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires subst...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.95.5.1126

    authors: O'Driscoll G,Green D,Taylor RR

    更新日期:1997-03-04 00:00:00

  • Blood velocity distribution in the human ascending aorta.

    abstract::Mapping of blood velocities across the lumen of the ascending aorta was performed in eight patients during open-heart surgery. A Doppler ultrasound probe was constructed to measure velocities in 2 mm steps from the maximum convexity to the maximum concavity of aorta, 6 to 7 cm above the aortic valve. In five patients ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.76.1.90

    authors: Segadal L,Matre K

    更新日期:1987-07-01 00:00:00

  • Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

    abstract:BACKGROUND:Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years, considerable variability has existed in the study design and quality of e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035070

    authors: Hosseini SM,Kim R,Udupa S,Costain G,Jobling R,Liston E,Jamal SM,Szybowska M,Morel CF,Bowdin S,Garcia J,Care M,Sturm AC,Novelli V,Ackerman MJ,Ware JS,Hershberger RE,Wilde AAM,Gollob MH,National Institutes of Health C

    更新日期:2018-09-18 00:00:00

  • Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel.

    abstract:BACKGROUND:Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reporte...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035931

    authors: van Leeuwen MAH,van der Hoeven NW,Janssens GN,Everaars H,Nap A,Lemkes JS,de Waard GA,van de Ven PM,van Rossum AC,Ten Cate TJF,Piek JJ,von Birgelen C,Escaned J,Valgimigli M,Diletti R,Riksen NP,van Mieghem NM,Nijveldt R,

    更新日期:2019-01-29 00:00:00

  • Prognostic value of pharmacological stress echocardiography is affected by concomitant antiischemic therapy at the time of testing.

    abstract:BACKGROUND:The aim of this study was to determine whether antianginal medications affect the prognostic value of pharmacological stress echocardiography. METHODS AND RESULTS:From the EPIC-EDIC Data Bank, 7333 patients (5452 men; age; 59+/-10 years) underwent pharmacological stress echocardiography with either high-dos...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.CIR.0000127427.03361.5E

    authors: Sicari R,Cortigiani L,Bigi R,Landi P,Raciti M,Picano E,Echo-Persantine International Cooperative (EPIC) Study Group.,Echo-Dobutamine International Cooperative (EDIC) Study Group.

    更新日期:2004-05-25 00:00:00

  • Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.

    abstract:BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000084503.91330.49

    authors: Verma S,Li SH,Wang CH,Fedak PW,Li RK,Weisel RD,Mickle DA

    更新日期:2003-08-12 00:00:00

  • Effects of continuous positive airway pressure on sleep apnea and ventricular irritability in patients with heart failure.

    abstract:BACKGROUND:Patients with heart failure and systolic dysfunction may develop disordered breathing during sleep. Repeated episodes of apnea and hypopnea may result in desaturation and arousals, which could adversely affect left ventricular function. The purpose of this study was to determine the short-term effects of con...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.4.392

    authors: Javaheri S

    更新日期:2000-02-01 00:00:00

  • Rheumatic fever and the HLA complex. A cosegregation study.

    abstract:BACKGROUND:Considering the controversial results published in the literature concerning associations between human leukocyte antigens (HLA) and rheumatic fever (RF), the purpose of the present study was to investigate by means of cosegregation analysis the participation of HLA genes in susceptibility to RF. METHODS AN...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.1.138

    authors: Gerbase-DeLima M,Scala LC,Temin J,Santos DV,Otto PA

    更新日期:1994-01-01 00:00:00

  • The tricuspid valve: current perspective and evolving management of tricuspid regurgitation.

    abstract::Cardiovascular specialists have entered an era of renewed interest and enthusiasm surrounding the diagnosis and treatment of valvular heart disease, driven in part by emerging percutaneous therapies for the treatment of aortic, pulmonic, and mitral valve disease. Despite this wave of investigation, little or no attent...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.108.842773

    authors: Rogers JH,Bolling SF

    更新日期:2009-05-26 00:00:00