Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.

abstract：BACKGROUND:There is an inverse relationship between HDL cholesterol and coronary heart disease. Experimental studies have indicated that HDL cholesterol may exert an antiatherogenic effect by inducing regression of atherosclerotic plaques and by turning lipid-rich plaques into more fibrotic lesions. In this prospective...

journal_title：Circulation

authors： Johnsen SH,Mathiesen EB,Fosse E,Joakimsen O,Stensland-Bugge E,Njølstad I,Arnesen E

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:The atrioventricular (AV) node is insensitive to changes in extracellular potassium concentration, [K+]o, because of the absence of the inward rectifier potassium current (IK1). However, we propose that in the presence of adenosine, elevated [K+]o should increase the adenosine-activated inward rectifier pota...

journal_title：Circulation

authors： Martynyuk AE,Morey TE,Belardinelli L,Dennis DM

更新日期：1999-01-19 00:00:00

abstract：BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

journal_title：Circulation

authors： Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

更新日期：1997-07-15 00:00:00

abstract：:The prognostic significance of a preoperative echocardiographic left ventricular end-systolic dimension (ESD) greater than 55 mm and/or fractional shortening (FS) of 25% or less was evaluated retrospectively in 84 patients who had undergone aortic valve replacement for isolated chronic aortic regurgitation due to vari...

journal_title：Circulation

authors： Daniel WG,Hood WP Jr,Siart A,Hausmann D,Nellessen U,Oelert H,Lichtlen PR

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studi...

journal_title：Circulation

authors： Khera AV,Demler OV,Adelman SJ,Collins HL,Glynn RJ,Ridker PM,Rader DJ,Mora S

更新日期：2017-06-20 00:00:00

abstract：:The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p less than 0.05) increased LV dP/dt,...

journal_title：Circulation

authors： Goldman S,Hager WD,Olajos M,Perrier D,Mayersohn M

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:The role of angiotensin as a vasoconstrictor is well established. Lately, several other actions of this hormone on vascular smooth muscle (VSM) cells have been recognized including the induction of hypertrophy and/or DNA synthesis. Platelet-derived growth factor (PDGF), a mitogen recently shown to increase p...

journal_title：Circulation

authors： van Leeuwen RT,Kol A,Andreotti F,Kluft C,Maseri A,Sperti G

更新日期：1994-07-01 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is...

journal_title：Circulation

authors： Taqueti VR,Shaw LJ,Cook NR,Murthy VL,Shah NR,Foster CR,Hainer J,Blankstein R,Dorbala S,Di Carli MF

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Factors predicting the occurrence of premature coronary artery disease (CAD) may not be quantitatively the same as those predicting CAD severity, particularly in women, in whom there have been few studies. METHODS AND RESULTS:To determine factors predictive of severity of CAD and of angina pectoris, we docu...

journal_title：Circulation

authors： Wang XL,Tam C,McCredie RM,Wilcken DE

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subje...

journal_title：Circulation

authors： Diamant M,Nieuwland R,Pablo RF,Sturk A,Smit JW,Radder JK

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:Since myocardial blood flow changes dynamically after reperfusion and since both hyperemia and impairment in microvascular function exist within the acutely reperfused bed, we sought to investigate the role of myocardial contrast echocardiography (MCE) in (1) defining the temporal variability in perfusion pa...

journal_title：Circulation

authors： Villanueva FS,Glasheen WP,Sklenar J,Kaul S

更新日期：1993-12-01 00:00:00

abstract：:Audible atrial sounds were noted in a patient with congestive cardiomyopathy and atrial fibrillation with slow ventricular rate. Oscillatory motion of similar periodicity as fibrillation waves in the ECG and the sounds in the phonocardiogram was demonstrated in aortic and left ventricular walls, mitral, tricuspid and ...

journal_title：Circulation

authors： Bamrah VS,Hughes CV,Tristani FE

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Regional variation in the incidence and outcomes of in-hospital cardiac arrest (IHCA) is not well studied and may have important health and policy implications. METHODS AND RESULTS:We used the 2003 to 2011 Nationwide Inpatient Sample databases to identify patients≥18 years of age who underwent cardiopulmona...

journal_title：Circulation

authors： Kolte D,Khera S,Aronow WS,Palaniswamy C,Mujib M,Ahn C,Iwai S,Jain D,Sule S,Ahmed A,Cooper HA,Frishman WH,Bhatt DL,Panza JA,Fonarow GC

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Sublingual nitrates are much more effective in relieving angina pectoris in patients with coronary artery disease than in patients with syndrome X, but it is not known whether their effect on exercise tolerance is also different in these two groups of patients. METHODS AND RESULTS:Treadmill exercise testing...

journal_title：Circulation

authors： Lanza GA,Manzoli A,Bia E,Crea F,Maseri A

更新日期：1994-12-01 00:00:00

abstract：:Vasodilatory or vasoconstrictive renal pharmacoangiography was applied in investigating the significance of 50 renal artery stenoses. The technique involves comparison of selective magnification renal arteriograms before and after intra-arterial injection of epinephrine or acetylcholine, seeking changes in direction o...

journal_title：Circulation

authors： Bookstein JJ,Walter JF,Stanley JC,Fry WJ

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Regional sympathetic denervation, such as that produced by a myocardial infarction, causes electrophysiological heterogeneity in the ventricles. The purpose of this study was to test the hypothesis that such denervation could cause drugs to exert heterogeneous myocardial effects. METHODS AND RESULTS:Sympath...

journal_title：Circulation

authors： Stanton MS,Zipes DP

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...

journal_title：Circulation

authors： Melter M,Exeni A,Reinders ME,Fang JC,McMahon G,Ganz P,Hancock WW,Briscoe DM

更新日期：2001-11-20 00:00:00

abstract：BACKGROUND:We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans. METHODS AND RESULTS:We conducted a randomized, double-blind, placebo-controlled crossover study in 14 nondiabetic overweight or obese (body mass index > ...

journal_title：Circulation

authors： Pierce GL,Lesniewski LA,Lawson BR,Beske SD,Seals DR

更新日期：2009-03-10 00:00:00

abstract：BACKGROUND:Bereavement is a period of increased risk of cardiovascular death. There is limited understanding of the potential contribution of quality of cardiovascular disease management to this increased risk. METHODS AND RESULTS:In a UK primary-care database, 12 722 older individuals with preexisting cardiovascular ...

journal_title：Circulation

authors： Shah SM,Carey IM,Harris T,Dewilde S,Victor CR,Cook DG

更新日期：2013-12-24 00:00:00

abstract：:Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...

journal_title：Circulation

authors： Hurwitz RA,Franken EA Jr,Girod DA,Smith JA,Smith WL

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) provides controlled operative conditions but induces a whole-body inflammatory response capable of initiating devastating morbidity and mortality. Although technically more demanding, deliberate avoidance of CPB in off-pump surgery att...

journal_title：Circulation

authors： Tomic V,Russwurm S,Möller E,Claus RA,Blaess M,Brunkhorst F,Bruegel M,Bode K,Bloos F,Wippermann J,Wahlers T,Deigner HP,Thiery J,Reinhart K,Bauer M

更新日期：2005-11-08 00:00:00

abstract：:Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor recordings from 15 clinically stable patients with various cardiac disorders. Mean hourly VPD frequencies ranged from 37--1,801 per hour. Data were subjected t...

journal_title：Circulation

authors： Morganroth J,Michelson EL,Horowitz LN,Josephson ME,Pearlman AS,Dunkman WB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Few studies have examined the association of race and outcomes after coronary artery bypass graft (CABG) surgery while controlling for both patient and hospital effects. METHODS AND RESULTS:We retrospectively analyzed data on a cohort of 566,785 white and 24,354 black Medicare beneficiaries 65 years old and...

journal_title：Circulation

authors： Konety SH,Vaughan Sarrazin MS,Rosenthal GE

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Basic fibroblast growth factor (bFGF) has been shown to reduce infarct size in canine acute myocardial infarction; however, the mechanism of tissue salvage remains uncertain. We evaluated the effect of bFGF on infarct size in a model of acute infarction in which coronary occlusion was followed by prolonged r...

journal_title：Circulation

authors： Horrigan MC,MacIsaac AI,Nicolini FA,Vince DG,Lee P,Ellis SG,Topol EJ

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Disturbed fibrinolytic function may influence the progression of coronary atherosclerosis and contribute to thrombotic cardiovascular (CV) events. METHODS AND RESULTS:In the Angina Prognosis Study in Stockholm (APSIS), patients with stable angina pectoris were studied prospectively during double-blind treat...

journal_title：Circulation

authors： Held C,Hjemdahl P,Rehnqvist N,Wallén NH,Björkander I,Eriksson SV,Forslund L,Wiman B

更新日期：1997-05-20 00:00:00

abstract：BACKGROUND:The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. METHODS:Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure ...

journal_title：Circulation

authors： Laforest I,Dumesnil JG,Briand M,Cartier PC,Pibarot P

更新日期：2002-09-24 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：:We studied 10 obese volunteers, mean age 36.5 +/- 10.3 years, who weighed 123.56 +/- 28.7 g and were 69.96 +/- 22.5 kg overweight. The subjects did not have diabetes, arterial hypertension or signs of cardiac and respiratory failure or disease and all underwent right- and left-heart catheterization. cardiac output and...

journal_title：Circulation

authors： de Divitiis O,Fazio S,Petitto M,Maddalena G,Contaldo F,Mancini M

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Myocardial uptake of either 201Tl or 99mTc-sestamibi (sestamibi) is known to plateau at high coronary flow rates. However, few direct comparisons have been made between these tracers to determine what effect differences in the uptake plateau for the two tracers may have on the detection of coronary stenoses ...

journal_title：Circulation

authors： Glover DK,Ruiz M,Edwards NC,Cunningham M,Simanis JP,Smith WH,Watson DD,Beller GA

更新日期：1995-02-01 00:00:00