Abstract:
BACKGROUND:Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT increases energy expenditure and is beneficial for metabolic diseases, little is known about the role of PVAT in vascular diseases such as atherosclerosis. We hypothesize that the thermogenic function of PVAT regulates intravascular temperature and reduces atherosclerosis. METHODS AND RESULTS:PVAT shares similar structural and proteomics with BAT. We demonstrated that PVAT has thermogenic properties similar to BAT in response to cold stimuli in vivo. Proteomics analysis of the PVAT from mice housed in a cold environment identified differential expression in proteins highly related to cellular metabolic processes. In a mouse model deficient in peroxisome proliferator-activated receptor-γ in smooth muscle cells (SMPG KO mice), we uncovered a complete absence of PVAT surrounding the vasculature, likely caused by peroxisome proliferator-activated receptor-γ deletion in the perivascular adipocyte precursor cells as well. Lack of PVAT, which results in loss of its thermogenic activity, impaired vascular homeostasis, which caused temperature loss and endothelial dysfunction. We further showed that cold exposure inhibits atherosclerosis and improves endothelial function in mice with intact PVAT but not in SMPG KO mice as a result of impaired lipid clearance. Proinflammatory cytokine expression in PVAT is not altered on exposure to cold. Finally, prostacyclin released from PVAT contributes to the vascular protection against endothelial dysfunction. CONCLUSIONS:PVAT is a vasoactive organ with functional characteristics similar to BAT and is essential for intravascular thermoregulation of cold acclimation. This thermogenic capacity of PVAT plays an important protective role in the pathogenesis of atherosclerosis.
journal_name
Circulationjournal_title
Circulationauthors
Chang L,Villacorta L,Li R,Hamblin M,Xu W,Dou C,Zhang J,Wu J,Zeng R,Chen YEdoi
10.1161/CIRCULATIONAHA.112.104489subject
Has Abstractpub_date
2012-08-28 00:00:00pages
1067-78issue
9eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.112.104489journal_volume
126pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.900704
更新日期:2010-01-05 00:00:00
abstract:BACKGROUND:We explored whether chronic hyperglycemia is associated with defects in endothelium-dependent vasodilatation in vivo and whether defects in the hemodynamic effects of insulin explain insulin resistance. METHODS AND RESULTS:Vasodilator responses to brachial artery infusions of acetylcholine, sodium nitroprus...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.6.1276
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:The Rho/Rho-associated kinase (Rho-kinase) system is implicated in various cellular functions, including migration, proliferation, and apoptosis. Because a possible role of the system is suggested in neointima formation after vascular injury, we sought to examine whether a new specific Rho-kinase inhibitor, ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.2.284
更新日期:2001-01-16 00:00:00
abstract:BACKGROUND:Congenital long-QT syndrome (LQTS) is a primary arrhythmogenic syndrome stemming from perturbed cardiac repolarization. LQTS, which affects approximately 1 in 3000 persons, is 1 of the most common causes of autopsy-negative sudden death in the young. Since the sentinel discovery of cardiac channel gene mutat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.635268
更新日期:2006-11-14 00:00:00
abstract:BACKGROUND:The cardiovascular adaptation to bed rest leads to orthostatic intolerance, characterized by an excessive fall in stroke volume (SV) in the upright position. We hypothesized that this large fall in SV is due to a change in cardiac mechanics. METHODS AND RESULTS:We measured pulmonary capillary wedge pressure...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.2.517
更新日期:1997-07-15 00:00:00
abstract:BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.5.1381
更新日期:1997-09-02 00:00:00
abstract:BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.572453
更新日期:2005-10-25 00:00:00
abstract::We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs (n = 8). Right atrial (RA), atrioventricular nodal (AVN), and right ventricular (RV) effective refractory period (ERP), and AVN functional ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.72.6.1380
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc37t1.094593
更新日期:2001-09-18 00:00:00
abstract:BACKGROUND:Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial. METHODS AND RESULTS:The Op...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.106.618421
更新日期:2006-07-11 00:00:00
abstract:BACKGROUND:Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. Clinically, high plasma adiponect...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127953.98131.ED
更新日期:2004-05-04 00:00:00
abstract:BACKGROUND:It remains unclear how mineralocorticoids induce cardiac hypertrophy and fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been shown to induce cardiac hypertrophy. In the present study, we examine the role of calcineurin in mineralocorticoid-induced cardiac hypertrophy an...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0602.104675
更新日期:2002-02-12 00:00:00
abstract:BACKGROUND:One or more brief episodes of coronary artery occlusion protect or "precondition" the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.3.893
更新日期:1993-03-01 00:00:00
abstract::The rapid injection into the coronary circulation of solutions containing microbubbles produces an ultrasonic contrast effect in the myocardium. The time-intensity curves generated by sequential videodensitometric analysis of contrast intensity, which is corrected for myocardial background intensity, resembles the cur...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.779
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude of myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions of profound microvascular obstruction at the infarct core are hypoenhanced and correspond to greate...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.8.765
更新日期:1998-03-03 00:00:00
abstract:BACKGROUND:Reduced renal function is associated with a poorer prognosis and increased bleeding risk in patients with acute coronary syndromes and may therefore alter the risk-benefit ratio with antiplatelet therapies. In the Platelet Inhibition and Patient Outcomes (PLATO) trial, ticagrelor compared with clopidogrel re...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.109.933796
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:The coexistence of atrial fibrillation (AF) and atrial flutter (AFL) is well recognized. AF precedes the onset of AFL in almost all instances. We evaluated the effect of 2 ablation strategies in patients with paroxysmal AF (PAF) and AFL. METHODS AND RESULTS:Ninety-eight patients with PAF/AFL were prospectiv...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.107.711622
更新日期:2007-12-11 00:00:00
abstract:BACKGROUND:Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. METHODS AND RESULTS:We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoprotein...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.521344
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:In our multicenter study of the total cavopulmonary connection (TCPC), a cohort of patients with long-segment left pulmonary artery (LPA) stenosis was observed (35%). The clinically recognized detrimental effects of LPA stenosis motivated a computational fluid dynamic simulation study within 3-dimensional pa...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.104.530931
更新日期:2005-11-22 00:00:00
abstract::We have shown previously that the physical properties of myocardium in dogs can be characterized with quantitative ultrasonic integrated backscatter and that interrogation of the tissue with ultrasound can delineate cardiac cycle-dependent changes in ultrasonic backscatter in normal tissue that disappear with ischemia...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.5.1067
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The impact of mitral regurgitation (MR) on elderly patients (> or = 70 years) undergoing isolated aortic valve replacement (AVR) is not clearly defined. This study investigates the long-term effects of preoperative, moderate MR on survival and functional outcome in elderly AVR patients. METHODS AND RESULTS:...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.526046
更新日期:2005-08-30 00:00:00
abstract:BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000118466.47982.CC
更新日期:2004-04-13 00:00:00
abstract:BACKGROUND:We have previously shown major differences in beta-adrenergic and muscarinic modulation of L-type calcium currents (ICa) in newborn and adult rabbit heart. However, little is known about developmental changes in modulation of ICa by phosphodiesterases (PDEs), which also regulate intracellular cAMP concentrat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.1.469
更新日期:1994-07-01 00:00:00
abstract::Eighty-six of 452 patients (19%) with chronic bifascicular block were found to have no clinically apparent associated organic heart disease (OHD) and were defined as having primary conduction disease (PCD). Comparison of patients with PCD and OHD revealed a significantly lower incidence of the following clinical varia...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.1.33
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by ce...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.119.042502
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Functional mitral regurgitation (MR) is common in patients with heart failure and left ventricular (LV) dysfunction, and its severity may vary over time, depending primarily on the loading conditions. Because dynamic changes in the severity of functional MR may affect forward stroke volume, we hypothesized t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000028812.98083.d9
更新日期:2002-09-10 00:00:00
abstract:BACKGROUND:The time constant of truncated exponential pulses used with implantable defibrillators is determined by the output capacitor size and defibrillation pathway resistance. The optimal capacitor size is unknown. METHODS AND RESULTS:This study compared defibrillation threshold (DFT) for standard 120-microF capac...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.90.4.1840
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.3.1306
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc2601.091704
更新日期:2001-07-03 00:00:00