Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited disease with a relatively early onset and a mortality rate of approximately 30% by the age of 30 years. Phenotypically, it is characterized by salvoes of bidirectional and polymorphic ventricular tachycardias in response to vigo...

journal_title：Circulation

authors： Laitinen PJ,Brown KM,Piippo K,Swan H,Devaney JM,Brahmbhatt B,Donarum EA,Marino M,Tiso N,Viitasalo M,Toivonen L,Stephan DA,Kontula K

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...

journal_title：Circulation

authors： Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

更新日期：2002-02-19 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:One of the features of high-risk atherosclerotic plaques is a preponderance of macrophages. Experimental studies with hyperlipidemic rabbits have shown that ultrasmall superparamagnetic particles of iron oxide (USPIOs) accumulate in plaques with a high macrophage content and that this induces magnetic resona...

journal_title：Circulation

authors： Kooi ME,Cappendijk VC,Cleutjens KB,Kessels AG,Kitslaar PJ,Borgers M,Frederik PM,Daemen MJ,van Engelshoven JM

更新日期：2003-05-20 00:00:00

abstract：:Asymptomatic ischemia after myocardial infarction is a common clinical problem. As much as 50% of the postinfarction patient population who have ischemia on exercise testing may have no symptoms at all. In these patients, ischemia detected by either exercise testing or ambulatory electrocardiographic monitoring, with ...

journal_title：Circulation

authors： Yeung AC,Barry J,Selwyn AP

更新日期：1990-09-01 00:00:00

abstract：:The mechanism of atrial flutter is controversial. A 76-year-old woman with rheumatic heart disease was referred to our clinic with an unusual rhythm disturbance which initially appeared to be classic atrial flutter at a rate of 300 beats/min. Later tracings, however, demonstrated a rate exactly one-half that of the ea...

journal_title：Circulation

authors： Homcy CJ,Lorell B,Yurchak PM

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

journal_title：Circulation

authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis. METHODS:We tested the hypothesis that DKK3 is atheroprotective using both epidemiological a...

journal_title：Circulation

authors： Yu B,Kiechl S,Qi D,Wang X,Song Y,Weger S,Mayr A,Le Bras A,Karamariti E,Zhang Z,Barco Barrantes ID,Niehrs C,Schett G,Hu Y,Wang W,Willeit J,Qu A,Xu Q

更新日期：2017-09-12 00:00:00

abstract：:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...

journal_title：Circulation

authors： Grundler W,Weil MH,Rackow EC

更新日期：1986-11-01 00:00:00

abstract：:To investigate whether a fixed external reference system should be used to most accurately describe regional left ventricular wall motion, we used vectors to analyze a simple model of ventricular contraction. If measured in a fixed external reference system, motion of implanted radiopaque midwall markers may contain t...

journal_title：Circulation

authors： Clayton PD,Jeppson GM,Klausner SC

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. METHODS AND RESULTS:We examined the relations between echocardiographic LV measurements and glucose tolerance status ...

journal_title：Circulation

authors： Rutter MK,Parise H,Benjamin EJ,Levy D,Larson MG,Meigs JB,Nesto RW,Wilson PW,Vasan RS

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:Patients with treated diabetes in the randomized-trial segment of the Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization with PTCA had significantly worse 5-year survival than patients assigned to CABG. This treatment difference was not seen among diabe...

journal_title：Circulation

authors： Detre KM,Guo P,Holubkov R,Califf RM,Sopko G,Bach R,Brooks MM,Bourassa MG,Shemin RJ,Rosen AD,Krone RJ,Frye RL,Feit F

更新日期：1999-02-09 00:00:00

abstract：BACKGROUND:A prior diagnosis of diabetes mellitus is associated with adverse outcomes after acute myocardial infarction (MI), but the risk associated with a new diagnosis of diabetes in this setting has not been well defined. METHODS AND RESULTS:We assessed the risk of death and major cardiovascular events associated ...

journal_title：Circulation

authors： Aguilar D,Solomon SD,Køber L,Rouleau JL,Skali H,McMurray JJ,Francis GS,Henis M,O'Connor CM,Diaz R,Belenkov YN,Varshavsky S,Leimberger JD,Velazquez EJ,Califf RM,Pfeffer MA

更新日期：2004-09-21 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：:Although for most children the process of atherosclerosis is subclinical, dramatically accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary events occurring in childhood and very early adult life. As with most scientific statements about children and the future risk for cardiovas...

journal_title：Circulation

authors： Kavey RE,Allada V,Daniels SR,Hayman LL,McCrindle BW,Newburger JW,Parekh RS,Steinberger J,American Heart Association Expert Panel on Population and Prevention Science.,American Heart Association Council on Cardiovascular Disease in the

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:More than 300 000 out-of-hospital cardiac arrests (OHCA) occur each year in the United States. The relationship between time of day and OHCA outcomes in the prehospital setting is unknown. Any such association may have important implications for emergency medical services resource allocation. METHODS AND RE...

journal_title：Circulation

authors： Wallace SK,Abella BS,Shofer FS,Leary M,Agarwal AK,Mechem CC,Gaieski DF,Becker LB,Neumar RW,Band RA

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We fo...

journal_title：Circulation

authors： Sesso HD,Paffenbarger RS Jr,Lee IM

更新日期：2000-08-29 00:00:00

abstract：:The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransm...

journal_title：Circulation

authors： Geltman EM,Biello D,Welch MJ,Ter-Pogossian MM,Roberts R,Sobel BE

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed. METHODS AND RESULTS:In a double-bli...

journal_title：Circulation

authors： Bezafibrate Infarction Prevention (BIP) study.

更新日期：2000-07-04 00:00:00

abstract：BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...

journal_title：Circulation

authors： Matitiau A,Perez-Atayde A,Sanders SP,Sluysmans T,Parness IA,Spevak PJ,Colan SD

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a dist...

journal_title：Circulation

authors： Kitani T,Ong SG,Lam CK,Rhee JW,Zhang JZ,Oikonomopoulos A,Ma N,Tian L,Lee J,Telli ML,Witteles RM,Sharma A,Sayed N,Wu JC

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:This article presents an update of the results achieved by modern surgery in congenital heart defects (CHDs) over the past 40 years regarding survival and the need for reoperations, especially focusing on the results from the past 2 decades. METHODS AND RESULTS:From 1971 to 2011, all 7038 patients <16 years...

journal_title：Circulation

authors： Erikssen G,Liestøl K,Seem E,Birkeland S,Saatvedt KJ,Hoel TN,Døhlen G,Skulstad H,Svennevig JL,Thaulow E,Lindberg HL

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. METHODS AND RESULTS:To minimize the systemic influence, soluble Fas ligand was injected directly into in vivo rat hearts and livers (as the control) ...

journal_title：Circulation

authors： Hayakawa K,Takemura G,Koda M,Kawase Y,Maruyama R,Li Y,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2002-06-25 00:00:00

abstract：BACKGROUND:Important in the postoperative management of neonates with single-ventricle complexes, such as hypoplastic left heart syndrome and pulmonary atresia with intact ventricular septum, is the fact that the pulmonary circulation is connected to the systemic circulation via a shunt. The distribution of flow to the...

journal_title：Circulation

authors： Mora GA,Pizarro C,Jacobs ML,Norwood WI

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Eplerenone is known to reduce time to first hospitalization for heart failure or cardiovascular death in patients with heart failure and mild symptoms. In chronic diseases such as heart failure, characterized by repeat hospitalizations, analyzing all heart failure hospitalizations, not just the first, should...

journal_title：Circulation

authors： Rogers JK,McMurray JJ,Pocock SJ,Zannad F,Krum H,van Veldhuisen DJ,Swedberg K,Shi H,Vincent J,Pitt B

更新日期：2012-11-06 00:00:00

abstract：:Twenty-two patients who underwent anatomic correction of transposition of the great arteries at the arterial level at the age of 8 weeks to 14 years were reinvestigated 1-4.6 years (mean 2.0 years) after operation. A Dacron tube was used to bridge the gap between the proximal pulmonary route and the distal pulmonary a...

journal_title：Circulation

authors： Yacoub MH,Bernhard A,Radley-Smith R,Lange P,Sievers H,Heintzen P

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:This multicenter trial was conducted to determine the efficacy and safety of pimobendan, an inotropic agent with calcium-sensitizing properties and activity as a phosphodiesterase inhibitor, in patients with heart failure. METHODS AND RESULTS:One hundred ninety-eight ambulatory patients with symptoms of mod...

journal_title：Circulation

authors： Kubo SH,Gollub S,Bourge R,Rahko P,Cobb F,Jessup M,Brozena S,Brodsky M,Kirlin P,Shanes J

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric protein that dynamically regulates thick-filament structure and function. In constitutive cMyBP-C knockout (cMyBP-C(-/-)) mice, loss of cMyBP-C has been linked to left ventricular dilation, cardiac hypertrophy, and systolic and diastolic dysfunction,...

journal_title：Circulation

authors： Chen PP,Patel JR,Powers PA,Fitzsimons DP,Moss RL

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP) levels are used in the evaluation of patients with heart disease, yet there is little understanding of the effect of hypoxia on natriuretic peptide secretion. Furthermore, recent data suggest that oxytocin may mediate stretch-induced atrial natriuretic peptide (ANP) secretion....

journal_title：Circulation

authors： Hopkins WE,Chen Z,Fukagawa NK,Hall C,Knot HJ,LeWinter MM

更新日期：2004-06-15 00:00:00