Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention,

abstract：BACKGROUND:Elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with higher risk of adverse outcomes in patients at risk for or with established coronary artery disease. Retrospective analyses suggest that this risk may be modified with statin therapy. However, a role for hsCRP in monitoring th...

journal_title：Circulation

authors： Morrow DA,de Lemos JA,Sabatine MS,Wiviott SD,Blazing MA,Shui A,Rifai N,Califf RM,Braunwald E

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in norepinephrine synthesis. The present study was a randomized, blinded, placebo-controlled investigation of the long-term effects of therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular (LV) dysfunction an...

journal_title：Circulation

authors： Sabbah HN,Stanley WC,Sharov VG,Mishima T,Tanimura M,Benedict CR,Hegde S,Goldstein S

更新日期：2000-10-17 00:00:00

abstract：:The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...

journal_title：Circulation

authors： Guazzi MD,De Cesare N,Fiorentini C,Galli C,Moruzzi P,Tamborini G

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arg...

journal_title：Circulation

authors： Wilson AM,Harada R,Nair N,Balasubramanian N,Cooke JP

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Patients with treated diabetes in the randomized-trial segment of the Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization with PTCA had significantly worse 5-year survival than patients assigned to CABG. This treatment difference was not seen among diabe...

journal_title：Circulation

authors： Detre KM,Guo P,Holubkov R,Califf RM,Sopko G,Bach R,Brooks MM,Bourassa MG,Shemin RJ,Rosen AD,Krone RJ,Frye RL,Feit F

更新日期：1999-02-09 00:00:00

abstract：BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

journal_title：Circulation

authors： Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:The possible contribution of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, to neurohumoral compensation for hemodynamic stress was examined in nine normal volunteers and six patients with severe congestive heart failure. METHODS AND RESULTS:Plasma levels of endothelin-1 were measured w...

journal_title：Circulation

authors： Stewart DJ,Cernacek P,Costello KB,Rouleau JL

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...

journal_title：Circulation

authors： Prager NA,Abendschein DR,McKenzie CR,Eisenberg PR

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:The cytoskeleton plays an important role in maintaining cell structure and integrity. Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy. We analyzed heart tissues from subjects with dilated cardiomyopathy for abnormalities in the cardiac cytoskeleton. Metavinculin, a car...

journal_title：Circulation

authors： Maeda M,Holder E,Lowes B,Valent S,Bies RD

更新日期：1997-01-07 00:00:00

abstract：BACKGROUND:Significant gender-related differences exist in the development of left ventricular hypertrophy (LVH). In addition, administration of 17beta-estradiol (E2) to ovariectomized female mice attenuates the development of LVH, demonstrating an antagonistic role for E2 in this process, although no molecular mechani...

journal_title：Circulation

authors： Babiker FA,De Windt LJ,van Eickels M,Thijssen V,Bronsaer RJ,Grohé C,van Bilsen M,Doevendans PA

更新日期：2004-01-20 00:00:00

abstract：:Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

journal_title：Circulation

authors： Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Elevated lipoprotein (Lp) (a) concentrations are associated with coronary artery disease and myocardial infarction. Lp(a) is structurally related to proteins involved in lipid transport, fibrinolysis, coagulation, and cellular mitogenesis and is known to have important physiological interactions with the coa...

journal_title：Circulation

authors： Desmarais RL,Sarembock IJ,Ayers CR,Vernon SM,Powers ER,Gimple LW

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Cardiac vagal predominance increases the RR interval and RR high-frequency (HF) variability during non-rapid eye movement (non-REM) sleep (stages I through IV) in young subjects. Aging suppresses deep sleep, but effects of age-related changes in sleep architecture on RR are unknown. Whether mechanical effect...

journal_title：Circulation

authors： Crasset V,Mezzetti S,Antoine M,Linkowski P,Degaute JP,van de Borne P

更新日期：2001-01-02 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is an important active protein for the induction of angiogenesis and improvement in cardiac function after myocardial ischemia; however, the lack of a delivery system targeted to the injured myocardium reduces the local therapeutic efficacy of VEGF and increases its ...

journal_title：Circulation

authors： Zhang J,Ding L,Zhao Y,Sun W,Chen B,Lin H,Wang X,Zhang L,Xu B,Dai J

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Ischemia-induced electrophysiological changes are more prominent in epicardial cells than in endocardial cells. Epicardial action potentials shorten more than endocardial action potentials during ischemia. Since the L-type Ca2+ current plays an important role in the maintenance of action potential duration, ...

journal_title：Circulation

authors： Kimura S,Bassett AL,Furukawa T,Furukawa N,Myerburg RJ

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...

journal_title：Circulation

authors： Chen LW,Dai XF,Lu L,Zhang GC,Cao H

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in ...

journal_title：Circulation

authors： Benschop L,Schalekamp-Timmermans S,Broere-Brown ZA,Roeters van Lennep JE,Jaddoe VWV,Roos-Hesselink JW,Ikram MK,Steegers EAP,Roberts JM,Gandley RE

更新日期：2019-04-02 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epi...

journal_title：Circulation

authors： Krishnan SC,Antzelevitch C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Whether and to what extent complement is activated in acute myocardial infarction (AMI) and how it contributes to inflammation of the ischemic area are not yet clear. Fibrinolytic agents used for thrombolysis are known to activate complement in vitro and may contribute to its activation in vivo. The aim of t...

journal_title：Circulation

authors： Frangi D,Gardinali M,Conciato L,Cafaro C,Pozzoni L,Agostoni A

更新日期：1994-01-01 00:00:00

abstract：:The continuity equation suggests that a ratio of velocities at two different cardiac valves is inversely proportional to the ratio of cross-sectional areas of the valves. To determine whether a ratio of mitral/aortic valve orifice velocities is useful in determining aortic valve area in patients with aortic stenosis, ...

journal_title：Circulation

authors： Richards KL,Cannon SR,Miller JF,Crawford MH

更新日期：1986-05-01 00:00:00

abstract：:Prior studies have demonstrated the presence of inhomogeneities in myocardial [K+]e after serial 10-minute occlusions of the left anterior descending coronary artery in the pig, even within restricted locations of an ischemic zone. These inhomogeneities are thought to underlie the electrophysiological abnormalities re...

journal_title：Circulation

authors： Johnson TA,Engle CL,Boyd LM,Koch GG,Gwinn M,Gettes LS

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefo...

journal_title：Circulation

authors： Zhang L,Zhang ZG,Ding GL,Jiang Q,Liu X,Meng H,Hozeska A,Zhang C,Li L,Morris D,Zhang RL,Lu M,Chopp M

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：:The evidence supporting the thesis that hypertension can be prevented by eliminating salt from the diet is based on four principal sources: (1) epidemiological studies in unacculturated peoples showing that the prevalence of hypertension is inversely correlated with the degree of salt intake; (2) hemodynamic studies s...

journal_title：Circulation

authors： Freis ED

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Abnormal vascular reactivity represents a fundamental disturbance in vascular biology with the development of atherosclerosis. Because endothelial vasodilator function plays a pivotal role in controlling vasomotor tone, we hypothesized that atherosclerotic wall thickening might directly interfere with defici...

journal_title：Circulation

authors： Zeiher AM,Schächlinger V,Hohnloser SH,Saurbier B,Just H

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

journal_title：Circulation

authors： Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...

journal_title：Circulation

authors： Miyazaki C,Powell BD,Bruce CJ,Espinosa RE,Redfield MM,Miller FA,Hayes DL,Cha YM,Oh JK

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00