Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.

abstract：BACKGROUND:Molecular imaging of thrombus within fissures of vulnerable atherosclerotic plaques requires sensitive detection of a robust thrombus-specific contrast agent. In this study, we report the development and characterization of a novel ligand-targeted paramagnetic molecular imaging agent with high avidity for fi...

journal_title：Circulation

authors： Flacke S,Fischer S,Scott MJ,Fuhrhop RJ,Allen JS,McLean M,Winter P,Sicard GA,Gaffney PJ,Wickline SA,Lanza GM

更新日期：2001-09-11 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:The Department of Veterans Affairs Randomized On/Off Bypass (ROOBY) trial compared clinical and angiographic outcomes in off-pump versus on-pump coronary artery bypass graft (CABG) surgery to ascertain the relative efficacy of the 2 techniques. METHODS AND RESULTS:From February 2002 to May 2007, the ROOBY t...

journal_title：Circulation

authors： Hattler B,Messenger JC,Shroyer AL,Collins JF,Haugen SJ,Garcia JA,Baltz JH,Cleveland JC Jr,Novitzky D,Grover FL,Veterans Affairs Randomized On\/Off Bypass (ROOBY) Study Group.

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

journal_title：Circulation

authors： Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

更新日期：2006-10-24 00:00:00

abstract：BACKGROUND:The mechanism and treatment of diastolic heart failure are poorly understood. We compared the effects of an ACE inhibitor, an angiotensin receptor blocker (ARB), and their combination on diastolic heart failure in Dahl salt-sensitive (DS) rats. METHODS AND RESULTS:DS rats fed an 8% NaCl diet from 7 weeks of...

journal_title：Circulation

authors： Kim S,Yoshiyama M,Izumi Y,Kawano H,Kimoto M,Zhan Y,Iwao H

更新日期：2001-01-02 00:00:00

abstract：:The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bio...

journal_title：Circulation

authors： Garcia-Garcia HM,McFadden EP,Farb A,Mehran R,Stone GW,Spertus J,Onuma Y,Morel MA,van Es GA,Zuckerman B,Fearon WF,Taggart D,Kappetein AP,Krucoff MW,Vranckx P,Windecker S,Cutlip D,Serruys PW,Academic Research Consortium

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Primum atrial septal defect (ASD) is a defect that is usually associated with few symptoms and can be electively repaired with good results. A review of our experience with primum ASD identified a subset of patients characterized by presentation with congestive heart failure (CHF) in the first months of life...

journal_title：Circulation

authors： Manning PB,Mayer JE Jr,Sanders SP,Coleman EA,Jonas RA,Keane JF,VanPraagh S,Castañeda AR

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...

journal_title：Circulation

authors： Magne J,Lancellotti P,Piérard LA

更新日期：2010-07-06 00:00:00

abstract：:The directions and magnitudes of time-normalized P, QRS, and ST vectors, and other ECG parameters were analyzed during and after multistage exercise in 56 ostensibly healthy men aged 23 to 62. By selective averaging with a digital computer system a single representative beat was obtained from each stage. Measurements ...

journal_title：Circulation

authors： Simoons ML,Hugenholtz PG

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...

journal_title：Circulation

authors： Singh GM,Danaei G,Pelizzari PM,Lin JK,Cowan MJ,Stevens GA,Farzadfar F,Khang YH,Lu Y,Riley LM,Lim SS,Ezzati M

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy in older versus younger patients with acute coronary syndromes is understudied. Low-dose prasugrel (5 mg/d) is recommended for younger, lower-body-weight patients and elderly patients with acute coronary syndromes to mitigate the bleeding risk of standard-dose prasugrel (10 mg/d). ...

journal_title：Circulation

authors： Roe MT,Goodman SG,Ohman EM,Stevens SR,Hochman JS,Gottlieb S,Martinez F,Dalby AJ,Boden WE,White HD,Prabhakaran D,Winters KJ,Aylward PE,Bassand JP,McGuire DK,Ardissino D,Fox KA,Armstrong PW

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...

journal_title：Circulation

authors： Kawata H,Aoki M,Mayer JE Jr

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...

journal_title：Circulation

authors： Kovanen PT,Kaartinen M,Paavonen T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The role of valve surgery in left-sided infective endocarditis has not been evaluated in randomized controlled trials. We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis. METHODS AND RESULTS:A total of 546 consecutive patie...

journal_title：Circulation

authors： Tleyjeh IM,Ghomrawi HM,Steckelberg JM,Hoskin TL,Mirzoyev Z,Anavekar NS,Enders F,Moustafa S,Mookadam F,Huskins WC,Wilson WR,Baddour LM

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. Mutations in the genes encoding for low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin 9 (PCSK9...

journal_title：Circulation

authors： van der Graaf A,Avis HJ,Kusters DM,Vissers MN,Hutten BA,Defesche JC,Huijgen R,Fouchier SW,Wijburg FA,Kastelein JJ,Wiegman A

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:The pathogenesis of sodium and water accumulation in chronic constrictive pericarditis is not well understood and may differ from that in patients with chronic congestive heart failure due to myocardial disease. This study was undertaken to investigate some of the mechanisms. METHODS AND RESULTS:Using stand...

journal_title：Circulation

authors： Anand IS,Ferrari R,Kalra GS,Wahi PL,Poole-Wilson PA,Harris PC

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:To examine the influence active-play video gaming (also referred to as exergaming, exertainment, and active gaming) might have on improving health-related skills, enhancing self-esteem and self-efficacy, promoting social support, and ultimately motivating positive changes in health behaviors, the American He...

journal_title：Circulation

authors： Lieberman DA,Chamberlin B,Medina E Jr,Franklin BA,Sanner BM,Vafiadis DK,Power of Play: Innovations in Getting Active Summit Planning Committee.

更新日期：2011-05-31 00:00:00

abstract：:Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...

journal_title：Circulation

authors： Steen PA,Tinker JH,Pluth JR,Barnh;rst DA,Tarhan S

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activ...

journal_title：Circulation

authors： Siegerink B,Govers-Riemslag JW,Rosendaal FR,Ten Cate H,Algra A

更新日期：2010-11-02 00:00:00

abstract：:Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Card...

journal_title：Circulation

authors： Franciosa JA,Jordan RA,Wilen MM,Leddy CL

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional cardiovascular risk factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on the causal pathway for certain risk factors to exert their effect. These associat...

journal_title：Circulation

authors： Stec JJ,Silbershatz H,Tofler GH,Matheney TH,Sutherland P,Lipinska I,Massaro JM,Wilson PF,Muller JE,D'Agostino RB Sr

更新日期：2000-10-03 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Friedreich's ataxia (FA), the most common inherited ataxia, is associated frequently with cardiac hypertrophy, and death is often cardiac related. Recently, the disease has been associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the gene encoding frataxin ...

journal_title：Circulation

authors： Isnard R,Kalotka H,Dürr A,Cossée M,Schmitt M,Pousset F,Thomas D,Brice A,Koenig M,Komajda M

更新日期：1997-05-06 00:00:00

abstract：:Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac...

journal_title：Circulation

authors： Roberts WC

更新日期：1976-09-01 00:00:00

abstract：:A series of 252 isolated aortic homograft valves in 248 patients have been followed for 9 to 16.5 years (mean 10.8). The valves were sterilized in antibiotic solution and stored in a nutrient medium at 4 degrees C and were nonvital. There were 15 in-hospital deaths (6%) and a mortality of 2.7% in patients undergoing a...

journal_title：Circulation

authors： Barratt-Boyes BG,Roche AH,Subramanyan R,Pemberton JR,Whitlock RM

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Persons with end-stage renal disease and those with lesser degrees of chronic kidney disease (CKD) have an increased risk of death after myocardial infarction (MI) that is not fully explained by associated comorbidities. Future cardiovascular event rates and the relative response to therapy in persons with m...

journal_title：Circulation

authors： Tokmakova MP,Skali H,Kenchaiah S,Braunwald E,Rouleau JL,Packer M,Chertow GM,Moyé LA,Pfeffer MA,Solomon SD

更新日期：2004-12-14 00:00:00

abstract：:Echocardiographic and hemodynamic data were measured in closed-chest dogs during graded cardiac tamponade (pericardial pressure 5, 10, and 15 mm Hg) before and after production of diffuse ischemic left ventricular dysfunction. Left ventricular dysfunction was produced by intracoronary injection of nonradioactive micro...

journal_title：Circulation

authors： Hoit BD,Gabel M,Fowler NO

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) is an accurate method for the quantitative assessment of organic mitral regurgitation (OMR). The aim of the present study was to compare the discriminative power of MRI quantification and the recommended Doppler echocardiography (ECHO)-derived integrative approach to identify...

journal_title：Circulation

authors： Penicka M,Vecera J,Mirica DC,Kotrc M,Kockova R,Van Camp G

更新日期：2018-03-27 00:00:00