Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction.

abstract：BACKGROUND:Recent studies indicate that serotonin (5-HT) has a growth-promoting effect on several different cell types, including smooth muscle cells. After percutaneous transluminal coronary angioplasty, there is damage and denudation of vascular endothelial cells, which promotes platelet aggregation at the site of in...

journal_title：Circulation

authors： Pakala R,Willerson JT,Benedict CR

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Lymphatic network and chemokine-mediated signals are essential for leukocyte traffic during the proximal steps of alloimmune response. We aimed to determine the role of lymphatic vessels and their principal growth signaling pathway, vascular endothelial growth factor (VEGF)-C/D/VEGFR-3, during acute and chro...

journal_title：Circulation

authors： Nykänen AI,Sandelin H,Krebs R,Keränen MA,Tuuminen R,Kärpänen T,Wu Y,Pytowski B,Koskinen PK,Ylä-Herttuala S,Alitalo K,Lemström KB

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Varicose veins are a common problem with no approved medical therapies. Although it is believed that varicose vein pathogenesis is multifactorial, there is limited understanding of the genetic and environmental factors that contribute to their formation. Large-scale studies of risk factors for varicose veins...

journal_title：Circulation

authors： Fukaya E,Flores AM,Lindholm D,Gustafsson S,Zanetti D,Ingelsson E,Leeper NJ

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

journal_title：Circulation

authors： Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

更新日期：1998-10-13 00:00:00

abstract：:Twelve consecutive patients who developed torsade de pointes (polymorphous ventricular tachycardia with marked QT prolongation, TdP) over a 4 year period were treated with intravenous injections of magnesium sulfate. In nine of the patients a single bolus of 2 g completely abolished the TdP within 1 to 5 min, and in t...

journal_title：Circulation

authors： Tzivoni D,Banai S,Schuger C,Benhorin J,Keren A,Gottlieb S,Stern S

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:After cardiopulmonary bypass (CPB), pulmonary hypertension and its associated increased vascular reactivity are a major source of morbidity, particularly for children with increased pulmonary blood flow. Although post-CPB pulmonary hypertension is well described, its mechanisms remain incompletely understood...

journal_title：Circulation

authors： Reddy VM,Hendricks-Munoz KD,Rajasinghe HA,Petrossian E,Hanley FL,Fineman JR

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. METHODS AND RESULTS:Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimi...

journal_title：Circulation

authors： Delsing DJ,Offerman EH,van Duyvenvoorde W,van Der Boom H,de Wit EC,Gijbels MJ,van Der Laarse A,Jukema JW,Havekes LM,Princen HM

更新日期：2001-04-03 00:00:00

abstract：BACKGROUND:According to the American Heart Association, passive smoking is an important risk factor for coronary heart disease (CHD), but the mechanisms underlying this association are not fully understood. We studied the acute effect of passive smoking on the factors that influence the development of CHD: the antioxid...

journal_title：Circulation

authors： Valkonen M,Kuusi T

更新日期：1998-05-26 00:00:00

abstract：:Expansion (regional dilatation and thinning) of acutely infarcted myocardium in man has been shown to correlate with overall cardiac dilatation and rupture. We studied gross and histopathologic features and the time course of expansion in rats. Infarcts were produced in 84 rats by ligation of the left coronary artery ...

journal_title：Circulation

authors： Hochman JS,Bulkley BH

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Eliminating out-of-pocket costs for patients after myocardial infarction (MI) improves adherence to preventive therapies and reduces clinical events. Because adherence to medical therapy is low among patients treated with coronary artery bypass graft surgery (CABG), we evaluated the impact of providing full ...

journal_title：Circulation

authors： Kulik A,Desai NR,Shrank WH,Antman EM,Glynn RJ,Levin R,Reisman L,Brennan T,Choudhry NK

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:MicroRNAs (miRs) participate in many cardiac pathophysiological processes, including ischemia/reperfusion (I/R)-induced cardiac injury. Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response ...

journal_title：Circulation

authors： Wang X,Zhang X,Ren XP,Chen J,Liu H,Yang J,Medvedovic M,Hu Z,Fan GC

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:We evaluated the prognosis of deferred and revascularized coronary stenoses after fractional flow reserve (FFR) measurement to assess its revascularization threshold in clinical practice. METHODS:The IRIS-FFR registry (Interventional Cardiology Research In-cooperation Society Fractional Flow Reserve) prospe...

journal_title：Circulation

authors： Ahn JM,Park DW,Shin ES,Koo BK,Nam CW,Doh JH,Kim JH,Chae IH,Yoon JH,Her SH,Seung KB,Chung WY,Yoo SY,Lee JB,Choi SW,Park K,Hong TJ,Lee SY,Han M,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park SJ,IRIS-FF

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit...

journal_title：Circulation

authors： Schrage B,Becher PM,Bernhardt A,Bezerra H,Blankenberg S,Brunner S,Colson P,Cudemus Deseda G,Dabboura S,Eckner D,Eden M,Eitel I,Frank D,Frey N,Funamoto M,Goßling A,Graf T,Hagl C,Kirchhof P,Kupka D,Landmesser U,Li

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Cyclosporin A is reported to impair endothelium-mediated vasorelaxation and induce endothelin release in some noncoronary vascular beds. We wished to determine whether acute cyclosporine administration induces endothelial dysfunction in coronary conductance or resistance arteries. METHODS AND RESULTS:We exa...

journal_title：Circulation

authors： Sudhir K,MacGregor JS,DeMarco T,De Groot CJ,Taylor RN,Chou TM,Yock PG,Chatterjee K

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...

journal_title：Circulation

authors： Crenshaw BS,Granger CB,Birnbaum Y,Pieper KS,Morris DC,Kleiman NS,Vahanian A,Califf RM,Topol EJ

更新日期：2000-01-04 00:00:00

abstract：BACKGROUND:Marine n-3 polyunsaturated fatty acids may reduce coronary mortality. Previous data in relation to nonfatal coronary disease, however, have been inconsistent, which may be explained by the use of heterogeneous methods to assess the intake of marine n-3 polyunsaturated fatty acids. We investigated the hypothe...

journal_title：Circulation

authors： Joensen AM,Overvad K,Dethlefsen C,Johnsen SP,Tjønneland A,Rasmussen LH,Schmidt EB

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study was to determine the predictive value of postoperative myocardial injury, as mea...

journal_title：Circulation

authors： van Waes JA,Nathoe HM,de Graaff JC,Kemperman H,de Borst GJ,Peelen LM,van Klei WA,Cardiac Health After Surgery (CHASE) Investigators.

更新日期：2013-06-11 00:00:00

abstract：:In 18 patients with stable effort angina, verapamil, 80 mg four times daily, was compared with propranolol, 80 mg four times daily, in a double-blind, placebo-controlled trial to assess the effects on anginal threshold, exercise capacity and left ventricular function measured by gated equilibrium blood pool scanning. ...

journal_title：Circulation

authors： Sadick NN,Tan AT,Fletcher PJ,Morris J,Kelly DT

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS:In TIMI 10B, 886 patients with acute ST-elevation myocardial in...

journal_title：Circulation

authors： Cannon CP,Gibson CM,McCabe CH,Adgey AA,Schweiger MJ,Sequeira RF,Grollier G,Giugliano RP,Frey M,Mueller HS,Steingart RM,Weaver WD,Van de Werf F,Braunwald E

更新日期：1998-12-22 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

journal_title：Circulation

authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population....

journal_title：Circulation

authors： O'Hare AM,Katz R,Shlipak MG,Cushman M,Newman AB

更新日期：2006-01-24 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...

journal_title：Circulation

authors： Mahoney EM,Wang K,Arnold SV,Proskorovsky I,Wiviott S,Antman E,Braunwald E,Cohen DJ

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Arterial hypertension is a prime cause of morbidity and mortality in the general population. Pharmacological treatment has limitations resulting from drug side effects, costs, and patient compliance. Thus, we investigated whether traditional Chinese medicine acupuncture is able to lower blood pressure. METH...

journal_title：Circulation

authors： Flachskampf FA,Gallasch J,Gefeller O,Gan J,Mao J,Pfahlberg AB,Wortmann A,Klinghammer L,Pflederer W,Daniel WG

更新日期：2007-06-19 00:00:00

abstract：BACKGROUND:Although LDL cholesterol (LDL-C) is generally accepted to be a major risk factor for progression of atherosclerosis, the traditional measurement of LDL-C includes measurement of IDL. Little is known about the relationship between IDL and progression of atherosclerosis. Therefore, we investigated the associat...

journal_title：Circulation

authors： Hodis HN,Mack WJ,Dunn M,Liu C,Liu C,Selzer RH,Krauss RM

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Cardiac arrest without evident cardiac disease may be caused by subclinical genetic conditions. Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening. METHODS AND RESULTS:Patients with apparently unexplained ca...

journal_title：Circulation

authors： Krahn AD,Healey JS,Chauhan V,Birnie DH,Simpson CS,Champagne J,Gardner M,Sanatani S,Exner DV,Klein GJ,Yee R,Skanes AC,Gula LJ,Gollob MH

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Exertional fatigue, which frequently limits exercise in patients with chronic heart failure, is associated with early anaerobic metabolism in skeletal muscle. The present study was designed to examine the skeletal muscle metabolic response to exercise in this disorder and determine the relation of reduced mu...

journal_title：Circulation

authors： Sullivan MJ,Green HJ,Cobb FR

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Simvastatin attenuates ischemia and reperfusion in normocholesterolemic animals by stabilizing endothelial nitric oxide synthase activity and inhibiting neutrophil-mediated injury. Because endothelial dysfunction is a detrimental effect of hypercholesterolemia, we examined whether short-term treatment with s...

journal_title：Circulation

authors： Scalia R,Gooszen ME,Jones SP,Hoffmeyer M,Rimmer DM 3rd,Trocha SD,Huang PL,Smith MB,Lefer AM,Lefer DJ

更新日期：2001-05-29 00:00:00

abstract：BACKGROUND:Abnormal vascular reactivity represents a fundamental disturbance in vascular biology with the development of atherosclerosis. Because endothelial vasodilator function plays a pivotal role in controlling vasomotor tone, we hypothesized that atherosclerotic wall thickening might directly interfere with defici...

journal_title：Circulation

authors： Zeiher AM,Schächlinger V,Hohnloser SH,Saurbier B,Just H

更新日期：1994-06-01 00:00:00