A double-blind randomized trial of propranolol and verapamil in the treatment of effort angina.

abstract：:Regional myocardial function and blood flow were determined for 48 hours after permanent occlusion of the left circumflex coronary artery in conscious swine. Systolic wall thickening and end-diastolic wall thickness (EDWTh) were correlated with regional myocardial flow (RMBF) at 15 minutes, 24 and 48 hours after occlu...

journal_title：Circulation

authors： Savage RM,Guth B,White FC,Hagan AD,Bloor CM

更新日期：1981-10-01 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

journal_title：Circulation

authors： Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

更新日期：2008-02-12 00:00:00

abstract：:An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, a...

journal_title：Circulation

authors： Hodgson JM,Marshall JJ

更新日期：1989-05-01 00:00:00

abstract：:Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicate...

journal_title：Circulation

authors： Myreng Y,Smiseth OA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the association between advanced age and atherosclerotic diseases are not clear. Because atherosclerosis develops in response to local endothelial injuries, we investigated the effect of aging on vascular healing and reendothelialization. METHODS AND RESULTS:Endothelium denuda...

journal_title：Circulation

authors： Gennaro G,Ménard C,Michaud SE,Rivard A

更新日期：2003-01-21 00:00:00

abstract：BACKGROUND:From 1958 to 1969, 592 patients (mostly children) with pulmonary stenosis were admitted to the First Natural History Study of Congenital Heart Defects (NHS-1) after cardiac catheterization. Most with gradients < 50 mm Hg were managed medically; most with gradients > or = 80 mm Hg had pulmonary valvotomy. Amo...

journal_title：Circulation

authors： Hayes CJ,Gersony WM,Driscoll DJ,Keane JF,Kidd L,O'Fallon WM,Pieroni DR,Wolfe RR,Weidman WH

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. METHODS AND RESULTS:(111)I...

journal_title：Circulation

authors： Mruk JS,Webster MW,Heras M,Reid JM,Grill DE,Chesebro JH

更新日期：2000-01-25 00:00:00

abstract：BACKGROUND:In patients with acute myocardial infarction (AMI), hyperglycemia predicts death, but the prognostic significance of hypoglycemia is controversial. METHODS AND RESULTS:We evaluated the prognostic significance of hypoglycemia and hyperglycemia in 30 536 AMI patients in a post hoc analysis of 2 large trials o...

journal_title：Circulation

authors： Goyal A,Mehta SR,Díaz R,Gerstein HC,Afzal R,Xavier D,Liu L,Pais P,Yusuf S

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Circulatory arrest (CA), which provides a bloodless field and good visualization without the need of aortic cross-clamp, is commonly used to facilitate repair of aortic lesions. However, extended periods of CA may impair cerebral metabolism and cause ischemic injury. Studies were performed to evaluate the ef...

journal_title：Circulation

authors： Lin PJ,Chang CH,Tan PP,Chang CN,Lee ST,Wang CC,Chang JP,Liu DW,Chu JJ,Tsai KT,Kao CL,Hsieh MJ,Hua MS

更新日期：1996-11-01 00:00:00

abstract：:The capability of a pulsed Doppler flowmeter combined with a phased-array imaging system to measure volume flow was tested in vitro and in patients undergoing cardiac catheterization. The Doppler-phased-array system (DPA) was used to determine vessel diameter and a superimposed cursor was used to locate the range and ...

journal_title：Circulation

authors： Magnin PA,Stewart JA,Myers S,von Ramm O,Kisslo JA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Specific thrombin inhibitors are considered to be more potent antithrombotics than heparin. However, the relation between the systemic anticoagulation generated by thrombin inhibitors and their antithrombotic effect is not well defined. In a guinea pig carotid thrombosis model, the activated clotting time (A...

journal_title：Circulation

authors： Carteaux JP,Gast A,Tschopp TB,Roux S

更新日期：1995-03-01 00:00:00

abstract：:This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...

journal_title：Circulation

authors： Schmidt DH,Blau FM,Hendrix LJ,Kamath ML,Ray G

更新日期：1985-04-01 00:00:00

abstract：:Platelet function can be assessed by various techniques in vitro or in vivo, but methodological problems in the field are considerable. By use of the conventional in vitro technique (Born aggregometry), it has been shown that sympathoadrenal activation in vivo (e.g., mental stress, epinephrine infusions, exercise, and...

journal_title：Circulation

authors： Hjemdahl P,Larsson PT,Wallén NH

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Statins are effective in the primary prevention of atherosclerotic cardiovascular disease. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline expands recommended statin use, but its cost-effectiveness has not been compared with other guidelines. METHODS:We used the Cardio...

journal_title：Circulation

authors： Heller DJ,Coxson PG,Penko J,Pletcher MJ,Goldman L,Odden MC,Kazi DS,Bibbins-Domingo K

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

journal_title：Circulation

authors： Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

更新日期：1996-09-15 00:00:00

abstract：:South Asians (from Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka) make up one quarter of the world's population and are one of the fastest-growing ethnic groups in the United States. Although native South Asians share genetic and cultural risk factors with South Asians abroad, South Asians in...

journal_title：Circulation

authors： Volgman AS,Palaniappan LS,Aggarwal NT,Gupta M,Khandelwal A,Krishnan AV,Lichtman JH,Mehta LS,Patel HN,Shah KS,Shah SH,Watson KE,American Heart Association Council on Epidemiology and Prevention; Cardiovascular Disease and Stroke i

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction

journal_title：Circulation

authors： Levy WC,Lee KL,Hellkamp AS,Poole JE,Mozaffarian D,Linker DT,Maggioni AP,Anand I,Poole-Wilson PA,Fishbein DP,Johnson G,Anderson J,Mark DB,Bardy GH

更新日期：2009-09-08 00:00:00

abstract：:Procainamide, a type 1A antiarrhythmic drug, blocks sodium channels and reduces the maximum rate of rise of the cardiac action potential (Vmax) in a rate-dependent fashion. In vitro, the magnitude of this rate-dependent reduction in Vmax is greater in tissue that is partially depolarized at rest than in tissue with a ...

journal_title：Circulation

authors： Cascio WE,Foster JR,Buchanan JW Jr,Johnson TA,Gettes LS

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:The Department of Veterans Affairs Randomized On/Off Bypass (ROOBY) trial compared clinical and angiographic outcomes in off-pump versus on-pump coronary artery bypass graft (CABG) surgery to ascertain the relative efficacy of the 2 techniques. METHODS AND RESULTS:From February 2002 to May 2007, the ROOBY t...

journal_title：Circulation

authors： Hattler B,Messenger JC,Shroyer AL,Collins JF,Haugen SJ,Garcia JA,Baltz JH,Cleveland JC Jr,Novitzky D,Grover FL,Veterans Affairs Randomized On\/Off Bypass (ROOBY) Study Group.

更新日期：2012-06-12 00:00:00

abstract：:Predictability of prognosis was analyzed in 630 patients who were alive 30 days after valve replacement (1965-1986) for aortic stenosis. Follow-up totaled 4,072 patient-years. During the operative periods of 1965-1971 (n = 62), 1972-1976 (n = 164), 1977-1981 (n = 158), and 1982-1986 (n = 246), decreases in cardiothora...

journal_title：Circulation

authors： Lund O

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:This study reports on the trends in the volume and outcomes of coronary revascularization procedures performed on Medicare beneficiaries between 2008 and 2012. METHODS AND RESULTS:This retrospective study identifies all Medicare beneficiaries undergoing a coronary revascularization procedure: coronary arter...

journal_title：Circulation

authors： Culler SD,Kugelmass AD,Brown PP,Reynolds MR,Simon AW

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00

abstract：BACKGROUND:Chemokines are important mediators of inflammatory cell recruitment that play a significant role in atherosclerosis. Fractalkine (CX3CL1) is an unusual membrane-bound chemokine that mediates chemotaxis through the CX3CR1 receptor. Recently, functional polymorphisms in the human CX3CR1 gene have been describe...

journal_title：Circulation

authors： Lucas AD,Bursill C,Guzik TJ,Sadowski J,Channon KM,Greaves DR

更新日期：2003-11-18 00:00:00

abstract：:A case history of a 46-year-old Negro male was presented with rheumatic aortic insufficiency, angina pectoris, and possible subacute bacterial endocarditis. While hospitalized, the patient developed angina pectoris associated with micturition. This was not accompanied by a change in blood pressure, pulse, or increase ...

journal_title：Circulation

authors： Morris JJ,McIntosh HD

更新日期：1963-01-01 00:00:00

abstract：:Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurren...

journal_title：Circulation

authors： El-Khatib MR,Chason JL,Lerner AM

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:A hallmark of heart failure is impaired cytoplasmic Ca(2+) handling of cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca(2+) handling via altered excitation-transcription coupling contribute to the development and progression of heart failure. METHODS AND RESULTS:Using tissue and...

journal_title：Circulation

authors： Ljubojevic S,Radulovic S,Leitinger G,Sedej S,Sacherer M,Holzer M,Winkler C,Pritz E,Mittler T,Schmidt A,Sereinigg M,Wakula P,Zissimopoulos S,Bisping E,Post H,Marsche G,Bossuyt J,Bers DM,Kockskämper J,Pieske B

更新日期：2014-07-15 00:00:00

abstract：:Although thrombolytic therapy has been a major advance in the treatment of acute myocardial infarction, in at least 25% of patients the artery remains occluded after administration. In these patients, the strategy of "rescue" or "salvage" angioplasty is frequently used although follow-up data are limited. Sixty-three ...

journal_title：Circulation

authors： Holmes DR Jr,Gersh BJ,Bailey KR,Reeder GS,Bresnahan JF,Bresnahan DR,Vlietstra RE

更新日期：1990-03-01 00:00:00

abstract：:Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...

journal_title：Circulation

authors： Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

更新日期：2020-03-24 00:00:00

abstract：:Left ventricular function was assessed by angiographic methods in 40 patients (ages 3-27), 1-12 years following repair of tetralogy of Fallot. Twenty of the 40 patients (group A) had a satisfactory repair with a pulmonary-systemic flow ratio (Qp/Qs) less then or equal to 1.5 and a right ventricular systolic pressure o...

journal_title：Circulation

authors： Rocchini AP,Keane JF,Freed MD,Castaneda AR,Nadas AS

更新日期：1978-04-01 00:00:00