Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo.

abstract：BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...

journal_title：Circulation

authors： van der Meer IM,Bots ML,Hofman A,del Sol AI,van der Kuip DA,Witteman JC

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:Patients with a non-ST-elevation acute coronary syndrome and prior CABG are at high risk of a recurrent ischemic event despite aspirin therapy. This trial investigated the potential benefit of secondary prevention with warfarin. METHODS AND RESULTS:In a double-blind randomized trial, 135 patients with unsta...

journal_title：Circulation

authors： Huynh T,Théroux P,Bogaty P,Nasmith J,Solymoss S

更新日期：2001-06-26 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Despite early recanalization of an occluded infarct artery, reperfusion at the level of the microcirculation may remain impaired owing to a process of microvascular reperfusion injury. METHODS AND RESULTS:Microvascular reperfusion injury was studied in 91 patients with acute myocardial infarction (AMI) by e...

journal_title：Circulation

authors： Claeys MJ,Bosmans J,Veenstra L,Jorens P,De RaedtH,Vrints CJ

更新日期：1999-04-20 00:00:00

abstract：BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....

journal_title：Circulation

authors： Gepstein L,Hayam G,Shpun S,Ben-Haim SA

更新日期：1997-11-18 00:00:00

abstract：:Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compl...

journal_title：Circulation

authors： Ishikawa K

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...

journal_title：Circulation

authors： Tulis DA,Mnjoyan ZH,Schiesser RL,Shelat HS,Evans AJ,Zoldhelyi P,Fujise K

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (AF) naturally progresses toward chronic AF at an estimated rate of 15% to 30% over a 1- to 3-year period. Pulmonary vein (PV) isolation is increasingly performed for the treatment of drug-refractory paroxysmal AF. The long-term data on clinical outcome after circumferential PV...

journal_title：Circulation

authors： Ouyang F,Tilz R,Chun J,Schmidt B,Wissner E,Zerm T,Neven K,Köktürk B,Konstantinidou M,Metzner A,Fuernkranz A,Kuck KH

更新日期：2010-12-07 00:00:00

abstract：:The outlook for patients with double-outlet right ventricle has improved since the development of corrective operations. Late arrhythmic deaths after successful procedures have been reported; however, the magnitude remains unknown. This study was undertaken to identify the magnitude of late sudden death and the signif...

journal_title：Circulation

authors： Shen WK,Holmes DR Jr,Porter CJ,McGoon DC,Ilstrup DM

更新日期：1990-01-01 00:00:00

abstract：:Since quinidine is one of the few agents available to treat and prevent ventricular arrhythmias in ambulatory patients, its hemodynamic effects have been reevaluated. When given in therapeutic doses to anesthetized mongrel dogs, quinidine significantly reduced heart rate, aortic pressure and flow, but it did not signi...

journal_title：Circulation

authors： Markiewicz W,Winkle R,Binetti G,Kernoff R,Harrison DC

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Even in high-performing health systems, some patients with diabetes mellitus have poor blood pressure (BP) control because of poor medication adherence and lack of medication intensification. We examined whether the Adherence and Intensification of Medications intervention, a pharmacist-led intervention comb...

journal_title：Circulation

authors： Heisler M,Hofer TP,Schmittdiel JA,Selby JV,Klamerus ML,Bosworth HB,Bermann M,Kerr EA

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG). METHODS AND RESULTS:A...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...

journal_title：Circulation

authors： Melter M,Exeni A,Reinders ME,Fang JC,McMahon G,Ganz P,Hancock WW,Briscoe DM

更新日期：2001-11-20 00:00:00

abstract：:In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...

journal_title：Circulation

authors： Boineau JP,Schuessler RB,Mooney CR,Wylds AC,Miller CB,Hudson RD,Borremans JM,Brockus CW

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS:We examined 1) the effects of HS on ANP- or br...

journal_title：Circulation

authors： Hirata Y,Matsuoka H,Suzuki E,Hayakawa H,Sugimoto T,Matsuda Y,Morishita Y,Kangawa K,Minamino N,Matsuo H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen...

journal_title：Circulation

authors： van der Bom JG,de Knijff P,Haverkate F,Bots ML,Meijer P,de Jong PT,Hofman A,Kluft C,Grobbee DE

更新日期：1997-06-17 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy of unknown etiology. Missense mutations of the cardiac beta-myosin-heavy-chain (beta-MHC) gene that may be responsible for cardiac hypertrophy have been detected in patients with HCM. On the other hand, gross structural abnormalitie...

journal_title：Circulation

authors： Nishi H,Kimura A,Harada H,Koga Y,Adachi K,Matsuyama K,Koyanagi T,Yasunaga S,Imaizumi T,Toshima H

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) after cardiac surgery is associated with increased risk of complications, length of stay, and cost of care. Observational evidence suggests that patients who have undergone previous statin therapy have a lower incidence of postoperative AF. We tested this observation in a randomized,...

journal_title：Circulation

authors： Patti G,Chello M,Candura D,Pasceri V,D'Ambrosio A,Covino E,Di Sciascio G

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes in the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective en...

journal_title：Circulation

authors： Shah ASV,McAllister DA,Gallacher P,Astengo F,Rodríguez Pérez JA,Hall J,Lee KK,Bing R,Anand A,Nathwani D,Mills NL,Newby DE,Marwick C,Cruden NL

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Gallbladder pathology has been associated with cardiovascular disease. Recently, we showed that gallbladder distension in anesthetized pigs reflexly increased heart rate, arterial pressure, and coronary and renal vascular resistance through efferent sympathetic mechanisms. Renin release is affected by sympat...

journal_title：Circulation

authors： Molinari C,Grossini E,Mary DA,Vacca G

更新日期：2000-05-30 00:00:00

abstract：BACKGROUND:Angiotensin (Ang) II type 1 receptor (AT1-R) induces cardiomyocyte hypertrophy and fibroblast proliferation, whereas the physiological role of AT2-R in cardiac remodeling remains poorly defined. METHODS AND RESULTS:Using Bio14.6 cardiomyopathic (CM) hamsters, we found that AT2-R sites were increased by 153%...

journal_title：Circulation

authors： Ohkubo N,Matsubara H,Nozawa Y,Mori Y,Murasawa S,Kijima K,Maruyama K,Masaki H,Tsutumi Y,Shibazaki Y,Iwasaka T,Inada M

更新日期：1997-12-02 00:00:00

abstract：:The evidence supporting the thesis that hypertension can be prevented by eliminating salt from the diet is based on four principal sources: (1) epidemiological studies in unacculturated peoples showing that the prevalence of hypertension is inversely correlated with the degree of salt intake; (2) hemodynamic studies s...

journal_title：Circulation

authors： Freis ED

更新日期：1976-04-01 00:00:00

abstract：:The antiarrhythmic efficacy and safety of oral flecainide acetate and quinidine sulfate were compared in a double-blind, 16-center parallel trial involving 280 patients with chronic premature ventricular complexes (PVCs). Eighty-five percent of the flecainide patients had at least 80% suppression of PVCs, vs 57% of th...

journal_title：Circulation

authors：

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Sudden cardiac death and life-threatening ventricular arrhythmia remain a concern in adult patients with repaired tetralogy of Fallot. Longitudinal left ventricular (LV) function is sensitive in detecting early myocardial damage and may have prognostic implications in this setting. METHODS AND RESULTS:We in...

journal_title：Circulation

authors： Diller GP,Kempny A,Liodakis E,Alonso-Gonzalez R,Inuzuka R,Uebing A,Orwat S,Dimopoulos K,Swan L,Li W,Gatzoulis MA,Baumgartner H

更新日期：2012-05-22 00:00:00

abstract：BACKGROUND:The myocardial velocity gradient (MVG) is a recent index of regional myocardial function derived from endocardial and epicardial velocities obtained by tissue Doppler imaging (TDI). This index might be useful for discriminating between physiological and pathological left ventricular hypertrophy (LVH) and for...

journal_title：Circulation

authors： Derumeaux G,Mulder P,Richard V,Chagraoui A,Nafeh C,Bauer F,Henry JP,Thuillez C

更新日期：2002-04-02 00:00:00

abstract：BACKGROUND:Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed. METHODS AND RESULTS:In a double-bli...

journal_title：Circulation

authors： Bezafibrate Infarction Prevention (BIP) study.

更新日期：2000-07-04 00:00:00

abstract：BACKGROUND:Endocardial mapping using standard electrode catheters is often technically limited in ventricular tachycardia and constitutes a major obstacle to successful ablation. We wished to examine the utility of a basket-shaped multielectrode mapping catheter (MMC) in the mapping and ablation of ventricular tachycar...

journal_title：Circulation

authors： Eldar M,Ohad DG,Goldberger JJ,Rotstein Z,Hsu S,Swanson DK,Greenspon AJ

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:An objective of the United States' Healthy People 2010 Initiative is to eliminate disparities based on socioeconomic status. We assessed the effect of difficulty affording health care on the health status (symptoms, function, and quality of life) of patients treated with percutaneous coronary intervention or...

journal_title：Circulation

authors： Spertus J,Decker C,Woodman C,House J,Jones P,O'Keefe J,Borkon AM

更新日期：2005-05-24 00:00:00

abstract：BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...

journal_title：Circulation

authors： Herrington DM,Howard TD,Brosnihan KB,McDonnell DP,Li X,Hawkins GA,Reboussin DM,Xu J,Zheng SL,Meyers DA,Bleecker ER

更新日期：2002-04-23 00:00:00