Treatment of torsade de pointes with magnesium sulfate.

abstract：BACKGROUND:Rapamycin (sirolimus)-eluting stents are associated with reduced restenosis rates in animal studies and initial human trials. The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) inhibits in-stent neointimal growth in rabbit iliac arteries. METHODS...

journal_title：Circulation

authors： Farb A,John M,Acampado E,Kolodgie FD,Prescott MF,Virmani R

更新日期：2002-10-29 00:00:00

abstract：BACKGROUND:The relation between left ventricular (LV) oxygen consumption (MVO2) and pressure-volume area (PVA) developed in isolated hearts provides a powerful method to understand cardiac energetics. We investigated application of this relation to the intact circulation, determining its response to steady-state and tr...

journal_title：Circulation

authors： Nozawa T,Cheng CP,Noda T,Little WC

更新日期：1994-02-01 00:00:00

abstract：:To investigate whether ergonovine acts directly on coronary arteries or via remote neurohumoral reflexes, we administered small titrated increments of intracoronary ergonovine up to a maximum cumulative dose of 50 micrograms to 15 patients. In six patients with variant angina (group 1), ischemic electrocardiographic S...

journal_title：Circulation

authors： Hackett D,Larkin S,Chierchia S,Davies G,Kaski JC,Maseri A

更新日期：1987-03-01 00:00:00

abstract：:The efficacy of a single oral dose combination of 120 mg diltiazem and 160 mg propranolol in terminating paroxysmal supraventricular tachycardia (PSVT) was evaluated in 15 patients. All 15 patients underwent electrical induction of PSVT that lasted longer than 15 min, and all underwent randomized crossover placebo and...

journal_title：Circulation

authors： Yeh SJ,Lin FC,Chou YY,Hung JS,Wu D

更新日期：1985-01-01 00:00:00

abstract：:Factors related to late narrowing of aortocoronary vein grafts are poorly understood. Repeat aortocoronary bypass graft angiography was performed in 34 patients at 13 +/- 5 months and 61 +/- 13 months after surgery. In these patients, 61 of 65 grafts (94%) were patent at 1 year; at 5 years, 39 of these patent grafts (...

journal_title：Circulation

authors： Palac RT,Meadows WR,Hwang MH,Loeb HS,Pifarre R,Gunnar RM

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. METHODS AND RESULTS:Asses...

journal_title：Circulation

authors： Witzenbichler B,Maehara A,Weisz G,Neumann FJ,Rinaldi MJ,Metzger DC,Henry TD,Cox DA,Duffy PL,Brodie BR,Stuckey TD,Mazzaferri EL Jr,Xu K,Parise H,Mehran R,Mintz GS,Stone GW

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...

journal_title：Circulation

authors： Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:The role of valve surgery in left-sided infective endocarditis has not been evaluated in randomized controlled trials. We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis. METHODS AND RESULTS:A total of 546 consecutive patie...

journal_title：Circulation

authors： Tleyjeh IM,Ghomrawi HM,Steckelberg JM,Hoskin TL,Mirzoyev Z,Anavekar NS,Enders F,Moustafa S,Mookadam F,Huskins WC,Wilson WR,Baddour LM

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Whether and to what extent complement is activated in acute myocardial infarction (AMI) and how it contributes to inflammation of the ischemic area are not yet clear. Fibrinolytic agents used for thrombolysis are known to activate complement in vitro and may contribute to its activation in vivo. The aim of t...

journal_title：Circulation

authors： Frangi D,Gardinali M,Conciato L,Cafaro C,Pozzoni L,Agostoni A

更新日期：1994-01-01 00:00:00

abstract：:Since quinidine is one of the few agents available to treat and prevent ventricular arrhythmias in ambulatory patients, its hemodynamic effects have been reevaluated. When given in therapeutic doses to anesthetized mongrel dogs, quinidine significantly reduced heart rate, aortic pressure and flow, but it did not signi...

journal_title：Circulation

authors： Markiewicz W,Winkle R,Binetti G,Kernoff R,Harrison DC

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Adenosine possesses marked cardioprotective properties, but the mechanisms for this beneficial effect are unclear. The objective of this study was to determine the effect of adenosine given before ischemia or at reperfusion on mechanical function, glucose oxidation, glycolysis, and metabolite levels in isola...

journal_title：Circulation

authors： Finegan BA,Lopaschuk GD,Coulson CS,Clanachan AS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:We sought to define the factors associated with the occurrence of stroke and systemic embolism in a large, international atrial fibrillation (AF) trial. METHODS AND RESULTS:In ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and...

journal_title：Circulation

authors： Piccini JP,Stevens SR,Chang Y,Singer DE,Lokhnygina Y,Go AS,Patel MR,Mahaffey KW,Halperin JL,Breithardt G,Hankey GJ,Hacke W,Becker RC,Nessel CC,Fox KA,Califf RM,ROCKET AF Steering Committee and Investigators.

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...

journal_title：Circulation

authors： Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

更新日期：2007-05-22 00:00:00

abstract：:Digital vasospastic phenomena have been reported to result from use of nonselective and cardioselective beta-adrenoreceptor-blocking drugs. The effects of 80 mg/day propranolol and 100 mg/day metoprolol on finger hemodynamics and clinical responses were compared with those of placebo in 16 patients with Raynaud's phen...

journal_title：Circulation

authors： Coffman JD,Rasmussen HM

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The antiarrhythmic drugs quinidine and verapamil are known to block alpha1-adrenoceptors (alpha1ARs). Alpha1ARs are a heterogeneous family of three subtypes (alpha1A, alpha1B, and alpha1D), and little is known about the effects of quinidine and verapamil on the different human alpha1AR subtypes. METHODS AND...

journal_title：Circulation

authors： Shibata K,Hirasawa A,Foglar R,Ogawa S,Tsujimoto G

更新日期：1998-04-07 00:00:00

abstract：BACKGROUND:Membrane contact sites are fundamental for transmission and translation of signals in multicellular organisms. The junctional membrane complexes in the cardiac dyads, where transverse (T) tubules are juxtaposed to the sarcoplasmic reticulum, are a prime example. T-tubule uncoupling and remodeling are well-kn...

journal_title：Circulation

authors： Liu C,Spinozzi S,Chen JY,Fang X,Feng W,Perkins G,Cattaneo P,Guimarães-Camboa N,Dalton ND,Peterson KL,Wu T,Ouyang K,Fu XD,Evans SM,Chen J

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...

journal_title：Circulation

authors： Grossi EA,Chinitz LA,Galloway AC,Delianides J,Schwartz DS,McLoughlin DE,Keller N,Kronzon I,Spencer FC,Colvin SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Venous coronary artery bypass grafts (CABGs) are prone to accelerated atherosclerosis. In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker. The origin of CRP in this setting remains to be elucidated. METHODS AND RESULTS:Monoclonal anti...

journal_title：Circulation

authors： Jabs WJ,Theissing E,Nitschke M,Bechtel JF,Duchrow M,Mohamed S,Jahrbeck B,Sievers HH,Steinhoff J,Bartels C

更新日期：2003-09-23 00:00:00

abstract：BACKGROUND:Coronary calcification detected by electron beam tomography may improve cardiovascular risk prediction. The technique is particularly promising in the elderly because the predictive power of cardiovascular risk factors weakens with age. We investigated the prognostic value of coronary calcification for cardi...

journal_title：Circulation

authors： Vliegenthart R,Oudkerk M,Hofman A,Oei HH,van Dijck W,van Rooij FJ,Witteman JC

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Cigarette smoking has been recognized as an important risk factor for cardiovascular disease in men and women. Whether the increased risk results from an atherogenic effect of smoking is still debated. We examined the relation between cigarette smoking and atherosclerotic changes in the abdominal aorta. MET...

journal_title：Circulation

authors： Witteman JC,Grobbee DE,Valkenburg HA,van Hemert AM,Stijnen T,Hofman A

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Disease-associated electrophysiological alterations may contribute to the increased predisposition to arrhythmias of the hypertrophied or failing myocardium. An I(f)-like current is expressed in rat left ventricular myocytes (LVMs), its amplitude being linearly related to the severity of cardiac hypertrophy....

journal_title：Circulation

authors： Cerbai E,Pino R,Porciatti F,Sani G,Toscano M,Maccherini M,Giunti G,Mugelli A

更新日期：1997-02-04 00:00:00

abstract：:An enzyme histochemical study of the sinoatrial node, the coronary sinus, and the atrial muscle extending into the anterior mitral valve was performed on human hearts. Investigation of the activity and localization of the structurally bound enzymes was performed by conventional histochemical techniques. Determination ...

journal_title：Circulation

authors： Théry C,Krivosic I,Asseman P,Meijer AE

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...

journal_title：Circulation

authors： Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known. METHODS:We linked adults ≥65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgic...

journal_title：Circulation

authors： Strom JB,Faridi KF,Butala NM,Zhao Y,Tamez H,Valsdottir LR,Brennan JM,Shen C,Popma JJ,Kazi DS,Yeh RW

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:With recognition of disease-causing genes in arrhythmogenic right ventricular cardiomyopathy, mutation analysis is being applied. METHODS AND RESULTS:The role of genotyping in familial assessment for arrhythmogenic right ventricular cardiomyopathy was investigated, including the prevalence of mutations in k...

journal_title：Circulation

authors： Quarta G,Muir A,Pantazis A,Syrris P,Gehmlich K,Garcia-Pavia P,Ward D,Sen-Chowdhry S,Elliott PM,McKenna WJ

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) may have proatherogenic but also vasoprotective properties. We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model. METHODS AND RESULTS:We investigated...

journal_title：Circulation

authors： Schwedler SB,Amann K,Wernicke K,Krebs A,Nauck M,Wanner C,Potempa LA,Galle J

更新日期：2005-08-16 00:00:00

abstract：:Children with congenital aortic stenosis have "excessive" left ventricular hypertrophy with reduced resting systolic wall stress that allows for supernormal ejection performance. If aortic stenosis is uncorrected, this pattern persists until adulthood. The effect of removing the aortic pressure gradient on left ventri...

journal_title：Circulation

authors： Dorn GW 2nd,Donner R,Assey ME,Spann JF Jr,Wiles HB,Carabello BA

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...

journal_title：Circulation

authors： Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) commonly presents with nonshockable rhythms (asystole and pulseless electric activity). It is unknown whether antiarrhythmic drugs are safe and effective when nonshockable rhythms evolve to shockable rhythms (ventricular fibrillation/pulseless ventricular tachycardia [VF...

journal_title：Circulation

authors： Kudenchuk PJ,Leroux BG,Daya M,Rea T,Vaillancourt C,Morrison LJ,Callaway CW,Christenson J,Ornato JP,Dunford JV,Wittwer L,Weisfeldt ML,Aufderheide TP,Vilke GM,Idris AH,Stiell IG,Colella MR,Kayea T,Egan D,Desvigne-Nick

更新日期：2017-11-28 00:00:00