当前位置： SCI文献检索 > CIRCULATION期刊下所有文献 > Oral everolimus inhibits in-stent neointimal growth.

Oral everolimus inhibits in-stent neointimal growth.

Abstract：

BACKGROUND:Rapamycin (sirolimus)-eluting stents are associated with reduced restenosis rates in animal studies and initial human trials. The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) inhibits in-stent neointimal growth in rabbit iliac arteries. METHODS AND RESULTS:New Zealand white rabbits were randomized to everolimus 1.5 mg/kg per day starting 3 days before stenting and reduced to 1 mg/kg per day from days 14 to 28 (group 1), everolimus 1.5 mg/kg given 1 day before stenting followed by 0.75 mg/kg per day for 28 days (group 2), or matching placebo for each group. Drugs were administered by oral gavage. Stents were deployed in both iliac arteries, and arteries were harvested 28 days after stenting. Group 1 everolimus-treated rabbits experienced weight loss and anorexia, which resolved after the everolimus dose was lowered on day 14. Group 2 animals were healthy for the duration of everolimus dosing. Both everolimus treatment groups significantly reduced in-stent neointimal growth (46% reduction and 42% reduction in intimal thickness in groups 1 and 2, respectively). In group 2 everolimus-treated animals, the neointima was healed or healing, characterized by stent struts covered by a thin neointima, overlying endothelial cells, and only small foci of fibrin. Scanning electron microscopy showed >80% stent surface endothelialization in group 2 everolimus-treated rabbits. CONCLUSIONS:Oral everolimus suppresses in-stent neointimal growth in the rabbit iliac artery. At a dose of 1.5 mg/kg given 1 day before stenting followed by 0.75 mg/kg per day for 28 days, everolimus was well tolerated and was associated with significant neointimal healing.

journal_name

Circulation

journal_title

Circulation

authors

Farb A,John M,Acampado E,Kolodgie FD,Prescott MF,Virmani R

doi

10.1161/01.cir.0000033973.06059.04

subject

Has Abstract

pub_date

2002-10-29 00:00:00

pages

2379-84

issue

18

eissn

0009-7322

issn

1524-4539

journal_volume

106

pub_type

杂志文章

相关文献

CIRCULATION文献大全
  • Endocardial excision: a new surgical technique for the treatment of recurrent ventricular tachycardia.

    abstract：:Twelve patients with medically refractory ventricular tachycardia secondary to ischemic heart disease underwent surgery for cure of their arrhythmia. Preoperatively, the tachycardia could be reproducibly initiated and terminated in each patient by programmed stimulation. In all instances, intraoperative mapping locali...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.60.7.1430

    authors： Josephson ME,Harken AH,Horowitz LN

    更新日期：1979-12-01 00:00:00

  • A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.

    abstract：BACKGROUND:Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS). METHODS AND RESULTS:S...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1161/01.cir.90.4.1765

    authors：

    更新日期：1994-10-01 00:00:00

  • Quantitative assessment of regional left ventricular function by densitometric analysis of digital-subtraction ventriculograms: correlation with myocardial systolic shortening in dogs.

    abstract：:Conventional wall motion analysis of contrast ventriculograms assesses only that part of the wall that is tangential to the x-ray beam. To assess regional left ventricular function in three dimensions, a new computerized method based on densitometric analysis of digital subtraction left ventriculograms was developed a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.77.2.457

    authors： Chappuis F,Widmann T,Guth B,Nicod P,Peterson KL

    更新日期：1988-02-01 00:00:00

  • Electrocardiographic changes suggestive of myocardial ischemia elicited by dipyridamole infusion in acute rejection early after heart transplantation.

    abstract：:Acute cardiac rejection, syndrome X, and arterial hypertension can induce small vessel damage and, therefore, restriction of coronary reserve in the presence of normal epicardial coronary arteries. A characteristic response pattern to dipyridamole (DIP) infusion has been previously described in syndrome X and arterial...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.81.1.72

    authors： Picano E,De Pieri G,Salerno JA,Arbustini E,Distante A,Martinelli L,Pucci A,Montemartini C,Viganò M,Donato L

    更新日期：1990-01-01 00:00:00

  • Inhibition of platelet-dependent thrombosis by local delivery of heparin with a hydrogel-coated balloon.

    abstract：BACKGROUND:Systemic administration of heparin can decrease mortality and morbidity of acute ischemic coronary syndromes such as unstable angina and myocardial infarction. Hemorrhage is the major limiting factor in the clinical use of systemic heparin. The objective of the present study was to determine whether local de...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.92.7.1697

    authors： Nunes GL,Thomas CN,Hanson SR,Barry JJ,King SB 3rd,Scott NA

    更新日期：1995-10-01 00:00:00

  • Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial.

    abstract：BACKGROUND:The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of dual-antiplatelet therapy in a broad all-comers patient population receiving a balanced pr...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/CIRCULATIONAHA.111.071589

    authors： Valgimigli M,Campo G,Monti M,Vranckx P,Percoco G,Tumscitz C,Castriota F,Colombo F,Tebaldi M,Fucà G,Kubbajeh M,Cangiano E,Minarelli M,Scalone A,Cavazza C,Frangione A,Borghesi M,Marchesini J,Parrinello G,Ferrari R,P

    更新日期：2012-04-24 00:00:00

  • Limitation of myocardial reperfusion injury by intravenous perfluorochemicals. Role of neutrophil activation.

    abstract：:Neutrophil activation and infiltration into the ischemic myocardium after reperfusion may limit the amount of salvageable myocardium (reperfusion injury). The effects of intravenous perfluorochemicals (Fluosol-DA) on infarct size, ventricular contractility, and neutrophil function were assessed in an occlusion-reperfu...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.79.3.645

    authors： Bajaj AK,Cobb MA,Virmani R,Gay JC,Light RT,Forman MB

    更新日期：1989-03-01 00:00:00

  • Thrombus regression in deep venous thrombosis. Quantification of spontaneous thrombolysis with duplex scanning.

    abstract：BACKGROUND:Thrombus regression in heparin-treated, acute deep venous thrombosis of the lower extremity is poorly documented in the literature; different rates of thrombus resolution and recanalization are reported. METHODS AND RESULTS:In a prospective follow-up study, duplex scanning was used to evaluate the thrombus ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.86.2.414

    authors： van Ramshorst B,van Bemmelen PS,Hoeneveld H,Faber JA,Eikelboom BC

    更新日期：1992-08-01 00:00:00

  • Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.

    abstract：:Iron catalysis is involved in oxygen-derived free radical generation and subsequent lipid peroxidation, which have been reported to occur during cardiopulmonary bypass in humans. We assessed the effects of the iron chelator deferoxamine on the susceptibility of circulating low density lipoproteins (LDLs) to induced pe...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Menasché P,Antebi H,Alcindor LG,Teiger E,Perez G,Giudicelli Y,Nordmann R,Piwnica A

    更新日期：1990-11-01 00:00:00

  • High-resolution, three-dimensional fluorescent imaging reveals multilayer conduction pattern in the atrioventricular node.

    abstract：BACKGROUND:The atrioventricular node (AVN) is the only normal electrical link between the upper and lower chambers of the heart. The AVN modulates transmission of impulses, thus coordinating the contraction of the atria and ventricles. METHODS AND RESULTS:Structural and functional complexity, combined with the absence...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.98.1.54

    authors： Efimov IR,Mazgalev TN

    更新日期：1998-07-07 00:00:00

  • The pathogenesis of coronary plaques, thromboses, and hemorrhages: an evaluative review.

    abstract：:The initial appearance and continuous development of a coronary plaque depends on a combination of hemodynamic trauma, deposition of excess cholesterol, and accretion and incorporation of thrombogenic elements as well as fully formed mural thrombi. Plaques become life-threatening when rupture of their intimal surface ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Friedman M

    更新日期：1975-12-01 00:00:00

  • Comparison of echocardiographic dyssynchrony assessment by tissue velocity and strain imaging in subjects with or without systolic dysfunction and with or without left bundle-branch block.

    abstract：BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.107.733675

    authors： Miyazaki C,Powell BD,Bruce CJ,Espinosa RE,Redfield MM,Miller FA,Hayes DL,Cha YM,Oh JK

    更新日期：2008-05-20 00:00:00

  • Determinants and prognostic impact of heart failure complicating acute coronary syndromes: observations from the Global Registry of Acute Coronary Events (GRACE).

    abstract：BACKGROUND:Few data are available on the impact of heart failure (HF) across all types of acute coronary syndromes (ACS). METHODS AND RESULTS:The Global Registry of Acute Coronary Events (GRACE) is a prospective study of patients hospitalized with ACS. Data from 16 166 patients were analyzed: 13 707 patients without p...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000109691.16944.DA

    authors： Steg PG,Dabbous OH,Feldman LJ,Cohen-Solal A,Aumont MC,López-Sendón J,Budaj A,Goldberg RJ,Klein W,Anderson FA Jr,Global Registry of Acute Coronary Events Investigators.

    更新日期：2004-02-03 00:00:00

  • Weight loss reduces C-reactive protein levels in obese postmenopausal women.

    abstract：BACKGROUND:C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease and has been positively associated with body weight and body fatness. We examined the hypothesis that weight loss would reduce plasma CRP levels in obese postmenopausal women. METHODS AND RESULTS:In a sample ...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/hc0502.103331

    authors： Tchernof A,Nolan A,Sites CK,Ades PA,Poehlman ET

    更新日期：2002-02-05 00:00:00

  • Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease.

    abstract：BACKGROUND:Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.116.023266

    authors： Taqueti VR,Shaw LJ,Cook NR,Murthy VL,Shah NR,Foster CR,Hainer J,Blankstein R,Dorbala S,Di Carli MF

    更新日期：2017-02-07 00:00:00

  • Long-term results (≤18 years) of the edge-to-edge mitral valve repair without annuloplasty in degenerative mitral regurgitation: implications for the percutaneous approach.

    abstract：BACKGROUND:To assess the long-term results of the edge-to-edge mitral repair performed without annuloplasty in degenerative mitral regurgitation (MR). METHODS AND RESULTS:From 1993 to 2002, 61 patients with degenerative MR were treated with an isolated edge-to-edge suture without any annuloplasty. Annuloplasty was omi...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.113.007885

    authors： De Bonis M,Lapenna E,Maisano F,Barili F,La Canna G,Buzzatti N,Pappalardo F,Calabrese M,Nisi T,Alfieri O

    更新日期：2014-09-09 00:00:00

  • Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.

    abstract：BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.102.18.2185

    authors： Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

    更新日期：2000-10-31 00:00:00

  • Sudden cardiac death in adult congenital heart disease.

    abstract：BACKGROUND:Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim of this study was to determine the adult CHD population at risk of SCD and the clinical parameters associated with SCD. METHODS AND RESULTS:We performed a multicenter case-control study. Patients ...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究

    doi：10.1161/CIRCULATIONAHA.112.104786

    authors： Koyak Z,Harris L,de Groot JR,Silversides CK,Oechslin EN,Bouma BJ,Budts W,Zwinderman AH,Van Gelder IC,Mulder BJ

    更新日期：2012-10-16 00:00:00

  • Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males.

    abstract：BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...

    journal_title：Circulation

    pub_type： 评论,杂志文章

    doi：10.1161/01.cir.97.18.1773

    authors： Fornage M,Amos CI,Kardia S,Sing CF,Turner ST,Boerwinkle E

    更新日期：1998-05-12 00:00:00

  • Myocarditis in beta-thalassemia major. A cause of heart failure.

    abstract：BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.91.1.66

    authors： Kremastinos DT,Tiniakos G,Theodorakis GN,Katritsis DG,Toutouzas PK

    更新日期：1995-01-01 00:00:00

  • Population characteristics according to recruitment source.

    abstract：:Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Hunninghake DB,Knoke J,LaDouceur M,Peterson F

    更新日期：1982-12-01 00:00:00

  • Body surface distributions of repolarization forces during acute myocardial infarction. I. Isopotential and isoarea mapping.

    abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.62.4.878

    authors： Mirvis DM

    更新日期：1980-10-01 00:00:00

  • Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction.

    abstract：:The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesi...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.53.3.483

    authors： Bulkley BH,Ridolfi RL,Salyer WR,Hutchins GM

    更新日期：1976-03-01 00:00:00

  • Effect of butorphanol tartrate on shock-related discomfort during internal atrial defibrillation.

    abstract：BACKGROUND:In patients with atrial fibrillation, intracardiac atrial defibrillation causes discomfort. An easily applicable, short-acting analgesic and anxiolytic drug would increase acceptability of this new treatment mode. METHODS AND RESULTS:In a double-blind, placebo-controlled manner, the effect of intranasal but...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.cir.99.14.1837

    authors： Timmermans C,Rodriguez LM,Ayers GM,Lambert H,Smeets JL,Vlaeyen JW,Albert A,Wellens HJ

    更新日期：1999-04-13 00:00:00

  • Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study.

    abstract：BACKGROUND:Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors to predict adult hypertension and furthermore whether newly identified genetic variants for blood pressure increase the predictio...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.111.085977

    authors： Juhola J,Oikonen M,Magnussen CG,Mikkilä V,Siitonen N,Jokinen E,Laitinen T,Würtz P,Gidding SS,Taittonen L,Seppälä I,Jula A,Kähönen M,Hutri-Kähönen N,Lehtimäki T,Viikari JS,Juonala M,Raitakari OT

    更新日期：2012-07-24 00:00:00

  • Cardiac sarcoplasmic reticulum calcium ATPase, an autoimmune antigen in experimental cardiomyopathy.

    abstract：BACKGROUND:Various myocardial cell surface and intracellular antigens have been associated with autoimmune myocarditis. Since sarcoplasmic calcium overload is a recognized pathobiochemical finding in cardiomyopathy, we reasoned that there might be a causal relation between inhibition of sarcoplasmic calcium exclusion a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.89.3.1217

    authors： Sharaf AR,Narula J,Nicol PD,Southern JF,Khaw BA

    更新日期：1994-03-01 00:00:00

  • Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.

    abstract：BACKGROUND:In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhag...

    journal_title：Circulation

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/CIRCULATIONAHA.119.040713

    authors： Johnston SC,Elm JJ,Easton JD,Farrant M,Barsan WG,Kim AS,Lindblad AS,Palesch YY,Zurita KG,Albers GW,Cucchiara BL,Kleindorfer DO,Lutsep HL,Pearson C,Sethi P,Vora N,POINT and Neurological Emergencies Treatment Trials Network

    更新日期：2019-08-20 00:00:00

  • Adherence to Antihypertensive Treatment and the Blood Pressure-Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) Trial.

    abstract：BACKGROUND:The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood press...

    journal_title：Circulation

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/CIRCULATIONAHA.116.022922

    authors： Azizi M,Pereira H,Hamdidouche I,Gosse P,Monge M,Bobrie G,Delsart P,Mounier-Véhier C,Courand PY,Lantelme P,Denolle T,Dourmap-Collas C,Girerd X,Michel Halimi J,Zannad F,Ormezzano O,Vaïsse B,Herpin D,Ribstein J,Chamont

    更新日期：2016-09-20 00:00:00

  • Temporal Trends and Clinical Consequences of Wait Times for Transcatheter Aortic Valve Replacement: A Population-Based Study.

    abstract：BACKGROUND:Transcatheter aortic valve replacement (TAVR) represents a paradigm shift in the therapeutic options for patients with severe aortic stenosis. However, rapid and exponential growth in TAVR demand may overwhelm capacity, translating to inadequate access and prolonged wait times. Our objective was to evaluate ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.117.033432

    authors： Elbaz-Greener G,Masih S,Fang J,Ko DT,Lauck SB,Webb JG,Nallamothu BK,Wijeysundera HC

    更新日期：2018-07-31 00:00:00

  • Adenosine-induced coronary vasodilation during transesophageal Doppler echocardiography. Rapid and safe measurement of coronary flow reserve ratio can predict significant left anterior descending coronary stenosis.

    abstract：BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.cir.92.2.190

    authors： Redberg RF,Sobol Y,Chou TM,Malloy M,Kumar S,Botvinick E,Kane J

    更新日期：1995-07-15 00:00:00