Population characteristics according to recruitment source.


:Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among recruitment sources. The variability encountered suggests that these characteristics might be exploited in selecting recruitment sources for clinical trials.






Hunninghake DB,Knoke J,LaDouceur M,Peterson F


Has Abstract


1982-12-01 00:00:00




6 Pt 2








  • Research related to medical treatment of cardiovascular disease.

    abstract::Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...


    pub_type: 临床试验,历史文章,杂志文章


    authors: Ross RS

    更新日期:1979-12-01 00:00:00

  • Arteriovenous carbon dioxide and pH gradients during cardiac arrest.

    abstract::In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...


    pub_type: 杂志文章


    authors: Grundler W,Weil MH,Rackow EC

    更新日期:1986-11-01 00:00:00

  • Effect of septal myotomy and myectomy on left ventricular systolic function at rest and during exercise in patients with IHSS.

    abstract::Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...


    pub_type: 杂志文章


    authors: Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

    更新日期:1979-08-01 00:00:00

  • Short-term synchronized retroperfusion before reperfusion reduces infarct size after prolonged ischemia in dogs.

    abstract:BACKGROUND:Previous studies have demonstrated that synchronized coronary venous retroperfusion (SRP) can restore blood flow to the ischemic myocardium, resulting in infarct size reduction and improvement of the left ventricular function. Despite the nutritive blood flow achieved by SRP being relatively limited, SRP has...


    pub_type: 杂志文章


    authors: Wakida Y,Nordlander R,Kobayashi S,Kar S,Haendchen R,Corday E

    更新日期:1993-11-01 00:00:00

  • Alterations in ventricular mass and performance induced by exercise training in man evaluated by echocardiography.

    abstract::Few data are available regarding the effects of exercise training upon cardiac structure and performance in man. We evaluated the echograms of 24 normals before (PRE) and after (POST) 11 weeks of endurance exercise training. Conditioning consisted of a walk-jog-run protocol at 70% maximal heart rate for one hour four ...


    pub_type: 杂志文章


    authors: DeMaria AN,Neumann A,Lee G,Fowler W,Mason DT

    更新日期:1978-02-01 00:00:00

  • Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of the coronary artery collateral circulation.

    abstract:BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...


    pub_type: 杂志文章


    authors: Schultz A,Lavie L,Hochberg I,Beyar R,Stone T,Skorecki K,Lavie P,Roguin A,Levy AP

    更新日期:1999-08-03 00:00:00

  • Coexistence of sick sinus rhythm and atrial flutter-fibrillation.

    abstract::A 58-year-old man with hypertensive cardiovascular disease and atrial flutter underwent electrophysiologic studies, including multiple intra-atrial recordings and atrial stimulation. Although the surface ECG suggested the presence of atrial flutter, intra-atrial recordings demonstrated the presence of (1) sinus-like r...


    pub_type: 杂志文章


    authors: Gomes JA,Kang PS,Matheson M,Gough WB Jr,El-Sherif N

    更新日期:1981-01-01 00:00:00

  • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function.

    abstract:BACKGROUND:BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small-molecule BET protein inhibitors such as JQ1 have demo...


    pub_type: 杂志文章


    authors: Kim SY,Zhang X,Schiattarella GG,Altamirano F,Ramos TAR,French KM,Jiang N,Szweda PA,Evers BM,May HI,Luo X,Li H,Szweda LI,Maracaja-Coutinho V,Lavandero S,Gillette TG,Hill JA

    更新日期:2020-12-15 00:00:00

  • Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease: results from the What Is the Optimal Method for Ischemia Evaluation

    abstract:BACKGROUND:There is a paucity of randomized trials regarding diagnostic testing in women with suspected coronary artery disease (CAD). It remains unclear whether the addition of myocardial perfusion imaging (MPI) to the standard ECG exercise treadmill test (ETT) provides incremental information to improve clinical deci...


    pub_type: 杂志文章,随机对照试验


    authors: Shaw LJ,Mieres JH,Hendel RH,Boden WE,Gulati M,Veledar E,Hachamovitch R,Arrighi JA,Merz CN,Gibbons RJ,Wenger NK,Heller GV,WOMEN Trial Investigators.

    更新日期:2011-09-13 00:00:00

  • Impact of angiographic complete revascularization after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary artery disease.

    abstract:BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...


    pub_type: 杂志文章


    authors: Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

    更新日期:2011-05-31 00:00:00

  • Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.

    abstract:BACKGROUND:There is no treatment proven to limit the growth of abdominal aortic aneurysms, in which the histological hallmarks include inflammation and medial atrophy, with apoptosis of smooth muscle cells and destruction of elastin. METHODS AND RESULTS:Aneurysm biopsies were used for explant cultures, the preparation...


    pub_type: 杂志文章


    authors: Walton LJ,Franklin IJ,Bayston T,Brown LC,Greenhalgh RM,Taylor GW,Powell JT

    更新日期:1999-07-06 00:00:00

  • Characterization of nontransmural myocardial infarction by positron-emission tomography.

    abstract::The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransm...


    pub_type: 杂志文章


    authors: Geltman EM,Biello D,Welch MJ,Ter-Pogossian MM,Roberts R,Sobel BE

    更新日期:1982-04-01 00:00:00

  • Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model.

    abstract:BACKGROUND:Considerable controversy exists regarding impairment of cardiac function in diabetes mellitus (DM). We investigated the serial changes in left ventricular (LV) histopathology and LV filling dynamics in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of type II D...


    pub_type: 杂志文章


    authors: Mizushige K,Yao L,Noma T,Kiyomoto H,Yu Y,Hosomi N,Ohmori K,Matsuo H

    更新日期:2000-02-29 00:00:00

  • Effect of distension of the gallbladder on plasma renin activity in anesthetized pigs.

    abstract:BACKGROUND:Gallbladder pathology has been associated with cardiovascular disease. Recently, we showed that gallbladder distension in anesthetized pigs reflexly increased heart rate, arterial pressure, and coronary and renal vascular resistance through efferent sympathetic mechanisms. Renin release is affected by sympat...


    pub_type: 杂志文章


    authors: Molinari C,Grossini E,Mary DA,Vacca G

    更新日期:2000-05-30 00:00:00

  • Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations: the CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Study.

    abstract:BACKGROUND:Sirolimus-eluting stents have been reported to be effective in the treatment of coronary bifurcations. Still, it has not been fully clarified which strategy would provide the best results with true bifurcation lesions. METHODS AND RESULTS:The CACTUS trial (Coronary bifurcations: Application of the Crushing ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Colombo A,Bramucci E,Saccà S,Violini R,Lettieri C,Zanini R,Sheiban I,Paloscia L,Grube E,Schofer J,Bolognese L,Orlandi M,Niccoli G,Latib A,Airoldi F

    更新日期:2009-01-06 00:00:00

  • Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats.

    abstract:BACKGROUND:Recent studies have shown that improved myocardial salvage after heat-shock pretreatment correlates with the amount of induced cardiac heat-shock protein (HSP)72. However, heat shock also induces myocardial catalase activity, potentially reducing free radical-mediated ischemic injury. The aim of the present ...


    pub_type: 杂志文章


    authors: Auyeung Y,Sievers RE,Weng D,Barbosa V,Wolfe CL

    更新日期:1995-12-01 00:00:00

  • Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study.

    abstract:BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...


    pub_type: 杂志文章


    authors: Kiechl S,Willeit J,Egger G,Poewe W,Oberhollenzer F

    更新日期:1997-11-18 00:00:00

  • Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model.

    abstract:BACKGROUND:It has recently been shown that mitochondrial aldehyde dehydrogenase 2 (mtALDH) catalyzes the formation of 1,2-glyceryl dinitrate and nitrite from nitroglycerin (glyceryl trinitrate [GTN]) within mitochondria, leading to production of cGMP and vasorelaxation. However, whether this mechanism operates in the s...


    pub_type: 杂志文章


    authors: Zhang J,Chen Z,Cobb FR,Stamler JS

    更新日期:2004-08-10 00:00:00

  • Operator-independent isotropic three-dimensional magnetic resonance imaging for morphology in congenital heart disease: a validation study.

    abstract:BACKGROUND:Operator-independent isotropic 3D MRI may greatly simplify the assessment of complex morphology in congenital heart disease. We sought to evaluate the reliability of this new approach. METHODS AND RESULTS:In 31 adolescent and adult patients (age, 6 to 42 years; median, 16 years) with congenital heart diseas...


    pub_type: 杂志文章


    authors: Sørensen TS,Körperich H,Greil GF,Eichhorn J,Barth P,Meyer H,Pedersen EM,Beerbaum P

    更新日期:2004-07-13 00:00:00

  • Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.

    abstract:BACKGROUND:The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS:Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometr...


    pub_type: 杂志文章


    authors: Mancini DM,Walter G,Reichek N,Lenkinski R,McCully KK,Mullen JL,Wilson JR

    更新日期:1992-04-01 00:00:00

  • Metabolic syndrome from adolescence to early adulthood: effect of infancy-onset dietary counseling of low saturated fat: the Special Turku Coronary Risk Factor Intervention Project (STRIP).

    abstract:BACKGROUND:Adolescent metabolic syndrome (MetS) predicts type 2 diabetes mellitus and subclinical atherosclerosis in adulthood. Our aim was to establish the relationship between an infancy-onset dietary intervention and risk of having MetS between 15 and 20 years of age. METHODS AND RESULTS:The Special Turku Coronary ...


    pub_type: 杂志文章,随机对照试验


    authors: Nupponen M,Pahkala K,Juonala M,Magnussen CG,Niinikoski H,Rönnemaa T,Viikari JS,Saarinen M,Lagström H,Jula A,Simell O,Raitakari OT

    更新日期:2015-02-17 00:00:00

  • Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.

    abstract:BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...


    pub_type: 杂志文章


    authors: Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

    更新日期:2004-02-03 00:00:00

  • Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study.

    abstract:BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...


    pub_type: 杂志文章,多中心研究


    authors: Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

    更新日期:2007-09-18 00:00:00

  • Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:We measured the content and activities of components of the beta-adrenergic receptor-G protein-adenylate cyclase complex and adrenergic neurotransmitter levels in left and right ventricular myocardial preparations derived from 77 end-stage failing human hearts from patients with idiopathic dilated cardiomyop...


    pub_type: 杂志文章


    authors: Bristow MR,Anderson FL,Port JD,Skerl L,Hershberger RE,Larrabee P,O'Connell JB,Renlund DG,Volkman K,Murray J

    更新日期:1991-09-01 00:00:00

  • Quantification of incomplete revascularization and its association with five-year mortality in the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) trial validation of the residual SYNTAX score.

    abstract:BACKGROUND:The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). METHODS AND RESULTS:In the randomized PCI cohort of the SYNTAX Trial (n=903)...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Farooq V,Serruys PW,Bourantas CV,Zhang Y,Muramatsu T,Feldman T,Holmes DR,Mack M,Morice MC,Ståhle E,Colombo A,de Vries T,Morel MA,Dawkins KD,Kappetein AP,Mohr FW

    更新日期:2013-07-09 00:00:00

  • Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation.

    abstract:BACKGROUND:Apolipoprotein E (apoE) has long been known to play an important role in the clearance of plasma lipoproteins. More recently, a direct role for apoE in delaying atherogenesis has been proposed. Macrophage production of apoE in the artery wall has been demonstrated to provide protection against atheroscleroti...


    pub_type: 杂志文章


    authors: Hasty AH,Linton MF,Brandt SJ,Babaev VR,Gleaves LA,Fazio S

    更新日期:1999-05-18 00:00:00

  • Transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era.

    abstract:BACKGROUND:Lung transplantation and heart-lung transplantation represent surgical options for treatment of medically refractory idiopathic pulmonary arterial hypertension. The effect of the lung allocation score on wait-list and transplantation outcomes in patients with idiopathic pulmonary arterial hypertension is poo...


    pub_type: 杂志文章


    authors: Schaffer JM,Singh SK,Joyce DL,Reitz BA,Robbins RC,Zamanian RT,Mallidi HR

    更新日期:2013-06-25 00:00:00

  • Correlation of pharmacological 99mTc-sestamibi myocardial perfusion imaging with poststenotic coronary flow reserve in patients with angiographically intermediate coronary artery stenoses.

    abstract:BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...


    pub_type: 杂志文章


    authors: Miller DD,Donohue TJ,Younis LT,Bach RG,Aguirre FV,Wittry MD,Goodgold HM,Chaitman BR,Kern MJ

    更新日期:1994-05-01 00:00:00

  • Characterization of spatial patterns of flow within the reperfused myocardium by myocardial contrast echocardiography. Implications in determining extent of myocardial salvage.

    abstract:BACKGROUND:Since myocardial blood flow changes dynamically after reperfusion and since both hyperemia and impairment in microvascular function exist within the acutely reperfused bed, we sought to investigate the role of myocardial contrast echocardiography (MCE) in (1) defining the temporal variability in perfusion pa...


    pub_type: 杂志文章


    authors: Villanueva FS,Glasheen WP,Sklenar J,Kaul S

    更新日期:1993-12-01 00:00:00

  • Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.

    abstract:BACKGROUND:In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhag...


    pub_type: 杂志文章,随机对照试验


    authors: Johnston SC,Elm JJ,Easton JD,Farrant M,Barsan WG,Kim AS,Lindblad AS,Palesch YY,Zurita KG,Albers GW,Cucchiara BL,Kleindorfer DO,Lutsep HL,Pearson C,Sethi P,Vora N,POINT and Neurological Emergencies Treatment Trials Network

    更新日期:2019-08-20 00:00:00