Coronary atherosclerosis. A multifactorial disease.

abstract：BACKGROUND:Operator-independent isotropic 3D MRI may greatly simplify the assessment of complex morphology in congenital heart disease. We sought to evaluate the reliability of this new approach. METHODS AND RESULTS:In 31 adolescent and adult patients (age, 6 to 42 years; median, 16 years) with congenital heart diseas...

journal_title：Circulation

authors： Sørensen TS,Körperich H,Greil GF,Eichhorn J,Barth P,Meyer H,Pedersen EM,Beerbaum P

更新日期：2004-07-13 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) commonly presents with nonshockable rhythms (asystole and pulseless electric activity). It is unknown whether antiarrhythmic drugs are safe and effective when nonshockable rhythms evolve to shockable rhythms (ventricular fibrillation/pulseless ventricular tachycardia [VF...

journal_title：Circulation

authors： Kudenchuk PJ,Leroux BG,Daya M,Rea T,Vaillancourt C,Morrison LJ,Callaway CW,Christenson J,Ornato JP,Dunford JV,Wittwer L,Weisfeldt ML,Aufderheide TP,Vilke GM,Idris AH,Stiell IG,Colella MR,Kayea T,Egan D,Desvigne-Nick

更新日期：2017-11-28 00:00:00

abstract：:Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm pr...

journal_title：Circulation

authors： Clarkson PM,Barratt-Boyles BG,Neutze JM

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Sudden cardiac death in children is a rare but devastating event. Experts have debated the merits of community-based screening programs using an ECG and targeting 2 potential high-risk groups: school-aged children initiating stimulant medications to treat attention-deficit/hyperactivity disorder and adolesce...

journal_title：Circulation

authors： Leslie LK,Cohen JT,Newburger JW,Alexander ME,Wong JB,Sherwin ED,Rodday AM,Parsons SK,Triedman JK

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:Cardiac parasympathetic nerves run alongside the superior vena cava (SVC) and accumulate particularly epicardially adjacent to the orifice of the coronary sinus (CS). In animals, these nerves can be electrically stimulated inside the SVC or CS, which results in negative chronotropic/dromotropic effects and n...

journal_title：Circulation

authors： Schauerte P,Mischke K,Plisiene J,Waldmann M,Zarse M,Stellbrink C,Schimpf T,Knackstedt C,Sinha A,Hanrath P

更新日期：2001-11-13 00:00:00

abstract：:Accumulating experimental and clinical evidence indicates that a time for reappraisal of therapeutic modalities designed to inhibit the eicosanoid pathway as it may affect vascular disease may be approaching. Pharmacologic agents originally used were chosen because they were capable of suppressing platelet functions s...

journal_title：Circulation

authors： Marcus AJ,Safier LB,Ullman HL,Broekman MJ,Islam N,Oglesby TD,Gorman RR,Ward JW

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Catheter-based ultrasound is a new imaging modality to examine endovascular detail in the coronary circulation. This technique requires direct placement of the catheter in the arterial segment of interest. METHODS AND RESULTS:We examined the feasibility of a less invasive approach by imaging the coronary ar...

journal_title：Circulation

authors： Sudhir K,Fitzgerald PJ,MacGregor JS,DeMarco T,Ports TA,Chatterjee K,Yock PG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:In patients with coronary artery disease (CAD), acute thrombosis frequently occurs in coronary arteries with only mild or moderate stenoses. Obesity increases the risk of atherosclerosis, but it is not known whether it also increases the risk of coronary thrombosis. We hypothesized that body mass index (BMI)...

journal_title：Circulation

authors： Wolk R,Berger P,Lennon RJ,Brilakis ES,Somers VK

更新日期：2003-11-04 00:00:00

abstract：BACKGROUND:Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are elevated in heart failure, and ET-1 may be involved in the pathophysiology of this condition. However, its effects on co...

journal_title：Circulation

authors： MacCarthy PA,Grocott-Mason R,Prendergast BD,Shah AM

更新日期：2000-01-18 00:00:00

abstract：:The specific and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AMI) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chlorid...

journal_title：Circulation

authors： Varat MA,Mercer DW

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:We hypothesized that a simple, unmeasured posterior annuloplasty technique (two thirds of a 27-mm Duran ring) offered advantages of standardization and ease of insertion. METHODS AND RESULTS:A consecutive series of all patients (n = 418; median age, 67 years) having mitral valve repair performed by two surg...

journal_title：Circulation

authors： Odell JA,Schaff HV,Orszulak TA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:A mortality follow-up of 12,866 men was conducted 16 years after randomization to special intervention (SI) or usual care (UC) groups of the Multiple Risk Factor Intervention Trial to assess the long-term effect of cardiovascular risk factor intervention on coronary heart disease (CHD), cardiovascular death ...

journal_title：Circulation

authors：

更新日期：1996-09-01 00:00:00

abstract：:Population cardiovascular health, or improving cardiovascular health among patients and the population at large, requires a redoubling of primordial and primary prevention efforts as declines in cardiovascular disease mortality have decelerated over the past decade. Great potential exists for healthcare systems-based ...

journal_title：Circulation

authors： Foraker RE,Benziger CP,DeBarmore BM,Cené CW,Loustalot F,Khan Y,Anderson CAM,Roger VL,American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Lifestyl

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:One of the features of high-risk atherosclerotic plaques is a preponderance of macrophages. Experimental studies with hyperlipidemic rabbits have shown that ultrasmall superparamagnetic particles of iron oxide (USPIOs) accumulate in plaques with a high macrophage content and that this induces magnetic resona...

journal_title：Circulation

authors： Kooi ME,Cappendijk VC,Cleutjens KB,Kessels AG,Kitslaar PJ,Borgers M,Frederik PM,Daemen MJ,van Engelshoven JM

更新日期：2003-05-20 00:00:00

abstract：:To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spre...

journal_title：Circulation

authors： Beppu S,Izumi S,Miyatake K,Nagata S,Park YD,Sakakibara H,Nimura Y

更新日期：1988-07-01 00:00:00

abstract：:Cardiac events of early diastole were studied in 50 normal subjects and 46 patients with mitral stenosis (MS) by simultaneous recordings of the mitral valve echogram (MVE), phonocardiogram, and apexcardiogram (ACG). Left ventricular isovolumic relaxation time (IRT), measured between A2 and onset of the MVE opening mot...

journal_title：Circulation

authors： Toutouzas P,Velimezis A,Castellanos S,Avgoustakis D

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans. METHODS AND RESULTS:We conducted a randomized, double-blind, placebo-controlled crossover study in 14 nondiabetic overweight or obese (body mass index > ...

journal_title：Circulation

authors： Pierce GL,Lesniewski LA,Lawson BR,Beske SD,Seals DR

更新日期：2009-03-10 00:00:00

abstract：:Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...

journal_title：Circulation

authors： Ranger S,Talajic M,Lemery R,Roy D,Nattel S

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:-Recent studies have suggested that testosterone has a protective effect in the arterial vascular system. However, little is known about the molecular aspects of the mechanism(s) involved in these processes. The aim of the present study was to investigate the effect of testosterone on neointimal plaque devel...

journal_title：Circulation

authors： Hanke H,Lenz C,Hess B,Spindler KD,Weidemann W

更新日期：2001-03-13 00:00:00

abstract：BACKGROUND:Myocardial uptake of either 201Tl or 99mTc-sestamibi (sestamibi) is known to plateau at high coronary flow rates. However, few direct comparisons have been made between these tracers to determine what effect differences in the uptake plateau for the two tracers may have on the detection of coronary stenoses ...

journal_title：Circulation

authors： Glover DK,Ruiz M,Edwards NC,Cunningham M,Simanis JP,Smith WH,Watson DD,Beller GA

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. METHODS AND RESULTS:A Langendorff-perfused epicardial ...

journal_title：Circulation

authors： Schalij MJ,Boersma L,Huijberts M,Allessie MA

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinase...

journal_title：Circulation

authors： Pat B,Chen Y,Killingsworth C,Gladden JD,Shi K,Zheng J,Powell PC,Walcott G,Ahmed MI,Gupta H,Desai R,Wei CC,Hase N,Kobayashi T,Sabri A,Granzier H,Denney T,Tillson M,Dillon AR,Husain A,Dell'italia LJ

更新日期：2010-10-12 00:00:00

abstract：:After addition of a low concentration of thrombin to normal plasma, a progressive and significant increase in crosslinked fibrin polymers was found by sodium dodecyl sulfate agarose gel electrophoresis, reaching 27% of total fibrinogen and fibrin before gel formation. As measured by enzyme-linked immunosorbent assay w...

journal_title：Circulation

authors： Francis CW,Doughney K,Brenner B,Klingbiel K,Marder VJ

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenovira...

journal_title：Circulation

authors： Pauschinger M,Bowles NE,Fuentes-Garcia FJ,Pham V,Kühl U,Schwimmbeck PL,Schultheiss HP,Towbin JA

更新日期：1999-03-16 00:00:00

abstract：:To determine whether multiple lead precordial electrocardiographic recordings offer an improved index for noninvasive estimation of left ventricular hemodynamic function and segmental dyssynergy, precordial mapping was performed in patients with anterior myocardial infarction, and the number of pathologic Q waves (gre...

journal_title：Circulation

authors： Awan NA,Miller RR,Vera Z,Janzen DA,Amsterdam EA,Mason DT

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coron...

journal_title：Circulation

authors： Egashira K,Hirooka Y,Kuga T,Mohri M,Takeshita A

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activ...

journal_title：Circulation

authors： Siegerink B,Govers-Riemslag JW,Rosendaal FR,Ten Cate H,Algra A

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:The mechanisms of ventricular enlargement and dysfunction during postinfarct remodeling remain largely unknown. Although global left ventricular architectural changes after myocardial infarction are well documented, differences in function between adjacent and remote noninfarcted myocardium during left ventr...

journal_title：Circulation

authors： Kramer CM,Lima JA,Reichek N,Ferrari VA,Llaneras MR,Palmon LC,Yeh IT,Tallant B,Axel L

更新日期：1993-09-01 00:00:00

abstract：:Continuous retrograde coronary sinus cardioplegia (CSCP) has previously been carefully evaluated experimentally and shown to be efficacious during ischemia, even in the presence of coronary lesions and in the hypertrophied state. A new technique of retrograde cardioplegia delivery through the right atrium, using right...

journal_title：Circulation

authors： Salter DR,Goldstein JP,Abd-Elfattah A,Murphy CE,Brunsting LA,Wechsler AS

更新日期：1987-11-01 00:00:00

abstract：:Resting left ventricular (LV) function was evaluated in 22 patients with permanent ventricular pacemakers. LV ejection fraction and volume indexes were determined by gated blood pool scintigraphy at ventricular pacing rates of 50-100 beats/min. In patients with a normal heart size, increases in pacing rates resulted i...

journal_title：Circulation

authors： Narahara KA,Blettel ML

更新日期：1983-02-01 00:00:00