Coronary atherosclerosis. A multifactorial disease.


BACKGROUND:Several of the theories on the pathogenesis of atherosclerosis may be integrated into a single multifactorial one. According to this theory, the most likely sequence of events involved in early atherosclerosis is vascular dysfunction and/or injury, monocyte recruitment and macrophage formation, lipid deposition, vascular smooth muscle cell proliferation (mitogenic factor mediated), and synthesis of extracellular matrix. The interaction of all these factors will configurate the typical characteristic of the atherosclerotic plaque. METHODS AND RESULTS:Accumulating experimental and clinical data suggest two pathways in atherosclerotic progression. In some cases, the very slow process of the pathogenesis of early lesions may be significantly accelerated by means of thrombus formation and organization. Thrombosis is a key process in the pathogenesis of late atherogenesis and in the development of acute ischemic syndromes. CONCLUSIONS:The possibility of retarding human atherosclerosis or even inducing its regression is one of the present therapeutic challenges. Of the different approaches to this question, one approach aims at better control of risk factors, especially plasma lipid levels. Another approach attempts to enhance the removal of lipids from the arterial wall by increasing plasma high density lipoprotein levels. Each of these approaches, by acting on the lipid-rich plaques more prone to rupture, might prevent plaque progression and induce regression to prevent acute coronary events. A third approach, based on the key role of platelet thrombus formation in the conversion of chronic to acute events, would be the use of antithrombotic therapy. This last approach may partially prevent progression of the disease.






Badimon JJ,Fuster V,Chesebro JH,Badimon L


Has Abstract


1993-03-01 00:00:00




3 Suppl








  • The Science Underlying COVID-19: Implications for the Cardiovascular System.

    abstract::The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of severe a...


    pub_type: 杂志文章


    authors: Liu PP,Blet A,Smyth D,Li H

    更新日期:2020-07-07 00:00:00

  • Effect of septal myotomy and myectomy on left ventricular systolic function at rest and during exercise in patients with IHSS.

    abstract::Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...


    pub_type: 杂志文章


    authors: Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

    更新日期:1979-08-01 00:00:00

  • Transposition of the great arteries. Results of treatment with early palliation and late intracardiac repair.

    abstract::A longitudinal study was made of 62 patients with dextro-transposition of the great arteries. The patients were managed with balloon atrial septostomy (BAS), palliative surgery if any operation was needed in the first year of life, and Mustard intra-atrial baffle repair after one year of age. Of the 47 patients with i...


    pub_type: 杂志文章


    authors: Gutgesell HP,McNamara DG

    更新日期:1975-01-01 00:00:00

  • Rapid-response extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in children with cardiac disease.

    abstract:BACKGROUND:Survival of children with in-hospital cardiac arrest that does not respond to conventional cardiopulmonary resuscitation (CPR) is poor. We report on survival and early neurological outcomes of children with heart disease supported with rapid-response extracorporeal membrane oxygenation (ECMO) to aid cardiopu...


    pub_type: 杂志文章


    authors: Kane DA,Thiagarajan RR,Wypij D,Scheurer MA,Fynn-Thompson F,Emani S,del Nido PJ,Betit P,Laussen PC

    更新日期:2010-09-14 00:00:00

  • Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.

    abstract:BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...


    pub_type: 杂志文章


    authors: Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

    更新日期:2006-11-28 00:00:00

  • Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.

    abstract:BACKGROUND:Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) vary in volume and quality. We evaluated whether fat volume or attenuation (indirect measure of quality) predicts metabolic risk factor changes. METHODS AND RESULTS:Framingham Heart Study Multi-detector Computed Tomography Substudy particip...


    pub_type: 杂志文章


    authors: Abraham TM,Pedley A,Massaro JM,Hoffmann U,Fox CS

    更新日期:2015-10-27 00:00:00

  • p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.

    abstract:BACKGROUND:The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk ...


    pub_type: 杂志文章


    authors: van Tiel CM,Bonta PI,Rittersma SZ,Beijk MA,Bradley EJ,Klous AM,Koch KT,Baas F,Jukema JW,Pons D,Sampietro ML,Pannekoek H,de Winter RJ,de Vries CJ

    更新日期:2009-08-25 00:00:00

  • Outcome of patients with low ejection fraction undergoing coronary artery bypass grafting: renal function and mortality after 3.8 years.

    abstract:BACKGROUND:There are few data regarding medium-term outcome of coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) systolic dysfunction, particularly in the modern era, and even less assessing preoperative factors that might identify patients at highest risk. METHODS AND RESULTS:Three ...


    pub_type: 杂志文章


    authors: Hillis GS,Zehr KJ,Williams AW,Schaff HV,Orzulak TA,Daly RC,Mullany CJ,Rodeheffer RJ,Oh JK

    更新日期:2006-07-04 00:00:00

  • Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between bleeding events as defined by BARC and 1-year mortality in patients undergoing percutaneous coronary intervention (PCI...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ndrepepa G,Schuster T,Hadamitzky M,Byrne RA,Mehilli J,Neumann FJ,Richardt G,Schulz S,Laugwitz KL,Massberg S,Schömig A,Kastrati A

    更新日期:2012-03-20 00:00:00

  • Recurrence of ventricular fibrillation in acute ischemic heart disease.

    abstract::We assessed factors during an initial episode of ventricular fibrillation that may be predictive of recurrence. Of 141 consecutive patients with acute ischemic heart disease who survived an initial episode of ventricular fibrillation, 41 (29%) had recurrent ventricular fibrillation during hospitalization. The incidenc...


    pub_type: 杂志文章


    authors: Logan KR,McIlwaine WJ,Adgey AA,Pantridge JF

    更新日期:1981-12-01 00:00:00

  • Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.

    abstract:BACKGROUND:Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS:To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overl...


    pub_type: 杂志文章


    authors: Lu Z,Fassett J,Xu X,Hu X,Zhu G,French J,Zhang P,Schnermann J,Bache RJ,Chen Y

    更新日期:2008-10-21 00:00:00

  • Effect of digoxin and diuretics on high altitude left ventricular dysfunction.

    abstract::Systolic time intervals, stroke volume, cardiac output and (dZ/dt)/RZ index were serially estimated in 51 normal healthy volunteers at sea level, for ten days after air induction to 3658 m altitude and on return to sea level. The subjects were divided into three groups and were administered a diuretic, beta methyldigo...


    pub_type: 临床试验,杂志文章


    authors: Balasubramanian V,Behl A,Das GS,Wadhwa AK,Mathew OP,Hoon RS

    更新日期:1978-06-01 00:00:00

  • Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.

    abstract:BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...


    pub_type: 临床试验,杂志文章


    authors: Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

    更新日期:2002-02-19 00:00:00

  • Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell: modulation by lysophosphatidylcholine.

    abstract:BACKGROUND:The effects of lysophosphatidylcholine (LPC) on electrophysiological activities and intracellular Ca2+ concentration ([Ca2+]i) were investigated in coronary arterial smooth muscle cells (CASMCs). METHODS AND RESULTS:The patch clamp techniques and Ca2+ measurements were applied to cultured rabbit CASMCs. The...


    pub_type: 杂志文章


    authors: Terasawa K,Nakajima T,Iida H,Iwasawa K,Oonuma H,Jo T,Morita T,Nakamura F,Fujimori Y,Toyo-oka T,Nagai R

    更新日期:2002-12-10 00:00:00

  • Frequency of early occlusion and stenosis in a left internal mammary artery to left anterior descending artery bypass graft after surgery through a median sternotomy on conventional bypass: benchmark for minimally invasive direct coronary artery bypass.

    abstract:BACKGROUND:Uncertainty exists regarding the frequency of early occlusion when the left internal mammary artery (LIMA) is anastomosed to the left anterior descending artery (LAD) through a sternotomy with conventional coronary artery bypass grafting (CABG). The issue has gained importance for comparison with less invasi...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Berger PB,Alderman EL,Nadel A,Schaff HV

    更新日期:1999-12-07 00:00:00

  • Aspirin, warfarin, or the combination for secondary prevention of coronary events in patients with acute coronary syndromes and prior coronary artery bypass surgery.

    abstract:BACKGROUND:Patients with a non-ST-elevation acute coronary syndrome and prior CABG are at high risk of a recurrent ischemic event despite aspirin therapy. This trial investigated the potential benefit of secondary prevention with warfarin. METHODS AND RESULTS:In a double-blind randomized trial, 135 patients with unsta...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Huynh T,Théroux P,Bogaty P,Nasmith J,Solymoss S

    更新日期:2001-06-26 00:00:00

  • Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation.

    abstract:BACKGROUND:Esophageal injury is a potential complication after intraoperative or percutaneous transcatheter ablation of the posterior aspect of the left atrium. Understanding the spatial relations between the esophagus and the left atrium is essential to reduce risks. METHODS AND RESULTS:We examined by gross dissectio...


    pub_type: 杂志文章


    authors: Sánchez-Quintana D,Cabrera JA,Climent V,Farré J,Mendonça MC,Ho SY

    更新日期:2005-09-06 00:00:00

  • Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.

    abstract:BACKGROUND:Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP). Clinical and experimental studies indicate ventricular action potential prolongation, increased regional dispersion of repolarization, and early afterdepolarizations as underlying factors. We examined whether K(+)-current alte...


    pub_type: 杂志文章


    authors: Volders PG,Sipido KR,Vos MA,Spätjens RL,Leunissen JD,Carmeliet E,Wellens HJ

    更新日期:1999-12-14 00:00:00

  • Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.

    abstract:BACKGROUND:We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS:To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared...


    pub_type: 杂志文章


    authors: Zhang X,Zhang W,Ma SF,Desai AA,Saraf S,Miasniakova G,Sergueeva A,Ammosova T,Xu M,Nekhai S,Abbasi T,Casanova NG,Steinberg MH,Baldwin CT,Sebastiani P,Prchal JT,Kittles R,Garcia JG,Machado RF,Gordeuk VR

    更新日期:2014-04-22 00:00:00

  • Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity.

    abstract:BACKGROUND:Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular thrombosis. Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of TF-induced coagulation that binds to factor Xa and the TF-FVIIa catalytic...


    pub_type: 杂志文章


    authors: Caplice NM,Mueske CS,Kleppe LS,Simari RD

    更新日期:1998-09-15 00:00:00

  • The lesser circulation in patients with systemic hypertension.

    abstract::The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...


    pub_type: 杂志文章


    authors: Guazzi MD,De Cesare N,Fiorentini C,Galli C,Moruzzi P,Tamborini G

    更新日期:1987-01-01 00:00:00

  • Circadian variation of blood pressure in autonomic failure.

    abstract::We have monitored ambulant intra-arterial blood pressure with the Oxford system in six subjects with autonomic failure who exhibited postural hypotension. Plotting pooled hourly mean values we have demonstrated a consistent circadian trend in blood pressure that was the inverse of the normal pattern, with the highest ...


    pub_type: 杂志文章


    authors: Mann S,Altman DG,Raftery EB,Bannister R

    更新日期:1983-09-01 00:00:00

  • Serial follow-up after optimized ultrasound-guided deployment of Palmaz-Schatz stents. In-stent neointimal proliferation without significant reference segment response.

    abstract:BACKGROUND:The effects of ultrasound-guided high-pressure stenting on late stent and reference segment dimensions are unknown. In this study, we report about angiographic and ultrasound measurements to assess the amount and distribution of neointimal ingrowth within the stent and the changes of plaque burden and dimens...


    pub_type: 杂志文章


    authors: Mudra H,Regar E,Klauss V,Werner F,Henneke KH,Sbarouni E,Theisen K

    更新日期:1997-01-21 00:00:00

  • Peak oxygen uptake correlates with survival without clinical deterioration in ambulatory children with dilated cardiomyopathy.

    abstract:BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...


    pub_type: 杂志文章


    authors: Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

    更新日期:2011-10-18 00:00:00

  • Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis.

    abstract::Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatation in patients with aortic stenosis. Left ventricular mass and volumes were qua...


    pub_type: 杂志文章


    authors: Vekshtein VI,Alexander RW,Yeung AC,Plappert T,Sutton MG,Ganz P,Selwyn AP,Bittl JA

    更新日期:1990-12-01 00:00:00

  • Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease.

    abstract:BACKGROUND:Angiotensin may play a pathophysiological role in experimental and human cardiovascular disease. Clinical studies have shown that ACE inhibitors reduce mortality, recurrent myocardial infarction, and ischemic events in patients with left ventricular dysfunction. Animal studies suggest that tissue ACE, partic...


    pub_type: 杂志文章


    authors: Diet F,Pratt RE,Berry GJ,Momose N,Gibbons GH,Dzau VJ

    更新日期:1996-12-01 00:00:00

  • Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction.

    abstract:BACKGROUND:Age is a predictor of cognitive dysfunction after cardiac surgery, but the mechanism is unknown. The purpose of our study was to determine whether age-related decrements in cognition are associated with cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB). METHODS AND RESULTS:Cogniti...


    pub_type: 临床试验,杂志文章


    authors: Newman MF,Croughwell ND,Blumenthal JA,White WD,Lewis JB,Smith LR,Frasco P,Towner EA,Schell RM,Hurwitz BJ

    更新日期:1994-11-01 00:00:00

  • Lipid lowering versus revascularization: an idea whose time (for testing) has come.

    abstract::There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...


    pub_type: 杂志文章


    authors: Forrester JS,Shah PK

    更新日期:1997-08-19 00:00:00

  • Family history of heart attack as an independent predictor of death due to cardiovascular disease.

    abstract::Although a family history of ischemic heart disease is a well-accepted risk factor for cardiovascular disease, only three prospective studies--all in men--have examined the predictive strength of a positive family history after adjusting for other heart disease risk factors. The present analysis is based on a 9 year f...


    pub_type: 杂志文章


    authors: Barrett-Connor E,Khaw K

    更新日期:1984-06-01 00:00:00

  • Influenza Vaccine in Heart Failure.

    abstract:BACKGROUND:Influenza infection is a serious event for patients with heart failure (HF). Little knowledge exists about the association between influenza vaccination and outcome in patients with HF. This study sought to determine whether influenza vaccination is associated with improved long-term survival in patients wit...


    pub_type: 杂志文章


    authors: Modin D,Jørgensen ME,Gislason G,Jensen JS,Køber L,Claggett B,Hegde SM,Solomon SD,Torp-Pedersen C,Biering-Sørensen T

    更新日期:2019-01-29 00:00:00