Body mass index: a risk factor for unstable angina and myocardial infarction in patients with angiographically confirmed coronary artery disease.

abstract：BACKGROUND:Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex. We hypothesize that the relationship between OSA and high-sensitivity troponin T (hs-TnT), cardiac structure, and CV outcomes differs by sex. METHODS AND RESULTS:Seven hundred fi...

journal_title：Circulation

authors： Roca GQ,Redline S,Claggett B,Bello N,Ballantyne CM,Solomon SD,Shah AM

更新日期：2015-10-06 00:00:00

abstract：:Reactive oxygen species such as the superoxide anion (.O2-) have recently been implicated as important agents involved in causing cell death in the setting of myocardial ischemia and reperfusion. When superoxide anion is involved in ischemic injury the administration of superoxide dismutase (SOD) may limit infarct siz...

journal_title：Circulation

authors： Uraizee A,Reimer KA,Murry CE,Jennings RB

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:In subjects of all ages, those who weigh the most often have the highest blood pressure. Thus, in epidemiological studies, weight is the most important correlate of blood pressure. Using the data from the Medical College of Virginia Twin Study, we asked these questions: 1) Do the same genetic paths that regu...

journal_title：Circulation

authors： Schieken RM,Mosteller M,Goble MM,Moskowitz WB,Hewitt JK,Eaves LJ,Nance WE

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP synthesis by activating soluble guanylate cyclase (sGC) in ventilated lung regions. Carbon monoxide (CO) has also been proposed to influence smooth muscle tone via activation of sGC. We examined whether direct stimu...

journal_title：Circulation

authors： Evgenov OV,Ichinose F,Evgenov NV,Gnoth MJ,Falkowski GE,Chang Y,Bloch KD,Zapol WM

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:NADH/NADPH oxidase is an important source of superoxide in the vasculature. Recently, we found that polymorphism of the gene p22phox, a critical component of this oxidase, is associated with a risk of coronary artery disease. The aim of this study was to investigate the localization of p22phox in human coron...

journal_title：Circulation

authors： Azumi H,Inoue N,Takeshita S,Rikitake Y,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：1999-10-05 00:00:00

abstract：BACKGROUND:Interaction of complement with endothelial cells (ECs) underlies the development of inflammation and coagulation in disease. Assembly of the membrane attack complex (MAC) of complement on EC membrane, like stimulation with cytokines, upregulates tissue factor and cyclooxygenase-2 but does so via the intermed...

journal_title：Circulation

authors： Saadi S,Holzknecht RA,Patte CP,Platt JL

更新日期：2000-04-18 00:00:00

abstract：:The widespread use of exercise testing for the detection of myocardial ischemia in patients suspected of having coronary artery disease led to the detection of ischemic changes in many subjects who subsequently were found to have angiographically normal epicardial vessels--the false positive response. Such a result is...

journal_title：Circulation

authors： Epstein SE,Cannon RO 3rd,Bonow RO

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction of coronary arteries with impaired vasodilation has been reported in patients with arterial hypertension. However, the effect of dynamic exercise on coronary vasomotion of a stenotic vessel segment before and after PTCA has not yet been evaluated in these patients. METHODS AND RESULT...

journal_title：Circulation

authors： Frielingsdorf J,Kaufmann P,Suter T,Hug R,Hess OM

更新日期：1998-09-22 00:00:00

abstract：BACKGROUND:The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain. METHODS AND RESULTS:We analyzed data from a prospective cohort of 754 patients with heart failure who had ejection fractio...

journal_title：Circulation

authors： McAlister FA,Ezekowitz J,Tonelli M,Armstrong PW

更新日期：2004-03-02 00:00:00

abstract：BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

journal_title：Circulation

authors： Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood. METHODS AND RESULTS:In vivo and cellular electrophysiological experiments were conducted to study IKs in canine ventricular repolarization. In conscious dogs, administration of the selective ...

journal_title：Circulation

authors： Volders PG,Stengl M,van Opstal JM,Gerlach U,Spätjens RL,Beekman JD,Sipido KR,Vos MA

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:High-sensitivity cardiac troponin assays can help to identify patients who are at low risk of myocardial infarction in the emergency department. We aimed to determine whether the addition of clinical risk scores would improve the safety of early rule-out pathways for myocardial infarction. METHODS:In 1935 p...

journal_title：Circulation

authors： Chapman AR,Hesse K,Andrews J,Lee KK,Anand A,Shah ASV,Sandeman D,Ferry AV,Jameson J,Piya S,Stewart S,Marshall L,Strachan FE,Gray A,Newby DE,Mills NL

更新日期：2018-10-16 00:00:00

abstract：OBJECTIVE:Previous studies comparing off-pump coronary artery bypass surgery (OPCABG) to conventional techniques utilizing cardiopulmonary bypass (CABG-CPB) have failed to provide patient selection guidelines. We sought to determine guidelines, attempting to rectify the limitations of previous studies. METHODS AND RES...

journal_title：Circulation

authors： Magee MJ,Coombs LP,Peterson ED,Mack MJ

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Survival of children with in-hospital cardiac arrest that does not respond to conventional cardiopulmonary resuscitation (CPR) is poor. We report on survival and early neurological outcomes of children with heart disease supported with rapid-response extracorporeal membrane oxygenation (ECMO) to aid cardiopu...

journal_title：Circulation

authors： Kane DA,Thiagarajan RR,Wypij D,Scheurer MA,Fynn-Thompson F,Emani S,del Nido PJ,Betit P,Laussen PC

更新日期：2010-09-14 00:00:00

abstract：:Prospective data was recorded on 217 percutaneous transluminal angioplasty (PTA) procedures performed in the superficial femoral and popliteal arteries over an 8-year period. After the initial procedure, patients were followed with serial noninvasive studies and, in 71 patients, repeat angiography. The mean follow-up ...

journal_title：Circulation

authors： Capek P,McLean GK,Berkowitz HD

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：:A prospective electrocardiographic study was designed to establish baseline values for electrocardiographic measurements, with specific reference to the QT interval during infancy, and to test the "QT hypothesis" for the sudden infant death syndrome (SIDS). In this ongoing study, ECGs are recorded on the fourth day of...

journal_title：Circulation

authors： Schwartz PJ,Montemerlo M,Facchini M,Salice P,Rosti D,Poggio G,Giorgetti R

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:The substitution variants K35A,E38A,K74A, E75A,R77A (SakSTAR.M38) and K74A,E75A,R77A,E80A, D82A (SakSTAR.M89) of recombinant staphylokinase (SakSTAR) with reduced antibody reactivity were assayed for thrombolytic potency and antibody induction in animal models and in patients. METHODS AND RESULTS:In a 125I-...

journal_title：Circulation

authors： Collen D,Moreau H,Stockx L,Vanderschueren S

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:The association between elevated blood triglyceride levels and subsequent mortality risk in patients with established coronary heart disease (CHD) has been investigated rarely. The aim of the present study was to investigate this association. METHODS AND RESULTS:We evaluated mortality over a mean follow-up ...

journal_title：Circulation

authors： Haim M,Benderly M,Brunner D,Behar S,Graff E,Reicher-Reiss H,Goldbourt U

更新日期：1999-08-03 00:00:00

abstract：BACKGROUND:This study proposes 2 new echocardiographic indices with potential application in acute coronary artery occlusion to differentiate between viable and necrotic myocardium and to identify reperfusion. We investigated whether the ratio between systolic lengthening and combined late and postsystolic shortening (...

journal_title：Circulation

authors： Lyseggen E,Skulstad H,Helle-Valle T,Vartdal T,Urheim S,Rabben SI,Opdahl A,Ihlen H,Smiseth OA

更新日期：2005-12-20 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Most survival prediction models for coronary artery bypass grafting surgery are limited to in-hospital or 30-day end points. We estimate a long-term survival model using data from the Society of Thoracic Surgeons Adult Cardiac Surgery Database and Centers for Medicare and Medicaid Services. METHODS AND RESU...

journal_title：Circulation

authors： Shahian DM,O'Brien SM,Sheng S,Grover FL,Mayer JE,Jacobs JP,Weiss JM,Delong ER,Peterson ED,Weintraub WS,Grau-Sepulveda MV,Klein LW,Shaw RE,Garratt KN,Moussa ID,Shewan CM,Dangas GD,Edwards FH

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Ultrafast computed tomography (CT), by acquiring images of the proximal coronary arteries, detects coronary calcifications and has been demonstrated to be highly sensitive for the detection of coronary artery disease in many small studies. The aim of this study was to determine the relationship between ultra...

journal_title：Circulation

authors： Budoff MJ,Georgiou D,Brody A,Agatston AS,Kennedy J,Wolfkiel C,Stanford W,Shields P,Lewis RJ,Janowitz WR,Rich S,Brundage BH

更新日期：1996-03-01 00:00:00

abstract：:Relationships between enzyme estimates (EE) and histologic measurements of infarct size (HIS) were analyzed in 14 conscious dogs with permanent occlusion of the circumflex coronary artery. EE were derived from serial CPK, CPK-MM, CPK-MB, and CPK-BB. Estimates were obtained using methods of Shell et al., Norris et al.,...

journal_title：Circulation

authors： Roe CR,Cobb FR,Starmer CF

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:The myocardial protective role of heat shock protein (HSP) has been demonstrated, and there has been increasing interest in stress response in the heart. We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during h...

journal_title：Circulation

authors： Nishizawa J,Nakai A,Higashi T,Tanabe M,Nomoto S,Matsuda K,Ban T,Nagata K

更新日期：1996-11-01 00:00:00

abstract：:Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor recordings from 15 clinically stable patients with various cardiac disorders. Mean hourly VPD frequencies ranged from 37--1,801 per hour. Data were subjected t...

journal_title：Circulation

authors： Morganroth J,Michelson EL,Horowitz LN,Josephson ME,Pearlman AS,Dunkman WB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach. METHODS AND RESULTS:In the nonpreconditioned state, eNOS-/- mice exhibited infarct sizes similar to...

journal_title：Circulation

authors： Xuan YT,Guo Y,Zhu Y,Wang OL,Rokosh G,Bolli R

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:Relieving the inhibition of sarcoplasmic reticular function by phospholamban is a major target of beta-adrenergic stimulation. Chronic beta-adrenergic receptor activity has been suggested to be detrimental, on the basis of transgenic overexpression of the receptor or its signaling effectors. However, it is n...

journal_title：Circulation

authors： Dash R,Kadambi V,Schmidt AG,Tepe NM,Biniakiewicz D,Gerst MJ,Canning AM,Abraham WT,Hoit BD,Liggett SB,Lorenz JN,Dorn GW 2nd,Kranias EG

更新日期：2001-02-13 00:00:00

abstract：BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...

journal_title：Circulation

authors： Niebauer J,Hambrecht R,Velich T,Hauer K,Marburger C,Kälberer B,Weiss C,von Hodenberg E,Schlierf G,Schuler G,Zimmermann R,Kübler W

更新日期：1997-10-21 00:00:00

abstract：BACKGROUND:Consensus guidelines and hospital quality-of-care programs recommend that ST-elevation myocardial infarction patients achieve a door-to-balloon time of < or = 90 minutes. However, there are limited prospective data on specific measures to significantly reduce door-to-balloon time. METHODS AND RESULTS:We pro...

journal_title：Circulation

authors： Khot UN,Johnson ML,Ramsey C,Khot MB,Todd R,Shaikh SR,Berg WJ

更新日期：2007-07-03 00:00:00