Noninvasive study of early diastole in mitral stenosis.

abstract：BACKGROUND:Approximately half of all patients with chronic heart failure (HF) have a decreased ejection fraction (EF) (systolic HF [SHF]); the other half have HF with a normal EF (diastolic HF [DHF]). However, the underlying pathophysiological differences between DHF and SHF patients are incompletely defined. The purpo...

journal_title：Circulation

authors： Zile MR,Bennett TD,St John Sutton M,Cho YK,Adamson PB,Aaron MF,Aranda JM Jr,Abraham WT,Smart FW,Stevenson LW,Kueffer FJ,Bourge RC

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:Frequently the definitive operation for patients with a right ventricle (RV) that is too small to support full cardiac output is a modified Fontan operation. However, other surgical options exist that incorporate a small RV in the atriopulmonary pathway when biventricular repair is not feasible because of RV...

journal_title：Circulation

authors： Gentles TL,Keane JF,Jonas RA,Marx GE,Mayer JE Jr

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...

journal_title：Circulation

authors： Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:The heart can synthesize epinephrine. Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine. The cardiac atrium contains primarily PNMT and the cardiac ventricle contains both P...

journal_title：Circulation

authors： Kennedy B,Ziegler MG

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:By the formation of cGMP, nitric oxide (NO)-sensitive guanylyl cyclase (GC) acts as the effector for the signaling molecule NO and mediates the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The compounds YC-1 and BAY 41-2272 are regarded as NO-independent activators and sen...

journal_title：Circulation

authors： Mullershausen F,Russwurm M,Friebe A,Koesling D

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:The pathophysiology of hypertension in the immediate postpartum period is unclear. METHODS AND RESULTS:We studied 988 consecutive women admitted to a tertiary medical center for cesarean section of a singleton pregnancy. The angiogenic factors soluble fms-like tyrosine kinase 1 and placental growth factor, ...

journal_title：Circulation

authors： Goel A,Maski MR,Bajracharya S,Wenger JB,Zhang D,Salahuddin S,Shahul SS,Thadhani R,Seely EW,Karumanchi SA,Rana S

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:Performance of coronary artery bypass graft (CABG) during an acute coronary syndrome (ACS) is mainly used in high-risk patients. Although potentially life-saving, patients undergoing early CABG are traditionally associated with a worse outcome than those not requiring CABG. Is this really true in an unselect...

journal_title：Circulation

authors： Monteiro P,Portuguese Registry on Acute Coronary Syndromes.

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:This experiment sought to determine the effects of fish oil on superoxide anion production in the myocardium and coronary arteries of atherosclerotic monkeys. Recent evidence indicates that dietary supplementation with fish oil preserves normal vasomotion of atherosclerotic coronary arteries and reduces dama...

journal_title：Circulation

authors： Supari F,Ungerer T,Harrison DG,Williams JK

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Muscle sympathetic nerve activity (MSNA) is increased in patients with obstructive sleep apnea (OSA). We tested the hypothesis that tonic activation of excitatory chemoreceptor afferents contributes to the elevated sympathetic activity in OSA. METHODS AND RESULTS:Using a double-blind, randomized, vehicle-co...

journal_title：Circulation

authors： Narkiewicz K,van de Borne PJ,Montano N,Dyken ME,Phillips BG,Somers VK

更新日期：1998-03-17 00:00:00

abstract：BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...

journal_title：Circulation

authors： Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

更新日期：2011-05-31 00:00:00

abstract：:Numerous criteria for the diagnosis of inferior wall myocardial infarction by electrocardiogram (ECG) and vectorcardiogram (VCG) have been published, but they have not been subjected to a systematic, independent evaluation. Accordingly, we studied 146 patients undergoing cardiac catheterization; 63 were normal and 83 ...

journal_title：Circulation

authors： Hurd HP 2nd,Starling MR,Crawford MH,Dlabal PW,O'Rourke RA

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown. METHODS AND RESULTS:This was an open-label, randomized, parallel-group, multicenter study. Patients with persistent AF, dual-chamber implantable...

journal_title：Circulation

authors： Di Biase L,Mohanty P,Mohanty S,Santangeli P,Trivedi C,Lakkireddy D,Reddy M,Jais P,Themistoclakis S,Dello Russo A,Casella M,Pelargonio G,Narducci ML,Schweikert R,Neuzil P,Sanchez J,Horton R,Beheiry S,Hongo R,Hao S,

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim of this study was to determine the adult CHD population at risk of SCD and the clinical parameters associated with SCD. METHODS AND RESULTS:We performed a multicenter case-control study. Patients ...

journal_title：Circulation

authors： Koyak Z,Harris L,de Groot JR,Silversides CK,Oechslin EN,Bouma BJ,Budts W,Zwinderman AH,Van Gelder IC,Mulder BJ

更新日期：2012-10-16 00:00:00

abstract：:In the United States each year, >5.3 million patients present to emergency departments with chest discomfort and related symptoms. Ultimately, >1.4 million individuals are hospitalized for unstable angina and non-ST-segment elevation myocardial infarction. For emergency physicians and cardiologists alike, these patien...

journal_title：Circulation

authors： Gibler WB,Cannon CP,Blomkalns AL,Char DM,Drew BJ,Hollander JE,Jaffe AS,Jesse RL,Newby LK,Ohman EM,Peterson ED,Pollack CV,American Heart Association Council on Clinical Cardiology (Subcommittee on Acute Cardiac Care).,Council on

更新日期：2005-05-24 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/sci...

journal_title：Circulation

authors： Zhou X,Nicoletti A,Elhage R,Hansson GK

更新日期：2000-12-12 00:00:00

abstract：BACKGROUND:We previously demonstrated that reduced vagal activity and/or increased sympathetic activity identify post-myocardial infarction patients at high risk for cardiac mortality. Simple and inexpensive autonomic markers are necessary to perform autonomic screening in large populations. We tested our hypothesis th...

journal_title：Circulation

authors： Falcone C,Buzzi MP,Klersy C,Schwartz PJ

更新日期：2005-09-27 00:00:00

abstract：INTRODUCTION:Patients with congenital heart disease frequently require graft material for repair of cardiac defects. However, currently available grafts lack growth potential and are noncontractile and thrombogenic. We have developed a viable cardiac graft that contracts spontaneously in tissue culture by seeding cells...

journal_title：Circulation

authors： Li RK,Jia ZQ,Weisel RD,Mickle DA,Choi A,Yau TM

更新日期：1999-11-09 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D...

journal_title：Circulation

authors： Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KH

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...

journal_title：Circulation

authors： Lindsey M,Wedin K,Brown MD,Keller C,Evans AJ,Smolen J,Burns AR,Rossen RD,Michael L,Entman M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non...

journal_title：Circulation

authors： Sirol M,Itskovich VV,Mani V,Aguinaldo JG,Fallon JT,Misselwitz B,Weinmann HJ,Fuster V,Toussaint JF,Fayad ZA

更新日期：2004-06-15 00:00:00

abstract：:A new technology, leadless pacemaker therapy, was recently introduced clinically to address lead- and pocket-related complications in conventional transvenous pacemaker therapy. These leadless devices are self-contained right ventricular single-chamber pacemakers implanted by using a femoral percutaneous approach. In ...

journal_title：Circulation

authors： Tjong FV,Reddy VY

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic di...

journal_title：Circulation

authors： Gullestad L,Ueland T,Fjeld JG,Holt E,Gundersen T,Breivik K,Følling M,Hodt A,Skårdal R,Kjekshus J,Andreassen A,Kjekshus E,Wergeland R,Yndestad A,Frøland SS,Semb AG,Aukrust P

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF. METHODS AND RESULTS:...

journal_title：Circulation

authors： Hocini M,Sanders P,Deisenhofer I,Jaïs P,Hsu LF,Scavée C,Weerasoriya R,Raybaud F,Macle L,Shah DC,Garrigue S,Le Metayer P,Clémenty J,Haïssaguerre M

更新日期：2003-09-09 00:00:00

abstract：:This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements neede...

journal_title：Circulation

authors： Cooper R,Soltero I,Liu K,Berkson D,Levinson S,Stamler J

更新日期：1980-07-01 00:00:00

abstract：:A mathematical model to measure infarct size from serial estimates of CPK has been developed by Shell et al. Norris et al. have recently introduced a modification of this method by calculating an individualized disappearance rate parameter (Kd) from the uniformly monoexponential portion of the CPK vs time curve. This ...

journal_title：Circulation

authors： Slutsky AS

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Regional sympathetic denervation, such as that produced by a myocardial infarction, causes electrophysiological heterogeneity in the ventricles. The purpose of this study was to test the hypothesis that such denervation could cause drugs to exert heterogeneous myocardial effects. METHODS AND RESULTS:Sympath...

journal_title：Circulation

authors： Stanton MS,Zipes DP

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases, is unclear at present. METHODS:The LV parameters were measured from the cardiovascular magnetic resonance studies of the UK Biobank. ...

journal_title：Circulation

authors： Aung N,Vargas JD,Yang C,Cabrera CP,Warren HR,Fung K,Tzanis E,Barnes MR,Rotter JI,Taylor KD,Manichaikul AW,Lima JAC,Bluemke DA,Piechnik SK,Neubauer S,Munroe PB,Petersen SE

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:The clinical significance of the interaction between clopidogrel and proton pump inhibitors (PPIs) remains unclear. METHODS AND RESULTS:We examined the relationship between PPI use and 1-year cardiovascular events (cardiovascular death, myocardial infarction, or stroke) in patients with acute coronary syndr...

journal_title：Circulation

authors： Goodman SG,Clare R,Pieper KS,Nicolau JC,Storey RF,Cantor WJ,Mahaffey KW,Angiolillo DJ,Husted S,Cannon CP,James SK,Kilhamn J,Steg PG,Harrington RA,Wallentin L,Platelet Inhibition and Patient Outcomes Trial Investigators.

更新日期：2012-02-28 00:00:00

abstract：:On May 20, 1984, the Surgeon General challenged the health community to work toward attainment of a smoke-free society by the year 2000. The leadership of the nation's three major voluntary organizations joined numerous associations of health professionals in accepting the challenge. The Subcommittee on Smoking of the...

journal_title：Circulation

authors： Warner KE,Ernster VL,Holbrook JH,Lewit EM,Pertschuk M,Steinfeld JL,Whelan EM

更新日期：1986-02-01 00:00:00