Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.

abstract：:In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

journal_title：Circulation

authors： Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

更新日期：1988-11-01 00:00:00

abstract：:To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...

journal_title：Circulation

authors： Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:The risk of recurrent venous thrombosis is 2-fold higher in men than in women. In contrast, no such sex difference in the risk of first venous thrombosis has been reported. We hypothesized that, for a first event, a risk difference between the sexes is masked by female exposure to reproductive factors (oral ...

journal_title：Circulation

authors： Roach RE,Lijfering WM,Rosendaal FR,Cannegieter SC,le Cessie S

更新日期：2014-01-07 00:00:00

abstract：BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...

journal_title：Circulation

authors： Weaver WD,Litwin PE,Martin JS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleuk...

journal_title：Circulation

authors： Liuzzo G,Buffon A,Biasucci LM,Gallimore JR,Caligiuri G,Vitelli A,Altamura S,Ciliberto G,Rebuzzi AG,Crea F,Pepys MB,Maseri A

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters ...

journal_title：Circulation

authors： Chung ES,Leon AR,Tavazzi L,Sun JP,Nihoyannopoulos P,Merlino J,Abraham WT,Ghio S,Leclercq C,Bax JJ,Yu CM,Gorcsan J 3rd,St John Sutton M,De Sutter J,Murillo J

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:Monocarboxylate transporters (MCTs) mediate lactate transport across the plasma membrane of cells. The molecular mechanisms regulating monocarboxylate transport in smooth muscle cells (SMCs) remain poorly characterized. The aim of this study was to investigate the effects of DNA methylation on MCT expression...

journal_title：Circulation

authors： Zhu S,Goldschmidt-Clermont PJ,Dong C

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALD...

journal_title：Circulation

authors： Mizuno Y,Harada E,Morita S,Kinoshita K,Hayashida M,Shono M,Morikawa Y,Murohara T,Nakayama M,Yoshimura M,Yasue H

更新日期：2015-05-12 00:00:00

abstract：BACKGROUND:The use of atherosclerotic cardiovascular disease (ASCVD) risk to personalize systolic blood pressure (SBP) treatment goals is a topic of increasing interest. Therefore, we studied whether coronary artery calcium (CAC) can further guide the allocation of anti-hypertensive treatment intensity. METHODS:We inc...

journal_title：Circulation

authors： McEvoy JW,Martin SS,Dardari ZA,Miedema MD,Sandfort V,Yeboah J,Budoff MJ,Goff DC Jr,Psaty BM,Post WS,Nasir K,Blumenthal RS,Blaha MJ

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Optimal management of acute pulmonary embolism (PE) requires medical expertise, diagnostic testing, and therapies that may not be available consistently throughout the entire week. We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay fo...

journal_title：Circulation

authors： Aujesky D,Jiménez D,Mor MK,Geng M,Fine MJ,Ibrahim SA

更新日期：2009-02-24 00:00:00

abstract：BACKGROUND:Elevated levels of oxidized phospholipids (OxPLs) on apolipoprotein B-100 particles (OxPL/apoB) are associated with cardiovascular disease and predict new cardiovascular events. Elevated lipoprotein (a) [Lp(a)] levels are a risk factor for cardiovascular disease in whites and also in blacks if they carry sma...

journal_title：Circulation

authors： Tsimikas S,Clopton P,Brilakis ES,Marcovina SM,Khera A,Miller ER,de Lemos JA,Witztum JL

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Recent transcatheter aortic valve replacement studies have raised concerns about adverse cerebrovascular events. The etiopathology of the embolized material is currently unknown. METHODS AND RESULTS:A total of 40 patients underwent transcatheter aortic valve replacement with the use of a dual filter-based e...

journal_title：Circulation

authors： Van Mieghem NM,Schipper ME,Ladich E,Faqiri E,van der Boon R,Randjgari A,Schultz C,Moelker A,van Geuns RJ,Otsuka F,Serruys PW,Virmani R,de Jaegere PP

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:Chronic heart failure (CHF) is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). There is evidence for increased radical formation in CHF, raising the possibility that nitric oxide is inactivated by radicals, thereby impairing endothelial function...

journal_title：Circulation

authors： Hornig B,Arakawa N,Kohler C,Drexler H

更新日期：1998-02-03 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) ha...

journal_title：Circulation

authors： Wadham C,Albanese N,Roberts J,Wang L,Bagley CJ,Gamble JR,Rye KA,Barter PJ,Vadas MA,Xia P

更新日期：2004-05-04 00:00:00

abstract：:All of the electrophysiological mechanisms of arrhythmias are sensitive to the influences of the autonomic nervous system, particularly to its adrenergic limb. Arrhythmogenic areas may also be dependent on the inhomogeneity of these influences because of their pathophysiological structure and/or the neurogenic or humo...

journal_title：Circulation

authors： Coumel P,Leenhardt A

更新日期：1991-04-01 00:00:00

abstract：:Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulm...

journal_title：Circulation

authors： Myers J,Froelicher VF

更新日期：1990-11-01 00:00:00

abstract：:Using a mechanical sector-scanner, two-dimensional echocardiograms were obtained from 28 normal subjects, 15 patients with tetralogy of Fallot, 11 patients with complete transposition of the great arteries and six patients with double outlet right ventricle. The image obtained perpendicular to the long axis of the lef...

journal_title：Circulation

authors： Henry WL,Maron BJ,Griffith JM

更新日期：1977-08-01 00:00:00

abstract：:For patients with stenotic native valves, the modified Bernoulli equation (delta P = 4V2) may be applied to Doppler-measured transvalvular velocities to yield an accurate estimate of transvalvular gradients. Although it would be useful if the same approach could be used for those with stenotic prosthetic valves, no pr...

journal_title：Circulation

authors： Wilkins GT,Gillam LD,Kritzer GL,Levine RA,Palacios IF,Weyman AE

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...

journal_title：Circulation

authors： Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

更新日期：2020-02-11 00:00:00

abstract：:For half a century the systolic click and late systolic murmur lay dormant as innocent auscultatory curiosities. The thirteen years since Barlow related these phenomena to mitral leaflet prolapse have witnessed an astonishing information explosion. We have sought to bring together the accumulated data in this review. ...

journal_title：Circulation

authors： Devereux RB,Perloff JK,Reichek N,Josephson ME

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Three trials demonstrated recently that a long detection window reduces implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients. Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients III (ADVANCE III) was the only trial that enrolled both primary and secondary pr...

journal_title：Circulation

authors： Kloppe A,Proclemer A,Arenal A,Lunati M,Martìnez Ferrer JB,Hersi A,Gulaj M,Wijffels MC,Santi E,Manotta L,Mangoni L,Gasparini M

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots. METHODS AND ...

journal_title：Circulation

authors： Spuentrup E,Fausten B,Kinzel S,Wiethoff AJ,Botnar RM,Graham PB,Haller S,Katoh M,Parsons EC Jr,Manning WJ,Busch T,Günther RW,Buecker A

更新日期：2005-07-19 00:00:00

abstract：:The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Myers S

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Increased activity of the sympathetic nervous system contributes significantly to the pathophysiology of heart failure. However, cardiac efferent sympathetic function has not been well characterized in this disorder. In this study, we evaluated cardiac sympathetic innervation using [123I]metaiodobenzylguanid...

journal_title：Circulation

authors： Simmons WW,Freeman MR,Grima EA,Hsia TW,Armstrong PW

更新日期：1994-06-01 00:00:00

abstract：:Sustained-release diltiazem (D-SR) and sustained-release verapamil (V-SR) when given twice a day have been successfully used to treat both essential hypertension and angina pectoris. Review of available studies indicates that 120 to 180 mg D-SR twice a day and 240 mg V-SR once or twice a day can lower diastolic pressu...

journal_title：Circulation

authors： Klein MD,Weiner DA

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Venous coronary artery bypass grafts (CABGs) are prone to accelerated atherosclerosis. In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker. The origin of CRP in this setting remains to be elucidated. METHODS AND RESULTS:Monoclonal anti...

journal_title：Circulation

authors： Jabs WJ,Theissing E,Nitschke M,Bechtel JF,Duchrow M,Mohamed S,Jahrbeck B,Sievers HH,Steinhoff J,Bartels C

更新日期：2003-09-23 00:00:00

abstract：BACKGROUND:Cardiac-targeted expression of truncated K(v)4.2 subunit (K(v)4.2N) reduces transient outward current (I(to)) density, prolongs action potentials (APs), and enhances contractility in 3- to 4-week-old transgenic mice. By 13 to 15 weeks of age, these mice develop severely impaired cardiac function and signs of...

journal_title：Circulation

authors： Sah R,Oudit GY,Nguyen TT,Lim HW,Wickenden AD,Wilson GJ,Molkentin JD,Backx PH

更新日期：2002-04-16 00:00:00

abstract：BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...

journal_title：Circulation

authors： Schultz A,Lavie L,Hochberg I,Beyar R,Stone T,Skorecki K,Lavie P,Roguin A,Levy AP

更新日期：1999-08-03 00:00:00

abstract：BACKGROUND:Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional cardiovascular risk factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on the causal pathway for certain risk factors to exert their effect. These associat...

journal_title：Circulation

authors： Stec JJ,Silbershatz H,Tofler GH,Matheney TH,Sutherland P,Lipinska I,Massaro JM,Wilson PF,Muller JE,D'Agostino RB Sr

更新日期：2000-10-03 00:00:00

abstract：BACKGROUND:Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental me...

journal_title：Circulation

authors： Medeiros K,O'Connor MJ,Baicu CF,Fitzgibbons TP,Shaw P,Tighe DA,Zile MR,Aurigemma GP

更新日期：2014-04-22 00:00:00