Molecular magnetic resonance imaging of atrial clots in a swine model.

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Vasomotor reactivity may contribute to the pathophysiology of ischemic injury. The atherosclerotic vessel may be particularly susceptible to vasoconstriction because of the damaged endothelial layer with resultant loss of vasodilatory factors. While dietary omega 3 fatty acids have been proposed to protect a...

journal_title：Circulation

authors： Malis CD,Leaf A,Varadarajan GS,Newell JB,Weber PC,Force T,Bonventre JV

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...

journal_title：Circulation

authors： Matt P,Schoenhoff F,Habashi J,Holm T,Van Erp C,Loch D,Carlson OD,Griswold BF,Fu Q,De Backer J,Loeys B,Huso DL,McDonnell NB,Van Eyk JE,Dietz HC,GenTAC Consortium.

更新日期：2009-08-11 00:00:00

abstract：:Experience with percutaneous transluminal coronary angioplasty (PTCA) of multiple vessels was reviewed to assess short-term outcome and long-term results. PTCA of multiple vessels was performed in 100 of the initial 500 patients (20%) who underwent PTCA at the Medical College of Virginia between July 1979 and August 1...

journal_title：Circulation

authors： Cowley MJ,Vetrovec GW,DiSciascio G,Lewis SA,Hirsh PD,Wolfgang TC

更新日期：1985-12-01 00:00:00

abstract：:We tested the hypothesis that different subsets of ischemia-induced wall motion disorders are characterized by specific patterns of abnormal regional left ventricular systolic function. Regional contraction was quantitatively assessed from two-dimensional echocardiograms by an automated integrative analysis considerin...

journal_title：Circulation

authors： Zeiher AM,Wollschlaeger H,Bonzel T,Kasper W,Just H

更新日期：1987-10-01 00:00:00

abstract：:An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, a...

journal_title：Circulation

authors： Hodgson JM,Marshall JJ

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

journal_title：Circulation

authors： Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

更新日期：2011-10-18 00:00:00

abstract：:In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a cl...

journal_title：Circulation

authors： Rinaldi G,Cingolani H

更新日期：1983-12-01 00:00:00

abstract：:Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

journal_title：Circulation

authors： Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

更新日期：1985-03-01 00:00:00

abstract：:Resting hemodynamics improve during vasodilator administration in patients, with congestive heart failure (CHF), but the effects of these agents on exercise is unknown. Twenty-two patients with class II or III CHF performed bicycle exercise to symptomatic maximum before and 90 minutes after random double-blind adminis...

journal_title：Circulation

authors： Franciosa JA,Cohn JN

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Isomerism is associated with a complex spectrum of anomalies. There is paucity of data on prenatally detected cases. METHODS AND RESULTS:Between January 1990 and February 2004, 83 of 166 cases (50%) had a prenatal diagnosis of left isomerism (LAI; 52 of 97) or right isomerism (RAI; 31 of 69) at our institut...

journal_title：Circulation

authors： Lim JS,McCrindle BW,Smallhorn JF,Golding F,Caldarone CA,Taketazu M,Jaeggi ET

更新日期：2005-10-18 00:00:00

abstract：BACKGROUND:Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a dist...

journal_title：Circulation

authors： Kitani T,Ong SG,Lam CK,Rhee JW,Zhang JZ,Oikonomopoulos A,Ma N,Tian L,Lee J,Telli ML,Witteles RM,Sharma A,Sayed N,Wu JC

更新日期：2019-05-21 00:00:00

abstract：:Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...

journal_title：Circulation

authors： Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

更新日期：2020-05-12 00:00:00

abstract：:Mitral pressure half-time (T1/2) is widely used as an independent measure of mitral valve area in patients undergoing percutaneous mitral valvotomy. However, fluid dynamics theory predicts T1/2 to be strongly dependent on chamber compliance and the peak transmitral gradient, which are variables that change dramaticall...

journal_title：Circulation

authors： Thomas JD,Wilkins GT,Choong CY,Abascal VM,Palacios IF,Block PC,Weyman AE

更新日期：1988-10-01 00:00:00

abstract：:Various electrocardiographic and vectorcardiographic (ECG-VCG) patterns of ventricular conduction disturbances are inducible by premature right atrial stimulation (PRAS). These patterns are a consequence of different degrees of refractoriness in the specialized ventricular conduction system. We observed that the inter...

journal_title：Circulation

authors： Piccolo E,Raviele A,Delise P,Dainese F,Pascotto P,Totaro G,Sartori F,D'Este D

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor-initiated phenotypes. Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and rabbits...

journal_title：Circulation

authors： Chatterjee S,Bedja D,Mishra S,Amuzie C,Avolio A,Kass DA,Berkowitz D,Renehan M

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:There are several potential physiological differences between the atriopulmonary (AP) and the total cavopulmonary connection (TCPC) Fontan circulations. Studies suggest that the TCPC reduces energy loss due to turbulence and may have more dependence on respiratory movement for pulmonary blood flow. We compar...

journal_title：Circulation

authors： Rosenthal M,Bush A,Deanfield J,Redington A

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP), as a cardiac hormone, is expressed together with atrial natriuretic peptide (ANP) in the ventricles in congestive heart failure. However, the ventricular expression of BNP in hypertrophic cardiomyopathy (HCM) with normal systolic function is still unclear. METHODS AND RESULT...

journal_title：Circulation

authors： Hasegawa K,Fujiwara H,Doyama K,Miyamae M,Fujiwara T,Suga S,Mukoyama M,Nakao K,Imura H,Sasayama S

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The role of doxazosin in treatment of hypertension remains controversial. METHODS AND RESULTS:We evaluated the effects on blood pressure (BP) and biochemical parameters of doxazosin GITS (gastrointestinal therapeutic system) as a third-line antihypertensive agent among 10,069 participants in the Anglo-Scand...

journal_title：Circulation

authors： Chapman N,Chang CL,Dahlöf B,Sever PS,Wedel H,Poulter NR,ASCOT Investigators.

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...

journal_title：Circulation

authors： van de Borne P,Montano N,Zimmerman B,Pagani M,Somers VK

更新日期：1997-12-16 00:00:00

abstract：:The acute hemodynamic effects of dobutamine and nitroprusside were compared in 19 patients with low output cardiac failure. At dosage levels yielding similar increases in cardiac index (12 patients), nitroprusside resulted in significantly lower arterial systolic and wedge pressures and did not increase heart rate sug...

journal_title：Circulation

authors： Berkowitz C,McKeever L,Croke RP,Jacobs WR,Loeb HS,Gunnar RM

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Orthostatic intolerance is characterized by postural tachycardia syndrome (POTS) with exaggerated tachycardia, orthostatic symptoms, and "pooling" (which comprises acrocyanosis and dependent edema when upright). My colleagues and I tested the hypothesis that pooling results from increased venous compliance i...

journal_title：Circulation

authors： Stewart JM

更新日期：2002-05-14 00:00:00

abstract：BACKGROUND:A recent study has shown that the implantable atrial defibrillator can restore sinus rhythm in patients with recurrent atrial fibrillation when therapy was delivered under physician observation. The objective of this study was to evaluate the safety and efficacy of ambulatory use of the implantable atrial de...

journal_title：Circulation

authors： Daoud EG,Timmermans C,Fellows C,Hoyt R,Lemery R,Dawson K,Ayers GM

更新日期：2000-09-19 00:00:00

abstract：BACKGROUND:Microsomal (m) prostaglandin (PG) E₂ synthase (S)-1 catalyzes the formation of PGE₂ from PGH₂, a cyclooxygenase product that is derived from arachidonic acid. Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibit...

journal_title：Circulation

authors： Wang M,Ihida-Stansbury K,Kothapalli D,Tamby MC,Yu Z,Chen L,Grant G,Cheng Y,Lawson JA,Assoian RK,Jones PL,Fitzgerald GA

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L ha...

journal_title：Circulation

authors： Olofsson PS,Söderström LA,Wågsäter D,Sheikine Y,Ocaya P,Lang F,Rabu C,Chen L,Rudling M,Aukrust P,Hedin U,Paulsson-Berne G,Sirsjö A,Hansson GK

更新日期：2008-03-11 00:00:00

abstract：BACKGROUND:Angina symptoms have been reported to predict mortality in men. The aim of this study was to investigate the association between angina symptoms and mortality in women. METHODS AND RESULTS:In 2004, 873 older participants in the Australian Longitudinal Study on Women's Health with self-reported ischemic hear...

journal_title：Circulation

authors： Berecki-Gisolf J,Humphreyes-Reid L,Wilson A,Dobson A

更新日期：2009-12-08 00:00:00

abstract：:Intermittent restoration of coronary flow during ischemia reduced myocardial damage and improved recovery of function. The mechanisms of the protective effects of intermittent perfusion were investigated in isolated rat hearts. Ventricular function was assessed as the product of developed pressure (left ventricular sy...

journal_title：Circulation

authors： Tani M,Neely JR

更新日期：1990-08-01 00:00:00

abstract：:The loss of coronary vasodilator reserve after ischemia-reperfusion may be due to endothelial injury, and this vascular dysfunction may contribute to functional alterations observed after ischemia. To determine whether endothelial dysfunction occurs after relatively brief periods of moderate low-flow ischemia in vivo,...

journal_title：Circulation

authors： Headrick JP,Angello DA,Berne RM

更新日期：1990-12-01 00:00:00

abstract：:The International Liaison Committee on Resuscitation has initiated a near-continuous review of cardiopulmonary resuscitation science that replaces the previous 5-year cyclic batch-and-queue approach process. This is the first of an annual series of International Consensus on Cardiopulmonary Resuscitation and Emergency...

journal_title：Circulation

authors： Olasveengen TM,de Caen AR,Mancini ME,Maconochie IK,Aickin R,Atkins DL,Berg RA,Bingham RM,Brooks SC,Castrén M,Chung SP,Considine J,Couto TB,Escalante R,Gazmuri RJ,Guerguerian AM,Hatanaka T,Koster RW,Kudenchuk PJ,Lang

更新日期：2017-12-05 00:00:00

abstract：:Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy t...

journal_title：Circulation

authors： Kannel WB,Dawber TR,McGee DL

更新日期：1980-06-01 00:00:00