Abstract:
BACKGROUND:Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis. METHODS AND RESULTS:This study shows that the tumor necrosis factor superfamily members CD137 and CD137 ligand (CD137L), which play a major role in several autoimmune diseases, may constitute a pathogenic pair in atherogenesis. We detected CD137 protein in human atherosclerotic lesions not only on T cells but also on endothelial cells and showed that CD137 in cultured endothelial cells and smooth muscle cells was induced by proinflammatory cytokines implicated in atherosclerosis. Activation of CD137 by CD137L induced adhesion molecule expression on endothelial cells and reduced smooth muscle cell proliferation. In addition, treatment of atherosclerosis-prone apolipoprotein E-deficient mice with a CD137 agonist caused increased inflammation. T-cell infiltration, mainly of CD8(+) cells, and expression of the murine major histocompatibility complex class II molecule I-A(b) increased significantly in atherosclerotic lesions, as did the aortic expression of proinflammatory cytokines. CONCLUSIONS:Taken together, these observations suggest that CD137-CD137L interactions in the vasculature may contribute to the progression of atherosclerosis via augmented leukocyte recruitment, increased inflammation, and development of a more disease-prone phenotype.
journal_name
Circulationjournal_title
Circulationauthors
Olofsson PS,Söderström LA,Wågsäter D,Sheikine Y,Ocaya P,Lang F,Rabu C,Chen L,Rudling M,Aukrust P,Hedin U,Paulsson-Berne G,Sirsjö A,Hansson GKdoi
10.1161/CIRCULATIONAHA.107.699173subject
Has Abstractpub_date
2008-03-11 00:00:00pages
1292-301issue
10eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.107.699173journal_volume
117pub_type
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