East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome.


BACKGROUND:Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese. METHODS AND RESULTS:The study subjects consisted of 202 patients in whom intracoronary injection of acetylcholine was performed by angiography on suspicion of CSA (119 men and 83 women; mean age, 66.2±11.4 years). They were divided into CSA (112 patients) and control groups (90 patients). ALDH2 genotyping was performed by the direct application of the TaqMan polymerase chain reaction system on dried whole blood. Clinical and laboratory data were examined using conventional methods. The frequencies of male sex, ALDH2*2 genotype carriers, alcohol flushing syndrome, tobacco smoking, and the plasma level of uric acid were higher (P<0.001, P<0.001, P<0.001, P<0.001, and P=0.007, respectively) and the plasma high-density lipoprotein cholesterol levels were lower (P<0.001) in the CSA group than in the control group. The multivariable logistic regression analysis revealed that ALDH2*2 genotype and smoking were significantly associated with CSA (P<0.001 and P=0.024, respectively). CONCLUSIONS:East Asian variant ALDH2*2 genotypes and, hence, deficient ALDH2 activity were associated with CSA in Japanese. These data support further investigation of treatment targeting aldehydes for CSA.






Mizuno Y,Harada E,Morita S,Kinoshita K,Hayashida M,Shono M,Morikawa Y,Murohara T,Nakayama M,Yoshimura M,Yasue H




Has Abstract


2015-05-12 00:00:00














  • Mechanisms of resetting reentrant circuits in canine ventricular tachycardia.

    abstract:BACKGROUND:Resetting has been used to characterize reentrant circuits causing clinical tachycardias. METHODS AND RESULTS:To determine the mechanisms of resetting, sustained ventricular tachycardia was induced in dogs with 4-day-old myocardial infarctions by programmed stimulation. Premature stimulation was accomplishe...


    pub_type: 杂志文章


    authors: Hanna MS,Coromilas J,Josephson ME,Wit AL,Peters NS

    更新日期:2001-02-27 00:00:00

  • Exercise echocardiography versus 201Tl single-photon emission computed tomography in evaluation of coronary artery disease. Analysis of 292 patients.

    abstract:BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality we...


    pub_type: 杂志文章


    authors: Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

    更新日期:1992-03-01 00:00:00

  • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...


    pub_type: 杂志文章


    authors: Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

    更新日期:2014-07-29 00:00:00

  • Autoregulation of cardiac output by passive elastic characteristics of the vascular capacitance system.

    abstract::After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...


    pub_type: 杂志文章


    authors: Rothe CF,Gaddis ML

    更新日期:1990-01-01 00:00:00

  • Mechanism of mitral regurgitation in hypertrophic cardiomyopathy: mismatch of posterior to anterior leaflet length and mobility.

    abstract:BACKGROUND:In hypertrophic cardiomyopathy, a spectrum of mitral leaflet abnormalities has been related to the mechanism of mitral systolic anterior motion (SAM), which causes both subaortic obstruction and mitral regurgitation. In the individual patient, SAM and regurgitation vary in parallel; clinically, however, grea...


    pub_type: 杂志文章


    authors: Schwammenthal E,Nakatani S,He S,Hopmeyer J,Sagie A,Weyman AE,Lever HM,Yoganathan AP,Thomas JD,Levine RA

    更新日期:1998-09-01 00:00:00

  • Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B.

    abstract:BACKGROUND:The timing of onset of angina before myocardial infarction in relation to outcome is unknown. METHODS AND RESULTS:We prospectively determined the importance of the time of onset of preinfarction angina in relation to 30-day outcomes in the TIMI-9B study from standardized forms. Of the 3002 patients entered ...


    pub_type: 杂志文章


    authors: Kloner RA,Shook T,Antman EM,Cannon CP,Przyklenk K,Yoo K,McCabe CH,Braunwald E

    更新日期:1998-03-24 00:00:00

  • Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study.

    abstract:BACKGROUND:Our objective was to investigate the association between hypertension and concurrent impairments in mobility, cognition, and mood; the role of brain white matter hyperintensities in mediating this association; and the impact of these impairments on disability and mortality in elderly hypertensive individuals...


    pub_type: 杂志文章


    authors: Hajjar I,Quach L,Yang F,Chaves PH,Newman AB,Mukamal K,Longstreth W Jr,Inzitari M,Lipsitz LA

    更新日期:2011-03-01 00:00:00

  • Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations: the CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Study.

    abstract:BACKGROUND:Sirolimus-eluting stents have been reported to be effective in the treatment of coronary bifurcations. Still, it has not been fully clarified which strategy would provide the best results with true bifurcation lesions. METHODS AND RESULTS:The CACTUS trial (Coronary bifurcations: Application of the Crushing ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Colombo A,Bramucci E,Saccà S,Violini R,Lettieri C,Zanini R,Sheiban I,Paloscia L,Grube E,Schofer J,Bolognese L,Orlandi M,Niccoli G,Latib A,Airoldi F

    更新日期:2009-01-06 00:00:00

  • Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets.

    abstract:BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...


    pub_type: 杂志文章


    authors: Santos MT,Moscardó A,Vallés J,Martínez M,Piñón M,Aznar J,Broekman MJ,Marcus AJ

    更新日期:2000-10-17 00:00:00

  • Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on

    abstract::Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there ar...


    pub_type: 杂志文章,meta分析


    authors: Zaragoza-Macias E,Zaidi AN,Dendukuri N,Marelli A

    更新日期:2019-04-02 00:00:00

  • Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and ther...


    pub_type: 杂志文章,随机对照试验


    authors: Abozguia K,Elliott P,McKenna W,Phan TT,Nallur-Shivu G,Ahmed I,Maher AR,Kaur K,Taylor J,Henning A,Ashrafian H,Watkins H,Frenneaux M

    更新日期:2010-10-19 00:00:00

  • Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age.

    abstract:BACKGROUND:Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1 alpha-mediated response to hypoxia associated with aging are poorly understood. Here, we report that swimming trai...


    pub_type: 杂志文章


    authors: Cheng XW,Kuzuya M,Kim W,Song H,Hu L,Inoue A,Nakamura K,Di Q,Sasaki T,Tsuzuki M,Shi GP,Okumura K,Murohara T

    更新日期:2010-08-17 00:00:00

  • Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children.

    abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) is initiated in hospitalized children with bradycardia and poor perfusion. However, their rate of progression to pulseless cardiac arrest despite CPR and the differences in survival compared with initially pulseless arrest are unknown. We examined the prevalence and predic...


    pub_type: 杂志文章


    authors: Khera R,Tang Y,Girotra S,Nadkarni VM,Link MS,Raymond TT,Guerguerian AM,Berg RA,Chan PS,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

    更新日期:2019-07-30 00:00:00

  • Multimodal fetal transesophageal echocardiography for fetal cardiac intervention in sheep.

    abstract:BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...


    pub_type: 杂志文章


    authors: Kohl T,Westphal M,Strümper D,Achenbach S,Halimeh S,Petry P,Aryee S,Buller T,Aleksiene R,Asfour B,Witteler R,Vogt J,Van Aken H,Scheld HH

    更新日期:2001-10-09 00:00:00

  • Intraoperative recording of the His bundle electrogram in man. An assessment of its precision.

    abstract::To estimate the effect of distance between the electrode and the signal source on the amplitude of the His bundle electrogram (HBE) recorded during open heart surgery, a specially designed probe, containing six pairs of closely spaced (1 mm) electrodes was placed on the endocardial surface of the right atrium such tha...


    pub_type: 杂志文章


    authors: Dick M 2nd,Krongrad E,Antar RE,Ross S,Bowman FO Jr,Malm JR,Hoffman BF

    更新日期:1976-02-01 00:00:00

  • The effects of coronary angioplasty and reperfusion on distribution of myocardial flow.

    abstract::To assess the effects of angioplasty (PTCA) and intracoronary streptokinase (ICSK) on relative myocardial perfusion, we administered 99mTc-macroaggregated albumin (MAA) to the uninvolved coronary artery before successful PTCA in 33 patients and before successful infusion of ICSK in eight patients and of 111In-MAA into...


    pub_type: 杂志文章


    authors: Wahr DW,Ports TA,Botvinick EH,Dae M,Schechtmann N,Huberty J,Hattner RS,O'Connell JW,Turley K

    更新日期:1985-08-01 00:00:00

  • Correlation between scintigraphic evidence of regional sympathetic neuronal dysfunction and ventricular refractoriness in the human heart.

    abstract:BACKGROUND:Denervation supersensitivity has been proposed as a mechanism for the relation between ventricular arrhythmias and the sympathetic nervous system. Evaluation of this phenomenon in humans has become feasible only recently with the development of noninvasive scintigraphic methods for evaluating the pattern of ...


    pub_type: 杂志文章


    authors: Calkins H,Allman K,Bolling S,Kirsch M,Wieland D,Morady F,Schwaiger M

    更新日期:1993-07-01 00:00:00

  • Outcome of alcohol septal ablation for obstructive hypertrophic cardiomyopathy.

    abstract:BACKGROUND:The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. METHODS AND RESULTS:Among 601 patients with severely symptomatic o...


    pub_type: 杂志文章


    authors: Sorajja P,Valeti U,Nishimura RA,Ommen SR,Rihal CS,Gersh BJ,Hodge DO,Schaff HV,Holmes DR Jr

    更新日期:2008-07-08 00:00:00

  • Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis.

    abstract:BACKGROUND:Monocarboxylate transporters (MCTs) mediate lactate transport across the plasma membrane of cells. The molecular mechanisms regulating monocarboxylate transport in smooth muscle cells (SMCs) remain poorly characterized. The aim of this study was to investigate the effects of DNA methylation on MCT expression...


    pub_type: 杂志文章


    authors: Zhu S,Goldschmidt-Clermont PJ,Dong C

    更新日期:2005-08-30 00:00:00

  • Distribution, morphology, and neurochemistry of endocardial and epicardial nerve terminal arborizations in the human heart.

    abstract:BACKGROUND:The heart contains a variety of morphologically distinct nerve terminals known to influence cardiac function. Little is known about the distribution, morphology, and neurochemistry of these terminals in the human heart. METHODS AND RESULTS:We examined the entire endocardial and epicardial surfaces of infant...


    pub_type: 杂志文章


    authors: Marron K,Wharton J,Sheppard MN,Fagan D,Royston D,Kuhn DM,de Leval MR,Whitehead BF,Anderson RH,Polak JM

    更新日期:1995-10-15 00:00:00

  • Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.

    abstract:BACKGROUND:Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS:We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Piccini JP,Hellkamp AS,Washam JB,Becker RC,Breithardt G,Berkowitz SD,Halperin JL,Hankey GJ,Hacke W,Mahaffey KW,Nessel CC,Singer DE,Fox KA,Patel MR

    更新日期:2016-01-26 00:00:00

  • Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.

    abstract:BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...


    pub_type: 杂志文章


    authors: Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

    更新日期:2010-11-16 00:00:00

  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

    abstract:BACKGROUND:The endothelium acts as the sensor of shear stress and as the mediator of flow-induced changes in vessel tone and structure. The purpose of this study was to delineate the signal transduction pathway of flow-induced release of endothelium-derived relaxing factor (EDRF). METHODS AND RESULTS:We used a shear s...


    pub_type: 杂志文章


    authors: Ohno M,Gibbons GH,Dzau VJ,Cooke JP

    更新日期:1993-07-01 00:00:00

  • Minimum hematocrit at differing cardiopulmonary bypass temperatures in dogs.

    abstract:BACKGROUND:The purpose of this study was to determine the minimum hematocrit (Hct) supporting cerebral oxygenation over the range clinically relevant cardiopulmonary bypass (CPB) temperatures in dogs. The effect of hemodilution on cerebral blood flow (CBF), cerebral metabolic rate (CMRO2), and cerebral oxygen delivery ...


    pub_type: 杂志文章


    authors: Cook DJ,Orszulak TA,Daly RC

    更新日期:1998-11-10 00:00:00

  • Response of blood pressure, cardiac output, peripheral resistance, and exercise performance to substitution of calcium blocker for beta-blocker plus thiazide diuretic therapy in patients with both systemic hypertension and mild stable angina.

    abstract::We studied 14 patients to determine whether sustained-release diltiazem is a satisfactory long-term substitute for the combination of propranolol plus hydrochlorothiazide (HCTZ), control phase, in the treatment of systemic hypertension with coexisting chronic stable angina pectoris. All patients had either one- or two...


    pub_type: 杂志文章


    authors: Kawanishi DT,Reid CL,Gonzales A,O'Rourke RA,Rahimtoola SH

    更新日期:1989-12-01 00:00:00

  • Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association.

    abstract:BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...


    pub_type: 杂志文章,实务指引


    authors: Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

    更新日期:2011-11-08 00:00:00

  • A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 15O-water and dynamic positron emission tomography.

    abstract:BACKGROUND:We have developed a new measure of myocardial viability, the water-perfusable tissue index (PTI), which is calculated from transmission, C15O, and H2(15)O positron emission tomography (PET) data sets. It is defined as the proportion of the total anatomical tissue within a given region of interest (ROI) that ...


    pub_type: 杂志文章


    authors: Yamamoto Y,de Silva R,Rhodes CG,Araujo LI,Iida H,Rechavia E,Nihoyannopoulos P,Hackett D,Galassi AR,Taylor CJ

    更新日期:1992-07-01 00:00:00

  • Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.

    abstract::A definitive diagnosis of myocarditis requires right ventricular biopsy. Despite its specificity, however, right ventricular biopsy may lack sensitivity due to the focal nature of the disease. Because indium 111-monoclonal antimyosin antibody imaging can be used to detect myocardial necrosis, this procedure was perfor...


    pub_type: 杂志文章


    authors: Yasuda T,Palacios IF,Dec GW,Fallon JT,Gold HK,Leinbach RC,Strauss HW,Khaw BA,Haber E

    更新日期:1987-08-01 00:00:00

  • Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association.

    abstract::Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...


    pub_type: 杂志文章


    authors: Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

    更新日期:2020-03-24 00:00:00

  • Re-entrant ventricular arrhythmias in the late myocardial infarction period. 2. Patterns of initiation and termination of re-entry.

    abstract::The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...


    pub_type: 杂志文章


    authors: El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

    更新日期:1977-05-01 00:00:00