Optimizing the exercise test for pharmacological investigations.

Abstract:

:Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulmonary function is assessed by exercise. Commonly used protocols are not always appropriate for all patients or all studies. Both cardiovascular disease and the exercise protocol can have an important impact on the relation between changes in work rate and oxygen uptake. Ramp protocols appear to offer the greatest promise for assessing cardiopulmonary function. Analyzing hemodynamic and gas exchange responses at several points submaximally, in addition to those at peak exercise, can add important information concerning the efficacy of a drug. A great deal of confusion continues to hinder the application of the gas exchange anaerobic threshold, and many of the commonly used testing end points are not reliable.

journal_name

Circulation

journal_title

Circulation

authors

Myers J,Froelicher VF

doi

10.1161/01.cir.82.5.1839

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

1839-46

issue

5

eissn

0009-7322

issn

1524-4539

journal_volume

82

pub_type

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