Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.

Abstract:

BACKGROUND:Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS:A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events. CONCLUSIONS:The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.

journal_name

Circulation

journal_title

Circulation

authors

Heckbert SR,Hindorff LA,Edwards KL,Psaty BM,Lumley T,Siscovick DS,Tang Z,Durda JP,Kronmal RA,Tracy RP

doi

10.1161/01.CIR.0000065231.07729.92

subject

Has Abstract

pub_date

2003-04-22 00:00:00

pages

2021-4

issue

15

eissn

0009-7322

issn

1524-4539

pii

01.CIR.0000065231.07729.92

journal_volume

107

pub_type

杂志文章
  • Oxygenation in patients with a functionally univentricular circulation and complete mixing of blood: are saturation and flow interchangeable?

    abstract:BACKGROUND:Perioperative management of patients with complete mixing of pulmonary and systemic blood centers on approximately equating pulmonary (Qp) and systemic (Qs) blood flow (Qp/Qs approximately 1). This empirically derived target is opposed by theoretical studies advocating a target Qp/Qs well below 1. We studied...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.21.2198

    authors: Francis DP,Willson K,Thorne SA,Davies LC,Coats AJ

    更新日期:1999-11-23 00:00:00

  • Cardiovascular and Ventilatory Consequences of Laparoscopic Surgery.

    abstract::Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.116.023262

    authors: Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

    更新日期:2017-02-14 00:00:00

  • Effect of potassium cardioplegia on myocardial ischemia and post arrest ventricular function.

    abstract::To assess the effects of moderate potassium cardioplegia (37 mEq/l KCl) on the severity of myocardial ischemia during arrest and on post arrest ventricular function, 32 isolated, isovolumic feline hearts were studied before, during and 1 hour after ischemic arrest. Normothermia (37 degrees C) was maintained in the rem...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.58.2.240

    authors: Schaff HV,Dombroff R,Flaherty JT,Bulkley BH,Hutchins GM,Goldman RA,Gott VL

    更新日期:1978-08-01 00:00:00

  • The opioid system in cardiac and vascular regulation of normal and hypertensive states.

    abstract::The endogenous opioid system includes three major families of peptides: dynorphins (derived from pre-proenkephalin B), endorphins (derived from pre-proopiomelanocortin), and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them poss...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Feuerstein G,Sirén AL

    更新日期:1987-01-01 00:00:00

  • Ultrasonic tissue characterization: detection of acute myocardial ischemia in dogs.

    abstract::Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.1.193

    authors: Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

    更新日期:1985-07-01 00:00:00

  • Absence of lethal reperfusion injury after 3 hours of reperfusion. A study in a single-canine-heart model of ischemia-reperfusion.

    abstract:BACKGROUND:Whether reperfusion can cause necrosis of previously viable myocytes (lethal reperfusion injury) remains controversial. Numerous studies examined the ability of various agents to prevent or limit reperfusion injury, but the results were contradictory. In a single-canine-heart model of ischemia-reperfusion, w...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.12.2989

    authors: Zahger D,Yano J,Chaux A,Fishbein MC,Ganz W

    更新日期:1995-06-15 00:00:00

  • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.

    abstract:BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.534271

    authors: Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

    更新日期:2005-07-12 00:00:00

  • Impact of infectious burden on extent and long-term prognosis of atherosclerosis.

    abstract:BACKGROUND:Recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. In hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. Moreover, this effect could be multiplied by the num...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc0102.101362

    authors: Espinola-Klein C,Rupprecht HJ,Blankenberg S,Bickel C,Kopp H,Rippin G,Victor A,Hafner G,Schlumberger W,Meyer J,AtheroGene Investigators.

    更新日期:2002-01-01 00:00:00

  • Intravascular ultrasound evaluation of the effect of rotational atherectomy in obstructive atherosclerotic coronary artery disease.

    abstract:BACKGROUND:High-speed rotational atherectomy uses a diamond-coated, elliptical burr to abrade occlusive atherosclerosis, especially noncompliant calcified plaque. METHODS AND RESULTS:Intravascular ultrasound (IVUS) was used to analyze 28 patients after atherectomy. Arteries treated and imaged were left main (three), l...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.86.5.1383

    authors: Mintz GS,Potkin BN,Keren G,Satler LF,Pichard AD,Kent KM,Popma JJ,Leon MB

    更新日期:1992-11-01 00:00:00

  • Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis.

    abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000146787.16297.E8

    authors: Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

    更新日期:2004-11-02 00:00:00

  • Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.

    abstract:BACKGROUND:Activated fibroblasts (myofibroblasts) play a critical role in cardiac fibrosis; however, their origin in the diseased heart remains unclear, warranting further investigation. Recent studies suggest the contribution of bone marrow fibroblast progenitor cells (BM-FPCs) in pressure overload-induced cardiac fib...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.117.027889

    authors: Verma SK,Garikipati VNS,Krishnamurthy P,Schumacher SM,Grisanti LA,Cimini M,Cheng Z,Khan M,Yue Y,Benedict C,Truongcao MM,Rabinowitz JE,Goukassian DA,Tilley D,Koch WJ,Kishore R

    更新日期:2017-09-05 00:00:00

  • Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.

    abstract:BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.15.1834

    authors: Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

    更新日期:2000-10-10 00:00:00

  • Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.

    abstract:BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.10.2919

    authors: Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

    更新日期:1995-11-15 00:00:00

  • Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

    abstract:BACKGROUND:Modeling of human arrhythmias with induced pluripotent stem cell-derived cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of human heart tissue ha...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.039711

    authors: Park SJ,Zhang D,Qi Y,Li Y,Lee KY,Bezzerides VJ,Yang P,Xia S,Kim SL,Liu X,Lu F,Pasqualini FS,Campbell PH,Geva J,Roberts AE,Kleber AG,Abrams DJ,Pu WT,Parker KK

    更新日期:2019-07-30 00:00:00

  • Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis.

    abstract::Platelets play an important role in the formation of a coronary thrombus and reocclusion after thrombolysis. Therefore, we examined the thrombolytic potential of concomitant intravenous administration of potent platelet inhibitor iloprost, a prostacyclin analogue, with tissue-type plasminogen activator (t-PA; n = 8) a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.3.1115

    authors: Nicolini FA,Mehta JL,Nichols WW,Saldeen TG,Grant M

    更新日期:1990-03-01 00:00:00

  • Lack of reflex increase in myocardial sympathetic tone after captopril: potential antianginal effect.

    abstract::Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.71.2.317

    authors: Daly P,Mettauer B,Rouleau JL,Cousineau D,Burgess JH

    更新日期:1985-02-01 00:00:00

  • Peak oxygen uptake correlates with survival without clinical deterioration in ambulatory children with dilated cardiomyopathy.

    abstract:BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.035956

    authors: Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

    更新日期:2011-10-18 00:00:00

  • The new 99mTc myocardial perfusion imaging agents: 99mTc-sestamibi and 99mTc-teboroxime.

    abstract::The two new 99m (99mTc) labeled myocardial perfusion agents, 99mTc-Sestamibi and 99mTc-Teboroxime, are now available for routine clinical application. Both agents allow assessment of ejection fraction by the first-pass technique at rest or during exercise, thus providing additional information not available with thall...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,评审

    doi:

    authors: Berman DS,Kiat H,Maddahi J

    更新日期:1991-09-01 00:00:00

  • Comparison of lifestyle-based and traditional cardiovascular disease prediction in a multiethnic cohort of nonsmoking women.

    abstract:BACKGROUND:Healthy levels of lifestyle factors can reduce the risk of cardiovascular disease. However, except for smoking status, often considered a traditional risk factor, their effect on cardiovascular risk prediction is unclear. METHODS AND RESULTS:We used a case-cohort design of postmenopausal nonsmokers in the m...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.012069

    authors: Paynter NP,LaMonte MJ,Manson JE,Martin LW,Phillips LS,Ridker PM,Robinson JG,Cook NR

    更新日期:2014-10-21 00:00:00

  • Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study.

    abstract:BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.109.928481

    authors: Khairy P,Aboulhosn J,Gurvitz MZ,Opotowsky AR,Mongeon FP,Kay J,Valente AM,Earing MG,Lui G,Gersony DR,Cook S,Ting JG,Nickolaus MJ,Webb G,Landzberg MJ,Broberg CS,Alliance for Adult Research in Congenital Cardiology (AARCC).

    更新日期:2010-08-31 00:00:00

  • Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles.

    abstract:BACKGROUND:Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to pl...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000093185.16083.95

    authors: Winter PM,Morawski AM,Caruthers SD,Fuhrhop RW,Zhang H,Williams TA,Allen JS,Lacy EK,Robertson JD,Lanza GM,Wickline SA

    更新日期:2003-11-04 00:00:00

  • Increased release of NO during ischemia reduces myocardial contractility and improves metabolic dysfunction.

    abstract:BACKGROUND:We have reported that myocardial ischemia increases nitric oxide (NO) production. Several lines of evidence suggest that NO reduces myocardial contraction. Therefore, we tested whether endogenous NO decreases the inotropic response of the ischemic myocardium and whether endogenous NO is beneficial in the met...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.2.356

    authors: Node K,Kitakaze M,Kosaka H,Komamura K,Minamino T,Inoue M,Tada M,Hori M,Kamada T

    更新日期:1996-01-15 00:00:00

  • Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.619056

    authors: Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

    更新日期:2006-07-04 00:00:00

  • Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

    abstract::To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.74.4.852

    authors: Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

    更新日期:1986-10-01 00:00:00

  • Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.

    abstract:BACKGROUND:We studied the growth-promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cultured cells from vascular smooth muscle (VSMCs) from human umbilical vein and a rat VSMC line, A7r5. METHODS AND RESULTS:Both ouabain and marinobufagenin activated proliferation of the...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000101919.00548.86

    authors: Abramowitz J,Dai C,Hirschi KK,Dmitrieva RI,Doris PA,Liu L,Allen JC

    更新日期:2003-12-16 00:00:00

  • Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha.

    abstract:BACKGROUND:Rel/NF-kappaB, an oxidative stress-responsive transcription factor, participates transiently in the control of gene expression. The cellular mechanisms that mediate NF-kappaB activation during ischemia (and during reperfusion in the course of treating ischemia) are not known. METHODS AND RESULTS:To investig...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.suppl_2.ii-361

    authors: Canty TG Jr,Boyle EM Jr,Farr A,Morgan EN,Verrier ED,Pohlman TH

    更新日期:1999-11-09 00:00:00

  • Differential clinical outcomes associated with hypoglycemia and hyperglycemia in acute myocardial infarction.

    abstract:BACKGROUND:In patients with acute myocardial infarction (AMI), hyperglycemia predicts death, but the prognostic significance of hypoglycemia is controversial. METHODS AND RESULTS:We evaluated the prognostic significance of hypoglycemia and hyperglycemia in 30 536 AMI patients in a post hoc analysis of 2 large trials o...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.108.837765

    authors: Goyal A,Mehta SR,Díaz R,Gerstein HC,Afzal R,Xavier D,Liu L,Pais P,Yusuf S

    更新日期:2009-12-15 00:00:00

  • Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

    abstract:BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.593483

    authors: Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

    更新日期:2006-10-24 00:00:00

  • Plasma and lipoprotein cholesterol and triglyceride concentrations in the Pima Indians: distributions differing from those of Caucasians.

    abstract::Plasma and lipoprotein cholesterol and triglyceride concentrations were measured in Pima Indians, a genetically homogeneous population with a high prevalence of obesity and diabetes and a low frequency of coronary heart disease. The data for nondiabetic Pima Indians were compared with those of U.S. Caucasians measured...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.68.4.714

    authors: Howard BV,Davis MP,Pettitt DJ,Knowler WC,Bennett PH

    更新日期:1983-10-01 00:00:00

  • Hemodynamic effects of direct biventricular compression studied in isovolumic and ejecting isolated canine hearts.

    abstract:BACKGROUND:Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS:A comput...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.16.2177

    authors: Artrip JH,Wang J,Leventhal AR,Tsitlik JE,Levin HR,Burkhoff D

    更新日期:1999-04-27 00:00:00