Endocardial excision: a new surgical technique for the treatment of recurrent ventricular tachycardia.

abstract：BACKGROUND:The wide range of clinical presentation of orthostatic vasovagal syncope suggests different underlying changes in the cardiac autonomic modulation. METHODS AND RESULTS:To evaluate the beat-by-beat modifications in the neural control of heart period preceding a syncopal event, we studied RR interval variabil...

journal_title：Circulation

authors： Furlan R,Piazza S,Dell'Orto S,Barbic F,Bianchi A,Mainardi L,Cerutti S,Pagani M,Malliani A

更新日期：1998-10-27 00:00:00

abstract：:Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart disease patients, a large number of victims of the disease who are apparently healthy die suddenly without prior sympto...

journal_title：Circulation

authors： Naghavi M,Libby P,Falk E,Casscells SW,Litovsky S,Rumberger J,Badimon JJ,Stefanadis C,Moreno P,Pasterkamp G,Fayad Z,Stone PH,Waxman S,Raggi P,Madjid M,Zarrabi A,Burke A,Yuan C,Fitzgerald PJ,Siscovick DS,de Korte CL

更新日期：2003-10-14 00:00:00

abstract：:After addition of a low concentration of thrombin to normal plasma, a progressive and significant increase in crosslinked fibrin polymers was found by sodium dodecyl sulfate agarose gel electrophoresis, reaching 27% of total fibrinogen and fibrin before gel formation. As measured by enzyme-linked immunosorbent assay w...

journal_title：Circulation

authors： Francis CW,Doughney K,Brenner B,Klingbiel K,Marder VJ

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D...

journal_title：Circulation

authors： Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KH

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:31P metabolite measurements in the human heart by magnetic resonance spectroscopy (MRS) have been reported previously. By use of a method in which metabolite content was quantified with reference to a standard located outside the chest, it has become possible to measure the content of phosphocreatine (PCr) a...

journal_title：Circulation

authors： Yabe T,Mitsunami K,Inubushi T,Kinoshita M

更新日期：1995-07-01 00:00:00

abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

journal_title：Circulation

authors： Mirvis DM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...

journal_title：Circulation

authors： Emdin CA,Khera AV,Klarin D,Natarajan P,Zekavat SM,Nomura A,Haas M,Aragam K,Ardissino D,Wilson JG,Schunkert H,McPherson R,Watkins H,Elosua R,Bown MJ,Samani NJ,Baber U,Erdmann J,Gormley P,Palotie A,Stitziel NO,Gup

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...

journal_title：Circulation

authors： Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:In vitro and in vivo studies have demonstrated both anticoagulant and antiproliferative effects of heparin. The purpose of this study was to assess the effect of local intramural delivery of heparin, using heparin-coated hydrogel balloons, on platelet deposition and early smooth muscle cell proliferation aft...

journal_title：Circulation

authors： Azrin MA,Mitchel JF,Fram DB,Pedersen CA,Cartun RW,Barry JJ,Bow LM,Waters DD,McKay RG

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Demonstration and quantification of site-specific intracoronary administration of compounds has been confined thus far to the experimental animal laboratory. The aim of this study was to describe a scintigraphic method to demonstrate site-specific intracoronary drug delivery in humans. The methods allow on-l...

journal_title：Circulation

authors： Camenzind E,Bakker WH,Reijs A,van Geijlswijk IM,Boersma E,Kutryk MJ,Krenning EP,Roelandt JR,Serruys PW

更新日期：1997-07-01 00:00:00

abstract：:Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm...

journal_title：Circulation

authors： Daly P,Mettauer B,Rouleau JL,Cousineau D,Burgess JH

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Many epidemiological studies have evaluated whether different alcoholic beverages protect against cardiovascular disease. We performed a meta-analysis of 26 studies on the relationship between wine or beer consumption and vascular risk. Methods and Results- General variance-based method and fitting models we...

journal_title：Circulation

authors： Di Castelnuovo A,Rotondo S,Iacoviello L,Donati MB,De Gaetano G

更新日期：2002-06-18 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Patients with heart failure and systolic dysfunction may develop disordered breathing during sleep. Repeated episodes of apnea and hypopnea may result in desaturation and arousals, which could adversely affect left ventricular function. The purpose of this study was to determine the short-term effects of con...

journal_title：Circulation

authors： Javaheri S

更新日期：2000-02-01 00:00:00

abstract：:Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar ...

journal_title：Circulation

authors： Sohi GS,Flowers NC,Horan LG,Sridharan MR,Johnson JC

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Myocardium irreversibly injured by ischemic stress must be efficiently repaired to maintain tissue integrity and contractile performance. Macrophages play critical roles in this process. These cells transform across a spectrum of phenotypes to accomplish diverse functions ranging from mediating the initial i...

journal_title：Circulation

authors： Cao DJ,Schiattarella GG,Villalobos E,Jiang N,May HI,Li T,Chen ZJ,Gillette TG,Hill JA

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression. METHODS AND RESULTS:Low-density lipoprotein receptor null mice in which Treg express gree...

journal_title：Circulation

authors： Maganto-García E,Tarrio ML,Grabie N,Bu DX,Lichtman AH

更新日期：2011-07-12 00:00:00

abstract：:A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a contradiction to that rule and suggests that further study must ...

journal_title：Circulation

authors： Bisset GS 3rd,Hirschfeld SS

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that thrombin is a potent though slow-acting mitogen for vascular smooth muscle cells (SMC). Because thrombin generation in vivo is accompanied by platelet activation, it has been suggested that platelet-derived factors might enhance thrombin-induced SMC proliferation. No informat...

journal_title：Circulation

authors： Zucker TP,Bönisch D,Muck S,Weber AA,Bretschneider E,Glusa E,Schrör K

更新日期：1998-02-17 00:00:00

abstract：:Conventional wall motion analysis of contrast ventriculograms assesses only that part of the wall that is tangential to the x-ray beam. To assess regional left ventricular function in three dimensions, a new computerized method based on densitometric analysis of digital subtraction left ventriculograms was developed a...

journal_title：Circulation

authors： Chappuis F,Widmann T,Guth B,Nicod P,Peterson KL

更新日期：1988-02-01 00:00:00

abstract：:Echocardiographic and hemodynamic data were measured in closed-chest dogs during graded cardiac tamponade (pericardial pressure 5, 10, and 15 mm Hg) before and after production of diffuse ischemic left ventricular dysfunction. Left ventricular dysfunction was produced by intracoronary injection of nonradioactive micro...

journal_title：Circulation

authors： Hoit BD,Gabel M,Fowler NO

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabeti...

journal_title：Circulation

authors： Rönnback M,Fagerudd J,Forsblom C,Pettersson-Fernholm K,Reunanen A,Groop PH,Finnish Diabetic Nephropathy (FinnDiane) Study Group.

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:The outcome of aortic valve replacement in patients with severe aortic stenosis, low transvalvular gradient, and severe left ventricular dysfunction is not well known. METHODS AND RESULTS:Between 1985 and 1995, 52 patients with left ventricular ejection fraction (EF) < or =35% and aortic stenosis with trans...

journal_title：Circulation

authors： Connolly HM,Oh JK,Schaff HV,Roger VL,Osborn SL,Hodge DO,Tajik AJ

更新日期：2000-04-25 00:00:00

abstract：BACKGROUND:Experimental studies suggest that arterial injury and inflammation lead to increased neointimal growth after stenting. Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis. METHODS AND RESULTS:Detailed histology...

journal_title：Circulation

authors： Farb A,Weber DK,Kolodgie FD,Burke AP,Virmani R

更新日期：2002-06-25 00:00:00

abstract：BACKGROUND:Several mortality risk scores exist in cardiac surgery. All include a considerable number of independent risk factors. In elective cardiac surgery patients, the operative mortality is low, the number of events recorded per year is limited, and the risk model may be overfitted. The present study aims to devel...

journal_title：Circulation

authors： Ranucci M,Castelvecchio S,Menicanti L,Frigiola A,Pelissero G

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([Na(...

journal_title：Circulation

authors： Satoh H,Ginsburg KS,Qing K,Terada H,Hayashi H,Bers DM

更新日期：2000-03-28 00:00:00

abstract：BACKGROUND:The usefulness of adriamycin (ADR), a potent antitumor antibiotic, is limited by the development of life-threatening cardiomyopathy and congestive heart failure. Subcellular changes leading to heart failure are suggested to be mediated by a drug-induced increase in free radicals and lipid peroxidation. In an...

journal_title：Circulation

authors： Siveski-Iliskovic N,Hill M,Chow DA,Singal PK

更新日期：1995-01-01 00:00:00