Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study.

abstract：BACKGROUND:Clinical trials have demonstrated that, compared with placebo, intensive statin therapy reduces ischemia in patients with acute coronary syndromes and in patients with stable coronary artery disease. However, no studies to date have assessed intensive versus moderate statin therapy in older patients with sta...

journal_title：Circulation

authors： Deedwania P,Stone PH,Bairey Merz CN,Cosin-Aguilar J,Koylan N,Luo D,Ouyang P,Piotrowicz R,Schenck-Gustafsson K,Sellier P,Stein JH,Thompson PL,Tzivoni D

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Right ventricular (RV) dilatation that occurs as a consequence of RV infarction is thought to produce hemodynamic instability by reducing left ventricular (LV) preload and compliance. We hypothesized that these geometric changes may also adversely affect LV systolic performance. METHODS AND RESULTS:Twelve 4...

journal_title：Circulation

authors： Brookes C,Ravn H,White P,Moeldrup U,Oldershaw P,Redington A

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Card...

journal_title：Circulation

authors： Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. METHODS AND RESULTS:BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic ...

journal_title：Circulation

authors： Kamihata H,Matsubara H,Nishiue T,Fujiyama S,Tsutsumi Y,Ozono R,Masaki H,Mori Y,Iba O,Tateishi E,Kosaki A,Shintani S,Murohara T,Imaizumi T,Iwasaka T

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:Gallbladder pathology has been associated with cardiovascular disease. Recently, we showed that gallbladder distension in anesthetized pigs reflexly increased heart rate, arterial pressure, and coronary and renal vascular resistance through efferent sympathetic mechanisms. Renin release is affected by sympat...

journal_title：Circulation

authors： Molinari C,Grossini E,Mary DA,Vacca G

更新日期：2000-05-30 00:00:00

abstract：BACKGROUND:There is evidence for increased formation of free radicals in patients with hypertension, raising the possibility that NO is inactivated by free radicals, which impairs coronary endothelial function. Therefore, we tested the hypothesis that the antioxidant vitamin C could improve abnormal endothelial functio...

journal_title：Circulation

authors： Solzbach U,Hornig B,Jeserich M,Just H

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude of myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions of profound microvascular obstruction at the infarct core are hypoenhanced and correspond to greate...

journal_title：Circulation

authors： Wu KC,Zerhouni EA,Judd RM,Lugo-Olivieri CH,Barouch LA,Schulman SP,Blumenthal RS,Lima JA

更新日期：1998-03-03 00:00:00

abstract：BACKGROUND:Recent studies suggest that the oxygen-sensing pathway consisting of transcription factor hypoxia-inducible factor and prolyl hydroxylase domain proteins (PHDs) plays a critical role in glucose metabolism. However, the role of adipocyte PHD in the development of obesity has not been clarified. We examined wh...

journal_title：Circulation

authors： Matsuura H,Ichiki T,Inoue E,Nomura M,Miyazaki R,Hashimoto T,Ikeda J,Takayanagi R,Fong GH,Sunagawa K

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...

journal_title：Circulation

authors： Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

更新日期：2006-11-28 00:00:00

abstract：BACKGROUND:In myocardial cells, relaxation is governed primarily by the sarcoplasmic reticulum (SR) Ca(2+)-ATPase transporting enzyme, which regulates Ca2+ sequestration into the SR. Human and experimental cardiomyopathies are associated with reduced SR Ca(2+)-ATPase activity. METHODS AND RESULTS:To modify intracellul...

journal_title：Circulation

authors： Hajjar RJ,Kang JX,Gwathmey JK,Rosenzweig A

更新日期：1997-01-21 00:00:00

abstract：BACKGROUND:Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader ...

journal_title：Circulation

authors： Hillege HL,Nitsch D,Pfeffer MA,Swedberg K,McMurray JJ,Yusuf S,Granger CB,Michelson EL,Ostergren J,Cornel JH,de Zeeuw D,Pocock S,van Veldhuisen DJ,Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity

更新日期：2006-02-07 00:00:00

abstract：:We assessed the effects of ethanol and autonomic blockade on left ventricular function in nine normal subjects, age 20--35 years, using M-mode echocardiography and systolic time intervals. On day 1, measurements were made of heart rate, mean velocity of circumferential fiber shortening, and left ventricular pre-ejecti...

journal_title：Circulation

authors： Child JS,Kovick RB,Levisman JA,Pearce ML

更新日期：1979-01-01 00:00:00

abstract：:To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...

journal_title：Circulation

authors： Fioretti P,Roelandt J,Bos RJ,Meltzer RS,van Hoogenhuijze D,Serruys PW,Nauta J,Hugenholtz PG

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. METHODS AND RESULTS:MLE entails grafting a glu...

journal_title：Circulation

authors： van der Lee C,Kofflard MJ,van Herwerden LA,Vletter WB,ten Cate FJ

更新日期：2003-10-28 00:00:00

abstract：BACKGROUND:Biventricular direct cardiac compression (DCC) has the potential to support the failing heart without the complications associated with a blood/device interface encountered with the use of current ventricular assist devices. A clinically designed DCC device that provides compression pressure around the base ...

journal_title：Circulation

authors： Artrip JH,Yi GH,Levin HR,Burkhoff D,Wang J

更新日期：1999-11-09 00:00:00

abstract：:The two-dimensional echocardiographic features of three patients with congenital aneurysms of the left atrium are described. The aneurysm arose from the left atrial appendage in two patients and from the posterior left atrial wall in one. The aneurysms were characterized by their origin from an otherwise normal left a...

journal_title：Circulation

authors： Foale RA,Gibson TC,Guyer DE,Gillam L,King ME,Weyman AE

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Exposure to risk factors such as hypertension or hypercholesterolemia decreases the bioavailability of endothelium-derived nitric oxide (NO) and impairs endothelium-dependent vasodilation. Recently, a circulating endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), has been detected in human...

journal_title：Circulation

authors： Miyazaki H,Matsuoka H,Cooke JP,Usui M,Ueda S,Okuda S,Imaizumi T

更新日期：1999-03-09 00:00:00

abstract：BACKGROUND:We have previously suggested that the primary arterial switch operation is a feasible strategy for patients with transposition of the great arteries and intact ventricular septum (TGA-IVS) up to age 2 months. This study reports our current results with this approach and examines whether this policy could be ...

journal_title：Circulation

authors： Kang N,de Leval MR,Elliott M,Tsang V,Kocyildirim E,Sehic I,Foran J,Sullivan I

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as...

journal_title：Circulation

authors： Bauer M,Wilkens H,Langer F,Schneider SO,Lausberg H,Schäfers HJ

更新日期：2002-03-05 00:00:00

abstract：BACKGROUND:Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general populations. The objective of this investigation was to determine whether aPWV is ...

journal_title：Circulation

authors： Sutton-Tyrrell K,Najjar SS,Boudreau RM,Venkitachalam L,Kupelian V,Simonsick EM,Havlik R,Lakatta EG,Spurgeon H,Kritchevsky S,Pahor M,Bauer D,Newman A,Health ABC Study.

更新日期：2005-06-28 00:00:00

abstract：BACKGROUND:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology, being involved in the development of coronary restenosis and atherosclerosis. The activation of nuclear proto-oncogenes appears to be a final common pathway onto which various mitogenic signals coverage. Accordingly...

journal_title：Circulation

authors： Shi Y,Hutchinson HG,Hall DJ,Zalewski A

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

journal_title：Circulation

authors： Hornig B,Maier V,Drexler H

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

journal_title：Circulation

authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

更新日期：2006-07-04 00:00:00

abstract：:To obtain insight into the mechanism(s) responsible for the direct visualization of acute myocardial infarcts by myocardial scintigraphy with technetium-99m stannous pyrophosphate (99mTc-PYP), scintigraphic and morphologic studies were performed in 22 dogs subjected to occlusion of the proximal left anterior descendin...

journal_title：Circulation

authors： Buja LM,Parkey RW,Dees JH,Stokely EM,Harris RA Jr,Bonte FJ,Willerson JT

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

journal_title：Circulation

authors： Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined. METHODS AND RESULTS:We compared various morphological, secretory, and proliferative respon...

journal_title：Circulation

authors： Burstein B,Libby E,Calderone A,Nattel S

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS inter...

journal_title：Circulation

authors： de Zeeuw D,Remuzzi G,Parving HH,Keane WF,Zhang Z,Shahinfar S,Snapinn S,Cooper ME,Mitch WE,Brenner BM

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy is a common response to circulatory or neurohumoral stressors as a mechanism to augment contractility. When the heart is under sustained stress, the hypertrophic response can evolve into decompensated heart failure, although the mechanism(s) underlying this transition remain largely unkno...

journal_title：Circulation

authors： Warren SA,Briggs LE,Zeng H,Chuang J,Chang EI,Terada R,Li M,Swanson MS,Lecker SH,Willis MS,Spinale FG,Maupin-Furlowe J,McMullen JR,Moss RL,Kasahara H

更新日期：2012-11-27 00:00:00

abstract：:Cardiac positron emission tomography (PET) has evolved rapidly from a relatively esoteric research tool into clinical applications providing unique, quantitative information on myocardial perfusion, metabolism, and cell membrane function and having a potentially significant impact on cardiovascular medicine. Although ...

journal_title：Circulation

authors： Gould KL

更新日期：1991-09-01 00:00:00