Abstract:
BACKGROUND:Exposure to risk factors such as hypertension or hypercholesterolemia decreases the bioavailability of endothelium-derived nitric oxide (NO) and impairs endothelium-dependent vasodilation. Recently, a circulating endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), has been detected in human plasma. The purpose of this study was to examine the relationship between plasma ADMA and atherosclerosis in humans. METHODS AND RESULTS:Subjects (n=116; age, 52+/-1 years; male:female ratio, 100:16) underwent a complete history and physical examination, determination of serum chemistries and ADMA levels, and duplex scanning of the carotid arteries. These individuals had no symptoms of coronary or peripheral artery disease and were taking no medications. Univariate and multivariate analyses revealed that plasma levels of ADMA were positively correlated with age (P<0.0001), mean arterial pressure (P<0.0001), and Sigma glucose (an index of glucose tolerance) (P=0.0006). Most intriguingly, stepwise regression analysis revealed that plasma ADMA levels were significantly correlated to the intima-media thickness of the carotid artery (as measured by high-resolution ultrasonography). CONCLUSIONS:This study reveals that plasma ADMA levels are positively correlated with risk factors for atherosclerosis. Furthermore, plasma ADMA level is significantly correlated with carotid intima-media thickness. Our results suggest that this endogenous antagonist of NO synthase may be a marker of atherosclerosis.
journal_name
Circulationjournal_title
Circulationauthors
Miyazaki H,Matsuoka H,Cooke JP,Usui M,Ueda S,Okuda S,Imaizumi Tdoi
10.1161/01.cir.99.9.1141subject
Has Abstractpub_date
1999-03-09 00:00:00pages
1141-6issue
9eissn
0009-7322issn
1524-4539journal_volume
99pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Endothelium-derived nitric oxide is an important modulator of resting vascular tone in animals and humans. However, the contribution of nitric oxide to exercise-induced vasodilation is unknown. METHODS AND RESULTS:The effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on ex...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.6.2853
更新日期:1994-12-01 00:00:00
abstract::Statistical multivariate and conventional deterministic methods of computerized interpretation of the electrocardiogram (ECG) were compared in the analysis of 1711 pediatric orthogonal ECGs validated by nonelectrocardiographic criteria on the basis of clinical and anatomic diagnoses. Among 642 children catheterized fo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.2.255
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach. METHODS AND RESULTS:In the nonpreconditioned state, eNOS-/- mice exhibited infarct sizes similar to...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.689471
更新日期:2007-07-31 00:00:00
abstract:BACKGROUND:Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute thrombotic events. Orally active GP IIb/IIIa antagonists are essential to evaluate the clinical benefit of long-term treatment. We therefore investigated platelet inhibition by the GP IIb/IIIa ant...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.96.4.1130
更新日期:1997-08-19 00:00:00
abstract:BACKGROUND:It is recommended that comatose survivors of out-of-hospital cardiac arrest should be cooled to 32° to 34°C for 12 to 24 hours. However, the optimal level of cooling is unknown. The aim of this pilot study was to obtain initial data on the effect of different levels of hypothermia. We hypothesized that deepe...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.112.136408
更新日期:2012-12-11 00:00:00
abstract::We studied 14 patients to determine whether sustained-release diltiazem is a satisfactory long-term substitute for the combination of propranolol plus hydrochlorothiazide (HCTZ), control phase, in the treatment of systemic hypertension with coexisting chronic stable angina pectoris. All patients had either one- or two...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.023266
更新日期:2017-02-07 00:00:00
abstract:BACKGROUND:Myocardial injury from ischemia can be aggravated by reperfusion of the jeopardized area. The precise underlying mechanisms have not been clearly defined, but proinflammatory events, including complement activation, leukocyte adhesion, and infiltration and release of diverse mediators, probably play importan...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.3.701
更新日期:1997-02-04 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.99.6.757
更新日期:1999-02-16 00:00:00
abstract:BACKGROUND:Ultrafast computed tomography (CT), by acquiring images of the proximal coronary arteries, detects coronary calcifications and has been demonstrated to be highly sensitive for the detection of coronary artery disease in many small studies. The aim of this study was to determine the relationship between ultra...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.cir.93.5.898
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.5.547
更新日期:1999-08-03 00:00:00
abstract::This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.4.646
更新日期:1996-02-15 00:00:00
abstract::Characteristics of blood-flow velocities were investigated at different sites in two types of coronary artery bypass grafts, sequential saphenous vein grafts (SSVG) and internal mammary artery grafts (IMAG). The latter appear to have the longest life span. The patency rate of the side-to-side anastomosis of the SSVG i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.5.1210
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Although autonomic imbalance is known to be characteristics of patients with clinically overt symptomatic congestive heart failure, it is currently unknown whether this autonomic response arises early in the course of left ventricular dysfunction or is restricted to the later stages of circulatory failure. ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.3.555
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Doppler echocardiography is frequently used to predict filling pressures in normal sinus rhythm, but it is unknown whether it can be applied in sinus tachycardia, with merging of E and A velocities. Tissue Doppler imaging (TDI) can record the mitral annular velocity. The early diastolic velocity (Ea) behaves...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.98.16.1644
更新日期:1998-10-20 00:00:00
abstract::This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.71.4.767
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to the interior of the cell and nucleus. The present study was designed to determine the effect of the tyrphostin AG1295, a selective blocker of PDGF-receptor PTK, on the growth of porcine and hu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.19.1960
更新日期:1998-05-19 00:00:00
abstract:BACKGROUND:Up to 30% of patients with end-stage heart failure experience biventricular failure that requires biventricular mechanical support. For these patients, only bulky extracorporeal or implantable displacement pumps or the total artificial heart have been available to date, which enables only limited quality of ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.011502
更新日期:2011-09-13 00:00:00
abstract:BACKGROUND:The production of left ventricular (LV) restoring forces generated during contraction, which are responsible for diastolic suction, is dependent on end-systolic volume (ESV) and systolic transmural and 3D deformation. We tested the hypothesis that acute coronary occlusion would result in loss of forces that ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.7.2348
更新日期:1997-10-07 00:00:00
abstract:BACKGROUND:After regular coronary balloon angioplasty, it would be helpful to identify those patients who have a low cardiac event rate. Coronary angiography alone is not sensitive enough for that purpose, but it has been suggested that the combination of optimal angiographic and optimal functional results indicates a ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.7.883
更新日期:1999-02-23 00:00:00
abstract:BACKGROUND:The possible contribution of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, to neurohumoral compensation for hemodynamic stress was examined in nine normal volunteers and six patients with severe congestive heart failure. METHODS AND RESULTS:Plasma levels of endothelin-1 were measured w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.510
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.96.8.2534
更新日期:1997-10-21 00:00:00
abstract:BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/sci...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.24.2919
更新日期:2000-12-12 00:00:00
abstract:BACKGROUND:Previous studies suggest that rigid fixation of the mitral annulus with an annuloplasty ring may impair left ventricular (LV) systolic performance. We used load-insensitive indexes of global and regional LV contractile mechanics to test the hypothesis that rigid fixation of the mitral annulus alters LV systo...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.112.000685
更新日期:2013-04-23 00:00:00
abstract:BACKGROUND:The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear. METHODS AND RESULTS:We simultaneously mapped epicardial membrane potential and Ca(i) during shock on T-wave episodes (n=104) and attempted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles. U...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.630509
更新日期:2006-12-12 00:00:00
abstract:BACKGROUND:Aldosterone and angiotensin (Ang) II both may cause organ damage. Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has been reported. Aldosterone concentrations depend on the activity of aldosterone synthase (CYP11B2). We tested the hypothesis that reducing aldosterone by...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.521625
更新日期:2005-06-14 00:00:00
abstract:BACKGROUND:Myocardial afterload depends on left ventricular (LV) cavity size, pressure, and wall thickness, all of which change markedly throughout ejection. We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.829366
更新日期:2009-06-02 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146377.15057.CC
更新日期:2004-11-02 00:00:00