PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.

abstract：:To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. ...

journal_title：Circulation

authors： Kurnik PB,Courtois MR,Ludbrook PA

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare differential effects of a segment of slow conduction during ventricular tachycardia (VT) due to depression of the action potential and electrical uncoupling. METHODS AND RESULTS:In 33 Langendorff-perfused rabbit hearts, a ring of anisotropic left ventricular subepica...

journal_title：Circulation

authors： Haberl K,Allessie M

更新日期：1999-02-23 00:00:00

abstract：BACKGROUND:Several methods exist by which to assess type A behavior (TAB). Although the videotaped clinical interview is regarded as the "gold standard," self-report measures have also proved useful in assessing TAB in large population studies. The purpose of this study was to examine prospectively the relationship of ...

journal_title：Circulation

authors： Kawachi I,Sparrow D,Kubzansky LD,Spiro A 3rd,Vokonas PS,Weiss ST

更新日期：1998-08-04 00:00:00

abstract：BACKGROUND:Metformin is first-line therapy for type 2 diabetes mellitus, although its effects on the cardiovascular system are unproved. METHODS:In this post hoc analysis, patients in SAVOR-TIMI 53 (Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus) with baseline biomarker samples (n=12...

journal_title：Circulation

authors： Bergmark BA,Bhatt DL,McGuire DK,Cahn A,Mosenzon O,Steg PG,Im K,Kanevsky E,Gurmu Y,Raz I,Braunwald E,Scirica BM,SAVOR-TIMI 53 Steering Committee and Investigators.

更新日期：2019-09-17 00:00:00

abstract：BACKGROUND:We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection. METHODS AND RESULTS:Hearts of FVB (H-2q) luciferase-green fluorescent protein transgenic mice (beta-actin...

journal_title：Circulation

authors： Tanaka M,Swijnenburg RJ,Gunawan F,Cao YA,Yang Y,Caffarelli AD,de Bruin JL,Contag CH,Robbins RC

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown. METHODS AND RESULTS:We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. ...

journal_title：Circulation

authors： Burke AP,Farb A,Malcom GT,Liang Y,Smialek J,Virmani R

更新日期：1998-06-02 00:00:00

abstract：:Platelets labeled with indium-111 have been used successfully as a marker of active thrombosis in man. To establish the diagnostic accuracy of platelet scintigraphy in comparison to contrast venography in the diagnosis of acute lower limb venous thrombosis, we evaluated 103 consecutive patients divided into two groups...

journal_title：Circulation

authors： Ezekowitz MD,Pope CF,Sostman HD,Smith EO,Glickman M,Rapoport S,Sniderman KW,Friedlaender G,Pelker RR,Taylor FB

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:A warm-water bath (WWB) or sauna bath (SB) has generally been considered inappropriate for patients with severe congestive heart failure (CHF). However, a comprehensive investigation of the hemodynamic effects of thermal vasodilation in CHF has not been previously undertaken. METHODS AND RESULTS:To investig...

journal_title：Circulation

authors： Tei C,Horikiri Y,Park JC,Jeong JW,Chang KS,Toyama Y,Tanaka N

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state of inflammation in which xanthine oxidase (XO)...

journal_title：Circulation

authors： Ou J,Ou Z,Jones DW,Holzhauer S,Hatoum OA,Ackerman AW,Weihrauch DW,Gutterman DD,Guice K,Oldham KT,Hillery CA,Pritchard KA Jr

更新日期：2003-05-13 00:00:00

abstract：BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunoh...

journal_title：Circulation

authors： Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DR

更新日期：1995-11-15 00:00:00

abstract：:In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

journal_title：Circulation

authors： Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothe...

journal_title：Circulation

authors： Conway DS,Pearce LA,Chin BS,Hart RG,Lip GY

更新日期：2002-10-08 00:00:00

abstract：BACKGROUND:The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases the progression of atheromatous plaques is unknown. The aim of our study was to examine the effect of sevelamer administration on the development o...

journal_title：Circulation

authors： Phan O,Ivanovski O,Nguyen-Khoa T,Mothu N,Angulo J,Westenfeld R,Ketteler M,Meert N,Maizel J,Nikolov IG,Vanholder R,Lacour B,Drüeke TB,Massy ZA

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The alpha(v)beta3 integrin plays a critical role in cell proliferation and migration. We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo. METHODS AND RESULTS:RP748, a novel 111In-labeled alpha(v)bet...

journal_title：Circulation

authors： Sadeghi MM,Krassilnikova S,Zhang J,Gharaei AA,Fassaei HR,Esmailzadeh L,Kooshkabadi A,Edwards S,Yalamanchili P,Harris TD,Sinusas AJ,Zaret BL,Bender JR

更新日期：2004-07-06 00:00:00

abstract：BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...

journal_title：Circulation

authors： Vecchione C,Fratta L,Rizzoni D,Notte A,Poulet R,Porteri E,Frati G,Guelfi D,Trimarco V,Mulvany MJ,Agabiti-Rosei E,Trimarco B,Cotecchia S,Lembo G

更新日期：2002-04-09 00:00:00

abstract：BACKGROUND:Intraoperative mapping studies suggest that an isthmus of myocardium between the mitral valve annulus and the border of inferior myocardial infarction may play a role in the genesis of ventricular tachycardia. We examined the frequency with which a slow conduction zone within the mitral isthmus was critical ...

journal_title：Circulation

authors： Wilber DJ,Kopp DE,Glascock DN,Kinder CA,Kall JG

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and ...

journal_title：Circulation

authors： Lee JZ,Ling J,Diehl NN,Hodge DO,Padmanabhan D,Killu AM,Madhavan M,Noseworthy PA,Kapa S,McLeod CJ,Cha YM,Deshmukh AJ,Srivathsan K,Kusumoto FM,Shen WK,Friedman PA,Munger TM,Asirvatham SJ,Packer DL,Mulpuru SK

更新日期：2018-01-02 00:00:00

abstract：BACKGROUND:Treatment with an antibody that binds beta3 integrins (abciximab; c7E3 Fab) at the time of coronary angioplasty decreases the need for repeat revascularization. Two potential mechanisms have been proposed to explain this effect: (1) inhibition of platelet aggregation or (2) interruption of ligand binding to ...

journal_title：Circulation

authors： Stouffer GA,Hu Z,Sajid M,Li H,Jin G,Nakada MT,Hanson SR,Runge MS

更新日期：1998-03-10 00:00:00

abstract：:For patients with stenotic native valves, the modified Bernoulli equation (delta P = 4V2) may be applied to Doppler-measured transvalvular velocities to yield an accurate estimate of transvalvular gradients. Although it would be useful if the same approach could be used for those with stenotic prosthetic valves, no pr...

journal_title：Circulation

authors： Wilkins GT,Gillam LD,Kritzer GL,Levine RA,Palacios IF,Weyman AE

更新日期：1986-10-01 00:00:00

abstract：:In 1948 knowledge of the role of the central nervous system in controlling blood pressure was rudimentary and the possibility that the brain could contribute to hypertension was barely acknowledged. Over the past 35 years the development of new technologies, particularly those of the neurosciences, and their applicati...

journal_title：Circulation

authors： Reis DJ

更新日期：1984-11-01 00:00:00

abstract：:Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs, and lower triglyceride levels in hypertriglyceridemic patients. Statins are well tolerated and have an excellent ...

journal_title：Circulation

authors： Maron DJ,Fazio S,Linton MF

更新日期：2000-01-18 00:00:00

abstract：BACKGROUND:Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS:Participants (n=203, 45-65 year...

journal_title：Circulation

authors： Kullo IJ,Jouni H,Austin EE,Brown SA,Kruisselbrink TM,Isseh IN,Haddad RA,Marroush TS,Shameer K,Olson JE,Broeckel U,Green RC,Schaid DJ,Montori VM,Bailey KR

更新日期：2016-03-22 00:00:00

abstract：:In 58 patients with uncomplicated acute anterior myocardial infarction, a mean decline in the sum of ST segments (sigmaST) of 34% was observed when comparing sigmaST values recorded at 3-6 hours with those recorded at 6-9 hours after the onset of symptoms (P less than 0.05). The mean absolute difference between 19 pai...

journal_title：Circulation

authors： Hardarson T,Henning H,O'Rourke RA,Karliner JS,Ryan W,Ross J Jr

更新日期：1978-06-01 00:00:00

abstract：:Echocardiography and Doppler ultrasound are useful in evaluating a variety of pathological conditions affecting the pericardium. Cardiac tamponade results in right atrial collapse and right ventricular diastolic collapse detectable by echocardiography. These echocardiographic signs have a high degree of sensitivity an...

journal_title：Circulation

authors： Chandraratna PA

更新日期：1991-09-01 00:00:00

abstract：:This study describes the efficacy of the right gastroepiploic artery (GEA) as graft material for coronary artery bypass grafting (CABG) as assessed by exercise thallium 201 myocardial scintigraphy in eight patients (age, 59.4 +/- 9.35 years [mean +/- SD]) who underwent CABG with the GEA graft in the past 2 years. Plan...

journal_title：Circulation

authors： Kusukawa J,Hirota Y,Kawamura K,Suma H,Takeuchi A,Adachi I,Akagi H

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). METHODS AND RESULTS:AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA....

journal_title：Circulation

authors： Sen S,Hinderliter A,Sen PK,Simmons J,Beck J,Offenbacher S,Ohman EM,Oppenheimer SM

更新日期：2007-08-21 00:00:00

abstract：:One hundred eighty-eight patients with acute myocardial infarction were studied prospectively from August 1980 to September 1982. One hundred thirty-six of these patients were entered into a intracoronary streptokinase study after informed consent was obtained. The remaining 52 patients, who either met exclusion crite...

journal_title：Circulation

authors： Smalling RW,Fuentes F,Matthews MW,Freund GC,Hicks CH,Reduto LA,Walker WE,Sterling RP,Gould KL

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....

journal_title：Circulation

authors： Gepstein L,Hayam G,Shpun S,Ben-Haim SA

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase of glycogen-debranching enzyme in the liver, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Because the redu...

journal_title：Circulation

authors： Arai M,Minatoguchi S,Takemura G,Uno Y,Kariya T,Takatsu H,Fujiwara T,Higashioka M,Yoshikuni Y,Fujiwara H

更新日期：1998-04-07 00:00:00

abstract：BACKGROUND:Aortic valve-preserving procedures have resulted in excellent outcomes in selected patients, particularly those with normal aortic valve leaflets and dilated aortic roots. However, several congenital heart lesions are associated with abnormal aortic valve leaflets. The long-term results of aortic valve repai...

journal_title：Circulation

authors： Rao V,Van Arsdell GS,David TE,Azakie A,Williams WG

更新日期：2000-11-07 00:00:00