High-resolution, three-dimensional fluorescent imaging reveals multilayer conduction pattern in the atrioventricular node.

abstract：BACKGROUND:Pulmonary hypertension caused by systolic left ventricular dysfunction is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in pati...

journal_title：Circulation

authors： Bonderman D,Ghio S,Felix SB,Ghofrani HA,Michelakis E,Mitrovic V,Oudiz RJ,Boateng F,Scalise AV,Roessig L,Semigran MJ,Left Ventricular Systolic Dysfunction Associated With Pulmonary Hypertension Riociguat Trial (LEPHT) Study Group.

更新日期：2013-07-30 00:00:00

abstract：:Primary aldosteronism (PA) is the most common form of secondary hypertension. In many cases, somatic mutations in ion channels and pumps within adrenal cells initiate the pathogenesis of PA, and this mechanism might explain why PA is so common and suggests that milder and evolving forms of PA must exist. Compared with...

journal_title：Circulation

authors： Byrd JB,Turcu AF,Auchus RJ

更新日期：2018-08-21 00:00:00

abstract：:Few data are available regarding the effects of exercise training upon cardiac structure and performance in man. We evaluated the echograms of 24 normals before (PRE) and after (POST) 11 weeks of endurance exercise training. Conditioning consisted of a walk-jog-run protocol at 70% maximal heart rate for one hour four ...

journal_title：Circulation

authors： DeMaria AN,Neumann A,Lee G,Fowler W,Mason DT

更新日期：1978-02-01 00:00:00

abstract：:Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

journal_title：Circulation

authors： Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Disease-associated electrophysiological alterations may contribute to the increased predisposition to arrhythmias of the hypertrophied or failing myocardium. An I(f)-like current is expressed in rat left ventricular myocytes (LVMs), its amplitude being linearly related to the severity of cardiac hypertrophy....

journal_title：Circulation

authors： Cerbai E,Pino R,Porciatti F,Sani G,Toscano M,Maccherini M,Giunti G,Mugelli A

更新日期：1997-02-04 00:00:00

abstract：:The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...

journal_title：Circulation

authors： El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

更新日期：1977-05-01 00:00:00

abstract：:The dynamics of acute mitral regurgitation were studied in six open-chest dogs in whom a portion of the anterior leaflet was excised. Phasic mitral and aortic flows were measured electromagnetically and left ventricular filling volume, regurgitant volume (RV) and forward stroke volume (SV) were calculated. The systoli...

journal_title：Circulation

authors： Yoran C,Yellin EL,Becker RM,Gabbay S,Frater RW,Sonnenblick EH

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Memory is a diverse biological phenomenon whose importance in the ventricle has been demonstrated. We hypothesized its occurrence in the atrium, contributing to the modulation of cardiac rhythm. METHODS AND RESULTS:We analyzed P and Ta waves in conscious chronically instrumented dogs with complete heart blo...

journal_title：Circulation

authors： Herweg B,Chang F,Chandra P,Danilo P Jr,Rosen MR

更新日期：2001-01-23 00:00:00

abstract：BACKGROUND:We studied the effect of an antioxidant, the intracoronary infusion of vitamin C, on basal and dobutamine-stimulated left ventricular (LV) contractility. METHODS AND RESULTS:Nineteen patients with normal ventricular function participated in this study. A micromanometer-tipped catheter was inserted into the ...

journal_title：Circulation

authors： Mak S,Newton GE

更新日期：2001-02-13 00:00:00

abstract：BACKGROUND:The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS:The study population co...

journal_title：Circulation

authors： Belton O,Byrne D,Kearney D,Leahy A,Fitzgerald DJ

更新日期：2000-08-22 00:00:00

abstract：BACKGROUND:Modeling of the time-[1-(11)C]acetate activity curve assumes a constant concentration of labeled tricarboxylic acid cycle intermediates and associated metabolites, such as glutamate and aspartate, which may, however, decrease in short-term hibernating myocardium. METHODS AND RESULTS:In 12 anesthetized pigs,...

journal_title：Circulation

authors： Schulz R,Kappeler C,Coenen H,Bockisch A,Heusch G

更新日期：1998-03-17 00:00:00

abstract：:Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...

journal_title：Circulation

authors： Hearse DJ,Yamamoto F,Shattock MJ

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:The transient outward potassium current (I(to)) encoded by the Kv4 family of potassium channels is important in the repolarization of cardiac myocytes. KChIPs are a recently identified group of Ca2+-binding accessory subunits that modulate Kv4-encoded currents. KChIP2 is the only family member expressed in t...

journal_title：Circulation

authors： Deschênes I,DiSilvestre D,Juang GJ,Wu RC,An WF,Tomaselli GF

更新日期：2002-07-23 00:00:00

abstract：:Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy t...

journal_title：Circulation

authors： Kannel WB,Dawber TR,McGee DL

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Activation of the sympathetic nervous system has important prognostic implications in chronic heart failure. Nonselective versus selective beta-adrenergic receptor antagonists may have differential effects on norepinephrine release from nerve terminals mediated by prejunctional beta(2)-adrenergic receptors. ...

journal_title：Circulation

authors： Azevedo ER,Kubo T,Mak S,Al-Hesayen A,Schofield A,Allan R,Kelly S,Newton GE,Floras JS,Parker JD

更新日期：2001-10-30 00:00:00

abstract：BACKGROUND:We investigated the association between trainees performing supervised operations and late outcomes of patients undergoing cardiac surgery. METHODS AND RESULTS:Data were prospectively collected on patients who underwent coronary artery bypass graft surgery, aortic valve replacement, or a combination of thes...

journal_title：Circulation

authors： Stoica SC,Kalavrouziotis D,Martin BJ,Buth KJ,Hirsch GM,Sullivan JA,Baskett RJ

更新日期：2008-09-30 00:00:00

abstract：:Systolic time intervals, stroke volume, cardiac output and (dZ/dt)/RZ index were serially estimated in 51 normal healthy volunteers at sea level, for ten days after air induction to 3658 m altitude and on return to sea level. The subjects were divided into three groups and were administered a diuretic, beta methyldigo...

journal_title：Circulation

authors： Balasubramanian V,Behl A,Das GS,Wadhwa AK,Mathew OP,Hoon RS

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...

journal_title：Circulation

authors： McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

更新日期：1994-11-01 00:00:00

abstract：:Esophageal perforation is a dreaded complication of atrial fibrillation ablation that occurs in 0.1% to 0.25% of atrial fibrillation ablation procedures. Delayed diagnosis is associated with the development of atrial-esophageal fistula (AEF) and increased mortality. The relationship between the esophagus and the left ...

journal_title：Circulation

authors： Kapur S,Barbhaiya C,Deneke T,Michaud GF

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:It is still unclear what role the sinus node may play in the genesis or perpetuation of atrial fibrillation. Therefore, we studied the electrical activity in different regions of the sinus node during atrial fibrillation. METHODS AND RESULTS:In Langendorff-perfused rabbit hearts, paroxysms of atrial fibrill...

journal_title：Circulation

authors： Kirchhof CJ,Allessie MA

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The isthmus between the inferior vena cava and the tricuspid annulus has been shown to be involved in the reentry circuit of common atrial flutter. The effects of radio-frequency catheter ablation of this isthmus were examined in the canine model of atrial flutter due to reentry around the tricuspid annulus....

journal_title：Circulation

authors： Tabuchi T,Okumura K,Matsunaga T,Tsunoda R,Jougasaki M,Yasue H

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Intimal thickenings of the coronary arteries of newborn children are composed mainly of smooth muscle cell proliferations. To investigate whether thickening of the intima in infants is associated with a family history of coronary artery disease (CAD), we studied the relation of coronary death of grandparents...

journal_title：Circulation

authors： Kaprio J,Norio R,Pesonen E,Sarna S

更新日期：1993-06-01 00:00:00

abstract：:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...

journal_title：Circulation

authors： Grundler W,Weil MH,Rackow EC

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reporte...

journal_title：Circulation

authors： van Leeuwen MAH,van der Hoeven NW,Janssens GN,Everaars H,Nap A,Lemkes JS,de Waard GA,van de Ven PM,van Rossum AC,Ten Cate TJF,Piek JJ,von Birgelen C,Escaned J,Valgimigli M,Diletti R,Riksen NP,van Mieghem NM,Nijveldt R,

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Joint National Committee goal blood pressure for all adults was <140/<90 mm Hg or lower from 1984 to 2013. Adults aged ≥60 years (older) have mainly isolated systolic hypertension, with major trials attaining systolic blood pressure <150 but not <140 mm Hg. The main objective was to assess changes in hyperte...

journal_title：Circulation

authors： Egan BM,Li J,Shatat IF,Fuller JM,Sinopoli A

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:We have previously suggested that the primary arterial switch operation is a feasible strategy for patients with transposition of the great arteries and intact ventricular septum (TGA-IVS) up to age 2 months. This study reports our current results with this approach and examines whether this policy could be ...

journal_title：Circulation

authors： Kang N,de Leval MR,Elliott M,Tsang V,Kocyildirim E,Sehic I,Foran J,Sullivan I

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases, is unclear at present. METHODS:The LV parameters were measured from the cardiovascular magnetic resonance studies of the UK Biobank. ...

journal_title：Circulation

authors： Aung N,Vargas JD,Yang C,Cabrera CP,Warren HR,Fung K,Tzanis E,Barnes MR,Rotter JI,Taylor KD,Manichaikul AW,Lima JAC,Bluemke DA,Piechnik SK,Neubauer S,Munroe PB,Petersen SE

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:With recognition of disease-causing genes in arrhythmogenic right ventricular cardiomyopathy, mutation analysis is being applied. METHODS AND RESULTS:The role of genotyping in familial assessment for arrhythmogenic right ventricular cardiomyopathy was investigated, including the prevalence of mutations in k...

journal_title：Circulation

authors： Quarta G,Muir A,Pantazis A,Syrris P,Gehmlich K,Garcia-Pavia P,Ward D,Sen-Chowdhry S,Elliott PM,McKenna WJ

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：:Fibrinopeptide A, platelet factor 4, beta-thromboglobulin, thromboxane B2, and 6-keto-prostaglandin F1 alpha were estimated by radioimmunoassay on venous plasma samples taken within 48 hr of admission from 16 consecutive patients with unstable angina and 15 patients with stable angina matched for clinical variables. T...

journal_title：Circulation

authors： Théroux P,Latour JG,Léger-Gauthier C,De Lara J

更新日期：1987-01-01 00:00:00