Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?

abstract：:The initial appearance and continuous development of a coronary plaque depends on a combination of hemodynamic trauma, deposition of excess cholesterol, and accretion and incorporation of thrombogenic elements as well as fully formed mural thrombi. Plaques become life-threatening when rupture of their intimal surface ...

journal_title：Circulation

authors： Friedman M

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Patients with advanced heart failure have bioenergetic abnormalities of skeletal muscle metabolism during exercise. Using 31P magnetic resonance spectroscopy, we sought to determine whether skeletal metabolic responses to exercise are normalized by orthotopic cardiac transplantation. METHODS AND RESULTS:Fou...

journal_title：Circulation

authors： Stratton JR,Kemp GJ,Daly RC,Yacoub M,Rajagopalan B

更新日期：1994-04-01 00:00:00

abstract：:The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

journal_title：Circulation

authors： Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Increased diastolic chamber stiffness (increased DCS) during angina (demand ischemia) has been postulated to be generated by increased diastolic myocyte calcium concentration. METHODS AND RESULTS:We reproduced demand ischemia in isolated isovolumically contracting red-cell-perfused rabbit hearts by imposing...

journal_title：Circulation

authors： Varma N,Eberli FR,Apstein CS

更新日期：2000-05-09 00:00:00

abstract：BACKGROUND:The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. METHODS AND RESULTS:To elucidate function of Speg gene ...

journal_title：Circulation

authors： Liu X,Ramjiganesh T,Chen YH,Chung SW,Hall SR,Schissel SL,Padera RF Jr,Liao R,Ackerman KG,Kajstura J,Leri A,Anversa P,Yet SF,Layne MD,Perrella MA

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:Anecdotal cases of familial clustering of peripartum cardiomyopathy (PPCM) and familial occurrences of PPCM and idiopathic dilated cardiomyopathy (DCM) together have been observed, suggesting that genetic factors play a role in the pathogenesis of PPCM. We hypothesized that some cases of PPCM are part of the...

journal_title：Circulation

authors： van Spaendonck-Zwarts KY,van Tintelen JP,van Veldhuisen DJ,van der Werf R,Jongbloed JD,Paulus WJ,Dooijes D,van den Berg MP

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:We developed a computer model to predict lysis rates of thrombi for intravenous thrombolytic regimens based on the convective/diffusive penetration of reacting and adsorbing fibrinolytic species from the circulation into the proximal face of a dissolving clot. METHODS AND RESULTS:Solution of a one-compartme...

journal_title：Circulation

authors： Anand S,Diamond SL

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...

journal_title：Circulation

authors： Redberg RF,Sobol Y,Chou TM,Malloy M,Kumar S,Botvinick E,Kane J

更新日期：1995-07-15 00:00:00

abstract：BACKGROUND:The myocardial protective role of heat shock protein (HSP) has been demonstrated, and there has been increasing interest in stress response in the heart. We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during h...

journal_title：Circulation

authors： Nishizawa J,Nakai A,Higashi T,Tanabe M,Nomoto S,Matsuda K,Ban T,Nagata K

更新日期：1996-11-01 00:00:00

abstract：:Although thrombolytic therapy has been a major advance in the treatment of acute myocardial infarction, in at least 25% of patients the artery remains occluded after administration. In these patients, the strategy of "rescue" or "salvage" angioplasty is frequently used although follow-up data are limited. Sixty-three ...

journal_title：Circulation

authors： Holmes DR Jr,Gersh BJ,Bailey KR,Reeder GS,Bresnahan JF,Bresnahan DR,Vlietstra RE

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...

journal_title：Circulation

authors： van de Borne P,Montano N,Zimmerman B,Pagani M,Somers VK

更新日期：1997-12-16 00:00:00

abstract：:Successful long-term myocardial preservation is dependent on optimizing conditions during arrest, storage, and reperfusion. Neonatal piglet hearts were arrested and stored in University of Wisconsin solution (UW) at 4 degrees C for 24 hours and reperfused on a blood-perfused, adult animal-supported isolated circuit. R...

journal_title：Circulation

authors： Stein DG,Permut LC,Drinkwater DC Jr,Bhuta S,Chang P,Wu A,Laks H

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Catheter-based ultrasound is a new imaging modality to examine endovascular detail in the coronary circulation. This technique requires direct placement of the catheter in the arterial segment of interest. METHODS AND RESULTS:We examined the feasibility of a less invasive approach by imaging the coronary ar...

journal_title：Circulation

authors： Sudhir K,Fitzgerald PJ,MacGregor JS,DeMarco T,Ports TA,Chatterjee K,Yock PG

更新日期：1991-11-01 00:00:00

abstract：:Absence of continuity between the heart and the pulmonary arteries has the potential for total correction. When the pulmonary arteries are narrow, a palliative first stage systemic-pulmonary arterial anastomosis serves to enlarge the pulmonary arteries so that, with time, they become of adequate caliber for total corr...

journal_title：Circulation

authors： Todd EP,Lindsay WG,Edwards JE

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

journal_title：Circulation

authors： Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

更新日期：2007-09-11 00:00:00

abstract：:Sequential control angiographic examinations were performed at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after aortocoronary saphenous vein bypass surgery in 82 unselected patients. Graft modifications consisting of wall irregularities and obstructive lesions of various severity and shapes that were found to d...

journal_title：Circulation

authors： Campeau L,Enjalbert M,Lespérance J,Vaislic C,Grondin CM,Bourassa MG

更新日期：1983-09-01 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS:Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior desce...

journal_title：Circulation

authors： Xiong Q,Ye L,Zhang P,Lepley M,Tian J,Li J,Zhang L,Swingen C,Vaughan JT,Kaufman DS,Zhang J

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET). METHODS AND RESULTS:Myocardial images were obtained after intravenous (18)F-fluorodeoxyglucose (18FDG) in 11 normal rats ...

journal_title：Circulation

authors： Kudo T,Fukuchi K,Annala AJ,Chatziioannou AF,Allada V,Dahlbom M,Tai YC,Inubushi M,Huang SC,Cherry SR,Phelps ME,Schelbert HR

更新日期：2002-07-02 00:00:00

abstract：BACKGROUND:Each month, the number of transplant candidates added to the waiting list exceeds the number of transplantations performed, and many outpatients deteriorate to require transplantation urgently. The current list of 2400 candidates and the average wait of 8 months continue to increase. METHODS AND RESULTS:To ...

journal_title：Circulation

authors： Stevenson LW,Warner SL,Steimle AE,Fonarow GC,Hamilton MA,Moriguchi JD,Kobashigawa JA,Tillisch JH,Drinkwater DC,Laks H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:There is an elevated risk for poor outcomes after heart transplant (HTx) in patients sensitized to human leukocyte antigens including graft dysfunction, acute cellular and antibody-mediated (AMR) rejection, and cardiac allograft vasculopathy. We report our experience with human leukocyte antigens-sensitized ...

journal_title：Circulation

authors： Pollock-BarZiv SM,den Hollander N,Ngan BY,Kantor P,McCrindle B,West LJ,Dipchand AI

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases the progression of atheromatous plaques is unknown. The aim of our study was to examine the effect of sevelamer administration on the development o...

journal_title：Circulation

authors： Phan O,Ivanovski O,Nguyen-Khoa T,Mothu N,Angulo J,Westenfeld R,Ketteler M,Meert N,Maizel J,Nikolov IG,Vanholder R,Lacour B,Drüeke TB,Massy ZA

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:A complete understanding of fluid mechanics in Fontan physiology includes knowledge of the caval contributions to right (RPA) and left (LPA) pulmonary arterial blood flow, total systemic venous return, and relative blood flow to each lung. METHODS AND RESULTS:Ten Fontan patients underwent cine MRI. Three ci...

journal_title：Circulation

authors： Fogel MA,Weinberg PM,Rychik J,Hubbard A,Jacobs M,Spray TL,Haselgrove J

更新日期：1999-03-09 00:00:00

abstract：:In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

journal_title：Circulation

authors： Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

更新日期：1988-11-01 00:00:00

abstract：:We have studied the effects of cardioplegic solution (CS) on angiographic and histologic anatomy of bilateral vein grafts interposed into the carotid arteries of 10 dogs for up to 1 year. One vein (exp) was infused with cardioplegic solution (pH 7.7, K + 25 mEq/l, temperature 12 degrees C) every 15 min four times at p...

journal_title：Circulation

authors： Singh AK,Capone RJ,O'Shea P,Karlson KE

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Gaps of sufficient cross-sectional dimensions within linear radiofrequency (RF) lesions may allow conduction through the lesion. The purpose of this study was to examine the effects of different gap geometries on conduction through discontinuous RF lesions. METHODS AND RESULTS:Radiofrequency lesions were cr...

journal_title：Circulation

authors： Pérez FJ,Wood MA,Schubert CM

更新日期：2006-04-11 00:00:00

abstract：BACKGROUND:Lead V(1) directly faces the right ventricle and may exhibit ST elevation during an acute inferior myocardial infarction when the right ventricle is also involved. Leads V(1) and V(3) indirectly face the posterolateral left ventricle, and ST depression ("mirror-image" ST elevation) in V(1) through V(3) may r...

journal_title：Circulation

authors： Wong CK,Gao W,Stewart RA,French JK,Aylward PE,Benatar J,White HD,Hirulog and Early Reperfusion or Occlusion-2 Investigators.

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:Epidemiological findings suggest an association between low-for-age birth weight and the risk to develop coronary heart diseases in adulthood. During pregnancy, an imbalance between fetal demands and supply may result in permanent alterations of neuroendocrine development in the fetus. We evaluated whether c...

journal_title：Circulation

authors： Ruijtenbeek K,le Noble FA,Janssen GM,Kessels CG,Fazzi GE,Blanco CE,De Mey JG

更新日期：2000-12-05 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00