Effect of butorphanol tartrate on shock-related discomfort during internal atrial defibrillation.

abstract：BACKGROUND:Chlamydia pneumoniae stimulates chronic inflammation in vascular cells. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) may have an ameliorating effect. We investigated possible mechanisms. METHODS AND RESULTS:We infected human macrophages that in coculture spread infection to vascular smoot...

journal_title：Circulation

authors： Dechend R,Gieffers J,Dietz R,Joerres A,Rupp J,Luft FC,Maass M

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：:All physicians increasingly will encounter patients who have implanted cardioverter-defibrillators (ICDs) for protection from ventricular arrhythmias. This advisory provides a concise summary relevant to the assessment and management of patients with ICDs, including those who present to primary care or emergency depar...

journal_title：Circulation

authors： Stevenson WG,Chaitman BR,Ellenbogen KA,Epstein AE,Gross WL,Hayes DL,Strickberger SA,Sweeney MO,Subcommittee on Electrocardiography and Arrhythmias of the American Heart Association Council on Clinical Cardiology.,Heart Rhythm Society.

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Primum atrial septal defect (ASD) is a defect that is usually associated with few symptoms and can be electively repaired with good results. A review of our experience with primum ASD identified a subset of patients characterized by presentation with congestive heart failure (CHF) in the first months of life...

journal_title：Circulation

authors： Manning PB,Mayer JE Jr,Sanders SP,Coleman EA,Jonas RA,Keane JF,VanPraagh S,Castañeda AR

更新日期：1994-11-01 00:00:00

abstract：:To investigate whether ergonovine acts directly on coronary arteries or via remote neurohumoral reflexes, we administered small titrated increments of intracoronary ergonovine up to a maximum cumulative dose of 50 micrograms to 15 patients. In six patients with variant angina (group 1), ischemic electrocardiographic S...

journal_title：Circulation

authors： Hackett D,Larkin S,Chierchia S,Davies G,Kaski JC,Maseri A

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

journal_title：Circulation

authors： Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...

journal_title：Circulation

authors： Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Macrophages in human atherosclerotic plaques produce a family of matrix metalloproteinases (MMPs), which may influence vascular remodeling and plaque disruption. Because oxidized LDL (ox-LDL) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissu...

journal_title：Circulation

authors： Xu XP,Meisel SR,Ong JM,Kaul S,Cercek B,Rajavashisth TB,Sharifi B,Shah PK

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...

journal_title：Circulation

authors： Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as ...

journal_title：Circulation

authors： Li L,Whiteman M,Guan YY,Neo KL,Cheng Y,Lee SW,Zhao Y,Baskar R,Tan CH,Moore PK

更新日期：2008-05-06 00:00:00

abstract：BACKGROUND:The sarcomeric protein titin is a molecular spring responsible for passive tension and restoring forces of cardiomyocytes. Extension of titin as a function of sarcomere length (SL) has been studied in rodents, which predominantly express the smaller, stiffer N2B titin isoform. Large mammals coexpress roughly...

journal_title：Circulation

authors： Lewinter MM,Popper J,McNabb M,Nyland L,Bell SB,Granzier H

更新日期：2010-02-16 00:00:00

abstract：BACKGROUND:In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined. METHODS AND RESULTS:We compared various morphological, secretory, and proliferative respon...

journal_title：Circulation

authors： Burstein B,Libby E,Calderone A,Nattel S

更新日期：2008-04-01 00:00:00

abstract：:We examined the cardiopulmonary effects of maximum bicycle ergometer exercise in seven patients with implanted Intermedics Nova MR pacemakers for three types of pacing in a randomized sequence: VVI or AAI at 70 beats/min (SSI 70), rate-adaptive temperature-controlled pacing with the implanted Nova MR, and rate-adaptiv...

journal_title：Circulation

authors： Alt E,Völker R,Högl B,MacCarter D

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:We previously reported beneficial effects of pentoxifylline, a xanthine-derived agent known to inhibit the production of tumor necrosis factor-alpha, in patients with idiopathic dilated cardiomyopathy treated with diuretics, digoxin, and ACE inhibitors. Since then, 3 large clinical trials showed important cl...

journal_title：Circulation

authors： Skudicky D,Bergemann A,Sliwa K,Candy G,Sareli P

更新日期：2001-02-27 00:00:00

abstract：BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...

journal_title：Circulation

authors： Li G,Oparil S,Kelpke SS,Chen YF,Thompson JA

更新日期：2002-08-13 00:00:00

abstract：BACKGROUND:The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain...

journal_title：Circulation

authors： Brunner EJ,Hemingway H,Walker BR,Page M,Clarke P,Juneja M,Shipley MJ,Kumari M,Andrew R,Seckl JR,Papadopoulos A,Checkley S,Rumley A,Lowe GD,Stansfeld SA,Marmot MG

更新日期：2002-11-19 00:00:00

abstract：:Twenty-six major cardiovascular centers participated in a cooperative study of all cases of infective endocarditis occurring during a single calendar year to obtain an overview of infective endocarditis. The study was designed to learn which patients appear to be at highest risk to develop this infection after palliat...

journal_title：Circulation

authors： Kaplan EL,Rich H,Gersony W,Manning J

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-st...

journal_title：Circulation

authors： Hasenfuss G,Maier LS,Hermann HP,Lüers C,Hünlich M,Zeitz O,Janssen PM,Pieske B

更新日期：2002-01-15 00:00:00

abstract：:The pulmonary perfusion of 25 children who had total surgical correction of tetralogy of Fallot was evaluated by radionuclide perfusion scans. In addition, 18 had 133Xe ventilation studies. Eighteen of the children previously had palliative systemic-pulmonary shunts; 14 had aortic-pulmonary shunts (Waterston or Potts-...

journal_title：Circulation

authors： Alderson PO,Boonvisut S,McKnight RC,Hartman AF Jr

更新日期：1976-02-01 00:00:00

abstract：:We have applied the new technique of dual echocardiography to determine the sequence of atrial contraction as reflected in the simultaneously recorded movements of the tricuspid and mitral valves. The study group included 29 normal subjects and 23 patients with either atrial flutter, coarse atrial fibrillation or atri...

journal_title：Circulation

authors： Fujii J,Foster JR,Mills PG,Moos S,Craige E

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Receptor-mediated activation of myocardial Gq signaling is postulated as a biochemical mechanism transducing pressure-overload hypertrophy. The specific effects of Gq activation on the functional and morphological adaptations to pressure overload are not known. METHODS AND RESULTS:To determine the effects o...

journal_title：Circulation

authors： Sakata Y,Hoit BD,Liggett SB,Walsh RA,Dorn GW 2nd

更新日期：1998-04-21 00:00:00

abstract：:Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...

journal_title：Circulation

authors： Haudenschild C,Gould KE,Quist WC,LoGerfo FW

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is responsible for a huge burden in hospital care. Our goal was to evaluate the value of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in predicting death or hospital readmission after discharge of HF patients. METHODS AND RESULTS:We included 182 patients consecutively admitted to ...

journal_title：Circulation

authors： Bettencourt P,Azevedo A,Pimenta J,Friões F,Ferreira S,Ferreira A

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS:To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared...

journal_title：Circulation

authors： Zhang X,Zhang W,Ma SF,Desai AA,Saraf S,Miasniakova G,Sergueeva A,Ammosova T,Xu M,Nekhai S,Abbasi T,Casanova NG,Steinberg MH,Baldwin CT,Sebastiani P,Prchal JT,Kittles R,Garcia JG,Machado RF,Gordeuk VR

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothe...

journal_title：Circulation

authors： Conway DS,Pearce LA,Chin BS,Hart RG,Lip GY

更新日期：2002-10-08 00:00:00

abstract：BACKGROUND:Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS:Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA w...

journal_title：Circulation

authors： Anderson JL,Horne BD,Stevens SM,Grove AS,Barton S,Nicholas ZP,Kahn SF,May HT,Samuelson KM,Muhlestein JB,Carlquist JF,Couma-Gen Investigators.

更新日期：2007-11-27 00:00:00

abstract：:Using nondenaturing polyacrylamide gel electrophoresis, we have identified two distinct myosin isoenzymes in human atrial tissue that correspond to the V1 and V3 isomyosins found in rat ventricular tissue. Normal left and right atrial appendages have approximately 50% V3. When the left atrium was exposed to hemodynami...

journal_title：Circulation

authors： Buttrick PM,Malhotra A,Brodman R,McDermott L,Lam L

更新日期：1986-09-01 00:00:00

abstract：:Ventricular tachycardia is unusual in infancy. Three infants are described in whom this arrhythmia was documented by electrophysiologic studies. The ability to start and terminate this rhythm by critically timed premature ventricular stimulation suggests a reentrant mechanism. All three patients have remained free of ...

journal_title：Circulation

authors： Gaum WE,Schwartz DC,Kaplan S

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:An objective of the United States' Healthy People 2010 Initiative is to eliminate disparities based on socioeconomic status. We assessed the effect of difficulty affording health care on the health status (symptoms, function, and quality of life) of patients treated with percutaneous coronary intervention or...

journal_title：Circulation

authors： Spertus J,Decker C,Woodman C,House J,Jones P,O'Keefe J,Borkon AM

更新日期：2005-05-24 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disorder involving inflammatory processes. These responses are associated with robust activation of signaling cascades by diverse cell surface receptors in a variety of cell types. The processes that are involved in atherosclerosis would likely require intact Ras pathways,...

journal_title：Circulation

authors： George J,Afek A,Keren P,Herz I,Goldberg I,Haklai R,Kloog Y,Keren G

更新日期：2002-05-21 00:00:00