Abstract:
:Using nondenaturing polyacrylamide gel electrophoresis, we have identified two distinct myosin isoenzymes in human atrial tissue that correspond to the V1 and V3 isomyosins found in rat ventricular tissue. Normal left and right atrial appendages have approximately 50% V3. When the left atrium was exposed to hemodynamic overload secondary to mitral stenosis, the percent V3 increased to 77 +/- 10% (n = 10); exposure to hemodynamic overload secondary to mitral regurgitation caused an increase to 70 +/- 14% (n = 6). Changes in the isoenzyme pattern were seen in the right atria of patients with mitral stenosis and markedly elevated pulmonary arterial pressures compared with control subjects and patients with mitral stenosis without severe pulmonary hypertension. Several clinical variables were examined to determine which factors might influence isoenzyme expression. Age, sex, the presence of atrial fibrillation, and pulmonary capillary wedge pressure did not predict the isoenzyme pattern. However, patients with mitral valvular disease and only slightly enlarged left atria tended to have a higher percent V3 than those with massively enlarged atria. These data confirm that human atrial tissue, like rat ventricular tissue, can alter its isomyosin composition in response to a hemodynamic load. The data further suggest that the isoenzyme shift is an early adaptation to the imposed load.
journal_name
Circulationjournal_title
Circulationauthors
Buttrick PM,Malhotra A,Brodman R,McDermott L,Lam Ldoi
10.1161/01.cir.74.3.477subject
Has Abstractpub_date
1986-09-01 00:00:00pages
477-83issue
3eissn
0009-7322issn
1524-4539journal_volume
74pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Paclitaxel drug-coated balloons and drug-eluting stents became commercially available for the treatment of intermittent claudication in 2015 and 2012, respectively. Both devices demonstrated superiority in limb revascularization compared with non-paclitaxel-coated devices and were rapidly accepted into clinical practi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.119.041099
更新日期:2019-10-15 00:00:00
abstract::Although the postoperative hemodynamic and echocardiographic features of idiopathic hypertrophic subaortic stenosis have been studied, the expected consistent postoperative thinning of the interventricular septum has not been reported. In this study, the short-term effects of septal myectomy were evaluated in 16 patie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.5.850
更新日期:1978-11-01 00:00:00
abstract::The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bio...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.117.029289
更新日期:2018-06-12 00:00:00
abstract::Physiological studies of the type we have described, when performed in patients with the WPW syndrome, can yield diagnostic information regarding the mechanism of arrhythmia, demonstrate functional properties of therapeutic import, facilitate therapeutic decision-making about drug regimens and presumptively localize t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.5.767
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Bradycardia and sinus node dysfunction are common causes of early postoperative morbidity in orthotopic heart transplant recipients and frequently require the use of chronotropic drugs or permanent pacemakers. Several causes have been postulated, including surgical trauma to the sinus node and its blood supp...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes in submaximal exercise performance and the ventilatory response to exercise in ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.2.324
更新日期:1989-02-01 00:00:00
abstract::Neutrophil activation and infiltration into the ischemic myocardium after reperfusion may limit the amount of salvageable myocardium (reperfusion injury). The effects of intravenous perfluorochemicals (Fluosol-DA) on infarct size, ventricular contractility, and neutrophil function were assessed in an occlusion-reperfu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.3.645
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Pulmonary hypertension caused by systolic left ventricular dysfunction is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in pati...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.113.001458
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:Direct thrombin inhibitors are a new class of drugs that may offer a more effective and potentially simpler alternative to heparin. Hirulog is a synthetic peptide based on the leech-derived compound hirudin and, like hirudin, is a highly specific, direct inhibitor of free and clot-bound thrombin. METHODS AN...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.92.4.727
更新日期:1995-08-15 00:00:00
abstract::Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheteri...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.1.206
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Although surgery is indicated in patients with mitral regurgitation (MR) when left ventricular (LV) end-systolic (LVES) dimension is >40 mm, LV ejection fraction may decrease after mitral valve surgery. We hypothesize that significant LV remodeling before surgery is not reflected by standard echocardiographi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.073239
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in the L-type calcium current, is a major factor in the initiation and maintenance of atrial fibrillation (AF). We investigated underlying molecular changes by studying the relation between gene expression of the...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.5.684
更新日期:2001-02-06 00:00:00
abstract:BACKGROUND:Arterial hypertension is a prime cause of morbidity and mortality in the general population. Pharmacological treatment has limitations resulting from drug side effects, costs, and patient compliance. Thus, we investigated whether traditional Chinese medicine acupuncture is able to lower blood pressure. METH...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.106.661140
更新日期:2007-06-19 00:00:00
abstract:BACKGROUND:Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis. We investigated the effects of genetic modulation of CSE and exogenous H2S therapy in the setting of pressure overload-induced heart failure. METHODS AND RESULTS:Transvers...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.112.000855
更新日期:2013-03-12 00:00:00
abstract:BACKGROUND:Guidelines for the management of patients with suspected coronary artery disease (CAD) rely on the age, sex, and angina typicality-based pretest probabilities of angiographically significant CAD derived from invasive coronary angiography (guideline probabilities). Reliability of guideline probabilities has n...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.111.039255
更新日期:2011-11-29 00:00:00
abstract::To assess the effects on the heart itself of coronary thrombolysis induced with either tissue-type plasminogen activator (t-PA) or streptokinase (SK), we performed positron emission tomography with 11C-palmitate in 19 patients with initial transmural myocardial infarction immediately after admission and again within 4...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.69.5.983
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists inhibit vascular smooth muscle proliferation and migration and improve endothelial function. It is unknown whether PPAR-gamma agonists favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote endothelial l...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000123231.49594.21
更新日期:2004-03-23 00:00:00
abstract:BACKGROUND:The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect stent strut coverage in vivo on a micron-sca...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.110.963181
更新日期:2011-01-25 00:00:00
abstract:BACKGROUND:To examine the influence active-play video gaming (also referred to as exergaming, exertainment, and active gaming) might have on improving health-related skills, enhancing self-esteem and self-efficacy, promoting social support, and ultimately motivating positive changes in health behaviors, the American He...
journal_title:Circulation
pub_type:
doi:10.1161/CIR.0b013e318219661d
更新日期:2011-05-31 00:00:00
abstract:BACKGROUND:Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS:Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA w...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.107.737312
更新日期:2007-11-27 00:00:00
abstract:BACKGROUND:Performance of coronary artery bypass graft (CABG) during an acute coronary syndrome (ACS) is mainly used in high-risk patients. Although potentially life-saving, patients undergoing early CABG are traditionally associated with a worse outcome than those not requiring CABG. Is this really true in an unselect...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.001420
更新日期:2006-07-04 00:00:00
abstract::Activation of the sympathetic nervous system is an important factor in the genesis of ventricular arrhythmias in patients with impaired ventricular function. Such patients have an appropriate substrate that is capable of generating rhythm abnormalities, which may be related to enhanced automaticity, triggered automati...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract::For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48. Apo B-100, an extremely large protein composed of 4,536 amino acids, is synthesized by the liver and is crucial for...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.82.5.1574
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:NO has been advocated as an adjunct to cardioplegia solutions. However, NO undergoes a rapid biradical reaction with superoxide anions to produce peroxynitrite (ONOO(-)). ONOO(-) in crystalloid cardioplegia solution induces injury to coronary endothelium and to systolic function after cardioplegia and reperf...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.suppl_3.iii-332
更新日期:2000-11-07 00:00:00
abstract:BACKGROUND:Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial nitric oxide synthase (eNOS) expression. The mechanism by which hypoxia decreases eNOS expression is not known but may involve Rho-kinase-induced ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000020682.73694.ab
更新日期:2002-07-02 00:00:00
abstract:BACKGROUND:Various myocardial cell surface and intracellular antigens have been associated with autoimmune myocarditis. Since sarcoplasmic calcium overload is a recognized pathobiochemical finding in cardiomyopathy, we reasoned that there might be a causal relation between inhibition of sarcoplasmic calcium exclusion a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.3.1217
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.24.2396
更新日期:1998-06-23 00:00:00
abstract:BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.733675
更新日期:2008-05-20 00:00:00
abstract:BACKGROUND:We compared ischemic preconditioning (IP) induced with a single cycle of transient ischemia and reperfusion with that induced by multiple cycles in terms of (1) efficacy of protection against myocardial necrosis and (2) susceptibility to pharmacological blockade by inhibition of protein kinase C (PKC) or ele...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.3.984
更新日期:1997-08-05 00:00:00