Effects of aging and cardiac denervation on heart rate variability during sleep.

abstract：BACKGROUND:Repolarization dispersion (Rd) is frequently mentioned as a predictor of cardiac abnormalities. We present a new measure of Rd based on the root-mean-square (RMS) curve of an ECG lead set and compare its performance with that of the commonly used QT dispersion (QTd) measure with the use of recovery times mea...

journal_title：Circulation

authors： Fuller MS,Sándor G,Punske B,Taccardi B,MacLeod RS,Ershler PR,Green LS,Lux RL

更新日期：2000-08-08 00:00:00

abstract：BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

journal_title：Circulation

authors： Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...

journal_title：Circulation

authors： Matitiau A,Perez-Atayde A,Sanders SP,Sluysmans T,Parness IA,Spevak PJ,Colan SD

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Epinephrine has been shown to impair pulmonary excretion of CO2 during resuscitation. This phenomenon was investigated in a rodent model of cardiac arrest and conventional resuscitation. METHODS AND RESULTS:The effects of racemic epinephrine were compared with the selective alpha 1-agonist methoxamine and w...

journal_title：Circulation

authors： Tang W,Weil MH,Gazmuri RJ,Sun S,Duggal C,Bisera J

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:A major advantage of coronary artery bypass graft surgery (CABG) relative to percutaneous coronary intervention is its durability, yet there is a paucity of information on rates and predictors of repeat coronary revascularization after CABG in the modern era. METHODS AND RESULTS:We included patients ≥65 yea...

journal_title：Circulation

authors： Fosbøl EL,Zhao Y,Shahian DM,Grover FL,Edwards FH,Peterson ED

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Despite successful surgical correction, morbidity of patients with coarctation of the aorta is increased. It is well known that these patients have impaired elastic properties of the prestenotic arteries. To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns b...

journal_title：Circulation

authors： Vogt M,Kühn A,Baumgartner D,Baumgartner C,Busch R,Kostolny M,Hess J

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen on MI in the rat left coronary artery ligation model. METHODS AND RESULTS:Female Sprague-Dawley rats (10 to 12 weeks, n=93), divided into 3 group...

journal_title：Circulation

authors： Smith PJ,Ornatsky O,Stewart DJ,Picard P,Dawood F,Wen WH,Liu PP,Webb DJ,Monge JC

更新日期：2000-12-12 00:00:00

abstract：BACKGROUND:Thrombolytic therapy of acute myocardial infarction (AMI) is evolving toward bolus administration. Derivatization of proteins with polyethylene glycol (PEG) may reduce their clearance. METHODS AND RESULTS:A staphylokinase (SakSTAR) variant with 12 amino acid substitutions to reduce its antigenicity, SakSTAR...

journal_title：Circulation

authors： Collen D,Sinnaeve P,Demarsin E,Moreau H,De Maeyer M,Jespers L,Laroche Y,Van de Werf F

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T c...

journal_title：Circulation

authors： Arkenbout EK,de Waard V,van Bragt M,van Achterberg TA,Grimbergen JM,Pichon B,Pannekoek H,de Vries CJ

更新日期：2002-09-17 00:00:00

abstract：BACKGROUND:The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect stent strut coverage in vivo on a micron-sca...

journal_title：Circulation

authors： Guagliumi G,Costa MA,Sirbu V,Musumeci G,Bezerra HG,Suzuki N,Matiashvili A,Lortkipanidze N,Mihalcsik L,Trivisonno A,Valsecchi O,Mintz GS,Dressler O,Parise H,Maehara A,Cristea E,Lansky AJ,Mehran R,Stone GW

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:Adenosine receptor activation has been proposed to explain the cardioprotective effect of ischemic preconditioning in rabbit hearts. We tested this hypothesis in a rat model by assessing whether administration of an adenosine antagonist could block the protective effect of preconditioning and whether adenosi...

journal_title：Circulation

authors： Li Y,Kloner RA

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...

journal_title：Circulation

authors： Lindsey M,Wedin K,Brown MD,Keller C,Evans AJ,Smolen J,Burns AR,Rossen RD,Michael L,Entman M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that serotonin (5-HT) has a growth-promoting effect on several different cell types, including smooth muscle cells. After percutaneous transluminal coronary angioplasty, there is damage and denudation of vascular endothelial cells, which promotes platelet aggregation at the site of in...

journal_title：Circulation

authors： Pakala R,Willerson JT,Benedict CR

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the transformation of stable angina to unstable angina, a major cause of morbidity and mortality, are commonly believed to be plaque rupture and thrombosis. We determined whether additional mechanisms are operative by analyzing the histopathology and immuno-histopathology of co...

journal_title：Circulation

authors： Flugelman MY,Virmani R,Correa R,Yu ZX,Farb A,Leon MB,Elami A,Fu YM,Casscells W,Epstein SE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

journal_title：Circulation

authors： Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:We wished to test previous hypotheses that sex-related differences in mortality and morbidity may be due to differences in the cause of heart failure or in left ventricular ejection fraction (LVEF) by comparing fatal and nonfatal outcomes in women and men with heart failure and a broad spectrum of left ventr...

journal_title：Circulation

authors： O'Meara E,Clayton T,McEntegart MB,McMurray JJ,Piña IL,Granger CB,Ostergren J,Michelson EL,Solomon SD,Pocock S,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

更新日期：2007-06-19 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide is a novel natriuretic peptide that is secreted predominantly from the ventricles, and its plasma levels have been shown to be markedly increased in patients with chronic congestive heart failure. This study was designed to examine the plasma levels of brain natriuretic peptide as w...

journal_title：Circulation

authors： Morita E,Yasue H,Yoshimura M,Ogawa H,Jougasaki M,Matsumura T,Mukoyama M,Nakao K

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Neuronal nitric oxide synthase (nNOS) has recently been shown to be a major regulator of cardiac contractility. In a cellular system, we have previously shown that nNOS is regulated by the isoform 4b of plasma membrane calcium/calmodulin-dependent ATPase (PMCA4b) through direct interaction mediated by a PDZ ...

journal_title：Circulation

authors： Oceandy D,Cartwright EJ,Emerson M,Prehar S,Baudoin FM,Zi M,Alatwi N,Venetucci L,Schuh K,Williams JC,Armesilla AL,Neyses L

更新日期：2007-01-30 00:00:00

abstract：BACKGROUND:The mechanisms responsible for tumor necrosis factor (TNF)-induced LV structural remodeling in the adult heart are not known. METHODS AND RESULTS:We generated a line of transgenic mice (MHCsTNF) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling from 4 to 12 weeks ...

journal_title：Circulation

authors： Sivasubramanian N,Coker ML,Kurrelmeyer KM,MacLellan WR,DeMayo FJ,Spinale FG,Mann DL

更新日期：2001-08-14 00:00:00

abstract：:Both the Veterans Administration Cooperative Study and the European Coronary Surgery Study have provided only brief accounts of graft patency rates in their surgically treated patients. In the Veterans Administration Cooperative Study, at an average of 1 year after operation, 69% of the grafts were patent among 208 pa...

journal_title：Circulation

authors： Bourassa MG,Fisher LD,Campeau L,Gillespie MJ,McConney M,Lespérance J

更新日期：1985-12-01 00:00:00

abstract：:Survival data after 8 years of follow-up for all patients and after 7 years for certain subgroups are reported from CASS, a randomized trial of surgical or medical treatment assignment in patients with coronary artery disease who have less than severe angina or are asymptomatic after myocardial infarction. After 8 yea...

journal_title：Circulation

authors： Killip T,Passamani E,Davis K

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:We developed a computer model to predict lysis rates of thrombi for intravenous thrombolytic regimens based on the convective/diffusive penetration of reacting and adsorbing fibrinolytic species from the circulation into the proximal face of a dissolving clot. METHODS AND RESULTS:Solution of a one-compartme...

journal_title：Circulation

authors： Anand S,Diamond SL

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Endothelin 1 has been implicated in various human diseases, including atherosclerosis. In this study, we examined the expression and localization of endothelin-converting enzyme-1 (ECE-1), the final key enzyme of endothelin 1 processing, in rat carotid arteries after balloon injury and in human coronary athe...

journal_title：Circulation

authors： Minamino T,Kurihara H,Takahashi M,Shimada K,Maemura K,Oda H,Ishikawa T,Uchiyama T,Tanzawa K,Yazaki Y

更新日期：1997-01-07 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

journal_title：Circulation

authors： Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

更新日期：2001-11-06 00:00:00

abstract：:It has been suggested that the beneficial effects of reperfusing ischemic myocardium might be in part reversed by the occurrence of "reperfusion injury." One possible mechanism could be the generation of oxygen free radicals. Superoxide dismutase enzymatically scavenges superoxide radicals by dismutation to hydrogen p...

journal_title：Circulation

authors： Ambrosio G,Weisfeldt ML,Jacobus WE,Flaherty JT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Recent data from this laboratory indicate that pretreatment with adenosine can protect the heart against infarction via A1-receptors, but because of systemic hypotension, adenosine had to be given into the coronary circulation. METHODS AND RESULTS:In this study, we tested whether the protection could be ach...

journal_title：Circulation

authors： Thornton JD,Liu GS,Olsson RA,Downey JM

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

journal_title：Circulation

authors： Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. METHODS:The present analysis included the 607 patients from ...

journal_title：Circulation

authors： Ciccarelli G,Barbato E,Toth GG,Gahl B,Xaplanteris P,Fournier S,Milkas A,Bartunek J,Vanderheyden M,Pijls N,Tonino P,Fearon WF,Jüni P,De Bruyne B

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-alpha activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-...

journal_title：Circulation

authors： Ferrari R,Bachetti T,Confortini R,Opasich C,Febo O,Corti A,Cassani G,Visioli O

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohor...

journal_title：Circulation

authors： Dufouil C,Beiser A,McLure LA,Wolf PA,Tzourio C,Howard VJ,Westwood AJ,Himali JJ,Sullivan L,Aparicio HJ,Kelly-Hayes M,Ritchie K,Kase CS,Pikula A,Romero JR,D'Agostino RB,Samieri C,Vasan RS,Chêne G,Howard G,Seshadri S

更新日期：2017-03-21 00:00:00