Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat.

abstract：BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...

journal_title：Circulation

authors： Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

更新日期：1999-11-30 00:00:00

abstract：BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...

journal_title：Circulation

authors： Matt P,Schoenhoff F,Habashi J,Holm T,Van Erp C,Loch D,Carlson OD,Griswold BF,Fu Q,De Backer J,Loeys B,Huso DL,McDonnell NB,Van Eyk JE,Dietz HC,GenTAC Consortium.

更新日期：2009-08-11 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...

journal_title：Circulation

authors： Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

更新日期：2000-11-14 00:00:00

abstract：BACKGROUND:The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS:The study population co...

journal_title：Circulation

authors： Belton O,Byrne D,Kearney D,Leahy A,Fitzgerald DJ

更新日期：2000-08-22 00:00:00

abstract：BACKGROUND:Restenosis after initial, successful percutaneous transluminal coronary angioplasty (PTCA) is due to fibrocellular proliferation. METHODS AND RESULTS:The present study focused on the nature of fibrocellular tissue in humans by use of immunocytochemical techniques. Four hearts (five coronary arteries) were i...

journal_title：Circulation

authors： Ueda M,Becker AE,Tsukada T,Numano F,Fujimoto T

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) plays a critical role in the development of vascular lesions in hypertension, atherosclerosis, and several renal diseases. Because Ang II may contribute to the leukocyte recruitment associated with these pathological states, the aim of the present study was to assess the role of Ang I...

journal_title：Circulation

authors： Piqueras L,Kubes P,Alvarez A,O'Connor E,Issekutz AC,Esplugues JV,Sanz MJ

更新日期：2000-10-24 00:00:00

abstract：:The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months a...

journal_title：Circulation

authors： Weidner G,Connor SL,Chesney MA,Burns JW,Connor WE,Matarazzo JD,Mendell NR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Postmortem-derived findings support the common beliefs that lipid-rich coronary plaques with a thin, fibrous cap are prone to rupture and that rupture and superimposed thrombosis are the primary mechanisms causing acute coronary syndromes. In vivo imaging with intracoronary techniques may disclose difference...

journal_title：Circulation

authors： de Feyter PJ,Ozaki Y,Baptista J,Escaned J,Di Mario C,de Jaegere PP,Serruys PW,Roelandt JR

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...

journal_title：Circulation

authors： Kovanen PT,Kaartinen M,Paavonen T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...

journal_title：Circulation

authors： Hirayama A,Adachi T,Asada S,Mishima M,Nanto S,Kusuoka H,Yamamoto K,Matsumura Y,Hori M,Inoue M

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:Chemokines are important mediators of inflammatory cell recruitment that play a significant role in atherosclerosis. Fractalkine (CX3CL1) is an unusual membrane-bound chemokine that mediates chemotaxis through the CX3CR1 receptor. Recently, functional polymorphisms in the human CX3CR1 gene have been describe...

journal_title：Circulation

authors： Lucas AD,Bursill C,Guzik TJ,Sadowski J,Channon KM,Greaves DR

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:This study was designed to investigate whether collagen type I degradation is altered in patients with essential hypertension and whether this alteration could be related to disturbances in the serum matrix metalloproteinase pathway of collagen degradation. A second aim of the study was to assess whether som...

journal_title：Circulation

authors： Laviades C,Varo N,Fernández J,Mayor G,Gil MJ,Monreal I,Díez J

更新日期：1998-08-11 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...

journal_title：Circulation

authors： Heidenreich PA,Trogdon JG,Khavjou OA,Butler J,Dracup K,Ezekowitz MD,Finkelstein EA,Hong Y,Johnston SC,Khera A,Lloyd-Jones DM,Nelson SA,Nichol G,Orenstein D,Wilson PW,Woo YJ,American Heart Association Advocacy Coordinating

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Worldwide, diabetes mellitus and heart failure represent frequent comorbidities with high socioeconomic impact and steadily growing incidence, calling for a better understanding of how diabetic metabolism promotes cardiac dysfunction. Paradoxically, some glucose-lowering drugs have been shown to worsen heart...

journal_title：Circulation

authors： Kronlage M,Dewenter M,Grosso J,Fleming T,Oehl U,Lehmann LH,Falcão-Pires I,Leite-Moreira AF,Volk N,Gröne HJ,Müller OJ,Sickmann A,Katus HA,Backs J

更新日期：2019-08-13 00:00:00

abstract：:Threshold bipolar pacing was performed from one of 12 selected atrial sites with temporary implanted electrodes in 69 patients following open-heart surgery in order to study P wave polarity and morphology and the P-R interval during paced ectopic atrial rhythms. A negative P wave was recorded in lead I only with paci...

journal_title：Circulation

authors： MacLean WA,Karp RB,Kouchoukos NT,James TN,Waldo AL

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) remains a concern in patients with β-thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and risk factors using systematic confirmation on right heart catheterization are lacking. METHODS AND RESULTS:This was a multicenter cross-sectio...

journal_title：Circulation

authors： Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction is a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocardial dysfunction, and early mortality. Left ventricular noncompaction has a heterogeneous clinical presentation that includes arrhythmia and sudden cardiac death. METHODS AND ...

journal_title：Circulation

authors： Brescia ST,Rossano JW,Pignatelli R,Jefferies JL,Price JF,Decker JA,Denfield SW,Dreyer WJ,Smith O,Towbin JA,Kim JJ

更新日期：2013-06-04 00:00:00

abstract：:Electrocardiograms from 5,129 examined persons, 2,449 men and 2,680 women, 16 years of age or older, were classified according to the Minnesota code of Blackburn and associates. The R wave amplitude criteria for possible left ventricular hypertrophy were fulfilled in 193 tracings from 135 men and 58 women. Age and sex...

journal_title：Circulation

authors： Ostrander LD Jr

更新日期：1966-02-01 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) in humans is associated with a marked sympathoexcitation, including an augmented muscle sympathetic nerve activity (MSNA) in intraneural multiunit recordings. In the present study, single-unit recording was used to evaluate whether the firing properties of individual muscle vas...

journal_title：Circulation

authors： Macefield VG,Rundqvist B,Sverrisdottir YB,Wallin BG,Elam M

更新日期：1999-10-19 00:00:00

abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

journal_title：Circulation

authors： Mirvis DM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy for heart failure with left bundle branch block reduces left ventricular (LV) conduction delay, contraction asynchrony, and LV end-systolic volume ("reverse remodeling"). Up to one third of patients do not improve, and the electric requirements for reverse remodeling are unc...

journal_title：Circulation

authors： Sweeney MO,van Bommel RJ,Schalij MJ,Borleffs CJ,Hellkamp AS,Bax JJ

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS:Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior desce...

journal_title：Circulation

authors： Xiong Q,Ye L,Zhang P,Lepley M,Tian J,Li J,Zhang L,Swingen C,Vaughan JT,Kaufman DS,Zhang J

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:Regional myocardial blood flow has been quantified using transaxial positron emission tomographic (PET) imaging and tracer kinetic modeling. However, the use of transaxial images limits the accuracy of regional partial volume corrections and the localization of the quantified regional flow values. The purpos...

journal_title：Circulation

authors： Kuhle WG,Porenta G,Huang SC,Buxton D,Gambhir SS,Hansen H,Phelps ME,Schelbert HR

更新日期：1992-09-01 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Mild oxidation of LDL enhances its atherogenic potential and induces a synergistic interaction with serotonin (5HT) on vascular smooth muscle cell (VSMC) proliferation. Because of its complex chemical nature, the mitogenic components of mildly oxidized LDL (moxLDL) remain unclear. METHODS AND RESULTS:We exa...

journal_title：Circulation

authors： Watanabe T,Pakala R,Koba S,Katagiri T,Benedict CR

更新日期：2001-03-13 00:00:00

abstract：BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...

journal_title：Circulation

authors： Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

journal_title：Circulation

authors： Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

更新日期：1991-10-01 00:00:00

abstract：:Originally described by Japanese authors in the 1990s, Takotsubo syndrome (TTS) generally presents as an acute myocardial infarction characterized by severe left ventricular dysfunction. TTS, however, differs from an acute coronary syndrome because patients have generally a normal coronary angiogram and left ventricul...

journal_title：Circulation

authors： Pelliccia F,Kaski JC,Crea F,Camici PG

更新日期：2017-06-13 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00