Calculation of aortic valve area by Doppler echocardiography: a direct application of the continuity equation.

abstract：BACKGROUND:Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their ...

journal_title：Circulation

authors： Suzuki K,Smolenski RT,Jayakumar J,Murtuza B,Brand NJ,Yacoub MH

更新日期：2000-11-07 00:00:00

abstract：:A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we p...

journal_title：Circulation

authors： Farrar DJ,Compton PG,Dajee H,Fonger JD,Hill JD

更新日期：1984-10-01 00:00:00

abstract：:We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs (n = 8). Right atrial (RA), atrioventricular nodal (AVN), and right ventricular (RV) effective refractory period (ERP), and AVN functional ...

journal_title：Circulation

authors： Tuna IC,Qi AC,Gornick C,Bolman RM 3rd,Benditt DG

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae (Cp) has been demonstrated in arteries and abdominal aortic aneurysms (AAAs). However, the validity of the methods used is questioned, and antibiotic treatment trials have thus far shown disappointing results. Nevertheless, antibodies against the Cp outer membrane proteins (OMPs) have be...

journal_title：Circulation

authors： Lindholt JS,Støvring J,Østergaard L,Urbonavicius S,Henneberg EW,Honoré B,Vorum H

更新日期：2004-05-04 00:00:00

abstract：BACKGROUND:Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate-lowering agent that acts specifically on the sinoatrial node. METHODS...

journal_title：Circulation

authors： Borer JS,Fox K,Jaillon P,Lerebours G,Ivabradine Investigators Group.

更新日期：2003-02-18 00:00:00

abstract：:This study was undertaken to assess the ability of proton magnetic resonance imaging (MRI) to detect myocardial ischemia shortly after coronary artery occlusion. Fifteen dogs were studied before and serially for up to 6 hr after anterior descending or circumflex coronary artery ligation in vivo by gated MRI with a 0.1...

journal_title：Circulation

authors： Pflugfelder PW,Wisenberg G,Prato FS,Carroll SE,Turner KL

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabeti...

journal_title：Circulation

authors： Rönnback M,Fagerudd J,Forsblom C,Pettersson-Fernholm K,Reunanen A,Groop PH,Finnish Diabetic Nephropathy (FinnDiane) Study Group.

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular e...

journal_title：Circulation

authors： Gowdak LH,Poliakova L,Wang X,Kovesdi I,Fishbein KW,Zacheo A,Palumbo R,Straino S,Emanueli C,Marrocco-Trischitta M,Lakatta EG,Anversa P,Spencer RG,Talan M,Capogrossi MC

更新日期：2000-08-01 00:00:00

abstract：:Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...

journal_title：Circulation

authors： Steen PA,Tinker JH,Pluth JR,Barnh;rst DA,Tarhan S

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to de...

journal_title：Circulation

authors： Holmes DR Jr,Savage M,LaBlanche JM,Grip L,Serruys PW,Fitzgerald P,Fischman D,Goldberg S,Brinker JA,Zeiher AM,Shapiro LM,Willerson J,Davis BR,Ferguson JJ,Popma J,King SB 3rd,Lincoff AM,Tcheng JE,Chan R,Granett JR,P

更新日期：2002-09-03 00:00:00

abstract：:The echographic isovolumic contraction time (ICT) of the left ventricle (LV) was measured in order to assess alterations of LV performance in children with various forms of cardiac disease. The echographic ICT was defined as the interval between coaptation of the anterior and posterior mitral valve leaflets and aortic...

journal_title：Circulation

authors： Hirschfeld S,Meyer R,Korfhagen J,Kaplan S,Liebman J

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare differential effects of a segment of slow conduction during ventricular tachycardia (VT) due to depression of the action potential and electrical uncoupling. METHODS AND RESULTS:In 33 Langendorff-perfused rabbit hearts, a ring of anisotropic left ventricular subepica...

journal_title：Circulation

authors： Haberl K,Allessie M

更新日期：1999-02-23 00:00:00

abstract：BACKGROUND:In the treatment of patients with life-threatening ventricular arrhythmia, transvenous implantable cardioverter/defibrillators provide significant advantages over devices requiring a thoracotomy. This study tested the hypothesis that a new carbon-fiber electrode, designed at the Technische Universität in Mun...

journal_title：Circulation

authors： Alt EU,Fotuhi PC,Callihan RL,Mestre E,Smith WM,Ideker RE

更新日期：1995-09-15 00:00:00

abstract：:In this study, we tested the hypothesis that the neural control of circulation in humans undergoes continuous but in part predictable changes throughout the day and night. Dynamic 24-hour recordings were obtained in two groups of ambulant subjects. In 18 hospitalized patients free to move, direct high-fidelity arteria...

journal_title：Circulation

authors： Furlan R,Guzzetti S,Crivellaro W,Dassi S,Tinelli M,Baselli G,Cerutti S,Lombardi F,Pagani M,Malliani A

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:The combination of statin therapy and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition markedly lowers low-density lipoprotein cholesterol (LDL-C) and reduces cardiovascular event rates. Whether residual inflammatory risk as measured by on-treatment high sensitivity C-reactive protein (hsCRP)...

journal_title：Circulation

authors： Pradhan AD,Aday AW,Rose LM,Ridker PM

更新日期：2018-07-10 00:00:00

abstract：BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunoh...

journal_title：Circulation

authors： Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DR

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:ST-segment depression during exercise testing is frequently observed in the absence of restenosis after coronary angioplasty. METHODS AND RESULTS:We studied the determinants of this phenomenon in 70 consecutive patients with unstable angina related to a single left anterior descending coronary artery lesion...

journal_title：Circulation

authors： Beregi JP,Bauters C,McFadden EP,Quandalle P,Bertrand ME,Lablanche JM

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

journal_title：Circulation

authors： Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...

journal_title：Circulation

authors： Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Children awaiting heart transplantation have severe limitations in their ability to exercise. The purpose of this study was to assess exercise capacity after pediatric heart transplantation and to identify factors influencing exercise performance. METHODS AND RESULTS:Progressive cycle ergometry testing was ...

journal_title：Circulation

authors： Hsu DT,Garofano RP,Douglas JM,Michler RE,Quaegebeur JM,Gersony WM,Addonizio LJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

journal_title：Circulation

authors： Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy in older versus younger patients with acute coronary syndromes is understudied. Low-dose prasugrel (5 mg/d) is recommended for younger, lower-body-weight patients and elderly patients with acute coronary syndromes to mitigate the bleeding risk of standard-dose prasugrel (10 mg/d). ...

journal_title：Circulation

authors： Roe MT,Goodman SG,Ohman EM,Stevens SR,Hochman JS,Gottlieb S,Martinez F,Dalby AJ,Boden WE,White HD,Prabhakaran D,Winters KJ,Aylward PE,Bassand JP,McGuire DK,Ardissino D,Fox KA,Armstrong PW

更新日期：2013-08-20 00:00:00

abstract：:Thirteen patients with proven Q fever endocarditis and three additional patients with probable endocarditis are reviewed. The most helpful diagnostic test is the demonstration of a high complement fixing antibody titre to Phase 1 antigen of Coxiella burneti. The macroscopic pathology of the aortic valve is described a...

journal_title：Circulation

authors： Wilson HG,Neilson GH,Galea EG,Stafford G,O'Brien MF

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studi...

journal_title：Circulation

authors： Khera AV,Demler OV,Adelman SJ,Collins HL,Glynn RJ,Ridker PM,Rader DJ,Mora S

更新日期：2017-06-20 00:00:00

abstract：BACKGROUND:The conjoint trait hypothesis proposes that combined low HDL cholesterol (HDL-C) and high triglyceride (TG) levels represent a single, inherited phenotype that adiposity may influence in an unspecified manner. We conducted formal statistical genetic tests of the conjoint trait hypothesis and the relation of ...

journal_title：Circulation

authors： Mahaney MC,Blangero J,Comuzzie AG,VandeBerg JL,Stern MP,MacCluer JW

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression. METHODS AND RESULTS:Low-density lipoprotein receptor null mice in which Treg express gree...

journal_title：Circulation

authors： Maganto-García E,Tarrio ML,Grabie N,Bu DX,Lichtman AH

更新日期：2011-07-12 00:00:00

abstract：BACKGROUND:The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the relationship between tissue heterogeneity in the infarct periphery a...

journal_title：Circulation

authors： Schmidt A,Azevedo CF,Cheng A,Gupta SN,Bluemke DA,Foo TK,Gerstenblith G,Weiss RG,Marbán E,Tomaselli GF,Lima JA,Wu KC

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury. METHODS AND RESULTS:We prospectively assessed the prevalen...

journal_title：Circulation

authors： Sibley CT,Estwick T,Zavodni A,Huang CY,Kwan AC,Soule BP,Long Priel DA,Remaley AT,Rudman Spergel AK,Turkbey EB,Kuhns DB,Holland SM,Malech HL,Zarember KA,Bluemke DA,Gallin JI

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Previous studies have shown that thrombin is a potent though slow-acting mitogen for vascular smooth muscle cells (SMC). Because thrombin generation in vivo is accompanied by platelet activation, it has been suggested that platelet-derived factors might enhance thrombin-induced SMC proliferation. No informat...

journal_title：Circulation

authors： Zucker TP,Bönisch D,Muck S,Weber AA,Bretschneider E,Glusa E,Schrör K

更新日期：1998-02-17 00:00:00