Abstract:
BACKGROUND:Children awaiting heart transplantation have severe limitations in their ability to exercise. The purpose of this study was to assess exercise capacity after pediatric heart transplantation and to identify factors influencing exercise performance. METHODS AND RESULTS:Progressive cycle ergometry testing was performed in 31 patients at 1.3 +/- 0.8 years after transplantation, and in 16 patients, follow-up studies were performed at 3.3 +/- 1.3 years after transplantation. Maximum work load (Wmax), peak oxygen consumption (VO2), and maximum heart rate (HRmax) were measured. Exercise capacity was defined as normal if Wmax was > or = 75% of predicted values and decreased if Wmax was < 75% of predicted values. Differences in age at transplantation, sex, diagnosis, duration of heart failure, New York Heart Association class before transplantation, resting cardiac index, body mass index, and rejections per patient month were compared between patients with normal and decreased exercise capacity. At initial study, Wmax was 62 +/- 38 W or 61% of that predicted, peak VO2 was 20 +/- 6 mL.kg-1 x min-1 (63% of that predicted), and HRmax was 136 +/- 22 beats per minute (66% of that predicted) for all 31 patients. Six patients had normal exercise capacity, and 25 patients had decreased exercise capacity. Peak VO2 was significantly higher in the normal versus the decreased exercise capacity patients (26 +/- 5 vs 19 +/- 5 mg.kg-1 x min-1). The mean age at transplantation was significantly less in patients with normal exercise capacity: 8.2 +/- 4.6 versus 12.5 +/- 3.6 years for patients with decreased capacity. On follow-up study, no significant differences in Wmax, peak VO2, or HRmax were found from the initial test. CONCLUSIONS:Similar to results obtained in adult patients, exercise capacity was decreased but stable in pediatric patients after heart transplantation.
journal_name
Circulationjournal_title
Circulationauthors
Hsu DT,Garofano RP,Douglas JM,Michler RE,Quaegebeur JM,Gersony WM,Addonizio LJsubject
Has Abstractpub_date
1993-11-01 00:00:00pages
II238-42issue
5 Pt 2eissn
0009-7322issn
1524-4539journal_volume
88pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.4.837
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Although diabetes confers an increased propensity toward accelerated atherogenesis, data are lacking on monocyte activity in type 2 diabetic patients with (DM2-MV) and without (DM2) macrovascular disease compared with control subjects. Thus, we tested whether (1) postsecretory modifications of LDL (glycation...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.2.191
更新日期:2000-07-11 00:00:00
abstract::Trapidil (triazolopyrimidine) possesses activity against platelet-derived growth factor-induced cellular proliferation in vitro and intimal proliferation in vivo. The objective of this study was to determine if trapidil could prevent restenosis in experimentally induced atherosclerotic rabbits. New Zealand White rabbi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.3.1089
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:The association of anticardiolipin (aCL) antibodies with coronary artery disease has been shown in several studies but remains controversial. We evaluated the association of aCL and anti-beta(2)-glycoprotein I (abeta(2)GPI) antibodies with the risk of recurrent cardiac events in postinfarction patients. MET...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.cir.102.11.1258
更新日期:2000-09-12 00:00:00
abstract:BACKGROUND:Few data are available on the long-term outcome of patients who undergo laser-assisted balloon angioplasty for recanalization of occluded peripheral arteries. Because the cost of laser angioplasty is high, the value of the method should be carefully analyzed before it can be considered a routine method for r...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.3.787
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. METHODS AND RESULTS:Twenty-one patients were enrolled...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000070596.30552.8B
更新日期:2003-05-13 00:00:00
abstract:BACKGROUND:The regulation of the cardiac neutral endopeptidase (EC 24.10, NEP) that degrades bradykinin and natriuretic peptides has been investigated in human cardiac hypertrophy and heart failure. Methods and Results- NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies f...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0302.103593
更新日期:2002-01-22 00:00:00
abstract::Six instances of sudden death were recorded by Holter monitoring, which showed ventricular fibrillation in five and a bradyarrhythmia in one. Complex ventricular ectopic activity preceded cardiac arrest in five patients, including the one with the bradyarrhythmic arrest. Two patients with chronic bifascicular block ar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.1.218
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:The enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) prevents inappropriate activation of the nonselective mineralocorticoid receptors by glucocorticoids. Renal activity of 11beta-HSD is decreased in patients with apparent mineralocorticoid excess (SAME), licorice-induced hypertension, and essential h...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.25.3129
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:Creation of a complete bidirectional inferior vena cava-tricuspid annulus isthmus block (CBIB) by radiofrequency catheter ablation is now a well-accepted criterion for prevention of common atrial flutter (AFl) recurrences. However, some patients still complain of palpitations after ablation, and it is not kn...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.4.534
更新日期:1999-02-02 00:00:00
abstract:BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.18.2185
更新日期:2000-10-31 00:00:00
abstract::The mosaic of essential hypertension seems to be gaining new tiles at an accelerating rate. Of the many pathophysiological factors and markers for the factors that can be considered as possible elements of a profiling algorithm, there are relatively few with solid data to support their use. Use of plasma renin activit...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1989-12-01 00:00:00
abstract::The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.3.610
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.779
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Our purpose was to use multislice MRI for detection of reversible myocardial ischemia and assessment of the effect of revascularization on tissue perfusion in patients with coronary artery disease. METHODS AND RESULTS:Eleven patients with single-vessel proximal left anterior descending coronary artery disea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.2859
更新日期:1997-11-04 00:00:00
abstract:BACKGROUND:Magnetic resonance (MR)--guided coronary artery stent placement is a challenging vascular intervention because of the small size of the coronary arteries combined with incessant motion during the respiratory and cardiac cycles. These obstacles necessitate higher temporal and higher spatial resolution real-ti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0702.104165
更新日期:2002-02-19 00:00:00
abstract:BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4601.098010
更新日期:2001-11-20 00:00:00
abstract:BACKGROUND:A line of block in the right atrium (RA) between the venae cavae is necessary to obtain classic atrial flutter (AFL). We tested the hypothesis that the location of that line of block would determine whether the AFL reentrant circuit would be due to single-loop reentry or figure-of-8 reentry. METHODS AND RES...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.7.1025
更新日期:2001-02-20 00:00:00
abstract:BACKGROUND:We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population. METHODS AND RESULTS:The WISE sample comprised 589 white and 122 black women who underwent angiograph...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.CIR.0000074207.85796.36
更新日期:2003-07-01 00:00:00
abstract::We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.6.1208
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF pat...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.103.2.220
更新日期:2001-01-16 00:00:00
abstract::Neutrophil activation and infiltration into the ischemic myocardium after reperfusion may limit the amount of salvageable myocardium (reperfusion injury). The effects of intravenous perfluorochemicals (Fluosol-DA) on infarct size, ventricular contractility, and neutrophil function were assessed in an occlusion-reperfu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.3.645
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Health-related quality-of-life instruments have become important measures of early health outcomes after cardiac surgery. The relationship between quality of life after recovery from surgery and subsequent long-term survival has not previously been explored. Our objective was to determine whether the Duke Ac...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.640573
更新日期:2007-02-13 00:00:00
abstract:BACKGROUND:Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.580506
更新日期:2006-02-07 00:00:00
abstract:BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Litt...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.023711
更新日期:2017-09-05 00:00:00
abstract:BACKGROUND:We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. METHODS AND RESULTS:Plasma glucose concentrations were acutely raised...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.19.2247
更新日期:2000-05-16 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) or idiopathic hypertrophic subaortic stenosis (IHSS) has been defined as an autosomal dominant myocardial disease characterized by specific physical findings, echocardiographic features, asymmetric septal hypertrophy and disordered myocardial architecture. Echocardiographic and scinti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.6.901
更新日期:1977-06-01 00:00:00
abstract::This paper provides guidelines for the optimal, rather than minimal, performance of ultrasonic examination of the heart for current clinical applications using conventional echocardiographic equipment. Since the original report of this Inter-Society Commission on Heart Disease Resources Committee in 1975, M-mode echoc...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known. METHODS:We linked adults ≥65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.120.046159
更新日期:2020-07-21 00:00:00
abstract::Platelet function can be assessed by various techniques in vitro or in vivo, but methodological problems in the field are considerable. By use of the conventional in vitro technique (Born aggregometry), it has been shown that sympathoadrenal activation in vivo (e.g., mental stress, epinephrine infusions, exercise, and...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00