Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.

abstract：BACKGROUND:The use of bipolar endocardial electrogram characteristics to guide radiofrequency (RF) current catheter ablation of accessory pathways (APs) has been advocated by several investigators. However, the influences of a varying anatomy of the AP and the atrioventricular groove, of different ablative approaches, ...

journal_title：Circulation

authors： Cappato R,Schlüter M,Mont L,Kuck KH

更新日期：1994-08-01 00:00:00

abstract：:Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac...

journal_title：Circulation

authors： Roberts WC

更新日期：1976-09-01 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：:Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicate...

journal_title：Circulation

authors： Myreng Y,Smiseth OA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The effect of human immunodeficiency virus (HIV) on the development of peripheral artery disease (PAD) remains unclear. We investigated whether HIV infection is associated with an increased risk of PAD after adjustment for traditional atherosclerotic risk factors in a large cohort of HIV-infected (HIV+) and ...

journal_title：Circulation

authors： Beckman JA,Duncan MS,Alcorn CW,So-Armah K,Butt AA,Goetz MB,Tindle HA,Sico JJ,Tracy RP,Justice AC,Freiberg MS

更新日期：2018-07-17 00:00:00

abstract：:To assess whether gross pathologic differences exist between hearts with left bundle branch block (LBBB) and left-axis deviation (LAXD) and those with LBBB and a normal frontal plane axis, we examined 70 hearts with LBBB in a series of 1410 sequential dissections (5%). Thirty-two hearts had LAXD and 34 had normal axes...

journal_title：Circulation

authors： Havelda CJ,Sohi GS,Flowers NC,Horan LG

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction may contribute to the risk of premature atherosclerosis in patients with diabetes. Endothelin (ET-1) may be involved in this process by activating smooth muscle cell mitogenesis and leukocyte adhesion. We sought to assess the activity of endogenous ET-1 in a group of patients with typ...

journal_title：Circulation

authors： Cardillo C,Campia U,Bryant MB,Panza JA

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

journal_title：Circulation

authors： Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...

journal_title：Circulation

authors： Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

更新日期：2005-07-12 00:00:00

abstract：BACKGROUND:The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenovira...

journal_title：Circulation

authors： Pauschinger M,Bowles NE,Fuentes-Garcia FJ,Pham V,Kühl U,Schwimmbeck PL,Schultheiss HP,Towbin JA

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:The excess risk of atherosclerosis among patients with non-insulin dependent diabetes mellitus (NIDDM) is well documented. However, the presence of conventional risk factors cannot fully account for this excess risk, and the underlying mechanism remains to be elucidated. The present study prospectively evalu...

journal_title：Circulation

authors： Austin MA,Mykkänen L,Kuusisto J,Edwards KL,Nelson C,Haffner SM,Pyörälä K,Laakso M

更新日期：1995-10-01 00:00:00

abstract：:Absence of continuity between the heart and the pulmonary arteries has the potential for total correction. When the pulmonary arteries are narrow, a palliative first stage systemic-pulmonary arterial anastomosis serves to enlarge the pulmonary arteries so that, with time, they become of adequate caliber for total corr...

journal_title：Circulation

authors： Todd EP,Lindsay WG,Edwards JE

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. METHODS AND RESULTS:We randomized 70 acute coronary syndrome patients undergoing percu...

journal_title：Circulation

authors： Batchelor WB,Tolleson TR,Huang Y,Larsen RL,Mantell RM,Dillard P,Davidian M,Zhang D,Cantor WJ,Sketch MH Jr,Ohman EM,Zidar JP,Gretler D,DiBattiste PM,Tcheng JE,Califf RM,Harrington RA

更新日期：2002-09-17 00:00:00

abstract：:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...

journal_title：Circulation

authors： Prince MR,LaMuraglia GM,MacNichol EF Jr

更新日期：1988-08-01 00:00:00

abstract：:We have shown previously that the physical properties of myocardium in dogs can be characterized with quantitative ultrasonic integrated backscatter and that interrogation of the tissue with ultrasound can delineate cardiac cycle-dependent changes in ultrasonic backscatter in normal tissue that disappear with ischemia...

journal_title：Circulation

authors： Vered Z,Barzilai B,Mohr GA,Thomas LJ 3rd,Genton R,Sobel BE,Shoup TA,Melton HE,Miller JG,Pérez JE

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:We developed autologous prosthetic implants by simple and safe in-body tissue architecture technology. We present the first report on the development of autologous valved conduit with the sinus of Valsalva (BIOVALVE) by using this unique technology and its subsequent implantation in the pulmonary valves in a...

journal_title：Circulation

authors： Yamanami M,Yahata Y,Uechi M,Fujiwara M,Ishibashi-Ueda H,Kanda K,Watanabe T,Tajikawa T,Ohba K,Yaku H,Nakayama Y

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Very early (day 4) hospital discharge has recently been proposed for selected patients with acute myocardial infarction (MI). The purpose of this study was to determine the most useful factors for identifying acute MI patients treated with aggressive interventional therapy who could be safely discharged on d...

journal_title：Circulation

authors： Mark DB,Sigmon K,Topol EJ,Kereiakes DJ,Pryor DB,Candela RJ,Califf RM

更新日期：1991-04-01 00:00:00

abstract：:High frequency notching of the QRS complex is associated with transmural infarction, cardiomyopathies, and ventricular hypertrophy from any cause. The mechanism producing notching is unknown; but the presence of a discrete anatomic lesion is not an essential feature. The hypothesis that notching was produced by activa...

journal_title：Circulation

authors： Vanderark CR,Reynolds EW

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Patients with primary amyloidosis (AL type) have a poor prognosis, in part due to frequent cardiac involvement. Although intracardiac thrombus has been reported in anecdotal cases, neither its frequency nor its role in causing mortality is known. Furthermore, the clinical and echocardiographic variables that...

journal_title：Circulation

authors： Feng D,Edwards WD,Oh JK,Chandrasekaran K,Grogan M,Martinez MW,Syed IS,Hughes DA,Lust JA,Jaffe AS,Gertz MA,Klarich KW

更新日期：2007-11-20 00:00:00

abstract：:In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...

journal_title：Circulation

authors： Fleet WF,Johnson TA,Graebner CA,Engle CL,Gettes LS

更新日期：1986-04-01 00:00:00

abstract：:Graft failure occurs in a sizeable proportion of coronary artery bypass conduits. We herein review relevant current evidence to give an overview of the incidence, pathophysiology, and clinical consequences of this multifactorial phenomenon. Thrombosis, endothelial dysfunction, vasospasm, and oxidative stress are diffe...

journal_title：Circulation

authors： Gaudino M,Antoniades C,Benedetto U,Deb S,Di Franco A,Di Giammarco G,Fremes S,Glineur D,Grau J,He GW,Marinelli D,Ohmes LB,Patrono C,Puskas J,Tranbaugh R,Girardi LN,Taggart DP,ATLANTIC (Arterial Grafting International Con

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:One of the features of high-risk atherosclerotic plaques is a preponderance of macrophages. Experimental studies with hyperlipidemic rabbits have shown that ultrasmall superparamagnetic particles of iron oxide (USPIOs) accumulate in plaques with a high macrophage content and that this induces magnetic resona...

journal_title：Circulation

authors： Kooi ME,Cappendijk VC,Cleutjens KB,Kessels AG,Kitslaar PJ,Borgers M,Frederik PM,Daemen MJ,van Engelshoven JM

更新日期：2003-05-20 00:00:00

abstract：BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...

journal_title：Circulation

authors： Matt P,Schoenhoff F,Habashi J,Holm T,Van Erp C,Loch D,Carlson OD,Griswold BF,Fu Q,De Backer J,Loeys B,Huso DL,McDonnell NB,Van Eyk JE,Dietz HC,GenTAC Consortium.

更新日期：2009-08-11 00:00:00

abstract：:The radial artery (RA) is a commonly used conduit for coronary artery bypass grafting, and recent studies have demonstrated that it provides superior long-term patency rates to the saphenous vein in most situations. In addition, the RA is also being used with increasing frequency as the access point for coronary angio...

journal_title：Circulation

authors： Mounsey CA,Mawhinney JA,Werner RS,Taggart DP

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：:Although exercise ECG testing has been shown to have important prognostic value after acute myocardial infarction, exercise 201Tl scintigraphy offers several potential advantages, including: 1) increased sensitivity for detecting residual myocardial ischemia; 2) the ability to localize ischemia to a specific area or a...

journal_title：Circulation

authors： Gibson RS,Watson DD

更新日期：1991-09-01 00:00:00

abstract：:To determine whether cardiac transplant rejection can be detected noninvasively with indium-111 (111In)-labeled lymphocytes, we studied 11 dogs with thoracic heterotopic cardiac transplants without immunosuppression and five dogs with transplants treated with cyclosporine (10 mg/kg/day) and prednisone (1 mg/kg/day). A...

journal_title：Circulation

authors： Eisen HJ,Eisenberg SB,Saffitz JE,Bolman RM 3rd,Sobel BE,Bergmann SR

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...

journal_title：Circulation

authors： Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

更新日期：2005-03-01 00:00:00

abstract：:The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 years indicate that obesity, measured by Metropolitan Relative Weight, was a significant indepen...

journal_title：Circulation

authors： Hubert HB,Feinleib M,McNamara PM,Castelli WP

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Epidemiological studies and animal experiments have provided evidence supporting the role of lipid peroxidation in atherogenesis and cardiovascular diseases. Direct evidence linking lipid oxidation to atherosclerotic progression in humans, however, has been lacking. We investigated the association of lipid o...

journal_title：Circulation

authors： Salonen JT,Nyyssönen K,Salonen R,Porkkala-Sarataho E,Tuomainen TP,Diczfalusy U,Björkhem I

更新日期：1997-02-18 00:00:00