Role of functional block extension in lesion-related atrial flutter.

abstract：BACKGROUND:Radiofrequency ablation of type 1 atrial flutter (AF1) has recently evolved toward an anatomically guided procedure directed to isthmuses at the lower part of the right atrium (RA). However, different types of block at these isthmuses may be observed and potentially correlated with different late outcomes. I...

journal_title：Circulation

authors： Poty H,Saoudi N,Nair M,Anselme F,Letac B

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...

journal_title：Circulation

authors： Bell MT,Puskas F,Agoston VA,Cleveland JC Jr,Freeman KA,Gamboni F,Herson PS,Meng X,Smith PD,Weyant MJ,Fullerton DA,Reece TB

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Protease-activated receptor-1 (PAR-1) is the high-affinity receptor for the coagulation protease thrombin. It is expressed by a variety of cell types in the heart, including cardiomyocytes and cardiac fibroblasts. We have shown that tissue factor (TF) and thrombin contribute to infarct size after cardiac isc...

journal_title：Circulation

authors： Pawlinski R,Tencati M,Hampton CR,Shishido T,Bullard TA,Casey LM,Andrade-Gordon P,Kotzsch M,Spring D,Luther T,Abe J,Pohlman TH,Verrier ED,Blaxall BC,Mackman N

更新日期：2007-11-13 00:00:00

abstract：:Postoperative fever and pericardial-pleural reaction, designated postpericardiotomy syndrome (PPS), is a common complication of cardiac surgery involving entry into the pericardium. To determine whether the etiology of PPS is viral or immunologic, we undertook a prospective, triple-blind study of consecutive long-term...

journal_title：Circulation

authors： Engle MA,Zabriskie JB,Senterfit LB,Gay WA Jr,O'Loughlin JE Jr,Ehlers KH

更新日期：1980-12-01 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00

abstract：:One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on 70 clinical, hemodynamic, radiographic, electrocardiographic, ...

journal_title：Circulation

authors： Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity. METHODS AND RESULTS:The in vitro study showed that TRX1 was dose-dependently increased conc...

journal_title：Circulation

authors： Shioji K,Kishimoto C,Nakamura H,Masutani H,Yuan Z,Oka S,Yodoi J

更新日期：2002-09-10 00:00:00

abstract：BACKGROUND:In animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to the rapidity of the decrease in body temperature after resuscitation. Because total liquid ventilation (TLV) with temperature-controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed to dete...

journal_title：Circulation

authors： Chenoune M,Lidouren F,Adam C,Pons S,Darbera L,Bruneval P,Ghaleh B,Zini R,Dubois-Randé JL,Carli P,Vivien B,Ricard JD,Berdeaux A,Tissier R

更新日期：2011-08-23 00:00:00

abstract：:Experimental studies have suggested that electrocardiographic recognition of left ventricular hypertrophy depends on geometric relationships involving wall thickness and chamber size. To determine the clinical significance of these observations, we studied the effects of echocardiographic LV mass (LVM), posterior wall...

journal_title：Circulation

authors： Devereux RB,Phillips MC,Casale PN,Eisenberg RR,Kligfield P

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways potentially involved in atherogenesis. OxLDLs induce smooth muscle cell (SMC) proliferation mediated by the activation of the sphingomyelin/ceramide pathway and tyros...

journal_title：Circulation

authors： Augé N,Maupas-Schwalm F,Elbaz M,Thiers JC,Waysbort A,Itohara S,Krell HW,Salvayre R,Nègre-Salvayre A

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:Ambulatory outpatients (n = 150) with a history of paroxysmal supraventricular arrhythmia were studied to establish the characteristics of the first recurrence of symptomatic tachycardia (time to first recurrence, heart rate during tachycardia, and observed rhythm that was regular versus irregular) when no a...

journal_title：Circulation

authors： Clair WK,Wilkinson WE,McCarthy EA,Page RL,Pritchett EL

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Early defibrillation is the most important intervention affecting survival from sudden cardiac arrest (SCA). To improve public access to early defibrillation, we established Piacenza Progetto Vita (PPV), the first system of out-of-hospital early defibrillation by first-responder volunteers. METHODS AND RESU...

journal_title：Circulation

authors： Capucci A,Aschieri D,Piepoli MF,Bardy GH,Iconomu E,Arvedi M

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined th...

journal_title：Circulation

authors： Rademaker MT,Charles CJ,Lewis LK,Yandle TG,Cooper GJ,Coy DH,Richards AM,Nicholls MG

更新日期：1997-09-16 00:00:00

abstract：BACKGROUND:Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS:Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA w...

journal_title：Circulation

authors： Anderson JL,Horne BD,Stevens SM,Grove AS,Barton S,Nicholas ZP,Kahn SF,May HT,Samuelson KM,Muhlestein JB,Carlquist JF,Couma-Gen Investigators.

更新日期：2007-11-27 00:00:00

abstract：BACKGROUND:prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation. METHODS AND RESULTS:superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) ...

journal_title：Circulation

authors： Yu L,Scherlag BJ,Dormer K,Nguyen KT,Pope C,Fung KM,Po SS

更新日期：2010-12-21 00:00:00

abstract：BACKGROUND:Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS:Using the Get With the Guidelines-Coronary...

journal_title：Circulation

authors： Jneid H,Fonarow GC,Cannon CP,Hernandez AF,Palacios IF,Maree AO,Wells Q,Bozkurt B,Labresh KA,Liang L,Hong Y,Newby LK,Fletcher G,Peterson E,Wexler L,Get With the Guidelines Steering Committee and Investigators.

更新日期：2008-12-16 00:00:00

abstract：:For monotherapy, beta-blockers and calcium-entry blockers are effective and safe antianginal medications. For prophylaxis of myocardial ischemia, a different mechanism of action for each class of drugs is reflected by the different heart rate and rate-pressure product during exercise. In patients who continue to have ...

journal_title：Circulation

authors： Kostuk WJ,Pflugfelder P

更新日期：1987-06-01 00:00:00

abstract：:Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac...

journal_title：Circulation

authors： Roberts WC

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin-aldosterone system is involved in the pathogenesis of atherosclerosis, partially because of its pro-oxidative properties. We questioned the effect and mechanisms of action of administration of aldosterone to apolipoprotein E-deficient (E(0)) mice on their macrophages and aorta oxidative...

journal_title：Circulation

authors： Keidar S,Kaplan M,Pavlotzky E,Coleman R,Hayek T,Hamoud S,Aviram M

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...

journal_title：Circulation

authors： Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:We developed a computer model to predict lysis rates of thrombi for intravenous thrombolytic regimens based on the convective/diffusive penetration of reacting and adsorbing fibrinolytic species from the circulation into the proximal face of a dissolving clot. METHODS AND RESULTS:Solution of a one-compartme...

journal_title：Circulation

authors： Anand S,Diamond SL

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

journal_title：Circulation

authors： Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Despite successful repair of coarctation of the aorta in childhood, adult survivors often have hypertension at rest or on exercise, and their life expectancy is shorter than normal because of premature coronary and cerebrovascular disease. This may be related to persistent structural and functional arterial ...

journal_title：Circulation

authors： Gardiner HM,Celermajer DS,Sorensen KE,Georgakopoulos D,Robinson J,Thomas O,Deanfield JE

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Left ventricular outflow tract obstruction (LVOTO) occurs in 4% to 5% of patients after prosthetic ring mitral valve repair. Major anatomic factors incriminated in the genesis of LVOTO include degenerative mitral valve insufficiency with excess leaflet tissue, nondilated left ventricular cavity, and narrow m...

journal_title：Circulation

authors： Jebara VA,Mihaileanu S,Acar C,Brizard C,Grare P,Latremouille C,Chauvaud S,Fabiani JN,Deloche A,Carpentier A

更新日期：1993-11-01 00:00:00

abstract：:The pulmonary function of ten adult patients with congenital pulmonary valvular stenosis was investigated. The patients clearly showed smaller lungs than healthy control subjects of equivalent age and height; lung elastic recoil pressure was normal at any given percentage of measured total lung capacity, indicating th...

journal_title：Circulation

authors： De Troyer A,Yernault JC,Englert M

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS:In TIMI 10B, 886 patients with acute ST-elevation myocardial in...

journal_title：Circulation

authors： Cannon CP,Gibson CM,McCabe CH,Adgey AA,Schweiger MJ,Sequeira RF,Grollier G,Giugliano RP,Frey M,Mueller HS,Steingart RM,Weaver WD,Van de Werf F,Braunwald E

更新日期：1998-12-22 00:00:00

abstract：BACKGROUND:Current consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but vein quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein h...

journal_title：Circulation

authors： Krishnamoorthy B,Critchley WR,Thompson AJ,Payne K,Morris J,Venkateswaran RV,Caress AL,Fildes JE,Yonan N

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS:We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein ...

journal_title：Circulation

authors： Piccini JP,Hellkamp AS,Washam JB,Becker RC,Breithardt G,Berkowitz SD,Halperin JL,Hankey GJ,Hacke W,Mahaffey KW,Nessel CC,Singer DE,Fox KA,Patel MR

更新日期：2016-01-26 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00