Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia.

abstract：:The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtai...

journal_title：Circulation

authors： Janicki JS

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...

journal_title：Circulation

authors： Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled t...

journal_title：Circulation

authors： Daemen J,Boersma E,Flather M,Booth J,Stables R,Rodriguez A,Rodriguez-Granillo G,Hueb WA,Lemos PA,Serruys PW

更新日期：2008-09-09 00:00:00

abstract：BACKGROUND:Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their ...

journal_title：Circulation

authors： Suzuki K,Smolenski RT,Jayakumar J,Murtuza B,Brand NJ,Yacoub MH

更新日期：2000-11-07 00:00:00

abstract：:Cardiovascular specialists have entered an era of renewed interest and enthusiasm surrounding the diagnosis and treatment of valvular heart disease, driven in part by emerging percutaneous therapies for the treatment of aortic, pulmonic, and mitral valve disease. Despite this wave of investigation, little or no attent...

journal_title：Circulation

authors： Rogers JH,Bolling SF

更新日期：2009-05-26 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with an impairment in exercise performance and muscle function that is not fully explained by the reduced leg blood flow during exercise. This study characterized the effects of PAD on muscle function, histology, and metabolism. METHODS AND RESULTS:Twenty-six ...

journal_title：Circulation

authors： Regensteiner JG,Wolfel EE,Brass EP,Carry MR,Ringel SP,Hargarten ME,Stamm ER,Hiatt WR

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...

journal_title：Circulation

authors： Almond CS,Morales DL,Blackstone EH,Turrentine MW,Imamura M,Massicotte MP,Jordan LC,Devaney EJ,Ravishankar C,Kanter KR,Holman W,Kroslowitz R,Tjossem C,Thuita L,Cohen GA,Buchholz H,St Louis JD,Nguyen K,Niebler RA,Walt

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Lung transplantation and heart-lung transplantation represent surgical options for treatment of medically refractory idiopathic pulmonary arterial hypertension. The effect of the lung allocation score on wait-list and transplantation outcomes in patients with idiopathic pulmonary arterial hypertension is poo...

journal_title：Circulation

authors： Schaffer JM,Singh SK,Joyce DL,Reitz BA,Robbins RC,Zamanian RT,Mallidi HR

更新日期：2013-06-25 00:00:00

abstract：BACKGROUND:Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1 alpha-mediated response to hypoxia associated with aging are poorly understood. Here, we report that swimming trai...

journal_title：Circulation

authors： Cheng XW,Kuzuya M,Kim W,Song H,Hu L,Inoue A,Nakamura K,Di Q,Sasaki T,Tsuzuki M,Shi GP,Okumura K,Murohara T

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:Very early (day 4) hospital discharge has recently been proposed for selected patients with acute myocardial infarction (MI). The purpose of this study was to determine the most useful factors for identifying acute MI patients treated with aggressive interventional therapy who could be safely discharged on d...

journal_title：Circulation

authors： Mark DB,Sigmon K,Topol EJ,Kereiakes DJ,Pryor DB,Candela RJ,Califf RM

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disorder involving inflammatory processes. These responses are associated with robust activation of signaling cascades by diverse cell surface receptors in a variety of cell types. The processes that are involved in atherosclerosis would likely require intact Ras pathways,...

journal_title：Circulation

authors： George J,Afek A,Keren P,Herz I,Goldberg I,Haklai R,Kloog Y,Keren G

更新日期：2002-05-21 00:00:00

abstract：BACKGROUND:Age is a predictor of cognitive dysfunction after cardiac surgery, but the mechanism is unknown. The purpose of our study was to determine whether age-related decrements in cognition are associated with cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB). METHODS AND RESULTS:Cogniti...

journal_title：Circulation

authors： Newman MF,Croughwell ND,Blumenthal JA,White WD,Lewis JB,Smith LR,Frasco P,Towner EA,Schell RM,Hurwitz BJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Residual mural thrombus on severely damaged arterial wall is very thrombogenic. We tested the hypothesis that direct thrombin inhibition will block thrombus growth on fresh thrombus better than indirect thrombin inhibition, cyclooxygenase inhibition, or both. METHODS AND RESULTS:A fresh mural thrombus was f...

journal_title：Circulation

authors： Meyer BJ,Badimon JJ,Mailhac A,Fernández-Ortiz A,Chesebro JH,Fuster V,Badimon L

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...

journal_title：Circulation

authors： Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

更新日期：2014-01-14 00:00:00

abstract：:To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...

journal_title：Circulation

authors： Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KE

更新日期：1990-04-01 00:00:00

abstract：UNLABELLED:BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species production. NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role is unkno...

journal_title：Circulation

authors： Craige SM,Chen K,Pei Y,Li C,Huang X,Chen C,Shibata R,Sato K,Walsh K,Keaney JF Jr

更新日期：2011-08-09 00:00:00

abstract：BACKGROUND:Passive ventricular constraint provides external cardiac support to reduce left ventricular (LV) wall stress and myocardial stretch, which are primary determinants of LV remodeling. Altered wall strain results in cytokine and reactive oxygen species production, which, in turn, stimulates apoptosis and extrac...

journal_title：Circulation

authors： Cheng A,Nguyen TC,Malinowski M,Langer F,Liang D,Daughters GT,Ingels NB Jr,Miller DC

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Adenosine possesses marked cardioprotective properties, but the mechanisms for this beneficial effect are unclear. The objective of this study was to determine the effect of adenosine given before ischemia or at reperfusion on mechanical function, glucose oxidation, glycolysis, and metabolite levels in isola...

journal_title：Circulation

authors： Finegan BA,Lopaschuk GD,Coulson CS,Clanachan AS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Serotonin (5-hydroxytryptamine; 5-HT) overproduction is responsible for cardiac valvular disease in patients with carcinoid tumors. Reduced 5-HT inactivation is one proposed mechanism of the valvulopathy observed in individuals treated with the appetite suppressants fenfluramine and phentermine. One key prot...

journal_title：Circulation

authors： Mekontso-Dessap A,Brouri F,Pascal O,Lechat P,Hanoun N,Lanfumey L,Seif I,Benhaiem-Sigaux N,Kirsch M,Hamon M,Adnot S,Eddahibi S

更新日期：2006-01-03 00:00:00

abstract：:It has been suggested that the beneficial effects of reperfusing ischemic myocardium might be in part reversed by the occurrence of "reperfusion injury." One possible mechanism could be the generation of oxygen free radicals. Superoxide dismutase enzymatically scavenges superoxide radicals by dismutation to hydrogen p...

journal_title：Circulation

authors： Ambrosio G,Weisfeldt ML,Jacobus WE,Flaherty JT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:This study was designed to define myocardial viability and establish practical cut-off values for differentiating normal myocardial tissue from subendocardial and transmural scar tissue by using electromechanical mapping (EMM). We validated our results by delayed-enhancement cardiac MRI (DE-MRI). METHODS AN...

journal_title：Circulation

authors： Perin EC,Silva GV,Sarmento-Leite R,Sousa AL,Howell M,Muthupillai R,Lambert B,Vaughn WK,Flamm SD

更新日期：2002-08-20 00:00:00

abstract：:Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related qu...

journal_title：Circulation

authors： Treat-Jacobson D,McDermott MM,Beckman JA,Burt MA,Creager MA,Ehrman JK,Gardner AW,Mays RJ,Regensteiner JG,Salisbury DL,Schorr EN,Walsh ME,American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular

更新日期：2019-09-24 00:00:00

abstract：BACKGROUND:Retinol-binding protein 4 (RBP4) may play an important role in the origin of insulin resistance and metabolic syndrome. Few prospective data are available on the relationship between RBP4 and coronary heart disease (CHD). Furthermore, previous studies did not distinguish among full-length and truncated forms...

journal_title：Circulation

authors： Sun Q,Kiernan UA,Shi L,Phillips DA,Kahn BB,Hu FB,Manson JE,Albert CM,Rexrode KM

更新日期：2013-05-14 00:00:00

abstract：:Left ventricular ejection fraction (LVEF) was measured by radionuclide angiography at rest and during supine bicycle exercise before and 3 months after coronary artery bypass graft surgery (CABG) in 20 patients with chronic stable angina. The right anterior oblique gated first-pass technique was used to assess LVEF re...

journal_title：Circulation

authors： Lim YL,Kalff V,Kelly MJ,Mason PJ,Currie PJ,Harper RW,Anderson ST,Federman J,Stirling GR,Pitt A

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Worldwide, diabetes mellitus and heart failure represent frequent comorbidities with high socioeconomic impact and steadily growing incidence, calling for a better understanding of how diabetic metabolism promotes cardiac dysfunction. Paradoxically, some glucose-lowering drugs have been shown to worsen heart...

journal_title：Circulation

authors： Kronlage M,Dewenter M,Grosso J,Fleming T,Oehl U,Lehmann LH,Falcão-Pires I,Leite-Moreira AF,Volk N,Gröne HJ,Müller OJ,Sickmann A,Katus HA,Backs J

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Relieving the inhibition of sarcoplasmic reticular function by phospholamban is a major target of beta-adrenergic stimulation. Chronic beta-adrenergic receptor activity has been suggested to be detrimental, on the basis of transgenic overexpression of the receptor or its signaling effectors. However, it is n...

journal_title：Circulation

authors： Dash R,Kadambi V,Schmidt AG,Tepe NM,Biniakiewicz D,Gerst MJ,Canning AM,Abraham WT,Hoit BD,Liggett SB,Lorenz JN,Dorn GW 2nd,Kranias EG

更新日期：2001-02-13 00:00:00

abstract：BACKGROUND:Simvastatin attenuates ischemia and reperfusion in normocholesterolemic animals by stabilizing endothelial nitric oxide synthase activity and inhibiting neutrophil-mediated injury. Because endothelial dysfunction is a detrimental effect of hypercholesterolemia, we examined whether short-term treatment with s...

journal_title：Circulation

authors： Scalia R,Gooszen ME,Jones SP,Hoffmeyer M,Rimmer DM 3rd,Trocha SD,Huang PL,Smith MB,Lefer AM,Lefer DJ

更新日期：2001-05-29 00:00:00

abstract：BACKGROUND:The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain. METHODS AND RESULTS:We analyzed data from a prospective cohort of 754 patients with heart failure who had ejection fractio...

journal_title：Circulation

authors： McAlister FA,Ezekowitz J,Tonelli M,Armstrong PW

更新日期：2004-03-02 00:00:00

abstract：:A longitudinal study was made of 62 patients with dextro-transposition of the great arteries. The patients were managed with balloon atrial septostomy (BAS), palliative surgery if any operation was needed in the first year of life, and Mustard intra-atrial baffle repair after one year of age. Of the 47 patients with i...

journal_title：Circulation

authors： Gutgesell HP,McNamara DG

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The therapeutic benefits that accompany the continuous administration of organic nitrates are attenuated by the development of tolerance to the compounds. Altered superoxide production and NO bioavailability have been implicated in contributing to the development of tolerance, an effect that may be ameliorat...

journal_title：Circulation

authors： McVeigh GE,Hamilton P,Wilson M,Hanratty CG,Leahey WJ,Devine AB,Morgan DG,Dixon LJ,McGrath LT

更新日期：2002-07-09 00:00:00