NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation.

abstract：BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

journal_title：Circulation

authors： Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:Since the atria are thin-walled structures, most studies that have examined the spread of activation in the atria have assumed that they behave electrophysiologically as a two-dimensional surface. It was the objective of this study to determine whether or not this assumption is true by simultaneously mapping...

journal_title：Circulation

authors： Schuessler RB,Kawamoto T,Hand DE,Mitsuno M,Bromberg BI,Cox JL,Boineau JP

更新日期：1993-07-01 00:00:00

abstract：:We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...

journal_title：Circulation

authors： Kenny JF,Plappert T,Doubilet P,Saltzman DH,Cartier M,Zollars L,Leatherman GF,St John Sutton MG

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...

journal_title：Circulation

authors： Takahashi M,Kitagawa S,Masuyama JI,Ikeda U,Kasahara T,Takahashi YI,Furukawa Y,Kano S,Shimada K

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:Although coronary thrombosis plays a critical role in the pathogenesis of unstable angina and non-Q-wave myocardial infarction (NQMI), the effects of thrombolytic therapy in these disorders is not clear. Also, the role of routine early coronary arteriography followed by revascularization has not been establi...

journal_title：Circulation

authors：

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

journal_title：Circulation

authors： Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:The acute effect of atrial fibrillation (AF) on the atrial effective refractory period (ERP) in humans is unknown. METHODS AND RESULTS:In 20 patients without structural heart disease, the atrial ERP was measured before and after pacing-induced AF at drive cycle lengths of 350 and 500 ms. Immediately after s...

journal_title：Circulation

authors： Daoud EG,Bogun F,Goyal R,Harvey M,Man KC,Strickberger SA,Morady F

更新日期：1996-10-01 00:00:00

abstract：:In 15 of 126 (12%) patients with truncus arteriosus who were catheterized at the Mayo Clinic from 1967 through 1975, natural agenesis of one pulmonary artery was present. Ten truncus patients with either natural or acquired absence of one pulmonary artery have undergone definitive operation. The criteria for operabili...

journal_title：Circulation

authors： Mair DD,Ritter DG,Danielson GK,Wallace RB,McGoon DC

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression. METHODS AND RESULTS:Low-density lipoprotein receptor null mice in which Treg express gree...

journal_title：Circulation

authors： Maganto-García E,Tarrio ML,Grabie N,Bu DX,Lichtman AH

更新日期：2011-07-12 00:00:00

abstract：BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...

journal_title：Circulation

authors： Brink PA,Crotti L,Corfield V,Goosen A,Durrheim G,Hedley P,Heradien M,Geldenhuys G,Vanoli E,Bacchini S,Spazzolini C,Lundquist AL,Roden DM,George AL Jr,Schwartz PJ

更新日期：2005-10-25 00:00:00

abstract：BACKGROUND:Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. METHODS AND RESULTS:We examined the relations between echocardiographic LV measurements and glucose tolerance status ...

journal_title：Circulation

authors： Rutter MK,Parise H,Benjamin EJ,Levy D,Larson MG,Meigs JB,Nesto RW,Wilson PW,Vasan RS

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

journal_title：Circulation

authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...

journal_title：Circulation

authors： Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

更新日期：2007-09-18 00:00:00

abstract：:Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...

journal_title：Circulation

authors： Harlan BJ,Ross D,Macmanus Q,Knight R,Luber J,Starr A

更新日期：1978-09-01 00:00:00

abstract：:Cerebral and retinal ischemic events have been described in mitral valve prolapse. To determine whether platelets play a part in the pathogenesis of thromboembolism we studied 29 patients with mitral valve prolapse, including nine (group I) with thromboembolism (cerebral, retinal and deep venous), eight (group II) wit...

journal_title：Circulation

authors： Walsh PN,Kansu TA,Corbett JJ,Savion PJ,Goldburgh WP,Schatz NJ

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET). METHODS AND RESULTS:Myocardial images were obtained after intravenous (18)F-fluorodeoxyglucose (18FDG) in 11 normal rats ...

journal_title：Circulation

authors： Kudo T,Fukuchi K,Annala AJ,Chatziioannou AF,Allada V,Dahlbom M,Tai YC,Inubushi M,Huang SC,Cherry SR,Phelps ME,Schelbert HR

更新日期：2002-07-02 00:00:00

abstract：:Sequential control angiographic examinations were performed at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after aortocoronary saphenous vein bypass surgery in 82 unselected patients. Graft modifications consisting of wall irregularities and obstructive lesions of various severity and shapes that were found to d...

journal_title：Circulation

authors： Campeau L,Enjalbert M,Lespérance J,Vaislic C,Grondin CM,Bourassa MG

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Patients with transfusional iron overload may develop a life-limiting cardiomyopathy. The sensitivity of lipid-metabolizing enzymes to peroxidative injury, as well as the reported effects of arachidonic acid (AA) and metabolites on cardiac rhythm, led us to hypothesize that iron-overloaded cardiomyocytes dis...

journal_title：Circulation

authors： Mattera R,Stone GP,Bahhur N,Kuryshev YA

更新日期：2001-05-15 00:00:00

abstract：BACKGROUND:From animal studies it emerged that nitric oxide is important for the modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the pressor-dependent mechanism (mechanoregulation). This hypothesis was tested in 18 healthy subjects. METHODS AND RESULTS:Peak velocity (PV), diastolic vel...

journal_title：Circulation

authors： Lavi S,Egbarya R,Lavi R,Jacob G

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....

journal_title：Circulation

authors： Gepstein L,Hayam G,Shpun S,Ben-Haim SA

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with co...

journal_title：Circulation

authors： Ndrepepa G,Braun S,Niemöller K,Mehilli J,von Beckerath N,von Beckerath O,Vogt W,Schömig A,Kastrati A

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:Pain triggers a homeostatic alarm reaction to injury. It remains unknown, however, whether nociceptive signaling activated by ischemia is relevant for progenitor cells (PC) release from bone marrow. To this end, we investigated the role of the neuropeptide substance P (SP) and cognate neurokinin 1 (NK1) noci...

journal_title：Circulation

authors： Amadesi S,Reni C,Katare R,Meloni M,Oikawa A,Beltrami AP,Avolio E,Cesselli D,Fortunato O,Spinetti G,Ascione R,Cangiano E,Valgimigli M,Hunt SP,Emanueli C,Madeddu P

更新日期：2012-04-10 00:00:00

abstract：BACKGROUND:Supply of sulfhydryl groups with the administration of N-acetylcysteine (NAC) has been reported to reverse tolerance to nitroglycerin but not to isosorbide dinitrate (ISDN). Lack of interaction between NAC and ISDN was suggested as an explanation for these findings. The present study was therefore designed t...

journal_title：Circulation

authors： Mehra A,Shotan A,Ostrzega E,Hsueh W,Vasquez-Johnson J,Elkayam U

更新日期：1994-06-01 00:00:00

abstract：:An external cardiac pacemaker-monitor has been developed that provides safe, effective noninvasive ventricular stimulation that is well tolerated in conscious patients and allows clear recognition of electrocardiographic response. The noninvasive temporary pacemaker (NTP) has now been applied in 134 patients in five h...

journal_title：Circulation

authors： Zoll PM,Zoll RH,Falk RH,Clinton JE,Eitel DR,Antman EM

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Abciximab is very effective in reducing major cardiac events in patients undergoing interventional procedures. Its antithrombotic effect is primarily attributable to the blocking of platelet glycoprotein IIb/IIIa receptors, but recent evidence suggests that it may have a direct antithrombin effect. No data a...

journal_title：Circulation

authors： Merlini PA,Repetto A,Lombardi A,Vetrano A,Fetiveau R,Cavallini C,Sappè D,Salvioni A,Canziani R,Savonitto S,Mannucci PM,Ardissino D

更新日期：2002-02-26 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) can cause an oxidative modification of nucleotides, such as 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), which can lead to defects in DNA replication. The misincorporation of 8-oxo-dGTP into DNA is prevented by 8-oxo-dGTPase, which hydrolyzes 8-oxo-dGTP into 8-oxo-...

journal_title：Circulation

authors： Tsutsui H,Ide T,Shiomi T,Kang D,Hayashidani S,Suematsu N,Wen J,Utsumi H,Hamasaki N,Takeshita A

更新日期：2001-12-11 00:00:00

abstract：BACKGROUND:Television viewing time, the predominant leisure-time sedentary behavior, is associated with biomarkers of cardiometabolic risk, but its relationship with mortality has not been studied. We examined the associations of prolonged television viewing time with all-cause, cardiovascular disease (CVD), cancer, an...

journal_title：Circulation

authors： Dunstan DW,Barr EL,Healy GN,Salmon J,Shaw JE,Balkau B,Magliano DJ,Cameron AJ,Zimmet PZ,Owen N

更新日期：2010-01-26 00:00:00

abstract：BACKGROUND:Recently, it was reported that the degree of microvascular injury and left ventricular functional recovery during the chronic period can be predicted after treatment of the infarct-related artery based on the coronary flow velocity (CFV) pattern assessed using a Doppler guidewire. The aim of this prospective...

journal_title：Circulation

authors： Yamamuro A,Akasaka T,Tamita K,Yamabe K,Katayama M,Takagi T,Morioka S

更新日期：2002-12-10 00:00:00

abstract：BACKGROUND:Insulin sensitivity varies up to threefold in apparently healthy individuals, but the mechanism for this is unknown. We have examined the hypothesis that vascular endothelial nitric oxide production and insulin sensitivity are directly related in humans. METHODS AND RESULTS:Nineteen healthy male subjects we...

journal_title：Circulation

authors： Petrie JR,Ueda S,Webb DJ,Elliott HL,Connell JM

更新日期：1996-04-01 00:00:00

abstract：:We used a canine preparation of experimental infarction to study the natural course of echocardiographically defined regional wall motion abnormalities in the 6 weeks after acute coronary ligation. Eight dogs underwent serial short-axis echocardiographic evaluation and microsphere blood flow determinations at control,...

journal_title：Circulation

authors： Gibbons EF,Hogan RD,Franklin TD,Nolting M,Weyman AE

更新日期：1985-02-01 00:00:00