Prognostic value of N-terminal pro-brain natriuretic peptide in patients with chronic stable angina.

Abstract:

BACKGROUND:Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with coronary stenting. METHODS AND RESULTS:Plasma levels of NT-proBNP were measured in 1059 patients with chronic stable angina and coronary angiographic confirmation of significant coronary artery disease. The primary end point of the study was mortality. After a median of 3.6 years (interquartile range, 3.3 to 4.5 years), there were 106 deaths. Kaplan-Meier estimates of 5-year mortality were 4.7% in the first quartile, 7.8% in the second quartile, 11.4% in the third quartile, and 32.7% in the fourth quartile of NT-proBNP (P<0.001). A Cox proportional hazards model showed that NT-proBNP was the strongest correlate of mortality (adjusted hazards ratio [HR], 5.83 [95% confidence interval: 2.07 to 16.44] for the fourth versus the first quartile). A similar prognostic value of NT-proBNP was demonstrated for cardiovascular mortality (HR, 5.98 [1.55 to 23.13] for the fourth versus the first quartile) and for patients with New York Heart Association class I and II (HR, 6.03 [2.07 to 17.52] for the fourth versus the first quartile). CONCLUSIONS:Circulating levels of NT-proBNP are a strong prognostic biomarker for patients with chronic stable angina.

journal_name

Circulation

journal_title

Circulation

authors

Ndrepepa G,Braun S,Niemöller K,Mehilli J,von Beckerath N,von Beckerath O,Vogt W,Schömig A,Kastrati A

doi

10.1161/CIRCULATIONAHA.105.550715

subject

Has Abstract

pub_date

2005-10-04 00:00:00

pages

2102-7

issue

14

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.105.550715

journal_volume

112

pub_type

杂志文章
  • Body-surface maps of heart potentials: tentative localization of pre-excited areas in forty-two Wolff-Parkinson-White patients.

    abstract::Heart potentials were recorded from the entire chest surface in 42 patients suffering from Wolff-Parkinson-White syndrome. We were able to identify six types of surface maps, according to the location of the potential maximum and minimum during the delta wave. For each of these types we suggested the most likely locat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.54.2.251

    authors: De Ambroggi L,Taccardi B,Macchi E

    更新日期:1976-08-01 00:00:00

  • The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials.

    abstract:BACKGROUND:Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular ...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/CIRCULATIONAHA.119.043052

    authors: Neelakantan N,Seah JYH,van Dam RM

    更新日期:2020-03-10 00:00:00

  • Management of Intraprocedural Anticoagulation in Patients on Non-Vitamin K Antagonist Oral Anticoagulants Undergoing Catheter Ablation for Atrial Fibrillation: Understanding the Gaps in Evidence.

    abstract::Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboem...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.117.033326

    authors: Martin AC,Godier A,Narayanan K,Smadja DM,Marijon E

    更新日期:2018-08-07 00:00:00

  • Effect of intense angiotensin II suppression on the diuretic response to furosemide during chronic ACE inhibition.

    abstract:BACKGROUND:Contrary to expectation, most studies have demonstrated that initiation of an angiotensin-converting enzyme (ACE) inhibitor in conventional doses in patients with heart failure reduces the diuretic efficacy of furosemide. Recently, it has been suggested that single low doses (1 mg) but not high doses (25 mg)...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.90.1.220

    authors: Good JM,Brady AJ,Noormohamed FH,Oakley CM,Cleland JG

    更新日期:1994-07-01 00:00:00

  • Application of the American Heart Association/American College of Sports Medicine Adult Preparticipation Screening Checklist to a nationally representative sample of US adults aged >=40 years from the National Health and Nutrition Examination Survey 2001

    abstract:BACKGROUND:Although the American Heart Association/American College of Sports Medicine's Preparticipation Questionnaire (AAPQ) is a recommended preexercise cardiovascular screening tool, it has never been systematically evaluated. The purpose of this research is to provide preliminary evidence of its effectiveness amon...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.004160

    authors: Whitfield GP,Pettee Gabriel KK,Rahbar MH,Kohl HW 3rd

    更新日期:2014-03-11 00:00:00

  • Mobilization of endothelial progenitor cells in patients with acute myocardial infarction.

    abstract:BACKGROUND:Endothelial progenitor cells (EPCs) circulate in adult peripheral blood (PB) and contribute to neovascularization. However, little is known regarding whether EPCs and their putative precursor, CD34-positive mononuclear cells (MNC(CD34+)), are mobilized into PB in acute ischemic events in humans. METHODS AND...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc2301.092122

    authors: Shintani S,Murohara T,Ikeda H,Ueno T,Honma T,Katoh A,Sasaki K,Shimada T,Oike Y,Imaizumi T

    更新日期:2001-06-12 00:00:00

  • Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group.

    abstract:BACKGROUND:Recognition of the complex pathophysiology of heart failure and its high mortality has emphasized the need for prognostic markers that can be used in clinical assessment as well as in the design of mortality trials. Data from the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Cohn JN,Johnson GR,Shabetai R,Loeb H,Tristani F,Rector T,Smith R,Fletcher R

    更新日期:1993-06-01 00:00:00

  • Targeting patients undergoing angioplasty for thrombus inhibition: a cost-effectiveness and decision support model.

    abstract:BACKGROUND:In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to receive antiplatelet therapy. METHODS AND RESULTS:All 4962 patient...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.4.392

    authors: Weintraub WS,Thompson TD,Culler S,Boccuzzi SJ,Becker ER,Kosinski AS,Mahoney E

    更新日期:2000-07-25 00:00:00

  • Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study.

    abstract::Experimental studies have shown that among dogs with a healed myocardial infarction, depressed baroreflex sensitivity (BRS) identifies a subgroup at higher risk for sudden death. We have examined the relation among BRS, several clinical cardiovascular variables, and subsequent mortality in 78 patients below the age of...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.78.4.816

    authors: La Rovere MT,Specchia G,Mortara A,Schwartz PJ

    更新日期:1988-10-01 00:00:00

  • Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest.

    abstract::An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.54.2.193

    authors: Hearse DJ,Stewart DA,Braimbridge MV

    更新日期:1976-08-01 00:00:00

  • Effect of the ouabain-quinidine interaction on left ventricular and left atrial function in conscious dogs.

    abstract::The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p less than 0.05) increased LV dP/dt,...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.67.5.1054

    authors: Goldman S,Hager WD,Olajos M,Perrier D,Mayersohn M

    更新日期:1983-05-01 00:00:00

  • Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?

    abstract:BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

    更新日期:1996-11-01 00:00:00

  • High-resolution intravascular magnetic resonance imaging: monitoring of plaque formation in heritable hyperlipidemic rabbits.

    abstract:BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.8.1054

    authors: Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

    更新日期:1999-03-02 00:00:00

  • Prevalence and risk factors for pulmonary arterial hypertension in a large group of β-thalassemia patients using right heart catheterization: a Webthal study.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) remains a concern in patients with β-thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and risk factors using systematic confirmation on right heart catheterization are lacking. METHODS AND RESULTS:This was a multicenter cross-sectio...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.113.002124

    authors: Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

    更新日期:2014-01-21 00:00:00

  • The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury.

    abstract:BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.080275

    authors: Smith PD,Puskas F,Meng X,Lee JH,Cleveland JC Jr,Weyant MJ,Fullerton DA,Reece TB

    更新日期:2012-09-11 00:00:00

  • Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise.

    abstract:BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.96.8.2534

    authors: Niebauer J,Hambrecht R,Velich T,Hauer K,Marburger C,Kälberer B,Weiss C,von Hodenberg E,Schlierf G,Schuler G,Zimmermann R,Kübler W

    更新日期:1997-10-21 00:00:00

  • De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs.

    abstract::Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.52.6.1152

    authors: James TN,Robertson BT,Waldo AL,Branch CE

    更新日期:1975-12-01 00:00:00

  • Blood oxygenation level-dependent magnetic resonance imaging of the skeletal muscle in patients with peripheral arterial occlusive disease.

    abstract:BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.605717

    authors: Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

    更新日期:2006-06-27 00:00:00

  • Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.

    abstract:BACKGROUND:Nitric oxide (NO)-mediated local regulation of vascular tone is considered to involve endothelial NO synthase (eNOS). However, we recently reported that human forearm basal microvascular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcholine-stimulated reduction i...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.822205

    authors: Seddon M,Melikian N,Dworakowski R,Shabeeh H,Jiang B,Byrne J,Casadei B,Chowienczyk P,Shah AM

    更新日期:2009-05-26 00:00:00

  • Waiting list mortality among children listed for heart transplantation in the United States.

    abstract:BACKGROUND:Children listed for heart transplantation face the highest waiting list mortality in solid-organ transplantation medicine. We examined waiting list mortality since the pediatric heart allocation system was revised in 1999 to determine whether the revised allocation system is prioritizing patients optimally a...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.108.815712

    authors: Almond CSD,Thiagarajan RR,Piercey GE,Gauvreau K,Blume ED,Bastardi HJ,Fynn-Thompson F,Singh TP

    更新日期:2009-02-10 00:00:00

  • Accuracy of volume measurement by conductance catheter in isolated, ejecting canine hearts.

    abstract::We evaluated the accuracy of the recently reported technique of estimating intraventricular volume by measurement of intracavitary electrical conductance in six isolated, ejecting, canine left ventricles. Left ventricular volumes were measured directly by a previously validated servosystem that employed an electrocond...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.2.440

    authors: Burkhoff D,van der Velde E,Kass D,Baan J,Maughan WL,Sagawa K

    更新日期:1985-08-01 00:00:00

  • Incidence, Microbiology, and Outcomes in Patients Hospitalized With Infective Endocarditis.

    abstract:BACKGROUND:Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes in the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective en...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044913

    authors: Shah ASV,McAllister DA,Gallacher P,Astengo F,Rodríguez Pérez JA,Hall J,Lee KK,Bing R,Anand A,Nathwani D,Mills NL,Newby DE,Marwick C,Cruden NL

    更新日期:2020-06-23 00:00:00

  • The effects of coronary angioplasty and reperfusion on distribution of myocardial flow.

    abstract::To assess the effects of angioplasty (PTCA) and intracoronary streptokinase (ICSK) on relative myocardial perfusion, we administered 99mTc-macroaggregated albumin (MAA) to the uninvolved coronary artery before successful PTCA in 33 patients and before successful infusion of ICSK in eight patients and of 111In-MAA into...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.2.334

    authors: Wahr DW,Ports TA,Botvinick EH,Dae M,Schechtmann N,Huberty J,Hattner RS,O'Connell JW,Turley K

    更新日期:1985-08-01 00:00:00

  • Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40.

    abstract:BACKGROUND:Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction system of mammals. To determine the role of Cx40, we correlated cardiac activation with Connexin distribution in normal and Cx40-deficient mice hearts. METHODS AND RESULTS:Epicardial and septal activation was ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.11.1591

    authors: van Rijen HV,van Veen TA,van Kempen MJ,Wilms-Schopman FJ,Potse M,Krueger O,Willecke K,Opthof T,Jongsma HJ,de Bakker JM

    更新日期:2001-03-20 00:00:00

  • Lysophosphatidylcholine and reactive oxygen species mediate the synergistic effect of mildly oxidized LDL with serotonin on vascular smooth muscle cell proliferation.

    abstract:BACKGROUND:Mild oxidation of LDL enhances its atherogenic potential and induces a synergistic interaction with serotonin (5HT) on vascular smooth muscle cell (VSMC) proliferation. Because of its complex chemical nature, the mitogenic components of mildly oxidized LDL (moxLDL) remain unclear. METHODS AND RESULTS:We exa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.10.1440

    authors: Watanabe T,Pakala R,Koba S,Katagiri T,Benedict CR

    更新日期:2001-03-13 00:00:00

  • Circus movement in the canine atrium around the tricuspid ring during experimental atrial flutter and during reentry in vitro.

    abstract::A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.76.5.1155

    authors: Frame LH,Page RL,Boyden PA,Fenoglio JJ Jr,Hoffman BF

    更新日期:1987-11-01 00:00:00

  • TNK-tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction: results of the TIMI 10B trial. Thrombolysis in Myocardial Infarction (TIMI) 10B Investigators.

    abstract:BACKGROUND:Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS:In TIMI 10B, 886 patients with acute ST-elevation myocardial in...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.98.25.2805

    authors: Cannon CP,Gibson CM,McCabe CH,Adgey AA,Schweiger MJ,Sequeira RF,Grollier G,Giugliano RP,Frey M,Mueller HS,Steingart RM,Weaver WD,Van de Werf F,Braunwald E

    更新日期:1998-12-22 00:00:00

  • Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus.

    abstract:BACKGROUND:We explored whether chronic hyperglycemia is associated with defects in endothelium-dependent vasodilatation in vivo and whether defects in the hemodynamic effects of insulin explain insulin resistance. METHODS AND RESULTS:Vasodilator responses to brachial artery infusions of acetylcholine, sodium nitroprus...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.6.1276

    authors: Mäkimattila S,Virkamäki A,Groop PH,Cockcroft J,Utriainen T,Fagerudd J,Yki-Järvinen H

    更新日期:1996-09-15 00:00:00

  • Prospective study of a self-report type A scale and risk of coronary heart disease: test of the MMPI-2 type A scale.

    abstract:BACKGROUND:Several methods exist by which to assess type A behavior (TAB). Although the videotaped clinical interview is regarded as the "gold standard," self-report measures have also proved useful in assessing TAB in large population studies. The purpose of this study was to examine prospectively the relationship of ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.5.405

    authors: Kawachi I,Sparrow D,Kubzansky LD,Spiro A 3rd,Vokonas PS,Weiss ST

    更新日期:1998-08-04 00:00:00

  • Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice.

    abstract:BACKGROUND:Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000028811.03056.bf

    authors: Arkenbout EK,de Waard V,van Bragt M,van Achterberg TA,Grimbergen JM,Pichon B,Pannekoek H,de Vries CJ

    更新日期:2002-09-17 00:00:00