Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study.

Abstract:

:Experimental studies have shown that among dogs with a healed myocardial infarction, depressed baroreflex sensitivity (BRS) identifies a subgroup at higher risk for sudden death. We have examined the relation among BRS, several clinical cardiovascular variables, and subsequent mortality in 78 patients below the age of 65 years who have had a first myocardial infarction. BRS was assessed by calculating the regression line relating phenylephrine-induced increases in systolic blood pressure to the attendant changes in the RR interval. A reduced BRS primarily reflects an impairment in the vagal efferent component of the baroreceptor reflexes. The BRS of the entire population was 7.8 +/- 4.9 msec/mm Hg. BRS was lower among patients with an inferior myocardial infarction (6.1 +/- 3.3 vs. 8.9 +/- 5.8 msec/mm Hg, p = 0.03), with a three- versus a one-vessel disease (4.8 +/- 2.7 vs. 7.1 +/- 3.1 msec/mm Hg, p = 0.04), and with episodes of ventricular tachycardia (5.1 +/- 3.0 vs. 8.3 +/- 5.1, p = 0.03). There was no correlation between BRS and left ventricular ejection fraction or with mean pulmonary capillary wedge pressure at peak exercise, but a correlation (r = 0.35, p less than 0.001) was present with exercise tolerance. During the 24 months mean follow-up period, there were six cardiovascular deaths (7.6%), and four were sudden.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Circulation

journal_title

Circulation

authors

La Rovere MT,Specchia G,Mortara A,Schwartz PJ

doi

10.1161/01.cir.78.4.816

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

816-24

issue

4

eissn

0009-7322

issn

1524-4539

journal_volume

78

pub_type

杂志文章
  • Cardiac hypertrophy and failure--a disease of adaptation. Modifications in membrane proteins provide a molecular basis for arrhythmogenicity.

    abstract::Cardiac hypertrophy is the physiological adaptation of the heart to chronic mechanical overload. Cardiac failure indicates the limits of the process. Cardiac hypertrophy is only one example of biological adaptation and results from the induction of several changes in gene expression, mostly of the fetal type, includin...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Moalic JM,Charlemagne D,Mansier P,Chevalier B,Swynghedauw B

    更新日期:1993-05-01 00:00:00

  • Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia.

    abstract::The relation between ventricular dysrhythmia during the first 20 hours after hospitalization for acute myocardial infarction and enzymatically estimated infarct size was studied prospectively. The duration of dyshythmia was measured by the total time during which the average premature ventricular depolarization (PVC) ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Cox JR Jr,Roberts R,Ambos HD,Oliver GC,Sobel BE

    更新日期:1976-03-01 00:00:00

  • Temporal relation between ischemic episodes and activation of the coagulation system in unstable angina.

    abstract:BACKGROUND:Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation be...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.12.2121

    authors: Biasucci LM,Liuzzo G,Caligiuri G,Quaranta G,Andreotti F,Sperti G,van de Greef W,Rebuzzi AG,Kluft C,Maseri A

    更新日期:1996-06-15 00:00:00

  • Interlesion dependence of the risk for restenosis in patients with coronary stent placement in in multiple lesions.

    abstract:BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.97.24.2396

    authors: Kastrati A,Schömig A,Elezi S,Schühlen H,Wilhelm M,Dirschinger J

    更新日期:1998-06-23 00:00:00

  • Esophageal Injury and Atrioesophageal Fistula Caused by Ablation for Atrial Fibrillation.

    abstract::Esophageal perforation is a dreaded complication of atrial fibrillation ablation that occurs in 0.1% to 0.25% of atrial fibrillation ablation procedures. Delayed diagnosis is associated with the development of atrial-esophageal fistula (AEF) and increased mortality. The relationship between the esophagus and the left ...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.117.025827

    authors: Kapur S,Barbhaiya C,Deneke T,Michaud GF

    更新日期:2017-09-26 00:00:00

  • Comparative effects of nitroglycerin, nifedipine and metoprolol on regional left ventricular function in patients with one-vessel coronary disease.

    abstract::To compare acute effects of nitroglycerin (0.8 mg sublingually), nifedipine (5 ng/kg/min i.v.) and metoprolol (0.15 mg/kg i.v.) on normal, ischemic and scarred myocardial segments in man, we performed simultaneous hemodynamic and radionuclide measurements of left ventricular functions. Sixteen patients with isolated l...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.67.2.291

    authors: Pfisterer M,Glaus L,Burkart F

    更新日期:1983-02-01 00:00:00

  • Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study.

    abstract:BACKGROUND:Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques has not been studied. Our hypothesis was that the lowest values of ESS are responsible for the development of high-risk c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.695254

    authors: Chatzizisis YS,Jonas M,Coskun AU,Beigel R,Stone BV,Maynard C,Gerrity RG,Daley W,Rogers C,Edelman ER,Feldman CL,Stone PH

    更新日期:2008-02-26 00:00:00

  • External beam radiation to prevent restenosis after superficial femoral artery balloon angioplasty.

    abstract:BACKGROUND:Femoropopliteal percutaneous transluminal angioplasty (PTA) remains limited by restenosis. Although vascular brachytherapy may be effective in reducing restenosis, external beam radiation would be more practical to administer after PTA. METHODS AND RESULTS:After femoropopliteal PTA without stent placement, ...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.104.502179

    authors: Therasse E,Donath D,Lespérance J,Tardif JC,Guertin MC,Oliva VL,Soulez G

    更新日期:2005-06-21 00:00:00

  • Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on

    abstract::Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.190769

    authors: Lichtman JH,Bigger JT Jr,Blumenthal JA,Frasure-Smith N,Kaufmann PG,Lespérance F,Mark DB,Sheps DS,Taylor CB,Froelicher ES,American Heart Association Prevention Committee of the Council on Cardiovascular Nursing.,American Heart Assoc

    更新日期:2008-10-21 00:00:00

  • Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia.

    abstract:BACKGROUND:We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. METHODS AND RESULTS:Plasma glucose concentrations were acutely raised...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.19.2247

    authors: Marfella R,Esposito K,Giunta R,Coppola G,De Angelis L,Farzati B,Paolisso G,Giugliano D

    更新日期:2000-05-16 00:00:00

  • Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.

    abstract::Iron catalysis is involved in oxygen-derived free radical generation and subsequent lipid peroxidation, which have been reported to occur during cardiopulmonary bypass in humans. We assessed the effects of the iron chelator deferoxamine on the susceptibility of circulating low density lipoproteins (LDLs) to induced pe...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Menasché P,Antebi H,Alcindor LG,Teiger E,Perez G,Giudicelli Y,Nordmann R,Piwnica A

    更新日期:1990-11-01 00:00:00

  • Plasma and lipoprotein cholesterol and triglyceride concentrations in the Pima Indians: distributions differing from those of Caucasians.

    abstract::Plasma and lipoprotein cholesterol and triglyceride concentrations were measured in Pima Indians, a genetically homogeneous population with a high prevalence of obesity and diabetes and a low frequency of coronary heart disease. The data for nondiabetic Pima Indians were compared with those of U.S. Caucasians measured...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.68.4.714

    authors: Howard BV,Davis MP,Pettitt DJ,Knowler WC,Bennett PH

    更新日期:1983-10-01 00:00:00

  • Wolff-Parkinson-White syndrome. The problem, evaluation, and surgical correction.

    abstract::Physiological studies of the type we have described, when performed in patients with the WPW syndrome, can yield diagnostic information regarding the mechanism of arrhythmia, demonstrate functional properties of therapeutic import, facilitate therapeutic decision-making about drug regimens and presumptively localize t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.51.5.767

    authors: Gallagher JJ,Gilbert M,Svenson RH,Sealy WC,Kasell J,Wallace AG

    更新日期:1975-05-01 00:00:00

  • Kinetics of electrophysiologic changes during oral loading of amiodarone and after withdrawal of amiodarone in the unsedated dog.

    abstract::We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs (n = 8). Right atrial (RA), atrioventricular nodal (AVN), and right ventricular (RV) effective refractory period (ERP), and AVN functional ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.6.1380

    authors: Tuna IC,Qi AC,Gornick C,Bolman RM 3rd,Benditt DG

    更新日期:1985-12-01 00:00:00

  • Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes.

    abstract:BACKGROUND:Thrombus formation within a coronary vessel is the acute precipitating event in most acute coronary syndromes. Recently, constitutive nitric oxide synthase (cNOS) has been identified in human platelets, and platelet-derived nitric oxide has been shown to inhibit platelet recruitment after aggregation. Howeve...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.15.1481

    authors: Freedman JE,Ting B,Hankin B,Loscalzo J,Keaney JF Jr,Vita JA

    更新日期:1998-10-13 00:00:00

  • Singlet oxygen-induced arrhythmias. Dose- and light-response studies for photoactivation of rose bengal in the rat heart.

    abstract::In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,00...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.5.1432

    authors: Kusama Y,Bernier M,Hearse DJ

    更新日期:1989-11-01 00:00:00

  • Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia.

    abstract:BACKGROUND:Right ventricular free wall (RVFW) ischemia impairs global RV performance and may result in acute hemodynamic compromise. However, RV function and hemodynamic performance typically improve spontaneously over time. This study was designed to determine whether reperfusion facilitates recovery of function in th...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.90.3.1398

    authors: Laster SB,Ohnishi Y,Saffitz JE,Goldstein JA

    更新日期:1994-09-01 00:00:00

  • Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.

    abstract:BACKGROUND:In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhag...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.119.040713

    authors: Johnston SC,Elm JJ,Easton JD,Farrant M,Barsan WG,Kim AS,Lindblad AS,Palesch YY,Zurita KG,Albers GW,Cucchiara BL,Kleindorfer DO,Lutsep HL,Pearson C,Sethi P,Vora N,POINT and Neurological Emergencies Treatment Trials Network

    更新日期:2019-08-20 00:00:00

  • A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

    abstract:BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.042178

    authors: Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

    更新日期:2020-01-21 00:00:00

  • Platelet accumulation in experimental angioplasty: time course and relation to vascular injury.

    abstract::Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.75.3.636

    authors: Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

    更新日期:1987-03-01 00:00:00

  • Effect of sympathoinhibition on exercise performance in patients with heart failure.

    abstract:BACKGROUND:In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition wit...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.96.1.238

    authors: Lang CC,Rayos GH,Chomsky DB,Wood AJ,Wilson JR

    更新日期:1997-07-01 00:00:00

  • The reversibility of canine vein-graft arterialization.

    abstract::We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

    更新日期:1990-11-01 00:00:00

  • Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function.

    abstract:BACKGROUND:Central aortic pressures and waveform convey important information about cardiovascular status, but direct measurements are invasive. Peripheral pressures can be measured noninvasively, and although they often differ substantially from central pressures, they may be mathematically transformed to approximate ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.7.1827

    authors: Chen CH,Nevo E,Fetics B,Pak PH,Yin FC,Maughan WL,Kass DA

    更新日期:1997-04-01 00:00:00

  • Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model.

    abstract:BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.699264

    authors: Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

    更新日期:2007-09-04 00:00:00

  • Sex differences in perioperative and long-term cardiac event-free survival in vascular surgery patients. An analysis of clinical and scintigraphic variables.

    abstract:BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.4.1044

    authors: Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

    更新日期:1995-02-15 00:00:00

  • Blood flow in sequential vein grafts.

    abstract::In 69 patients undergoing coronary artery bypass grafting for complete coronary revascularization, blood flow was measured in 140 grafts with 243 distal anastomoses (3.52 bypasses/patient). Total blood flow in single grafts and double and triple sequential grafts did not differ significantly, although mean distal flow...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.60.2.33

    authors: McNamara JJ,Bjerke HS,Chung GK,Dang CR

    更新日期:1979-08-01 00:00:00

  • Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial.

    abstract::The Beta-Blocker Heart Attack Trial was a multicenter, randomized, double-blind, placebo-controlled trial of propranolol therapy in 3837 men and women with acute myocardial infarction. The patients began their treatment 5-21 days after hospital admission (mean 13.8 days). During an average follow-up of 25 months, ther...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Goldstein S

    更新日期:1983-06-01 00:00:00

  • Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.

    abstract:BACKGROUND:Estradiol (E2) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown. METHODS AND RESULTS:In response to E2, mig...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.631465

    authors: Hamada H,Kim MK,Iwakura A,Ii M,Thorne T,Qin G,Asai J,Tsutsumi Y,Sekiguchi H,Silver M,Wecker A,Bord E,Zhu Y,Kishore R,Losordo DW

    更新日期:2006-11-21 00:00:00

  • Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior beta-adrenergic blockade. ISAM Study Group.

    abstract::The time of acute myocardial infarction was determined in all 1,741 patients of the ISAM (Intravenous Streptokinase in Acute Myocardial Infarction) Study, based on onset of clinical symptoms and evaluation of plasma CK-MB enzyme time-activity curves. The incidence of myocardial infarction was markedly increased betwee...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.4.853

    authors: Willich SN,Linderer T,Wegscheider K,Leizorovicz A,Alamercery I,Schröder R

    更新日期:1989-10-01 00:00:00

  • Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits.

    abstract:BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.22.2254

    authors: Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

    更新日期:1999-11-30 00:00:00