Blood flow in sequential vein grafts.

abstract：BACKGROUND:Acute coronary ischemia is usually initiated by rupture of atherosclerotic plaque, leading to intracoronary thrombosis and clinical sequelae. The proximate cause of plaque rupture is unknown. Accordingly, we investigated the potential role of the 92-kD gelatinase member of the matrix metalloproteinase family...

journal_title：Circulation

authors： Brown DL,Hibbs MS,Kearney M,Loushin C,Isner JM

更新日期：1995-04-15 00:00:00

abstract：:A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotr...

journal_title：Circulation

authors： Moss J,Fahmy NR,Sunder N,Beaven MA

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor-initiated phenotypes. Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and rabbits...

journal_title：Circulation

authors： Chatterjee S,Bedja D,Mishra S,Amuzie C,Avolio A,Kass DA,Berkowitz D,Renehan M

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:The present study was designed to define the prevalence and characteristics of skeletal muscle alterations in patients with chronic heart failure (CHF) and their relation to exercise capacity. METHODS AND RESULTS:The ultrastructure of skeletal muscle was analyzed by ultrastructural morphometry in 57 patient...

journal_title：Circulation

authors： Drexler H,Riede U,Münzel T,König H,Funke E,Just H

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS:Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron mi...

journal_title：Circulation

authors： Seko Y,Shinkai Y,Kawasaki A,Yagita H,Okumura K,Takaku F,Yazaki Y

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Several clinical studies have demonstrated a general superiority of biphasic waveform defibrillation compared with monophasic waveform defibrillation using epicardial lead systems. To test the breadth of utility of biphasic waveforms in humans, a prospective, randomized evaluation of defibrillation efficacy ...

journal_title：Circulation

authors： Bardy GH,Troutman C,Johnson G,Mehra R,Poole JE,Dolack GL,Kudenchuk PJ,Gartman DM

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

journal_title：Circulation

authors： Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:Cyclosporin A is reported to impair endothelium-mediated vasorelaxation and induce endothelin release in some noncoronary vascular beds. We wished to determine whether acute cyclosporine administration induces endothelial dysfunction in coronary conductance or resistance arteries. METHODS AND RESULTS:We exa...

journal_title：Circulation

authors： Sudhir K,MacGregor JS,DeMarco T,De Groot CJ,Taylor RN,Chou TM,Yock PG,Chatterjee K

更新日期：1994-12-01 00:00:00

abstract：:Echocardiographic measurements of the left ventricle were used to define rates of circumferential fiber lengthening at the endocardium and midwall in 12 normal subjects and six patients with concentric left ventricular hypertrophy (wall thickness 11 to 16 mm). There was no difference in chamber size and systolic short...

journal_title：Circulation

authors： Shimizu G,Conrad CH,Gaasch WH

更新日期：1987-01-01 00:00:00

abstract：:Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...

journal_title：Circulation

authors： Goldstein RE,Michaelis LL,Morrow AG,Epstein SE

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) can cause an oxidative modification of nucleotides, such as 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), which can lead to defects in DNA replication. The misincorporation of 8-oxo-dGTP into DNA is prevented by 8-oxo-dGTPase, which hydrolyzes 8-oxo-dGTP into 8-oxo-...

journal_title：Circulation

authors： Tsutsui H,Ide T,Shiomi T,Kang D,Hayashidani S,Suematsu N,Wen J,Utsumi H,Hamasaki N,Takeshita A

更新日期：2001-12-11 00:00:00

abstract：BACKGROUND:Clinical studies have demonstrated the efficacy of intravenous administration of agents that block platelet glycoprotein IIb/IIIa receptors in the setting of percutaneous coronary revascularization. Although the optimal duration of treatment has not been determined, more prolonged receptor blockade has been ...

journal_title：Circulation

authors： Simpfendorfer C,Kottke-Marchant K,Lowrie M,Anders RJ,Burns DM,Miller DP,Cove CS,DeFranco AC,Ellis SG,Moliterno DJ,Raymond RE,Sutton JM,Topol EJ

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

journal_title：Circulation

authors： Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose of this multicenter clinical trial was to determine the dose-effect characteristics of beta-blockade...

journal_title：Circulation

authors： Bristow MR,O'Connell JB,Gilbert EM,French WJ,Leatherman G,Kantrowitz NE,Orie J,Smucker ML,Marshall G,Kelly P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：:Recent studies have shown that blood flow during closed-chest cardiopulmonary resuscitation (CPR) results primarily from generalized changes in intrathoracic pressure rather than direct compression of the heart. Since ascending aortic and right atrial pressures rise and fall synchronously and to comparable levels duri...

journal_title：Circulation

authors： Ditchey RV,Winkler JV,Rhodes CA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:We investigated whether electrical stimulation (STIM) of efferent vagus nerves may suppress nuclear factor (NF)-kappaB activation and the inflammatory cascade in hemorrhagic (Hem) shock. METHODS AND RESULTS:Rats were subjected to bilateral cervical vagotomy (VGX) or sham surgical procedures. Hem shock was i...

journal_title：Circulation

authors： Guarini S,Altavilla D,Cainazzo MM,Giuliani D,Bigiani A,Marini H,Squadrito G,Minutoli L,Bertolini A,Marini R,Adamo EB,Venuti FS,Squadrito F

更新日期：2003-03-04 00:00:00

abstract：:Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

journal_title：Circulation

authors： McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

journal_title：Circulation

authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in the L-type calcium current, is a major factor in the initiation and maintenance of atrial fibrillation (AF). We investigated underlying molecular changes by studying the relation between gene expression of the...

journal_title：Circulation

authors： Brundel BJ,Van Gelder IC,Henning RH,Tieleman RG,Tuinenburg AE,Wietses M,Grandjean JG,Van Gilst WH,Crijns HJ

更新日期：2001-02-06 00:00:00

abstract：BACKGROUND:Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction i...

journal_title：Circulation

authors： Wang CY,Wen MS,Wang HW,Hsieh IC,Li Y,Liu PY,Lin FC,Liao JK

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:In a correlative functional/histopathologic study, we investigated the regional deformation characteristics of both chronic nontransmural and transmural infarctions before and after a dobutamine challenge. METHODS AND RESULTS:After stenosing copper-coated stent implantation to produce circumflex artery endo...

journal_title：Circulation

authors： Weidemann F,Dommke C,Bijnens B,Claus P,D'hooge J,Mertens P,Verbeken E,Maes A,Van de Werf F,De Scheerder I,Sutherland GR

更新日期：2003-02-18 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and ther...

journal_title：Circulation

authors： Abozguia K,Elliott P,McKenna W,Phan TT,Nallur-Shivu G,Ahmed I,Maher AR,Kaur K,Taylor J,Henning A,Ashrafian H,Watkins H,Frenneaux M

更新日期：2010-10-19 00:00:00

abstract：:Fifty-six patients undergoing orthotopic cardiac transplantation were given Minnesota ALG prophylactically or therapeutically for acute cardiac rejection. During a follow-up period of 0-28 months (mean follow-up period, 11.9 months), the actuarial survival for the entire group was 96% and 86% at 30 days and 1 year, re...

journal_title：Circulation

authors： Keith FM,Magilligan DJ Jr,Lakier JB,Drost CJ

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

journal_title：Circulation

authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...

journal_title：Circulation

authors： Moreau M,Brocheriou I,Petit L,Ninio E,Chapman MJ,Rouis M

更新日期：1999-01-26 00:00:00

abstract：BACKGROUND:Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a syst...

journal_title：Circulation

authors： Chung AK,Das SR,Leonard D,Peshock RM,Kazi F,Abdullah SM,Canham RM,Levine BD,Drazner MH

更新日期：2006-03-28 00:00:00

abstract：BACKGROUND:Patients with bicuspid aortic valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAVR) devices. We sought to evaluate the outcomes of TAVR in patients with bicuspid AV stenosis in comparison with those with tricuspid AV stenosis. METHODS:We used data from the Soc...

journal_title：Circulation

authors： Halim SA,Edwards FH,Dai D,Li Z,Mack MJ,Holmes DR,Tuzcu EM,Thourani VH,Harrison JK,Brennan JM

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the influence of clinical characteristics on shock occurrence and survival in 241 patients with implantable cardioverter-defibrillator (ICD) therapy. METHODS AND RESULTS:Two hundred forty-one consecutive patients underwent ICD implantation between November 1982 and...

journal_title：Circulation

authors： Grimm W,Flores BT,Marchlinski FE

更新日期：1993-06-01 00:00:00