Abstract:
BACKGROUND:Acute coronary ischemia is usually initiated by rupture of atherosclerotic plaque, leading to intracoronary thrombosis and clinical sequelae. The proximate cause of plaque rupture is unknown. Accordingly, we investigated the potential role of the 92-kD gelatinase member of the matrix metalloproteinase family in acute coronary ischemia. METHODS AND RESULTS:Coronary atherectomy specimens from patients with atherosclerosis and an acute ischemic syndrome consistent with recent plaque rupture (unstable angina) (n = 12) were immunostained for the presence of 92-kD gelatinase; the results were compared with those obtained by identical study of atherectomy specimens from patients with atherosclerosis and angina but without acute ischemia (stable angina) (n = 12). Positive immunostaining for 92-kD gelatinase was present in 83% of specimens from both unstable and stable angina patients. However, intracellular localization of enzyme (indicating active synthesis) was documented in 10 of 10 positively stained specimens from patients with unstable angina compared with 3 of 10 positively stained specimens from patients with stable angina. Macrophages and smooth muscle cells were the major sources of 92-kD gelatinase in all specimens examined by immunostaining of adjacent sections. CONCLUSIONS:92-kD gelatinase is commonly expressed in coronary arterial atherosclerotic lesions. Active synthesis of 92-kD gelatinase by macrophages and smooth muscle cells in atherosclerotic lesions may play a pathogenic role in the development of acute coronary ischemia.
journal_name
Circulationjournal_title
Circulationauthors
Brown DL,Hibbs MS,Kearney M,Loushin C,Isner JMdoi
10.1161/01.cir.91.8.2125subject
Has Abstractpub_date
1995-04-15 00:00:00pages
2125-31issue
8eissn
0009-7322issn
1524-4539journal_volume
91pub_type
临床试验,杂志文章,随机对照试验相关文献
CIRCULATION文献大全abstract::The dominance of the coronary arterial system was determined angiographically in 75 adult patients with isolated aortic stenosis with or without insufficiency, 25 adult patients with pure aortic insufficiency, 51 adult patients with combined aortic stenosis and mitral valve disease, and 44 children with bicuspid aorti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.52.2.292
更新日期:1975-08-01 00:00:00
abstract::Prenalterol, a beta-adrenergic agonist, was given to nine patients with angiographically proved coronary artery disease. Subjects were studied during chronic beta-adrenergic blockade. The adequacy of blockade was assessed by the exercise heart rate response and by plasma concentrations of blocking agents. After increm...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.6.1135
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the i...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.CIR.0000147186.83715.95
更新日期:2004-11-09 00:00:00
abstract:BACKGROUND:Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc0402.102931
更新日期:2002-01-29 00:00:00
abstract:BACKGROUND:C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease and has been positively associated with body weight and body fatness. We examined the hypothesis that weight loss would reduce plasma CRP levels in obese postmenopausal women. METHODS AND RESULTS:In a sample ...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc0502.103331
更新日期:2002-02-05 00:00:00
abstract::More accurate characterization of coronary artery lesions is needed for evaluation of short and long-term interventions in coronary disease. A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms. Coronary lesions are traced from two projected, perpendi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.2.329
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect stent strut coverage in vivo on a micron-sca...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.110.963181
更新日期:2011-01-25 00:00:00
abstract:BACKGROUND:Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and ...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.117.030523
更新日期:2018-01-02 00:00:00
abstract:BACKGROUND:Increased carotid intimal-medial thickness (IMT) and coronary artery calcification (CAC) are used as 2 markers of early atherosclerosis. Our objectives were to assess whether increased IMT and CAC are related and to determine the relationship between cardiovascular risk factors and carotid IMT in young adult...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.8.838
更新日期:1999-08-24 00:00:00
abstract:BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.9.428
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The physiological effects of ACE inhibitors may act in part through a kinin-dependent mechanism. We investigated the effect of chronic ACE-inhibitor treatment on functional kinin B(1)- and B(2)-receptor expression, which are the molecular entities responsible for the biological effects of kinins. METHODS AN...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0502.102965
更新日期:2002-02-05 00:00:00
abstract:BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.2.814
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely. METHODS AND RESULTS:We analyzed data from 2174 participants aged 40...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000137913.26087.F0
更新日期:2004-08-10 00:00:00
abstract:BACKGROUND:Endocardial mapping using standard electrode catheters is often technically limited in ventricular tachycardia and constitutes a major obstacle to successful ablation. We wished to examine the utility of a basket-shaped multielectrode mapping catheter (MMC) in the mapping and ablation of ventricular tachycar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.7.2430
更新日期:1997-10-07 00:00:00
abstract:BACKGROUND:The incidence, determinants, and outcome of postoperative atrial fibrillation (AF) after surgery for mitral regurgitation (MR) are poorly defined but may have important implications for timing of mitral valve surgery. METHODS AND RESULTS:In 762 patients in sinus rhythm with no AF history undergoing MR surgi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000145121.25259.54
更新日期:2004-10-19 00:00:00
abstract:BACKGROUND:To evaluate the effect of plasminogen activator inhibitor type 1 (PAI-1) levels on the clearance of total tissue plasminogen activator (TPA) antigen, we studied the clearance of active TPA and TPA/PAI-1 complex in subjects with low (181+/-109 pmol/L; n=7) and high (1166+/-322 pmol/L; n=4) baseline active PAI...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.3.761
更新日期:1997-08-05 00:00:00
abstract:BACKGROUND:The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. METHODS AND RESULTS:We randomized 70 acute coronary syndrome patients undergoing percu...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.0000029744.01096.1f
更新日期:2002-09-17 00:00:00
abstract::Population cardiovascular health, or improving cardiovascular health among patients and the population at large, requires a redoubling of primordial and primary prevention efforts as declines in cardiovascular disease mortality have decelerated over the past decade. Great potential exists for healthcare systems-based ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIR.0000000000000913
更新日期:2021-01-12 00:00:00
abstract::To determine whether calcium channel blockers influence the progression of coronary atherosclerosis, 383 patients age 65 years or less with 5-75% stenoses in at least four coronary artery segments were selected at random within 1 month of coronary arteriography to participate in double-blind therapy with a placebo or ...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.82.6.1940
更新日期:1990-12-01 00:00:00
abstract::Six cases of classical dissecting aneurysm of the aorta complicating aortic valvular disease in which aortic stenosis was dominant are described. In three of the cases the aortic complication occurred after the natural aortic valve had been replaced by a prosthetic valve. The longest postoperative period was four mont...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.1.169
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS:To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.005296
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.5.1381
更新日期:1997-09-02 00:00:00
abstract:BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.012211
更新日期:2011-06-21 00:00:00
abstract:BACKGROUND:Coronary perforation is a life-threatening complication of percutaneous interventions. In the past few years, the implantation of covered stents has emerged as a strategy for treatment when the traditional conservative approach (ie, prolonged balloon inflation and reversal of anticoagulation) fails. METHODS...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.102.25.3028
更新日期:2000-12-19 00:00:00
abstract:BACKGROUND:Clinical studies have implicated preinfarct angina (brief antecedent ischemia/reperfusion [I/R]) as a predictor of more rapid thrombolysis and lower rates of reocclusion. However, the effects of antecedent ischemia on the efficacy of thrombolysis have not been rigorously assessed. Using a canine model of cor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.1.88
更新日期:2000-07-04 00:00:00
abstract:BACKGROUND:Hypertension decreases myocardial perfusion capacity in adults for several reasons, including insufficient coronary angiogenesis with left ventricular (LV) hypertrophy, arteriolar hypertrophy, and altered vasomotion. Heparin influences growth factors that promote angiogenesis and vasodilation and inhibit art...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.9.981
更新日期:1999-08-31 00:00:00
abstract:BACKGROUND:Experimental studies suggest that arterial injury and inflammation lead to increased neointimal growth after stenting. Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis. METHODS AND RESULTS:Detailed histology...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000019071.72887.bd
更新日期:2002-06-25 00:00:00
abstract::Two hundred forty-five patients with variant angina were followed for an average of 80.5 months (range, 36-184 months). Survival rate at 1, 3, 5, and 10 years was 98%, 97%, 97%, and 93%, respectively. Survival rate without myocardial infarction at 1, 3, 5, and 10 years was 86%, 85%, 83%, and 81%, respectively. By univ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.1.1
更新日期:1988-07-01 00:00:00
abstract::Ten patients with the long QT syndrome and recurrent syncope and/or cardiac arrest caused by ventricular arrhythmias underwent left stellate (one patient) or left cervicothoracic sympathectomy (nine patients) after failing to respond to high-dose beta-blocker therapy. The syndrome was familial in four and idiopathic i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.6.1018
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Previous reports have suggested that an attenuated exercise heart rate response may be associated with coronary heart disease risk and with mortality. These observations may parallel the association between reduced heart rate variability during normal activities and adverse outcome. This investigation was de...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.cir.93.8.1520
更新日期:1996-04-15 00:00:00