8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts.

abstract：:One hundred consecutive men with a normal ECG at rest had a maximal treadmill test using 14 leads during and post-exercise. Coronary arteriography performed the following day revealed coronary stenoses greater than or equal to 70% in 66 patients. Test results obtained from a V5 lead were compared to different lead com...

journal_title：Circulation

authors： Chaitman BR,Bourassa MG,Wagniart P,Corbara F,Ferguson RJ

更新日期：1978-01-01 00:00:00

abstract：:Labetalol was administered to six hypertensive subjects in increasing doses for seven days. A decrease in both supine and standing arterial pressure and heart rate was observed with no change in cardiac output and few side effects. Exercise tolerance was unaltered by the drug, but the heart rate and arterial pressure ...

journal_title：Circulation

authors： Mehta J,Cohn JN

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte a...

journal_title：Circulation

authors： Zhang WJ,Bird KE,McMillen TS,LeBoeuf RC,Hagen TM,Frei B

更新日期：2008-01-22 00:00:00

abstract：:Although immediate and late changes in coronary stenoses after percutaneous transluminal coronary angioplasty (PTCA) have been reported, most investigators have employed qualitative or semiquantitative techniques to analyze the angiograms. Such data is not optimal because of considerable interobserver variability and ...

journal_title：Circulation

authors： Johnson MR,Brayden GP,Ericksen EE,Collins SM,Skorton DJ,Harrison DG,Marcus ML,White CW

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS:We performe...

journal_title：Circulation

authors： Pieper PG,Balci A,Aarnoudse JG,Kampman MA,Sollie KM,Groen H,Mulder BJ,Oudijk MA,Roos-Hesselink JW,Cornette J,van Dijk AP,Spaanderman ME,Drenthen W,van Veldhuisen DJ,ZAHARA II investigators.

更新日期：2013-12-03 00:00:00

abstract：BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

journal_title：Circulation

authors： Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

更新日期：2006-06-27 00:00:00

abstract：:Cardiac events of early diastole were studied in 50 normal subjects and 46 patients with mitral stenosis (MS) by simultaneous recordings of the mitral valve echogram (MVE), phonocardiogram, and apexcardiogram (ACG). Left ventricular isovolumic relaxation time (IRT), measured between A2 and onset of the MVE opening mot...

journal_title：Circulation

authors： Toutouzas P,Velimezis A,Castellanos S,Avgoustakis D

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...

journal_title：Circulation

authors： Bozkurt B,Kribbs SB,Clubb FJ Jr,Michael LH,Didenko VV,Hornsby PJ,Seta Y,Oral H,Spinale FG,Mann DL

更新日期：1998-04-14 00:00:00

abstract：BACKGROUND:Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because such thera...

journal_title：Circulation

authors： Chyu KY,Babbidge SM,Zhao X,Dandillaya R,Rietveld AG,Yano J,Dimayuga P,Cercek B,Shah PK

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：:To assess whether gross pathologic differences exist between hearts with left bundle branch block (LBBB) and left-axis deviation (LAXD) and those with LBBB and a normal frontal plane axis, we examined 70 hearts with LBBB in a series of 1410 sequential dissections (5%). Thirty-two hearts had LAXD and 34 had normal axes...

journal_title：Circulation

authors： Havelda CJ,Sohi GS,Flowers NC,Horan LG

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:The involvement of the complement system in brain injury has been scarcely investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic injury. METHODS AND RESULTS:Focal cerebral ischemia was induced in...

journal_title：Circulation

authors： Orsini F,Villa P,Parrella S,Zangari R,Zanier ER,Gesuete R,Stravalaci M,Fumagalli S,Ottria R,Reina JJ,Paladini A,Micotti E,Ribeiro-Viana R,Rojo J,Pavlov VI,Stahl GL,Bernardi A,Gobbi M,De Simoni MG

更新日期：2012-09-18 00:00:00

abstract：BACKGROUND:The positions, sizes, and shapes of ventricular septal defects (VSDs) can be difficult to assess by 2-dimensional echocardiography (2DE). Volume-rendered 3-dimensional echocardiography (3DE) can provide unique views of VSDs from the left ventricular (LV) side, allowing complete assessment of their circumfere...

journal_title：Circulation

authors： Kardon RE,Cao QL,Masani N,Sugeng L,Supran S,Warner KG,Pandian NG,Marx GR

更新日期：1998-09-29 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：:Systolic time intervals, stroke volume, cardiac output and (dZ/dt)/RZ index were serially estimated in 51 normal healthy volunteers at sea level, for ten days after air induction to 3658 m altitude and on return to sea level. The subjects were divided into three groups and were administered a diuretic, beta methyldigo...

journal_title：Circulation

authors： Balasubramanian V,Behl A,Das GS,Wadhwa AK,Mathew OP,Hoon RS

更新日期：1978-06-01 00:00:00

abstract：:Many basic concepts of cardiac output and arterial pressure control have changed considerably in the past few years. In general, each tissue controls its own local resistance and blood flow regardless of the level of arterial pressure; the sum of the local flows then determines the venous return and cardiac output. Ho...

journal_title：Circulation

authors： Guyton AC

更新日期：1981-12-01 00:00:00

abstract：:Recent molecular studies have suggested that viral myocarditis frequently underlies human congestive cardiomyopathy; however, only moderately sensitive and specific techniques were used. Polymerase chain reaction (PCR) gene amplification is a sensitive, specific technique ideally suited for the diagnosis of viral dise...

journal_title：Circulation

authors： Jin O,Sole MJ,Butany JW,Chia WK,McLaughlin PR,Liu P,Liew CC

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that intracoronary delivery of an adenovirus encoding adenylyl cyclase type VI (Ad.AC(VI)) would be associated with increased left ventricular (LV) function in pigs with congestive heart failure. METHODS AND RESULTS:Pigs (52+/-6 kg; n=16) underwent placement of pacemakers, LV pressu...

journal_title：Circulation

authors： Lai NC,Roth DM,Gao MH,Tang T,Dalton N,Lai YY,Spellman M,Clopton P,Hammond HK

更新日期：2004-07-20 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:We investigated the effects of candesartan (an angiotensin II antagonist) alone, enalapril alone, and their combination on exercise tolerance, ventricular function, quality of life (QOL), neurohormone levels, and tolerability in congestive heart failure (CHF). METHODS AND RESULTS:Seven hundred sixty-eight p...

journal_title：Circulation

authors： McKelvie RS,Yusuf S,Pericak D,Avezum A,Burns RJ,Probstfield J,Tsuyuki RT,White M,Rouleau J,Latini R,Maggioni A,Young J,Pogue J

更新日期：1999-09-07 00:00:00

abstract：BACKGROUND:Epidemiological studies and animal experiments have provided evidence supporting the role of lipid peroxidation in atherogenesis and cardiovascular diseases. Direct evidence linking lipid oxidation to atherosclerotic progression in humans, however, has been lacking. We investigated the association of lipid o...

journal_title：Circulation

authors： Salonen JT,Nyyssönen K,Salonen R,Porkkala-Sarataho E,Tuomainen TP,Diczfalusy U,Björkhem I

更新日期：1997-02-18 00:00:00

abstract：:The pathogenesis of paradoxical hypertension after resection of coarctation of the aorta was investigated by comparing the course of seven children undergoing repair of coarctation with five acyanotic children undergoing elective cardiovascular surgery. During the first 24 hours after surgery, all coarctation patients...

journal_title：Circulation

authors： Rocchini AP,Rosenthal A,Barger AC,Castaneda AR,Nadas AS

更新日期：1976-09-01 00:00:00

abstract：:Eleven patients underwent exercise testing after operative repair of anomalous origin of the left coronary artery from the pulmonary artery. Five patients repaired after 2 years of age comprised a childhood surgery group, and six patients repaired before 2 years of age comprised an infant surgery group. All patients w...

journal_title：Circulation

authors： Paridon SM,Farooki ZQ,Kuhns LR,Arciniegas E,Pinsky WW

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Functional mitral regurgitation (MR) is common in patients with heart failure and left ventricular (LV) dysfunction, and its severity may vary over time, depending primarily on the loading conditions. Because dynamic changes in the severity of functional MR may affect forward stroke volume, we hypothesized t...

journal_title：Circulation

authors： Lapu-Bula R,Robert A,Van Craeynest D,D'Hondt AM,Gerber BL,Pasquet A,Melin JA,De Kock M,Vanoverschelde JL

更新日期：2002-09-10 00:00:00

abstract：BACKGROUND:Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. METHODS AND ...

journal_title：Circulation

authors： Kodama K,Nishigami K,Sakamoto T,Sawamura T,Hirayama T,Misumi H,Nakao K

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...

journal_title：Circulation

authors： Khairy P,Aboulhosn J,Gurvitz MZ,Opotowsky AR,Mongeon FP,Kay J,Valente AM,Earing MG,Lui G,Gersony DR,Cook S,Ting JG,Nickolaus MJ,Webb G,Landzberg MJ,Broberg CS,Alliance for Adult Research in Congenital Cardiology (AARCC).

更新日期：2010-08-31 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...

journal_title：Circulation

authors： Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

更新日期：1995-11-15 00:00:00

abstract：:Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...

journal_title：Circulation

authors： Haudenschild C,Gould KE,Quist WC,LoGerfo FW

更新日期：1981-08-01 00:00:00