Abstract:
:Labetalol was administered to six hypertensive subjects in increasing doses for seven days. A decrease in both supine and standing arterial pressure and heart rate was observed with no change in cardiac output and few side effects. Exercise tolerance was unaltered by the drug, but the heart rate and arterial pressure response to exercise were significantly blunted. The infusion rate of isoproterenol required to produce tachycardia was increased sevenfold by 800 mg/day labetalol and tenfold by 1600 mg/day. More than twice the control dose of phenylephrine was required during labetalol therapy to produce a rise in diastolic arterial pressure reflex tachycardia to amyl nitrite-induced hypotension was attenuated. These studies indingina pectoris.
journal_name
Circulationjournal_title
Circulationauthors
Mehta J,Cohn JNdoi
10.1161/01.cir.55.2.370subject
Has Abstractpub_date
1977-02-01 00:00:00pages
370-5issue
2eissn
0009-7322issn
1524-4539journal_volume
55pub_type
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